JP2002524153A5 - - Google Patents
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- Publication number
- JP2002524153A5 JP2002524153A5 JP2000568524A JP2000568524A JP2002524153A5 JP 2002524153 A5 JP2002524153 A5 JP 2002524153A5 JP 2000568524 A JP2000568524 A JP 2000568524A JP 2000568524 A JP2000568524 A JP 2000568524A JP 2002524153 A5 JP2002524153 A5 JP 2002524153A5
- Authority
- JP
- Japan
- Prior art keywords
- heparin
- high affinity
- composition according
- functional group
- bound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims 7
- 229960002897 Heparin Drugs 0.000 claims 7
- 229920000669 heparin Polymers 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 125000000524 functional group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 229920002873 Polyethylenimine Polymers 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- SENIYBUOEMCWRA-UHFFFAOYSA-N 3-methyl-1-(methyliminomethylideneamino)pentan-3-amine Chemical compound CCC(C)(N)CCN=C=NC SENIYBUOEMCWRA-UHFFFAOYSA-N 0.000 claims 1
- 229960000686 Benzalkonium Chloride Drugs 0.000 claims 1
- 210000003709 Heart Valves Anatomy 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 150000003841 chloride salts Chemical class 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 229920001002 functional polymer Polymers 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000001453 nonthrombogenic Effects 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- -1 polyacrylic acid Chemical class 0.000 claims 1
- 229920001888 polyacrylic acid Polymers 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- SBHRWOBHKASWGU-UHFFFAOYSA-M tridodecyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(CCCCCCCCCCCC)CCCCCCCCCCCC SBHRWOBHKASWGU-UHFFFAOYSA-M 0.000 claims 1
Claims (6)
- 動脈血栓の形成を防止するための非トロンボゲン形成表面を用意するために任意に好適なキャリアと一緒に、表面に結合した高親和性のＨＡヘパリンに富んだヘパリンを含む組成物の使用。
- 前記高親和性のＨＡヘパリンが精製されたものであることを特徴とする、請求項１に記載の組成物の使用。
- 前記高親和性のＨＡヘパリンが、エンドポイントアタッチメント（ｅｎｄ ｐｏｉｎｔ ａｔｔａｃｈｍｅｎｔ）によって表面に結合していることを特徴とする、請求項１に記載の組成物の使用。
- 前記キャリアが、アミノ、アルデヒド、ヒドロキシル、カルボン酸、カルボジイミドなどの官能基、あるいは、ヘパリン中に存在するかヘパリンに導入される官能基と結合できる他の反応性官能基を有する有機化合物からなる群から選択され、官能性化合物が低分子化合物またはポリマーであってもよく、官能基を有する低分子化合物の例としては、塩化トリドデシルメチルアンモニウム、塩化ベンザルコニウム誘導体、エチルジメチルアミノプロピルカルボジイミドおよびグルタルアルデヒドがあげられ、ポリマーの例としては、たとえば、ポリエチレンイミン（ＰＥＩ）またはポリリシンなどのポリアミン、ポリアクリル酸などのポリカルボン酸、ポリビニルアルコールまたは多糖類などのポリアルコール、他の官能性ポリマーまたはこれらの混合物があげられることを特徴とする、請求項１に記載の組成物の使用。
- 前記高親和性のＨＡヘパリンが装置の表面に結合していることを特徴とする請求項１乃至４のいずれか１項に記載の組成物の使用。
- 前記装置は、ステント、グラフト、ステントグラフト、カテーテル、心臓弁、フィルタ、管類および膜式装置からなる群から選択されることを特徴とする、請求項５に記載の組成物の使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO19984144 | 1998-09-09 | ||
| NO984144A NO984144L (no) | 1998-09-09 | 1998-09-09 | Sammensetning som omfatter heparin som et ikke-trombogent overflatebelegg |
| PCT/NO1999/000278 WO2000013719A1 (en) | 1998-09-09 | 1999-09-09 | Composition comprising heparin as a non-thrombogenic surface coating agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002524153A JP2002524153A (ja) | 2002-08-06 |
| JP2002524153A5 true JP2002524153A5 (ja) | 2005-09-29 |
| JP4489297B2 JP4489297B2 (ja) | 2010-06-23 |
Family
ID=19902394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000568524A Expired - Lifetime JP4489297B2 (ja) | 1998-09-09 | 1999-09-09 | ヘパリンを含む組成物の使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6559132B1 (ja) |
| EP (1) | EP1112098B1 (ja) |
| JP (1) | JP4489297B2 (ja) |
| KR (1) | KR100603224B1 (ja) |
| AT (1) | ATE232113T1 (ja) |
| AU (1) | AU762201B2 (ja) |
| BR (1) | BR9913517A (ja) |
| CA (1) | CA2342992C (ja) |
| DE (1) | DE69905258T2 (ja) |
| DK (1) | DK1112098T3 (ja) |
| ES (1) | ES2192860T3 (ja) |
| NO (1) | NO984144L (ja) |
| WO (1) | WO2000013719A1 (ja) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000015147A1 (en) * | 1998-09-10 | 2000-03-23 | Percardia, Inc. | Transmycardial shunt and its attachment mechanism, for left ventricular revascularization |
| EP1112043B1 (en) * | 1998-09-10 | 2006-04-05 | Percardia, Inc. | Tmr shunt |
| US6290728B1 (en) * | 1998-09-10 | 2001-09-18 | Percardia, Inc. | Designs for left ventricular conduit |
| US6254564B1 (en) | 1998-09-10 | 2001-07-03 | Percardia, Inc. | Left ventricular conduit with blood vessel graft |
| JP3782297B2 (ja) * | 2000-03-28 | 2006-06-07 | 株式会社東芝 | 固体撮像装置及びその製造方法 |
| US6854467B2 (en) * | 2000-05-04 | 2005-02-15 | Percardia, Inc. | Methods and devices for delivering a ventricular stent |
| US20020032478A1 (en) * | 2000-08-07 | 2002-03-14 | Percardia, Inc. | Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel |
| US6783525B2 (en) | 2001-12-12 | 2004-08-31 | Megadyne Medical Products, Inc. | Application and utilization of a water-soluble polymer on a surface |
| US6685704B2 (en) | 2002-02-26 | 2004-02-03 | Megadyne Medical Products, Inc. | Utilization of an active catalyst in a surface coating of an electrosurgical instrument |
| US6619357B1 (en) | 2002-04-24 | 2003-09-16 | The Goodyear Tire & Rubber Company | Belt package for super single truck tires |
| US6951559B1 (en) | 2002-06-21 | 2005-10-04 | Megadyne Medical Products, Inc. | Utilization of a hybrid material in a surface coating of an electrosurgical instrument |
| US7326219B2 (en) * | 2002-09-09 | 2008-02-05 | Wilk Patent Development | Device for placing transmyocardial implant |
| US6702850B1 (en) | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
| FR2846520B1 (fr) * | 2002-11-06 | 2006-09-29 | Roquette Freres | Utilisation de maltodextrines branchees comme liants de granulation |
| US7335334B2 (en) * | 2003-01-14 | 2008-02-26 | Medtronic, Inc. | Active air removal from an extracorporeal blood circuit |
| US7201870B2 (en) * | 2003-01-14 | 2007-04-10 | Medtronic, Inc. | Active air removal system operating modes of an extracorporeal blood circuit |
| US7204958B2 (en) * | 2003-01-14 | 2007-04-17 | Medtronic, Inc. | Extracorporeal blood circuit air removal system and method |
| US7198751B2 (en) * | 2003-01-14 | 2007-04-03 | Medtronic, Inc. | Disposable, integrated, extracorporeal blood circuit |
| US7189352B2 (en) * | 2003-01-14 | 2007-03-13 | Medtronic, Inc. | Extracorporeal blood circuit priming system and method |
| EP2329852A1 (en) * | 2004-03-26 | 2011-06-08 | SurModics, Inc. | Composition and method for preparing biocompatible surfaces |
| EP1735024A1 (en) * | 2004-03-26 | 2006-12-27 | SurModics, Inc. | Process and systems for biocompatible surfaces |
| US20050281857A1 (en) * | 2004-05-25 | 2005-12-22 | Heyer Toni M | Methods and reagents for preparing biomolecule-containing coatings |
| WO2006083328A2 (en) * | 2004-09-15 | 2006-08-10 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| US20060159650A1 (en) * | 2005-01-14 | 2006-07-20 | Bacterin, Inc. | Composition and method for covalently coupling an antithrombotic substance and a hydrophilic polymer |
| DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
| US20080200421A1 (en) | 2007-02-21 | 2008-08-21 | Zhao Jonathon Z | Coating for a medical device having an anti-thrombotic conjugate |
| US20090281059A1 (en) * | 2007-02-21 | 2009-11-12 | Robert Falotico | Coating for a medical device having an anti-thrombotic conjugate |
| WO2008122034A1 (en) | 2007-04-02 | 2008-10-09 | Ension, Inc. | Process for preparing a substrate coated with a biomolecule |
| US9693841B2 (en) | 2007-04-02 | 2017-07-04 | Ension, Inc. | Surface treated staples, sutures and dental floss and methods of manufacturing the same |
| US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
| US8383156B2 (en) * | 2007-04-30 | 2013-02-26 | Cordis Corporation | Coating for a medical device having an anti-thrombotic conjugate |
| US20090018646A1 (en) * | 2007-07-10 | 2009-01-15 | Zhao Jonathon Z | Coating Employing an Anti-Thrombotic Conjugate |
| US20090036841A1 (en) * | 2007-08-01 | 2009-02-05 | Mckale James M | Coatings for blood and bone marrow-contacting devices |
| US20090192079A1 (en) * | 2007-10-09 | 2009-07-30 | Genzyme Corporation | Prolonged delivery of heparin-binding growth factors from heparin-derivatized collagen |
| WO2011104269A1 (en) | 2008-02-26 | 2011-09-01 | Jenavalve Technology Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
| US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
| GB0816783D0 (en) | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
| WO2010095044A2 (en) * | 2009-02-21 | 2010-08-26 | Sofradim Production | Medical device with degradation-retarding coating |
| EP2398524B1 (en) | 2009-02-21 | 2017-07-12 | Covidien LP | Medical devices having activated surfaces |
| US20110196478A1 (en) * | 2010-02-10 | 2011-08-11 | Beoptima Inc. | Devices and methods for lumen treatment |
| JP2013526388A (ja) | 2010-05-25 | 2013-06-24 | イエナバルブ テクノロジー インク | 人工心臓弁、及び人工心臓弁とステントを備える経カテーテル搬送体内プロテーゼ |
| US9180274B2 (en) | 2010-09-09 | 2015-11-10 | W. L. G ore & Associates, Inc | Indwelling luminal devices |
| IT1402059B1 (it) * | 2010-09-29 | 2013-08-28 | Rand Srl | Sistema indossabile per eseguire terapie depurative di fluidi organici con l'impiego di circuiti extracorporei |
| US9775933B2 (en) | 2012-03-02 | 2017-10-03 | W. L. Gore & Associates, Inc. | Biocompatible surfaces and devices incorporating such surfaces |
| JP6432346B2 (ja) | 2013-04-12 | 2018-12-05 | 東レ株式会社 | 抗血栓性を有する人工血管 |
| JP6563394B2 (ja) | 2013-08-30 | 2019-08-21 | イェーナヴァルヴ テクノロジー インコーポレイテッド | 人工弁のための径方向に折り畳み自在のフレーム及び当該フレームを製造するための方法 |
| EP3632378B1 (en) | 2015-05-01 | 2024-05-29 | JenaValve Technology, Inc. | Device with reduced pacemaker rate in heart valve replacement |
| EP3095509A1 (en) | 2015-05-18 | 2016-11-23 | Defymed | Membranes functionalized with heparin for bioartificial organs |
| CN109475419B (zh) | 2016-05-13 | 2021-11-09 | 耶拿阀门科技股份有限公司 | 用于通过引导鞘和装载系统来递送心脏瓣膜假体的心脏瓣膜假体递送系统和方法 |
| EP3318294A1 (en) | 2016-11-08 | 2018-05-09 | Defymed | Kit for in situ delivery of a compound of interest |
| JP7094965B2 (ja) | 2017-01-27 | 2022-07-04 | イエナバルブ テクノロジー インク | 心臓弁模倣 |
| KR20200037574A (ko) | 2018-10-01 | 2020-04-09 | (주)우리비앤비 | 헤파린을 포함하는 탈모방지용 화장료 조성물 |
| EP4132462A1 (en) | 2020-04-09 | 2023-02-15 | Defymed | Membranes for medical devices |
| EP3892259A1 (en) | 2020-04-09 | 2021-10-13 | Defymed | Membranes for medical devices |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446126A (en) * | 1980-09-30 | 1984-05-01 | Cutter Laboratories, Inc. | Antithrombin-heparin complex and method for its production |
| SE456347B (sv) | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
| US6174326B1 (en) | 1996-09-25 | 2001-01-16 | Terumo Kabushiki Kaisha | Radiopaque, antithrombogenic stent and method for its production |
-
1998
- 1998-09-09 NO NO984144A patent/NO984144L/no not_active Application Discontinuation
-
1999
- 1999-09-09 DE DE69905258T patent/DE69905258T2/de not_active Expired - Lifetime
- 1999-09-09 DK DK99944937T patent/DK1112098T3/da active
- 1999-09-09 US US09/763,856 patent/US6559132B1/en not_active Expired - Lifetime
- 1999-09-09 AT AT99944937T patent/ATE232113T1/de active
- 1999-09-09 CA CA2342992A patent/CA2342992C/en not_active Expired - Lifetime
- 1999-09-09 JP JP2000568524A patent/JP4489297B2/ja not_active Expired - Lifetime
- 1999-09-09 EP EP99944937A patent/EP1112098B1/en not_active Expired - Lifetime
- 1999-09-09 ES ES99944937T patent/ES2192860T3/es not_active Expired - Lifetime
- 1999-09-09 BR BR9913517-5A patent/BR9913517A/pt not_active Application Discontinuation
- 1999-09-09 AU AU57653/99A patent/AU762201B2/en not_active Expired
- 1999-09-09 KR KR1020017002937A patent/KR100603224B1/ko not_active IP Right Cessation
- 1999-09-09 WO PCT/NO1999/000278 patent/WO2000013719A1/en active IP Right Grant
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