JP2002528115A5 - - Google Patents
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- Publication number
- JP2002528115A5 JP2002528115A5 JP2000579719A JP2000579719A JP2002528115A5 JP 2002528115 A5 JP2002528115 A5 JP 2002528115A5 JP 2000579719 A JP2000579719 A JP 2000579719A JP 2000579719 A JP2000579719 A JP 2000579719A JP 2002528115 A5 JP2002528115 A5 JP 2002528115A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- amount
- present
- cell
- tcrγδ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 52
- 210000004027 cell Anatomy 0.000 description 32
- 210000001744 T-lymphocyte Anatomy 0.000 description 26
- 102000000588 Interleukin-2 Human genes 0.000 description 13
- 108010002350 Interleukin-2 Proteins 0.000 description 13
- 102000004388 Interleukin-4 Human genes 0.000 description 8
- 108090000978 Interleukin-4 Proteins 0.000 description 8
- 239000003226 mitogen Substances 0.000 description 7
- 238000012258 culturing Methods 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 3
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 3
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 3
- 229940028885 interleukin-4 Drugs 0.000 description 3
- 230000002062 proliferating effect Effects 0.000 description 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 2
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 description 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 description 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 2
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 210000005087 mononuclear cell Anatomy 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108010062580 Concanavalin A Proteins 0.000 description 1
- 102100035716 Glycophorin-A Human genes 0.000 description 1
- 108091005250 Glycophorins Proteins 0.000 description 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10700698P | 1998-11-04 | 1998-11-04 | |
| US60/107,006 | 1998-11-04 | ||
| PCT/CA1999/001024 WO2000026347A1 (en) | 1998-11-04 | 1999-11-04 | Methods for the production of tcr gamma delta t cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002528115A JP2002528115A (ja) | 2002-09-03 |
| JP2002528115A5 true JP2002528115A5 (https=) | 2006-12-28 |
| JP4435985B2 JP4435985B2 (ja) | 2010-03-24 |
Family
ID=22314363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000579719A Expired - Fee Related JP4435985B2 (ja) | 1998-11-04 | 1999-11-04 | ＴｃＲγδＴ細胞の生産方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6537812B1 (https=) |
| EP (1) | EP1127107B1 (https=) |
| JP (1) | JP4435985B2 (https=) |
| AT (1) | ATE421573T1 (https=) |
| AU (1) | AU759373B2 (https=) |
| CA (1) | CA2349629C (https=) |
| DE (1) | DE69940352D1 (https=) |
| ES (1) | ES2319942T3 (https=) |
| NZ (1) | NZ511760A (https=) |
| WO (1) | WO2000026347A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030157060A1 (en) * | 2000-04-03 | 2003-08-21 | Bell David N | Production of tcr gamma delta t cells |
| ES2336302T3 (es) * | 2000-04-03 | 2010-04-12 | Therapure Biopharma Inc. | Produccion de celulas ttcr gamma delta. |
| DE602005022728D1 (de) * | 2004-08-19 | 2010-09-16 | Univ Cardiff | Präparation antigenpräsentierender menschlicher gamma delta t-zellen und verwendung in der immuntherapie |
| CN101313061B (zh) * | 2005-11-18 | 2013-05-15 | 大学健康网络 | 扩增双阴性t细胞的方法 |
| CA2659697A1 (en) | 2006-08-01 | 2008-02-07 | Arigen Pharmaceuticals, Inc. | Method of proliferating lak cell |
| GB201421716D0 (en) * | 2014-12-05 | 2015-01-21 | King S College London | Cell expansion procedure |
| AU2016274633B2 (en) | 2015-06-09 | 2022-04-21 | Gammadelta Therapeutics Ltd | Methods for the production of TCR gamma delta+ T cells |
| DK3307875T3 (da) | 2015-06-09 | 2022-03-21 | Lymphact Lymphocyte Activation Tech S A | Fremgangsmåder til fremstilling af tcr-gamma-delta+-t-celler |
| WO2017072367A1 (en) | 2015-10-30 | 2017-05-04 | Cancer Research Technology Limited | EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT γδ T CELLS AND USES OF THESE CELLS |
| GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| CN113423820A (zh) * | 2018-11-08 | 2021-09-21 | 伽马三角洲疗法有限公司 | 分离和扩增细胞的方法 |
| WO2022032665A1 (zh) * | 2020-08-14 | 2022-02-17 | 上海星华生物医药科技有限公司 | 一种制备通用型免疫细胞的方法及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639653A (en) * | 1993-07-19 | 1997-06-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy | Method for proliferating Vγ2Vδ2 T cells |
| US5877299A (en) * | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| EP0937258A2 (en) * | 1996-10-29 | 1999-08-25 | Fred Hutchinson Cancer Research Center, Inc. | Cell stress regulated human mhc class i gene |
| CA2278847A1 (en) * | 1997-01-31 | 1998-08-06 | Hemosol Inc. | Method for the production of selected lymphocytes |
| WO1999046365A1 (en) | 1998-03-12 | 1999-09-16 | Emory University | Methods and compositions for the selective expansion of gamma/delta t-cells |
-
1999
- 1999-11-04 AT AT99953463T patent/ATE421573T1/de not_active IP Right Cessation
- 1999-11-04 ES ES99953463T patent/ES2319942T3/es not_active Expired - Lifetime
- 1999-11-04 US US09/807,987 patent/US6537812B1/en not_active Expired - Lifetime
- 1999-11-04 WO PCT/CA1999/001024 patent/WO2000026347A1/en not_active Ceased
- 1999-11-04 DE DE69940352T patent/DE69940352D1/de not_active Expired - Lifetime
- 1999-11-04 AU AU10219/00A patent/AU759373B2/en not_active Ceased
- 1999-11-04 EP EP99953463A patent/EP1127107B1/en not_active Expired - Lifetime
- 1999-11-04 NZ NZ511760A patent/NZ511760A/en unknown
- 1999-11-04 CA CA2349629A patent/CA2349629C/en not_active Expired - Fee Related
- 1999-11-04 JP JP2000579719A patent/JP4435985B2/ja not_active Expired - Fee Related
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