JP2002531564A - ピリジル−橋頭誘導体およびそれらの類縁体、医用組成物およびニコチン性コリン作用性受容体の阻害物質としてのそれらの使用 - Google Patents
ピリジル−橋頭誘導体およびそれらの類縁体、医用組成物およびニコチン性コリン作用性受容体の阻害物質としてのそれらの使用Info
- Publication number
- JP2002531564A JP2002531564A JP2000586722A JP2000586722A JP2002531564A JP 2002531564 A JP2002531564 A JP 2002531564A JP 2000586722 A JP2000586722 A JP 2000586722A JP 2000586722 A JP2000586722 A JP 2000586722A JP 2002531564 A JP2002531564 A JP 2002531564A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- bond
- group
- azabicyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 238000000034 method Methods 0.000 claims description 88
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- 125000002877 alkyl aryl group Chemical group 0.000 claims description 42
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- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 12
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- 239000000126 substance Substances 0.000 description 11
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
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- QCIUVDYZQNETIG-UHFFFAOYSA-N 2-(pyridin-3-ylmethylidene)-1-azabicyclo[2.2.2]octan-3-one Chemical compound O=C1C(CC2)CCN2C1=CC1=CC=CN=C1 QCIUVDYZQNETIG-UHFFFAOYSA-N 0.000 description 9
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- QJZUKDFHGGYHMC-UHFFFAOYSA-N pyridine-3-carbaldehyde Chemical compound O=CC1=CC=CN=C1 QJZUKDFHGGYHMC-UHFFFAOYSA-N 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- 230000002194 synthesizing effect Effects 0.000 description 7
- WKYVGBPCXOPWEA-UHFFFAOYSA-N 4-bromopyridine-3-carbaldehyde Chemical group BrC1=CC=NC=C1C=O WKYVGBPCXOPWEA-UHFFFAOYSA-N 0.000 description 6
- PVUKGNBRJFTFNJ-UHFFFAOYSA-N 6-bromopyridine-3-carbaldehyde Chemical group BrC1=CC=C(C=O)C=N1 PVUKGNBRJFTFNJ-UHFFFAOYSA-N 0.000 description 6
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- HALWUDBBYKMYPW-STOWLHSFSA-M trimethaphan camsylate Chemical compound C1C[C@@]2(CS([O-])(=O)=O)C(=O)C[C@@H]1C2(C)C.C12C[S+]3CCCC3C2N(CC=2C=CC=CC=2)C(=O)N1CC1=CC=CC=C1 HALWUDBBYKMYPW-STOWLHSFSA-M 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/210,113 US6432975B1 (en) | 1998-12-11 | 1998-12-11 | Pharmaceutical compositions and methods for use |
| US09/210,113 | 1998-12-11 | ||
| PCT/US1999/019906 WO2000034276A1 (en) | 1998-12-11 | 1999-08-31 | Pyridyl-bridgehead derivatives and their analogues, pharmaceutical compositions and their use as inhibitors of nicotinic cholinergic receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531564A true JP2002531564A (ja) | 2002-09-24 |
| JP2002531564A5 JP2002531564A5 (https=) | 2006-12-28 |
Family
ID=22781623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586722A Withdrawn JP2002531564A (ja) | 1998-12-11 | 1999-08-31 | ピリジル−橋頭誘導体およびそれらの類縁体、医用組成物およびニコチン性コリン作用性受容体の阻害物質としてのそれらの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6432975B1 (https=) |
| EP (1) | EP1053236A1 (https=) |
| JP (1) | JP2002531564A (https=) |
| AU (1) | AU5699399A (https=) |
| BR (1) | BR9907169A (https=) |
| CA (1) | CA2317025A1 (https=) |
| WO (1) | WO2000034276A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006518746A (ja) * | 2003-02-21 | 2006-08-17 | ターガセプト，インコーポレイテッド | ３−置換−２（アリールアルキル）−１−アザビシクロアルカンおよびこれらの使用方法 |
| JP2008088090A (ja) * | 2006-09-29 | 2008-04-17 | Kanto Chem Co Inc | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| JP2008088089A (ja) * | 2006-09-29 | 2008-04-17 | Kanto Chem Co Inc | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1212301A1 (en) * | 1999-08-31 | 2002-06-12 | Targacept, Inc. | Arylalkyloxyalkylamines and arylalkylthioalkylamines, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors |
| US6890935B2 (en) * | 1999-11-01 | 2005-05-10 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| JP2003513054A (ja) * | 1999-11-01 | 2003-04-08 | ターガセプト，インコーポレイテッド | アリールオレフィンアザ環式化合物及びアリールアセチレンアザ環式化合物、それらを含有する薬剤組成物、及び、ニコチンコリン作動性受容体の阻害薬としてのそれらの使用 |
| WO2002024692A1 (en) * | 2000-09-20 | 2002-03-28 | Karolinska Innovations Ab | 1-azabicyclo[2.2.2]octan-3-one derivatives and maleimide derivatives and their use for treating cancer tumors |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| US7659278B2 (en) | 2002-02-21 | 2010-02-09 | Aprea Ab | Use of low molecular weight compounds for preparing a medicament useful in treating mutant p53 mediated diseases |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| WO2004039815A2 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases |
| WO2004052365A2 (en) * | 2002-12-06 | 2004-06-24 | North Shore-Long Island Jewish Research Institute | Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists |
| US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
| SE0400708D0 (sv) * | 2004-03-22 | 2004-03-22 | Aprea Ab | New compounds and use thereof |
| PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| KR20180011888A (ko) | 2008-11-19 | 2018-02-02 | 포럼 파마슈티칼즈 인크. | (ｒ)-７-클로로-ｎ-(퀴누클리딘-３-일)벤조［ｂ］티오펜-２-카르복사미드 및 그 약학적으로 허용가능한 염을 이용한 인지 장애의 치료 |
| TW201031664A (en) * | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| AR081402A1 (es) | 2010-05-17 | 2012-08-29 | Envivo Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato |
| CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| SG11201407336PA (en) | 2012-05-25 | 2015-03-30 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| EA201790376A1 (ru) * | 2014-09-05 | 2017-08-31 | Селджен Квонтисел Рисёрч, Инк. | Ингибиторы лизин-специфической деметилазы-1 |
| US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
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| US4203990A (en) * | 1979-04-30 | 1980-05-20 | G. D. Searle & Co. | Anti-diarrheal 2-substituted quinuclidines |
| EP0353189B1 (de) * | 1988-07-28 | 1994-01-12 | Ciba-Geigy Ag | Kupfer- und Nickeldihalogenidkomplexe, Verfahren zu deren Herstellung und deren Verwendung |
| EP0402056A3 (en) | 1989-06-06 | 1991-09-04 | Beecham Group p.l.c. | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them |
| EP0412798A3 (en) | 1989-08-08 | 1992-07-01 | Merck Sharp & Dohme Ltd. | Substituted pyridines, their preparation, formulations and use in dementia |
| EP0492903A1 (en) | 1990-12-21 | 1992-07-01 | MERCK SHARP & DOHME LTD. | Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma |
| US5212188A (en) | 1992-03-02 | 1993-05-18 | R. J. Reynolds Tabacco Company | Method for treatment of neurodegenerative diseases |
| US5276043A (en) | 1992-04-10 | 1994-01-04 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| IL107184A (en) | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
| US5852041A (en) | 1993-04-07 | 1998-12-22 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acethylcholine receptors |
| AU7474794A (en) | 1993-07-22 | 1995-02-20 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
| US5510355A (en) | 1994-09-06 | 1996-04-23 | Bencherif; Merouane | Depolarizing skeletal muscle relaxants |
| US5998404A (en) | 1994-10-24 | 1999-12-07 | Eli Lilly And Company | Heterocyclic compounds and their use |
| US5616707A (en) | 1995-01-06 | 1997-04-01 | Crooks; Peter A. | Compounds which are useful for prevention and treatment of central nervous system disorders |
| US5604231A (en) | 1995-01-06 | 1997-02-18 | Smith; Carr J. | Pharmaceutical compositions for prevention and treatment of ulcerative colitis |
| US5597919A (en) | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5824692A (en) | 1995-01-06 | 1998-10-20 | Lippiello; Patrick Michael | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5859004A (en) | 1995-02-17 | 1999-01-12 | Novo Nordisk A/S | Use of heterocyclic compounds for the treatment of conditions caused by malfunctioning of the nicotinic cholinergic system |
| US5583140A (en) | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| EP0842172A1 (en) | 1995-06-29 | 1998-05-20 | Novo Nordisk A/S | Novel substituted azacyclic or azabicyclic compounds |
| JPH11512443A (ja) | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
| US5616716A (en) | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
| US5663356A (en) | 1996-04-23 | 1997-09-02 | Ruecroft; Graham | Method for preparation of aryl substituted alefinic secondary amino compounds |
| ZA9711092B (en) | 1996-12-11 | 1999-07-22 | Smithkline Beecham Corp | Novel compounds. |
| US5861423A (en) | 1997-02-21 | 1999-01-19 | Caldwell; William Scott | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
| US5811442A (en) | 1997-02-21 | 1998-09-22 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow |
| CA2289574C (en) | 1997-05-30 | 2007-04-24 | Neurosearch A/S | 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors |
| PT994875E (pt) | 1997-06-30 | 2004-06-30 | Targacept Inc | Derivados de 3-piridil-1-aza-biciclo-alcano para a prevencao e tratamento de desordens do snc |
| WO1999051602A1 (en) | 1998-04-02 | 1999-10-14 | R.J. Reynolds Tobacco Company | Azatricyclo[3.3.1.1] decane derivatives and pharmaceutical compositions containing them |
| US5952339A (en) | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
-
1998
- 1998-12-11 US US09/210,113 patent/US6432975B1/en not_active Expired - Lifetime
-
1999
- 1999-08-31 WO PCT/US1999/019906 patent/WO2000034276A1/en not_active Ceased
- 1999-08-31 EP EP99944011A patent/EP1053236A1/en not_active Withdrawn
- 1999-08-31 AU AU56993/99A patent/AU5699399A/en not_active Abandoned
- 1999-08-31 CA CA002317025A patent/CA2317025A1/en not_active Abandoned
- 1999-08-31 JP JP2000586722A patent/JP2002531564A/ja not_active Withdrawn
- 1999-08-31 BR BR9907169-0A patent/BR9907169A/pt not_active Application Discontinuation
-
2002
- 2002-06-04 US US10/162,129 patent/US20030045523A1/en not_active Abandoned
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006518746A (ja) * | 2003-02-21 | 2006-08-17 | ターガセプト，インコーポレイテッド | ３−置換−２（アリールアルキル）−１−アザビシクロアルカンおよびこれらの使用方法 |
| JP2011137009A (ja) * | 2003-02-21 | 2011-07-14 | Targacept Inc | ３−置換−２（アリールアルキル）−１−アザビシクロアルカンおよびこれらの使用方法 |
| JP2011137010A (ja) * | 2003-02-21 | 2011-07-14 | Targacept Inc | ３−置換−２（アリールアルキル）−１−アザビシクロアルカンおよびこれらの使用方法 |
| JP4828407B2 (ja) * | 2003-02-21 | 2011-11-30 | ターガセプト，インコーポレイテッド | ３−置換−２（アリールアルキル）−１−アザビシクロアルカンおよびこれらの使用方法 |
| JP2008088090A (ja) * | 2006-09-29 | 2008-04-17 | Kanto Chem Co Inc | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| JP2008088089A (ja) * | 2006-09-29 | 2008-04-17 | Kanto Chem Co Inc | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| US7687630B2 (en) | 2006-09-29 | 2010-03-30 | Kanto Kagaku Kabushiki Kaisha | Method for producing optically active quinuclidinols having one or more substituted groups at the 2-position |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000034276A1 (en) | 2000-06-15 |
| US20030045523A1 (en) | 2003-03-06 |
| BR9907169A (pt) | 2000-10-17 |
| CA2317025A1 (en) | 2000-06-15 |
| EP1053236A1 (en) | 2000-11-22 |
| US6432975B1 (en) | 2002-08-13 |
| AU5699399A (en) | 2000-06-26 |
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