JP2002515223A5 - - Google Patents

Info

Publication number

JP2002515223A5

JP2002515223A5 JP2000543623A JP2000543623A JP2002515223A5 JP 2002515223 A5 JP2002515223 A5 JP 2002515223A5 JP 2000543623 A JP2000543623 A JP 2000543623A JP 2000543623 A JP2000543623 A JP 2000543623A JP 2002515223 A5 JP2002515223 A5 JP 2002515223A5

Authority

JP

Japan

Prior art keywords

polypeptide

composition

polynucleotide

mek3

seq

Prior art date

1999-04-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229920001184 polypeptide Polymers 0.000 description 42
• 102000004196 processed proteins & peptides Human genes 0.000 description 42
• 108090000765 processed proteins & peptides Proteins 0.000 description 42
• 239000002157 polynucleotide Substances 0.000 description 23
• 102000040430 polynucleotide Human genes 0.000 description 23
• 108091033319 polynucleotide Proteins 0.000 description 23
• 239000000203 mixture Substances 0.000 description 20
• 101001115394 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 3 Proteins 0.000 description 19
• 102100023275 Dual specificity mitogen-activated protein kinase kinase 3 Human genes 0.000 description 15
• 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 description 14
• 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 description 14
• 239000008194 pharmaceutical composition Substances 0.000 description 14
• 102000043136 MAP kinase family Human genes 0.000 description 13
• 108091054455 MAP kinase family Proteins 0.000 description 13
• 230000037361 pathway Effects 0.000 description 13
• 238000000034 method Methods 0.000 description 9
• 150000001875 compounds Chemical class 0.000 description 7
• 230000000865 phosphorylative effect Effects 0.000 description 7
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 5
• 125000000539 amino acid group Chemical group 0.000 description 5
• 239000000427 antigen Substances 0.000 description 5
• 102000036639 antigens Human genes 0.000 description 5
• 108091007433 antigens Proteins 0.000 description 5
• 230000000694 effects Effects 0.000 description 5
• 239000012634 fragment Substances 0.000 description 5
• 239000002773 nucleotide Substances 0.000 description 5
• 125000003729 nucleotide group Chemical group 0.000 description 5
• 230000026731 phosphorylation Effects 0.000 description 5
• 238000006366 phosphorylation reaction Methods 0.000 description 5
• 125000003275 alpha amino acid group Chemical group 0.000 description 4
• 239000003795 chemical substances by application Substances 0.000 description 4
• 239000013604 expression vector Substances 0.000 description 4
• 230000011664 signaling Effects 0.000 description 4
• 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 description 3
• 102100023401 Dual specificity mitogen-activated protein kinase kinase 6 Human genes 0.000 description 3
• 101001115395 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Proteins 0.000 description 3
• 101000624426 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 6 Proteins 0.000 description 3
• 108091000080 Phosphotransferase Proteins 0.000 description 3
• 230000003213 activating effect Effects 0.000 description 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 102000020233 phosphotransferase Human genes 0.000 description 3
• 238000006467 substitution reaction Methods 0.000 description 3
• 229940124647 MEK inhibitor Drugs 0.000 description 2
• 150000001413 amino acids Chemical class 0.000 description 2
• 230000000295 complement effect Effects 0.000 description 2
• 201000010099 disease Diseases 0.000 description 2
• 208000015122 neurodegenerative disease Diseases 0.000 description 2
• 238000003259 recombinant expression Methods 0.000 description 2
• 238000012216 screening Methods 0.000 description 2
• 208000023275 Autoimmune disease Diseases 0.000 description 1
• 102100031480 Dual specificity mitogen-activated protein kinase kinase 1 Human genes 0.000 description 1
• 101710146526 Dual specificity mitogen-activated protein kinase kinase 1 Proteins 0.000 description 1
• 102100023266 Dual specificity mitogen-activated protein kinase kinase 2 Human genes 0.000 description 1
• 101710146529 Dual specificity mitogen-activated protein kinase kinase 2 Proteins 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 206010022491 Insulin resistant diabetes Diseases 0.000 description 1
• 206010028980 Neoplasm Diseases 0.000 description 1
• 201000011510 cancer Diseases 0.000 description 1
• 208000035475 disorder Diseases 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 208000030159 metabolic disease Diseases 0.000 description 1
• 230000004770 neurodegeneration Effects 0.000 description 1