DE69940352D1 - Verfahren zur herstellung von gamma delta t zellen - Google Patents
Verfahren zur herstellung von gamma delta t zellenInfo
- Publication number
- DE69940352D1 DE69940352D1 DE69940352T DE69940352T DE69940352D1 DE 69940352 D1 DE69940352 D1 DE 69940352D1 DE 69940352 T DE69940352 T DE 69940352T DE 69940352 T DE69940352 T DE 69940352T DE 69940352 D1 DE69940352 D1 DE 69940352D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- tcrgammadelta
- interleukin
- culturing
- culture medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 5
- 210000004027 cell Anatomy 0.000 abstract 4
- 238000012258 culturing Methods 0.000 abstract 4
- 102000011778 gamma-delta T-Cell Antigen Receptors Human genes 0.000 abstract 4
- 108010062214 gamma-delta T-Cell Antigen Receptors Proteins 0.000 abstract 4
- 239000001963 growth medium Substances 0.000 abstract 4
- 102000000588 Interleukin-2 Human genes 0.000 abstract 3
- 108010002350 Interleukin-2 Proteins 0.000 abstract 3
- 102000004388 Interleukin-4 Human genes 0.000 abstract 2
- 108090000978 Interleukin-4 Proteins 0.000 abstract 2
- 229940028885 interleukin-4 Drugs 0.000 abstract 2
- 239000003226 mitogen Substances 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/59—Lectins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10700698P | 1998-11-04 | 1998-11-04 | |
| PCT/CA1999/001024 WO2000026347A1 (en) | 1998-11-04 | 1999-11-04 | Methods for the production of tcr gamma delta t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69940352D1 true DE69940352D1 (de) | 2009-03-12 |
Family
ID=22314363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69940352T Expired - Lifetime DE69940352D1 (de) | 1998-11-04 | 1999-11-04 | Verfahren zur herstellung von gamma delta t zellen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6537812B1 (https=) |
| EP (1) | EP1127107B1 (https=) |
| JP (1) | JP4435985B2 (https=) |
| AT (1) | ATE421573T1 (https=) |
| AU (1) | AU759373B2 (https=) |
| CA (1) | CA2349629C (https=) |
| DE (1) | DE69940352D1 (https=) |
| ES (1) | ES2319942T3 (https=) |
| NZ (1) | NZ511760A (https=) |
| WO (1) | WO2000026347A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030157060A1 (en) * | 2000-04-03 | 2003-08-21 | Bell David N | Production of tcr gamma delta t cells |
| ES2336302T3 (es) * | 2000-04-03 | 2010-04-12 | Therapure Biopharma Inc. | Produccion de celulas ttcr gamma delta. |
| DE602005022728D1 (de) * | 2004-08-19 | 2010-09-16 | Univ Cardiff | Präparation antigenpräsentierender menschlicher gamma delta t-zellen und verwendung in der immuntherapie |
| CN101313061B (zh) * | 2005-11-18 | 2013-05-15 | 大学健康网络 | 扩增双阴性t细胞的方法 |
| CA2659697A1 (en) | 2006-08-01 | 2008-02-07 | Arigen Pharmaceuticals, Inc. | Method of proliferating lak cell |
| GB201421716D0 (en) * | 2014-12-05 | 2015-01-21 | King S College London | Cell expansion procedure |
| AU2016274633B2 (en) | 2015-06-09 | 2022-04-21 | Gammadelta Therapeutics Ltd | Methods for the production of TCR gamma delta+ T cells |
| DK3307875T3 (da) | 2015-06-09 | 2022-03-21 | Lymphact Lymphocyte Activation Tech S A | Fremgangsmåder til fremstilling af tcr-gamma-delta+-t-celler |
| WO2017072367A1 (en) | 2015-10-30 | 2017-05-04 | Cancer Research Technology Limited | EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT γδ T CELLS AND USES OF THESE CELLS |
| GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| CN113423820A (zh) * | 2018-11-08 | 2021-09-21 | 伽马三角洲疗法有限公司 | 分离和扩增细胞的方法 |
| WO2022032665A1 (zh) * | 2020-08-14 | 2022-02-17 | 上海星华生物医药科技有限公司 | 一种制备通用型免疫细胞的方法及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639653A (en) * | 1993-07-19 | 1997-06-17 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva Universtiy | Method for proliferating Vγ2Vδ2 T cells |
| US5877299A (en) * | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| EP0937258A2 (en) * | 1996-10-29 | 1999-08-25 | Fred Hutchinson Cancer Research Center, Inc. | Cell stress regulated human mhc class i gene |
| CA2278847A1 (en) * | 1997-01-31 | 1998-08-06 | Hemosol Inc. | Method for the production of selected lymphocytes |
| WO1999046365A1 (en) | 1998-03-12 | 1999-09-16 | Emory University | Methods and compositions for the selective expansion of gamma/delta t-cells |
-
1999
- 1999-11-04 AT AT99953463T patent/ATE421573T1/de not_active IP Right Cessation
- 1999-11-04 ES ES99953463T patent/ES2319942T3/es not_active Expired - Lifetime
- 1999-11-04 US US09/807,987 patent/US6537812B1/en not_active Expired - Lifetime
- 1999-11-04 WO PCT/CA1999/001024 patent/WO2000026347A1/en not_active Ceased
- 1999-11-04 DE DE69940352T patent/DE69940352D1/de not_active Expired - Lifetime
- 1999-11-04 AU AU10219/00A patent/AU759373B2/en not_active Ceased
- 1999-11-04 EP EP99953463A patent/EP1127107B1/en not_active Expired - Lifetime
- 1999-11-04 NZ NZ511760A patent/NZ511760A/en unknown
- 1999-11-04 CA CA2349629A patent/CA2349629C/en not_active Expired - Fee Related
- 1999-11-04 JP JP2000579719A patent/JP4435985B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU1021900A (en) | 2000-05-22 |
| AU759373B2 (en) | 2003-04-10 |
| ATE421573T1 (de) | 2009-02-15 |
| ES2319942T3 (es) | 2009-05-14 |
| US6537812B1 (en) | 2003-03-25 |
| EP1127107A1 (en) | 2001-08-29 |
| EP1127107B1 (en) | 2009-01-21 |
| WO2000026347A1 (en) | 2000-05-11 |
| CA2349629C (en) | 2010-01-26 |
| CA2349629A1 (en) | 2000-05-11 |
| NZ511760A (en) | 2003-10-31 |
| JP4435985B2 (ja) | 2010-03-24 |
| JP2002528115A (ja) | 2002-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R079 | Amendment of ipc main class |
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