JP2002520431A5 - - Google Patents
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- Publication number
- JP2002520431A5 JP2002520431A5 JP2000559167A JP2000559167A JP2002520431A5 JP 2002520431 A5 JP2002520431 A5 JP 2002520431A5 JP 2000559167 A JP2000559167 A JP 2000559167A JP 2000559167 A JP2000559167 A JP 2000559167A JP 2002520431 A5 JP2002520431 A5 JP 2002520431A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- copolymer
- units
- unit
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229920001577 copolymer Polymers 0.000 description 16
- 239000000178 monomer Substances 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 6
- 238000000034 method Methods 0.000 description 3
- 125000005702 oxyalkylene group Chemical group 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 229920000578 graft copolymer Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- -1 polyoxyethylene Polymers 0.000 description 2
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 2
- 229920005604 random copolymer Polymers 0.000 description 2
- 229940117986 sulfobetaine Drugs 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- FQOWJGGXNSRNJS-YFKPBYRVSA-N (2s)-2-(2-methylprop-2-enoylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)C(C)=C FQOWJGGXNSRNJS-YFKPBYRVSA-N 0.000 description 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- STVDIZSDTABYLF-UHFFFAOYSA-N 2-[hydroxy(prop-2-enoyl)amino]acetic acid Chemical compound OC(=O)CN(O)C(=O)C=C STVDIZSDTABYLF-UHFFFAOYSA-N 0.000 description 1
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 description 1
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 description 1
- BCAIDFOKQCVACE-UHFFFAOYSA-N 3-[dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azaniumyl]propane-1-sulfonate Chemical compound CC(=C)C(=O)OCC[N+](C)(C)CCCS([O-])(=O)=O BCAIDFOKQCVACE-UHFFFAOYSA-N 0.000 description 1
- OFNISBHGPNMTMS-UHFFFAOYSA-N 3-methylideneoxolane-2,5-dione Chemical compound C=C1CC(=O)OC1=O OFNISBHGPNMTMS-UHFFFAOYSA-N 0.000 description 1
- NYUTUWAFOUJLKI-UHFFFAOYSA-N 3-prop-2-enoyloxypropane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCOC(=O)C=C NYUTUWAFOUJLKI-UHFFFAOYSA-N 0.000 description 1
- GDFCSMCGLZFNFY-UHFFFAOYSA-N Dimethylaminopropyl Methacrylamide Chemical compound CN(C)CCCNC(=O)C(C)=C GDFCSMCGLZFNFY-UHFFFAOYSA-N 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000012431 aqueous reaction media Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 239000007870 radical polymerization initiator Substances 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9212398P | 1998-07-09 | 1998-07-09 | |
| US60/092,123 | 1998-07-09 | ||
| PCT/EP1999/005024 WO2000002938A2 (en) | 1998-07-09 | 1999-07-07 | Water-soluble or water-dispersible grafted copolymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520431A JP2002520431A (ja) | 2002-07-09 |
| JP2002520431A5 true JP2002520431A5 (https=) | 2006-08-31 |
Family
ID=22231734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559167A Pending JP2002520431A (ja) | 1998-07-09 | 1999-07-07 | 水溶性又は水分散性グラフト共重合体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6239227B1 (https=) |
| EP (1) | EP1095077B1 (https=) |
| JP (1) | JP2002520431A (https=) |
| CN (1) | CN1239545C (https=) |
| AT (1) | ATE292644T1 (https=) |
| AU (1) | AU5283099A (https=) |
| BR (1) | BR9911935A (https=) |
| CA (1) | CA2336842A1 (https=) |
| DE (1) | DE69924612T2 (https=) |
| ES (1) | ES2241304T3 (https=) |
| WO (1) | WO2000002938A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10160720A1 (de) * | 2001-12-11 | 2003-06-18 | Basf Ag | Kosmetisches Mittel enthaltend wenigstens ein Copolymer mit N-Vinyllactameinheiten |
| BR0316630A (pt) * | 2002-11-27 | 2005-10-11 | Isp Investments Inc | Polìmeros resistentes |
| WO2018031968A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| CN121177507A (zh) | 2016-08-12 | 2025-12-23 | L.E.A.F.控股集团公司 | α和γ-D聚谷氨酸化抗叶酸剂及其用途 |
| JP7491572B2 (ja) | 2018-02-07 | 2024-05-28 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | アルファポリグルタミン酸化ペメトレキセドおよびその使用 |
| WO2019157121A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| WO2019157129A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| CN111867593A (zh) | 2018-02-07 | 2020-10-30 | L.E.A.F.控股集团公司 | α聚谷氨酸化抗叶酸剂及其用途 |
| US12310966B2 (en) | 2018-02-07 | 2025-05-27 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| WO2019157145A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pemetrexed and uses thereof |
| EP3749318A4 (en) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMATED RALTITREXED AND ITS USES |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| EP3749319A4 (en) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | TETRAHYDROFOLATES ALPHA POLYGLUTAMATE AND THEIR USES |
| EP3749314A4 (en) | 2018-02-07 | 2022-02-23 | L.E.A.F Holdings Group LLC | ALPHA-POLYGLUTAMATE METHOTREXATE AND ITS USES |
| WO2019160735A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated tetrahydrofolates and uses thereof |
| JP7462950B2 (ja) | 2018-02-14 | 2024-04-08 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | ガンマポリグルタミン酸化メトトレキセートおよびその使用 |
| CA3090753A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pralatrexate and uses thereof |
| WO2019160734A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| US12350271B2 (en) | 2018-02-14 | 2025-07-08 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
| CN114426752B (zh) * | 2020-10-14 | 2024-02-09 | 中国石油化工股份有限公司 | 聚乙烯醇树脂组合物及膜 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3364940D1 (en) * | 1982-07-06 | 1986-09-04 | Ciba Geigy Ag | Water-soluble or dispersible graft polymers, their production and use |
| JPH0617421B2 (ja) * | 1986-06-25 | 1994-03-09 | 日本ペイント株式会社 | 乳化重合組成物 |
| US5132284A (en) * | 1988-04-26 | 1992-07-21 | National Starch And Chemical Investment Holding Corporation | Polyamphoteric polysaccharide graft copolymers neutrally charged |
| JP2538659B2 (ja) * | 1988-12-28 | 1996-09-25 | 花王株式会社 | 感熱記録材料 |
| US5166276A (en) * | 1989-07-12 | 1992-11-24 | Mitsubishi Petrochemical Company Ltd. | Polymer for hair-care products |
| US5739212A (en) * | 1992-12-08 | 1998-04-14 | Skw Trostberg Aktiengesellschaft | Water-soluble graft polymers |
| JPH0762044A (ja) * | 1993-08-26 | 1995-03-07 | Nippon Paint Co Ltd | 単分散重合体粒子の製造方法 |
| JPH07300513A (ja) * | 1994-05-09 | 1995-11-14 | Nippon Oil & Fats Co Ltd | 表面グラフト化材料 |
| JPH1180288A (ja) * | 1997-08-29 | 1999-03-26 | Nippon Shokubai Co Ltd | 親水性グラフト重合体含有組成物およびその用途 |
-
1999
- 1999-07-07 CN CNB998083887A patent/CN1239545C/zh not_active Expired - Fee Related
- 1999-07-07 CA CA002336842A patent/CA2336842A1/en not_active Abandoned
- 1999-07-07 EP EP99938259A patent/EP1095077B1/en not_active Expired - Lifetime
- 1999-07-07 BR BR9911935-8A patent/BR9911935A/pt not_active Application Discontinuation
- 1999-07-07 JP JP2000559167A patent/JP2002520431A/ja active Pending
- 1999-07-07 AU AU52830/99A patent/AU5283099A/en not_active Abandoned
- 1999-07-07 DE DE69924612T patent/DE69924612T2/de not_active Expired - Lifetime
- 1999-07-07 ES ES99938259T patent/ES2241304T3/es not_active Expired - Lifetime
- 1999-07-07 WO PCT/EP1999/005024 patent/WO2000002938A2/en not_active Ceased
- 1999-07-07 AT AT99938259T patent/ATE292644T1/de not_active IP Right Cessation
- 1999-07-09 US US09/350,615 patent/US6239227B1/en not_active Expired - Lifetime
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