JP2002535378A5 - - Google Patents

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Publication number
JP2002535378A5
JP2002535378A5 JP2000595715A JP2000595715A JP2002535378A5 JP 2002535378 A5 JP2002535378 A5 JP 2002535378A5 JP 2000595715 A JP2000595715 A JP 2000595715A JP 2000595715 A JP2000595715 A JP 2000595715A JP 2002535378 A5 JP2002535378 A5 JP 2002535378A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
bmp
composition according
protein
osteochondral graft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000595715A
Other languages
English (en)
Other versions
JP2002535378A (ja
Filing date
Publication date
Priority claimed from US09/493,543 external-priority patent/US6281638B1/en
Application filed filed Critical
Priority claimed from PCT/US2000/002430 external-priority patent/WO2000044413A1/en
Publication of JP2002535378A publication Critical patent/JP2002535378A/ja
Publication of JP2002535378A5 publication Critical patent/JP2002535378A5/ja
Pending legal-status Critical Current

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Description

【特許請求の範囲】
【請求項１】
骨軟骨移植片および少なくとも１種の精製骨形態形成蛋白（ＢＭＰ）を含む、骨関節炎を治療するための医薬組成物。
【請求項２】
ＢＭＰがＢＭＰ−２である請求項１の医薬組成物。
【請求項３】
Ｖｇｒ−２、成長および分化因子（ＧＤＦ）、ならびにＢＩＰからなる群より選択される少なくとも１種の精製蛋白をさらに含む、請求項１の医薬組成物。
【請求項４】
腱または靭帯様組織の形成を誘導する蛋白をさらに含む請求項１の医薬組成物。
【請求項５】
腱または靭帯様組織の形成を誘導する蛋白がＢＭＰ−１２、ＢＭＰ−１３、ＢＭＰ−１２サブファミリーのメンバーおよびＭＰ５２からなる群より選択されるものである、請求項４の医薬組成物。
【請求項６】
骨軟骨移植片が異型移植片である請求項１の医薬組成物。
【請求項７】
骨軟骨移植片が自家移植片である請求項１の医薬組成物。
【請求項８】
骨軟骨移植片がモザイク形成術により得られるものである請求項１の医薬組成物。

JP2000595715A 1999-02-01 2000-01-31 関節軟骨の治癒および修復のための方法および組成物 Pending JP2002535378A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11816099P 1999-02-01 1999-02-01
US60/118,160 1999-02-01
US09/493,543 2000-01-28
US09/493,543 US6281638B1 (en) 1997-10-10 2000-01-28 Converter/inverter full bridge ballast circuit
PCT/US2000/002430 WO2000044413A1 (en) 1999-02-01 2000-01-31 Methods and compositions for healing and repair of articular cartilage

Publications (2)

Publication Number Publication Date
JP2002535378A JP2002535378A (ja) 2002-10-22
JP2002535378A5 true JP2002535378A5 (ja) 2006-12-21

Family

ID=26816029

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000595715A Pending JP2002535378A (ja) 1999-02-01 2000-01-31 関節軟骨の治癒および修復のための方法および組成物

Country Status (10)

Country Link
EP (1) EP1148897B1 (ja)
JP (1) JP2002535378A (ja)
AT (1) ATE255920T1 (ja)
BR (1) BR0007892A (ja)
CZ (1) CZ20012782A3 (ja)
HU (1) HUP0105312A3 (ja)
IL (1) IL144523A0 (ja)
NO (1) NO323630B1 (ja)
PT (1) PT1148897E (ja)
WO (1) WO2000044413A1 (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2685349C (en) 1999-11-15 2013-09-17 Bio Syntech Canada Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
EP1294414B1 (en) 2000-06-29 2006-03-15 Biosyntech Canada Inc. Composition and method for the repair and regeneration of cartilage and other tissues
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2438934A1 (en) * 2001-02-23 2002-09-06 Wyeth Chondrogenic potential of human bone marrow-derived cd105+ cells by bmp
US7005127B2 (en) * 2002-03-29 2006-02-28 Tissuegene, Inc. Mixed-cell gene therapy
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8221780B2 (en) * 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
JP5201987B2 (ja) * 2004-05-25 2013-06-05 ストライカー コーポレイション 軟骨欠損を処置するための、形態形成タンパク質の使用
US20060194726A1 (en) * 2004-05-25 2006-08-31 Rueger David C Methods of treating cartilage defects

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
IL106278A0 (en) * 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
AU689184B2 (en) * 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5902785A (en) * 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
WO1998031788A1 (en) * 1997-01-21 1998-07-23 Genetics Institute, Inc. Injectable formulations for treatment of osteoporotic bone
AU756785B2 (en) * 1998-07-13 2003-01-23 University Of Southern California Methods for accelerating bone and cartilage growth and repair

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