JP2002522452A - 蛋白質キナーゼの調節剤3−メチリデニル−2−インドリノン - Google Patents
蛋白質キナーゼの調節剤3−メチリデニル−2−インドリノンInfo
- Publication number
- JP2002522452A JP2002522452A JP2000563824A JP2000563824A JP2002522452A JP 2002522452 A JP2002522452 A JP 2002522452A JP 2000563824 A JP2000563824 A JP 2000563824A JP 2000563824 A JP2000563824 A JP 2000563824A JP 2002522452 A JP2002522452 A JP 2002522452A
- Authority
- JP
- Japan
- Prior art keywords
- dihydroindol
- group
- hydrogen
- indole
- methoxybenzylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12925698A | 1998-08-04 | 1998-08-04 | |
US09/129,256 | 1998-08-04 | ||
US9547098P | 1998-08-05 | 1998-08-05 | |
US60/095,470 | 1998-08-05 | ||
US10217898P | 1998-09-28 | 1998-09-28 | |
US60/102,178 | 1998-09-28 | ||
US11610799P | 1999-01-15 | 1999-01-15 | |
US60/116,107 | 1999-01-15 | ||
PCT/US1999/017845 WO2000008202A2 (en) | 1998-08-04 | 1999-08-04 | 3-methylidenyl-2-indolinone modulators of protein kinase |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2002522452A true JP2002522452A (ja) | 2002-07-23 |
JP2002522452A5 JP2002522452A5 (ru) | 2006-09-14 |
Family
ID=27492796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000563824A Withdrawn JP2002522452A (ja) | 1998-08-04 | 1999-08-04 | 蛋白質キナーゼの調節剤3−メチリデニル−2−インドリノン |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP2002522452A (ru) |
AU (1) | AU5468499A (ru) |
CA (1) | CA2383623A1 (ru) |
WO (1) | WO2000008202A2 (ru) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006512400A (ja) * | 2002-11-27 | 2006-04-13 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
JP2011037848A (ja) * | 2009-08-04 | 2011-02-24 | Lab Servier | 新規なジヒドロインドロン化合物、それらの調製方法及びそれらを含む薬学的組成物 |
JP2012522729A (ja) * | 2009-04-06 | 2012-09-27 | ユニバーシティ・ヘルス・ネットワーク | キナーゼインヒビターおよびこれを用いた癌の治療方法 |
US9139563B2 (en) | 2010-04-06 | 2015-09-22 | University Health Network | Kinase inhibitors and method of treating cancer |
US20160250220A1 (en) | 2013-10-18 | 2016-09-01 | University Health Network | Treatment for pancreatic cancer |
JP2018533600A (ja) * | 2015-11-12 | 2018-11-15 | エルジー・ケム・リミテッド | 7−アザインドリン−2−オン誘導体又はその薬学的に許容される塩を有効成分として含有する医薬組成物 |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
JP2002532492A (ja) * | 1998-12-17 | 2002-10-02 | エフ.ホフマン−ラ ロシュ アーゲー | サイクリン−依存性キナーゼ、特にcdk2のインヒビターとしての4−アルケニル(及びアルキニル)オキシドール |
US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
KR20010108024A (ko) | 1998-12-17 | 2001-12-07 | 프리돌린 클라우스너, 롤란드 비. 보레르 | 단백질 키나제 억제제로서의 4,5-피라진옥신돌 |
CA2354591A1 (en) | 1998-12-17 | 2000-06-22 | F. Hoffmann-La Roche Ag | 4-aryloxindoles as inhibitors of jnk protein kinases |
US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
EP1233943B1 (en) * | 1999-11-24 | 2011-06-29 | Sugen, Inc. | Ionizable indolinone derivatives and their use as ptk ligands |
US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
JP2003531895A (ja) | 2000-05-02 | 2003-10-28 | スージェン・インコーポレーテッド | (2−オキシインドール−3−イリデニル)酢酸誘導体およびその蛋白質キナーゼ阻害剤としての使用 |
MY128449A (en) | 2000-05-24 | 2007-02-28 | Sugen Inc | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
CA2410509A1 (en) * | 2000-06-02 | 2001-12-13 | Sugen, Inc. | Indolinone derivatives as protein kinase/phosphatase inhibitors |
CA2432114A1 (en) * | 2000-12-20 | 2002-07-18 | Sugen, Inc. | 4-(hetero)aryl substituted indolinones |
JP2004529110A (ja) | 2001-03-06 | 2004-09-24 | アストラゼネカ アクチボラグ | 脈管損傷活性を有するインドール誘導体 |
US7081454B2 (en) | 2001-03-28 | 2006-07-25 | Bristol-Myers Squibb Co. | Tyrosine kinase inhibitors |
WO2002081466A1 (en) * | 2001-04-09 | 2002-10-17 | Sugen, Inc. | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
WO2002094809A1 (en) * | 2001-05-24 | 2002-11-28 | Yamanouchi Pharmaceutical Co., Ltd. | 3-quinoline-2-(1h)-ylideneindolin-2-one derivatives |
AU2002303892A1 (en) | 2001-05-30 | 2002-12-09 | Jingrong Cui | 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors |
EP1436259A1 (en) | 2001-09-10 | 2004-07-14 | Congxin Liang | 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene)-2-indolinone derivatives as kinase inhibitors |
ATE343575T1 (de) * | 2001-09-27 | 2006-11-15 | Smithkline Beecham Corp | Azaoxoindol derivate als trk protein kinase hemmstoffe zur behandlung von krebs und chronischem schmerz |
AU2003284572A1 (en) * | 2002-11-22 | 2004-06-18 | Yamanouchi Pharmaceutical Co., Ltd. | 2-oxoindoline derivatives |
US7517697B2 (en) * | 2003-02-05 | 2009-04-14 | Applied Biosystems, Llc | Compositions and methods for preserving RNA in biological samples |
US7312215B2 (en) | 2003-07-29 | 2007-12-25 | Bristol-Myers Squibb Company | Benzimidazole C-2 heterocycles as kinase inhibitors |
GT200500321A (es) * | 2004-11-09 | 2006-09-04 | Compuestos y composiciones como inhibidores de proteina kinase. | |
WO2006119148A2 (en) * | 2005-04-29 | 2006-11-09 | The Ohio State University Research Foundation | Keratinocyte growth factor receptor - tyrosine specific inhibitors for the prevention of cancer metastatis |
WO2009030270A1 (en) * | 2007-09-03 | 2009-03-12 | Novartis Ag | Dihydroindole derivatives useful in parkinson's disease |
CA2709536C (en) * | 2007-12-21 | 2016-05-31 | University Health Network | Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer |
WO2012048411A1 (en) * | 2010-10-13 | 2012-04-19 | University Health Network | Plk-4 inhibitors and method of treating cancer with same |
WO2012142029A2 (en) * | 2011-04-10 | 2012-10-18 | Florida A&M University | Serms for the treatment of estrogen receptor-mediated disorders |
CN104619701B (zh) | 2012-09-13 | 2016-10-19 | 霍夫曼-拉罗奇有限公司 | 用于治疗cns疾病的2-氧代-2,3-二氢-吲哚类化合物 |
WO2014066840A1 (en) | 2012-10-26 | 2014-05-01 | Regents Of The University Of Minnesota | Aurora kinase inhibitors |
US10487054B2 (en) | 2017-04-21 | 2019-11-26 | Regents Of The University Of Minnesota | Therapeutic compounds |
JP7101311B2 (ja) * | 2018-10-05 | 2022-07-14 | イクノス サイエンシズ エスエー | Map4k1阻害剤として使用するためのインドリノン化合物 |
GR1010103B (el) * | 2020-07-02 | 2021-10-18 | Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε, | 3-ινδολ-2-υλομεθυλιδενο-ινδολιν-2-ονες με δραση αναστολης της αυτοταξινης |
WO2022006412A2 (en) * | 2020-07-02 | 2022-01-06 | The Regents Of The University Of Colorado, A Body Corporate | Conjugates of ampk inhibitors and protac degraders and related uses |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9004483D0 (en) * | 1990-02-28 | 1990-04-25 | Erba Carlo Spa | New aryl-and heteroarylethenylene derivatives and process for their preparation |
FR2678911A1 (fr) * | 1991-07-10 | 1993-01-15 | Prospection & Inventions | Cartouche tubulaire de stockage et d'application d'un produit non solide et ensemble d'entrainement et de poussee pour la cartouche. |
GB9115160D0 (en) * | 1991-07-12 | 1991-08-28 | Erba Carlo Spa | Methylen-oxindole derivatives and process for their preparation |
FR2694004B1 (fr) * | 1992-07-21 | 1994-08-26 | Adir | Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
-
1999
- 1999-08-04 CA CA002383623A patent/CA2383623A1/en not_active Abandoned
- 1999-08-04 AU AU54684/99A patent/AU5468499A/en not_active Abandoned
- 1999-08-04 JP JP2000563824A patent/JP2002522452A/ja not_active Withdrawn
- 1999-08-04 WO PCT/US1999/017845 patent/WO2000008202A2/en active Application Filing
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006512400A (ja) * | 2002-11-27 | 2006-04-13 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
JP2011225582A (ja) * | 2002-11-27 | 2011-11-10 | Allergan Inc | 疾患の治療のためのキナーゼ阻害剤 |
JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
JP2012522729A (ja) * | 2009-04-06 | 2012-09-27 | ユニバーシティ・ヘルス・ネットワーク | キナーゼインヒビターおよびこれを用いた癌の治療方法 |
US8999968B2 (en) | 2009-04-06 | 2015-04-07 | University Health Network | Kinase inhibitors and method of treating cancer with same |
USRE47731E1 (en) | 2009-04-06 | 2019-11-19 | University Health Network | Kinase inhibitors and method of treating cancer with same |
JP2011037848A (ja) * | 2009-08-04 | 2011-02-24 | Lab Servier | 新規なジヒドロインドロン化合物、それらの調製方法及びそれらを含む薬学的組成物 |
JP2013116908A (ja) * | 2009-08-04 | 2013-06-13 | Lab Servier | 新規なジヒドロインドロン化合物、それらの調製方法及びそれらを含む薬学的組成物 |
US9907800B2 (en) | 2010-04-06 | 2018-03-06 | University Health Network | Kinase inhibitors and method of treating cancer |
US9579327B2 (en) | 2010-04-06 | 2017-02-28 | University Health Network | Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones |
US9796703B2 (en) | 2010-04-06 | 2017-10-24 | University Health Network | Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones |
US10077255B2 (en) | 2010-04-06 | 2018-09-18 | University Health Network | Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones |
US10358436B2 (en) | 2010-04-06 | 2019-07-23 | University Health Network | Kinase inhibitors and method of treating cancer |
US9139563B2 (en) | 2010-04-06 | 2015-09-22 | University Health Network | Kinase inhibitors and method of treating cancer |
US9642856B2 (en) | 2013-10-18 | 2017-05-09 | University Health Network | Treatment for pancreatic cancer |
US20160250220A1 (en) | 2013-10-18 | 2016-09-01 | University Health Network | Treatment for pancreatic cancer |
JP2018533600A (ja) * | 2015-11-12 | 2018-11-15 | エルジー・ケム・リミテッド | 7−アザインドリン−2−オン誘導体又はその薬学的に許容される塩を有効成分として含有する医薬組成物 |
Also Published As
Publication number | Publication date |
---|---|
CA2383623A1 (en) | 2000-02-17 |
AU5468499A (en) | 2000-02-28 |
WO2000008202A9 (en) | 2000-07-27 |
WO2000008202A2 (en) | 2000-02-17 |
WO2000008202A3 (en) | 2000-05-18 |
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Legal Events
Date | Code | Title | Description |
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A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060711 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060711 |
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A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20070205 |