JP2002516061A5 - - Google Patents
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- Publication number
- JP2002516061A5 JP2002516061A5 JP2000516019A JP2000516019A JP2002516061A5 JP 2002516061 A5 JP2002516061 A5 JP 2002516061A5 JP 2000516019 A JP2000516019 A JP 2000516019A JP 2000516019 A JP2000516019 A JP 2000516019A JP 2002516061 A5 JP2002516061 A5 JP 2002516061A5
- Authority
- JP
- Japan
- Prior art keywords
- thymidine kinase
- enzyme
- nucleic acid
- acid molecule
- mutations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000006601 Thymidine Kinase Human genes 0.000 description 78
- 108020004440 Thymidine kinase Proteins 0.000 description 78
- 102000039446 nucleic acids Human genes 0.000 description 39
- 108020004707 nucleic acids Proteins 0.000 description 39
- 150000007523 nucleic acids Chemical class 0.000 description 39
- 239000002777 nucleoside Substances 0.000 description 35
- 230000035772 mutation Effects 0.000 description 34
- -1 DRH nucleoside Chemical class 0.000 description 24
- 102000004190 Enzymes Human genes 0.000 description 19
- 108090000790 Enzymes Proteins 0.000 description 19
- 241000700586 Herpesviridae Species 0.000 description 18
- 150000003833 nucleoside derivatives Chemical class 0.000 description 17
- 238000006467 substitution reaction Methods 0.000 description 16
- 125000003275 alpha amino acid group Chemical group 0.000 description 15
- 239000013598 vector Substances 0.000 description 15
- 108020004202 Guanylate Kinase Proteins 0.000 description 12
- 150000001413 amino acids Chemical class 0.000 description 12
- 108020001507 fusion proteins Proteins 0.000 description 12
- 102000037865 fusion proteins Human genes 0.000 description 12
- 102000006638 guanylate kinase Human genes 0.000 description 12
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 12
- 230000004071 biological effect Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 230000007923 virulence factor Effects 0.000 description 9
- 239000000304 virulence factor Substances 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- 230000026731 phosphorylation Effects 0.000 description 8
- 238000006366 phosphorylation reaction Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 6
- WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 description 6
- 229960004150 aciclovir Drugs 0.000 description 6
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 6
- XACKNLSZYYIACO-DJLDLDEBSA-N edoxudine Chemical compound O=C1NC(=O)C(CC)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XACKNLSZYYIACO-DJLDLDEBSA-N 0.000 description 6
- 239000013604 expression vector Substances 0.000 description 6
- 229960002963 ganciclovir Drugs 0.000 description 6
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 6
- 229960004716 idoxuridine Drugs 0.000 description 6
- 229940113082 thymine Drugs 0.000 description 6
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 6
- 229960003962 trifluridine Drugs 0.000 description 6
- 229960000523 zalcitabine Drugs 0.000 description 6
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 5
- 230000000865 phosphorylative effect Effects 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 241000700588 Human alphaherpesvirus 1 Species 0.000 description 4
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 4
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
- 210000004899 c-terminal region Anatomy 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 101000614191 Homo sapiens Guanylate kinase Proteins 0.000 description 2
- 101001139305 Mus musculus Guanylate kinase Proteins 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229940104230 thymidine Drugs 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- VUFVGYBIFMCJPB-UHFFFAOYSA-N 1-iodopyrimidine-2,4-dione Chemical compound IN1C=CC(=O)NC1=O VUFVGYBIFMCJPB-UHFFFAOYSA-N 0.000 description 1
- BTOTXLJHDSNXMW-POYBYMJQSA-N 2,3-dideoxyuridine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(=O)NC(=O)C=C1 BTOTXLJHDSNXMW-POYBYMJQSA-N 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000713869 Moloney murine leukemia virus Species 0.000 description 1
- 108090000472 Phosphoenolpyruvate carboxykinase (ATP) Proteins 0.000 description 1
- 102100034792 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Human genes 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 108091000117 Tyrosine 3-Monooxygenase Proteins 0.000 description 1
- 102000048218 Tyrosine 3-monooxygenases Human genes 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 102000013529 alpha-Fetoproteins Human genes 0.000 description 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6181297P | 1997-10-14 | 1997-10-14 | |
| US60/061,812 | 1997-10-14 | ||
| PCT/US1998/021672 WO1999019466A2 (en) | 1997-10-14 | 1998-10-14 | Thymidine kinase mutants and fusion proteins having thymidine kinase and guanylate kinase activities |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008176378A Division JP5070145B2 (ja) | 1997-10-14 | 2008-07-04 | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516061A JP2002516061A (ja) | 2002-06-04 |
| JP2002516061A5 true JP2002516061A5 (https=) | 2006-01-05 |
Family
ID=22038301
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000516019A Withdrawn JP2002516061A (ja) | 1997-10-14 | 1998-10-14 | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
| JP2008176378A Expired - Fee Related JP5070145B2 (ja) | 1997-10-14 | 2008-07-04 | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
| JP2012000673A Withdrawn JP2012115270A (ja) | 1997-10-14 | 2012-01-05 | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008176378A Expired - Fee Related JP5070145B2 (ja) | 1997-10-14 | 2008-07-04 | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
| JP2012000673A Withdrawn JP2012115270A (ja) | 1997-10-14 | 2012-01-05 | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US7888091B2 (https=) |
| EP (3) | EP2386629A1 (https=) |
| JP (3) | JP2002516061A (https=) |
| AT (1) | ATE374247T1 (https=) |
| CA (1) | CA2306443A1 (https=) |
| DE (1) | DE69838483T2 (https=) |
| WO (1) | WO1999019466A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002516061A (ja) * | 1997-10-14 | 2002-06-04 | ダーウィン モレキュラー コーポレイション | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
| GB0008966D0 (en) | 2000-04-13 | 2000-05-31 | Imp College Innovations Ltd | Vectors for gene therapy |
| GB0010105D0 (en) * | 2000-04-26 | 2000-06-14 | Ml Lab Plc | Cell ablation |
| US20040072168A1 (en) * | 2000-05-12 | 2004-04-15 | Wolfgang Knecht | Novel deoxynucleoside kinase enzyme variants |
| EP1360324A2 (en) | 2000-08-31 | 2003-11-12 | Mayo Foundation For Medical Education And Research | Detection of varicella-zoster virus |
| US7691571B2 (en) | 2001-01-31 | 2010-04-06 | Mayo Foundation For Medical Education And Research | Detection of bordetella |
| DE60236068D1 (de) | 2001-01-31 | 2010-06-02 | Mayo Foundation | Nachweis von herpex-simplex-virus |
| US7439271B2 (en) | 2001-06-27 | 2008-10-21 | The Gillette Company | Reduction of hair growth |
| PT1509600E (pt) | 2002-05-23 | 2009-03-26 | Birgitte Munch-Petersen | Timidina-quinases vegetais e sua utilização |
| WO2003100045A1 (en) * | 2002-05-23 | 2003-12-04 | Wolfgang Knecht | Plant thymidine kinases and their use |
| US7074598B2 (en) | 2002-09-25 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of vancomycin-resistant enterococcus spp. |
| US7365176B2 (en) | 2002-09-26 | 2008-04-29 | Mayo Foundation For Medical Education And Research | Detection of Epstein-Barr virus |
| US7074599B2 (en) | 2002-09-27 | 2006-07-11 | Mayo Foundation For Medical Education And Research | Detection of mecA-containing Staphylococcus spp. |
| US7427475B2 (en) | 2003-11-18 | 2008-09-23 | Mayo Foundation For Medical Education And Research | Detection of group B streptococcus |
| GB0413702D0 (en) | 2004-06-18 | 2004-07-21 | Molmed Spa | Thymidine kinase |
| CN103930543B (zh) | 2011-09-06 | 2020-11-27 | 诺维信公司 | 葡糖淀粉酶变体和编码它们的多核苷酸 |
| CA2901907C (en) | 2013-02-20 | 2023-06-20 | Emory University | Methods of sequencing nucleic acids in mixtures and compositions related thereto |
| AU2014236208B2 (en) | 2013-03-14 | 2018-07-19 | Genvivo, Inc. | Thymidine kinase diagnostic assay for gene therapy applications |
| WO2014209553A1 (en) | 2013-06-04 | 2014-12-31 | Virginia Commonwealth University | Use of a truncated ccn1 promoter for cancer diagnostics, therapeutics and theranostics |
| EP3004153B1 (en) | 2013-06-04 | 2019-10-30 | Virginia Commonwealth University | Recombinant cancer therapeutic cytokine |
| WO2014197586A1 (en) | 2013-06-04 | 2014-12-11 | Virginia Commonwealth University | Mda-9/syntenin promoter to image and treat metastatic cancer cells |
| US9454494B2 (en) * | 2014-08-01 | 2016-09-27 | Honeywell International Inc. | Encrypting a communication from a device |
| FI3240805T3 (fi) | 2014-12-15 | 2025-02-17 | Univ California | Cd19- ja cd20-vasteellinen bispesifinen tai-veräjän kimeerinen antigeenireseptori |
| EP3234120B1 (en) | 2014-12-15 | 2025-09-03 | The Regents of the University of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
| PL3368571T3 (pl) | 2015-10-30 | 2023-05-02 | The Regents Of The University Of California | Polipeptydy odpowiadające na transformujący czynnik wzrostu beta i sposoby ich zastosowania |
| AU2017290805B2 (en) | 2016-07-01 | 2023-11-16 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
| AU2017319702B2 (en) | 2016-09-02 | 2024-11-14 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
| WO2019108777A1 (en) * | 2017-11-29 | 2019-06-06 | Research Development Foundation | Elimination of proliferating cells from stem cell-derived grafts |
| EP3781130A4 (en) | 2018-04-11 | 2022-01-26 | Precision Molecular Inc. | THERAPEUTIC CONSTRUCTS FOR TREATMENT OF CANCER |
| WO2020165730A1 (en) * | 2019-02-14 | 2020-08-20 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
| CN109735571A (zh) * | 2019-03-11 | 2019-05-10 | 四川药智联恒科技有限公司 | 双自杀基因慢病毒表达载体及其应用 |
| CA3235894A1 (en) | 2021-10-25 | 2023-05-04 | Brile Chung | Compositions and methods for therapeutic delivery |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018884A (en) | 1975-06-26 | 1977-04-19 | Hoffmann-La Roche Inc. | Fluorogenic materials and labeling techniques |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4411993A (en) | 1981-04-29 | 1983-10-25 | Steven Gillis | Hybridoma antibody which inhibits interleukin 2 activity |
| US4769331A (en) | 1981-09-16 | 1988-09-06 | University Patents, Inc. | Recombinant methods and materials |
| USRE32011E (en) | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
| US4514497B1 (en) | 1983-12-30 | 1998-02-24 | Novagene Inc | Modified live pseudorabies viruses |
| US4859587A (en) | 1984-06-04 | 1989-08-22 | Institut Merieux | Recombinant herpes simplex viruses, vaccines and methods |
| US5288641A (en) | 1984-06-04 | 1994-02-22 | Arch Development Corporation | Herpes Simplex virus as a vector |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US4801542A (en) | 1984-10-12 | 1989-01-31 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4902614A (en) | 1984-12-03 | 1990-02-20 | Teijin Limited | Monoclonal antibody to human protein C |
| US4897255A (en) | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| US4744981A (en) | 1985-10-17 | 1988-05-17 | Neorx Corporation | Trichothecene antibody conjugates |
| US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US5643758A (en) * | 1987-03-10 | 1997-07-01 | New England Biolabs, Inc. | Production and purification of a protein fused to a binding protein |
| WO1989001973A2 (en) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| EP0329184A3 (en) | 1988-02-19 | 1990-05-23 | Neorx Corporation | Antimers and antimeric conjugation |
| US4988496A (en) | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| WO1990007936A1 (en) | 1989-01-23 | 1990-07-26 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
| GB8914543D0 (en) | 1989-06-23 | 1989-08-09 | Parker David | Chemical compounds |
| AU648261B2 (en) | 1989-08-18 | 1994-04-21 | Novartis Vaccines And Diagnostics, Inc. | Recombinant retroviruses delivering vector constructs to target cells |
| GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
| US5328688A (en) | 1990-09-10 | 1994-07-12 | Arch Development Corporation | Recombinant herpes simplex viruses vaccines and methods |
| SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| US5203975A (en) | 1991-10-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Process for cathodic electrodeposition of a clear coating over a conductive paint layer |
| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
| GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
| EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES. |
| CA2137361A1 (en) | 1992-06-10 | 1993-12-23 | W. French Anderson | Vector particles resistant to inactivation by human serum |
| GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
| DE69332678T2 (de) | 1992-12-23 | 2004-02-05 | Arch Development Corp., Chicago | Synthetische promotoren von herpes simplex virus |
| FR2705361B1 (fr) | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| WO1995004139A1 (en) | 1993-07-27 | 1995-02-09 | The Wistar Institute Of Anatomy And Biology | Modified dna virus vectors and uses therefor |
| DK0814154T3 (da) | 1993-09-15 | 2009-08-31 | Novartis Vaccines & Diagnostic | Rekombinante alfavirusvektorer |
| FR2712603B1 (fr) | 1993-11-18 | 1996-02-09 | Centre Nat Rech Scient | Virus recombinants, préparation et utilisation en thérapie génique. |
| AU2434195A (en) * | 1994-05-02 | 1995-11-29 | University Of Washington | Thymidine kinase mutants |
| FR2723962B1 (fr) * | 1994-08-25 | 1996-10-31 | Univ Paris Curie | Hsv1-tk modifiee fonctionnelle |
| HUP9902571A3 (en) * | 1996-02-09 | 2002-01-28 | Gencell Sa | Variants of thymidine kinase, related nucleic acids sequences and their use in genic therapy |
| FR2746016B1 (fr) * | 1996-03-15 | 1998-04-17 | Combinaisons d'enzymes pour la destruction de cellules proliferatives | |
| JP2002516061A (ja) * | 1997-10-14 | 2002-06-04 | ダーウィン モレキュラー コーポレイション | チミジンキナーゼ変異体ならびにチミジンキナーゼ活性およびグアニル酸キナーゼ活性を有する融合タンパク質 |
-
1998
- 1998-10-14 JP JP2000516019A patent/JP2002516061A/ja not_active Withdrawn
- 1998-10-14 EP EP10182771A patent/EP2386629A1/en not_active Withdrawn
- 1998-10-14 CA CA002306443A patent/CA2306443A1/en not_active Abandoned
- 1998-10-14 EP EP98953487A patent/EP1025212B1/en not_active Expired - Lifetime
- 1998-10-14 DE DE69838483T patent/DE69838483T2/de not_active Expired - Lifetime
- 1998-10-14 WO PCT/US1998/021672 patent/WO1999019466A2/en not_active Ceased
- 1998-10-14 AT AT98953487T patent/ATE374247T1/de not_active IP Right Cessation
- 1998-10-14 EP EP10182819A patent/EP2386630A1/en not_active Withdrawn
-
2008
- 2008-07-04 JP JP2008176378A patent/JP5070145B2/ja not_active Expired - Fee Related
-
2009
- 2009-05-08 US US12/463,261 patent/US7888091B2/en not_active Expired - Fee Related
- 2009-05-08 US US12/463,283 patent/US7888114B2/en not_active Expired - Fee Related
-
2010
- 2010-12-29 US US12/981,428 patent/US8236541B2/en not_active Expired - Fee Related
- 2010-12-29 US US12/981,418 patent/US8163528B2/en not_active Expired - Fee Related
-
2011
- 2011-11-30 US US13/308,188 patent/US20120142071A1/en not_active Abandoned
- 2011-11-30 US US13/308,164 patent/US20120149890A1/en not_active Abandoned
-
2012
- 2012-01-05 JP JP2012000673A patent/JP2012115270A/ja not_active Withdrawn
- 2012-06-29 US US13/538,503 patent/US20130011903A1/en not_active Abandoned
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