JP2002518373A5 - - Google Patents
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- Publication number
- JP2002518373A5 JP2002518373A5 JP2000554703A JP2000554703A JP2002518373A5 JP 2002518373 A5 JP2002518373 A5 JP 2002518373A5 JP 2000554703 A JP2000554703 A JP 2000554703A JP 2000554703 A JP2000554703 A JP 2000554703A JP 2002518373 A5 JP2002518373 A5 JP 2002518373A5
- Authority
- JP
- Japan
- Prior art keywords
- penten
- isopropoxy
- pyridyl
- amine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 10
- 208000024827 Alzheimer disease Diseases 0.000 description 8
- 239000008194 pharmaceutical composition Substances 0.000 description 8
- RPCVIAXDAUMJJP-HOSRBBHYSA-N (e,2r)-n-methyl-5-(5-propan-2-yloxypyridin-3-yl)pent-4-en-2-amine Chemical compound CN[C@H](C)C\C=C\C1=CN=CC(OC(C)C)=C1 RPCVIAXDAUMJJP-HOSRBBHYSA-N 0.000 description 5
- RPCVIAXDAUMJJP-PZBABLGHSA-N ispronicline Chemical compound CN[C@@H](C)C\C=C\C1=CN=CC(OC(C)C)=C1 RPCVIAXDAUMJJP-PZBABLGHSA-N 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 208000023105 Huntington disease Diseases 0.000 description 2
- 206010026749 Mania Diseases 0.000 description 2
- 206010036631 Presenile dementia Diseases 0.000 description 2
- 206010039966 Senile dementia Diseases 0.000 description 2
- 206010043118 Tardive Dyskinesia Diseases 0.000 description 2
- 208000000323 Tourette Syndrome Diseases 0.000 description 2
- 208000016620 Tourette disease Diseases 0.000 description 2
- 230000036506 anxiety Effects 0.000 description 2
- 206010013932 dyslexia Diseases 0.000 description 2
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 description 2
- 201000000980 schizophrenia Diseases 0.000 description 2
- 0 CC1=IC(*)=C(C(*)=C(*)**)C(*)=*1 Chemical compound CC1=IC(*)=C(C(*)=C(*)**)C(*)=*1 0.000 description 1
- 206010020651 Hyperkinesia Diseases 0.000 description 1
- 208000000269 Hyperkinesis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000027089 Parkinsonian disease Diseases 0.000 description 1
- 206010034010 Parkinsonism Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9828598A | 1998-06-16 | 1998-06-16 | |
| US09/098,133 US6232316B1 (en) | 1998-06-16 | 1998-06-16 | Methods for treatment of CNS disorders |
| US09/098,285 | 1998-06-16 | ||
| US09/098,133 | 1998-06-16 | ||
| PCT/US1999/012340 WO1999065876A1 (en) | 1998-06-16 | 1999-06-03 | Aryl substituted olefinic amines and their use as cholinergic receptors agonists |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008130502A Division JP4972608B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2008130504A Division JP4896923B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002518373A JP2002518373A (ja) | 2002-06-25 |
| JP2002518373A5 true JP2002518373A5 (https=) | 2008-07-10 |
| JP4240815B2 JP4240815B2 (ja) | 2009-03-18 |
Family
ID=26794206
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000554703A Expired - Fee Related JP4240815B2 (ja) | 1998-06-16 | 1999-06-03 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2008130502A Expired - Fee Related JP4972608B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2008130504A Expired - Fee Related JP4896923B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2010135746A Pending JP2010229149A (ja) | 1998-06-16 | 2010-06-15 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008130502A Expired - Fee Related JP4972608B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2008130504A Expired - Fee Related JP4896923B2 (ja) | 1998-06-16 | 2008-05-19 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
| JP2010135746A Pending JP2010229149A (ja) | 1998-06-16 | 2010-06-15 | アリール置換オレフィンアミンと、コリン受容体アゴニストとしてのアリール置換オレフィンアミンの使用 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1086082B9 (https=) |
| JP (4) | JP4240815B2 (https=) |
| KR (1) | KR100593433B1 (https=) |
| AT (1) | ATE273956T1 (https=) |
| AU (1) | AU4230799A (https=) |
| BR (1) | BR9911325A (https=) |
| CA (3) | CA2677519A1 (https=) |
| DE (1) | DE69919537T2 (https=) |
| DK (1) | DK1086082T3 (https=) |
| ES (1) | ES2228054T3 (https=) |
| PT (1) | PT1086082E (https=) |
| WO (1) | WO1999065876A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979695B2 (en) * | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
| CA2677519A1 (en) * | 1998-06-16 | 1999-12-23 | Targacept, Inc. | Aryl substituted olefinic amines and their use as cholinergic receptors agonists |
| JP2003501416A (ja) * | 1999-06-07 | 2003-01-14 | ターガセプト，インコーポレイテッド | 医薬組成物およびその使用法 |
| EP1212301A1 (en) * | 1999-08-31 | 2002-06-12 | Targacept, Inc. | Arylalkyloxyalkylamines and arylalkylthioalkylamines, pharmaceutical compositions containing them and their use as inhibitors of nicotinic cholinergic receptors |
| AU2001257449A1 (en) * | 2000-05-01 | 2001-11-12 | Targacept, Inc. | Imaging of nicotinic acetylcholine receptor subtypes |
| US6432954B1 (en) * | 2000-07-14 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| EP1463481A4 (en) | 2001-12-14 | 2008-06-25 | Targacept Inc | METHOD AND COMPOSITIONS FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM |
| US8580842B2 (en) | 2003-09-30 | 2013-11-12 | Abbott Gmbh & Co. Kg | Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them |
| AU2004282201A1 (en) | 2003-10-15 | 2005-04-28 | Targacept, Inc. | Azabicycyclic compounds for relieving pain and treating central nervous system disorders |
| US7459469B2 (en) | 2004-11-10 | 2008-12-02 | Targacept, Inc. | Hydroxybenzoate salts of metanicotine compounds |
| UA88792C2 (ru) * | 2004-11-10 | 2009-11-25 | Таргасепт, Інк. | Гидроксибензоатные соли метаникотиновых соединений |
| TWI389889B (zh) | 2006-05-09 | 2013-03-21 | Targacept Inc | （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型 |
| US8017785B2 (en) | 2006-05-09 | 2011-09-13 | Astrazeneca Ab | Salt forms of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)y1]-4-penten 2-amine |
| US20100234349A1 (en) | 2006-09-04 | 2010-09-16 | Olsen Gunnar M | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
| US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US8486979B2 (en) | 2006-12-12 | 2013-07-16 | Abbvie Inc. | 1,2,4 oxadiazole compounds and methods of use thereof |
| UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
| KR20100052490A (ko) * | 2007-07-31 | 2010-05-19 | 타가셉트 인코포레이티드 | (2ｓ)-(4ｅ)-ｎ-메틸-5-(3-(5-이소프로폭시피리딘)일)-4-펜텐-2-아민의 경피투여 |
| WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
| EP2231644B1 (de) | 2007-12-07 | 2014-01-15 | AbbVie Deutschland GmbH & Co KG | 5,6-Disubstitutierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen |
| KR20100097195A (ko) | 2007-12-07 | 2010-09-02 | 애보트 게엠베하 운트 콤파니 카게 | ５－할로겐－치환된 옥스인돌 유도체 및 바소프레신－의존성 질병을 치료하기 위한 이의 용도 |
| JP5701607B2 (ja) | 2007-12-07 | 2015-04-15 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | アミドメチル置換オキシインドール誘導体およびバソプレッシン依存性疾患の治療へのこれらの使用 |
| US8383657B2 (en) | 2007-12-21 | 2013-02-26 | Abbott Laboratories | Thiazolylidine urea and amide derivatives and methods of use thereof |
| WO2009146031A1 (en) | 2008-03-31 | 2009-12-03 | University Of South Florida | Methods of treating disease-induced ataxia and non-ataxic imbalance |
| EP2435080A2 (en) | 2009-05-29 | 2012-04-04 | Abbott Laboratories | Pharmaceutical compositions for the treatment of pain |
| US8703802B2 (en) * | 2010-05-20 | 2014-04-22 | Targacept, Inc. | Process for the preparation of aryl substituted olefinic amines |
| WO2013184732A1 (en) * | 2012-06-06 | 2013-12-12 | Targacept, Inc. | Crystalline (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]4-penten-2-amine 1,5-naphthalenedisulfonate |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242935A (en) * | 1992-03-06 | 1993-09-07 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| US5597716A (en) * | 1993-11-18 | 1997-01-28 | Mitsubishi Rayon Co., Ltd. | Process for producing D-lactic acid and L-lactamide |
| US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5616707A (en) * | 1995-01-06 | 1997-04-01 | Crooks; Peter A. | Compounds which are useful for prevention and treatment of central nervous system disorders |
| AU4610896A (en) * | 1995-01-06 | 1996-07-24 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| AU5383196A (en) * | 1995-05-17 | 1996-11-29 | R.J. Reynolds Tobacco Company | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
| US5616716A (en) * | 1996-01-06 | 1997-04-01 | Dull; Gary M. | (3-(5-ethoxypyridin)yl)-alkenyl 1 amine compounds |
| JP4357001B2 (ja) * | 1996-04-23 | 2009-11-04 | ターガセプト，インコーポレイテッド | 中枢神経系障害の予防及び治療のための医薬組成物 |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| AU749151B2 (en) * | 1997-02-21 | 2002-06-20 | Targacept, Inc. | Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds |
| CA2677519A1 (en) * | 1998-06-16 | 1999-12-23 | Targacept, Inc. | Aryl substituted olefinic amines and their use as cholinergic receptors agonists |
-
1999
- 1999-06-03 CA CA002677519A patent/CA2677519A1/en not_active Abandoned
- 1999-06-03 DK DK99926152T patent/DK1086082T3/da active
- 1999-06-03 AU AU42307/99A patent/AU4230799A/en not_active Abandoned
- 1999-06-03 PT PT99926152T patent/PT1086082E/pt unknown
- 1999-06-03 KR KR1020007014279A patent/KR100593433B1/ko not_active Expired - Fee Related
- 1999-06-03 ES ES99926152T patent/ES2228054T3/es not_active Expired - Lifetime
- 1999-06-03 CA CA2709735A patent/CA2709735A1/en not_active Abandoned
- 1999-06-03 EP EP99926152A patent/EP1086082B9/en not_active Expired - Lifetime
- 1999-06-03 DE DE69919537T patent/DE69919537T2/de not_active Expired - Lifetime
- 1999-06-03 BR BR9911325-2A patent/BR9911325A/pt not_active Application Discontinuation
- 1999-06-03 WO PCT/US1999/012340 patent/WO1999065876A1/en not_active Ceased
- 1999-06-03 CA CA002334923A patent/CA2334923C/en not_active Expired - Fee Related
- 1999-06-03 JP JP2000554703A patent/JP4240815B2/ja not_active Expired - Fee Related
- 1999-06-03 AT AT99926152T patent/ATE273956T1/de active
-
2008
- 2008-05-19 JP JP2008130502A patent/JP4972608B2/ja not_active Expired - Fee Related
- 2008-05-19 JP JP2008130504A patent/JP4896923B2/ja not_active Expired - Fee Related
-
2010
- 2010-06-15 JP JP2010135746A patent/JP2010229149A/ja active Pending
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