CN100374568C - Tao蛋白激酶及其使用方法 - Google Patents

Tao蛋白激酶及其使用方法 Download PDF

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Publication number
CN100374568C
CN100374568C CNB99806761XA CN99806761A CN100374568C CN 100374568 C CN100374568 C CN 100374568C CN B99806761X A CNB99806761X A CN B99806761XA CN 99806761 A CN99806761 A CN 99806761A CN 100374568 C CN100374568 C CN 100374568C
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CN
China
Prior art keywords
glu
leu
polypeptide
ser
gln
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Expired - Fee Related
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CNB99806761XA
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English (en)
Chinese (zh)
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CN1303435A (zh
Inventor
M·考博
M·哈啻森
陈祝
K·比尔曼
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University of Texas System
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University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CNB99806761XA 1998-04-14 1999-04-14 Tao蛋白激酶及其使用方法 Expired - Fee Related CN100374568C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/060,410 1998-04-14
US09/060,410 US6165461A (en) 1998-04-14 1998-04-14 Tao protein kinases and methods of use therefor

Publications (2)

Publication Number Publication Date
CN1303435A CN1303435A (zh) 2001-07-11
CN100374568C true CN100374568C (zh) 2008-03-12

Family

ID=22029289

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB99806761XA Expired - Fee Related CN100374568C (zh) 1998-04-14 1999-04-14 Tao蛋白激酶及其使用方法

Country Status (8)

Country Link
US (2) US6165461A (enExample)
EP (1) EP1071787A1 (enExample)
JP (1) JP2002515223A (enExample)
CN (1) CN100374568C (enExample)
AU (1) AU758731B2 (enExample)
BR (1) BR9909679A (enExample)
CA (1) CA2325824A1 (enExample)
WO (1) WO1999053076A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165461A (en) 1998-04-14 2000-12-26 Board Of Regents, University Of Texas System Tao protein kinases and methods of use therefor
US7078182B1 (en) 1998-04-14 2006-07-18 Board Of Regents, The University Of Texas System TAO protein kinase polypeptides and methods of use therefor
US7148330B2 (en) * 1999-07-30 2006-12-12 Schering Corporation Binding compounds for IL-27
US6806293B1 (en) 2001-03-12 2004-10-19 Darley Pharmaceuticals Ltd Use of pheromone compounds having MAP kinase modulating activity
WO2002072809A1 (en) * 2001-03-12 2002-09-19 Alydar Pharmaceuticals, Inc. Screening non-peptide, non-steroid invertebrate pheromone compounds for mitogen-activated protein kinase modulating activity
CA2449289A1 (en) * 2001-06-05 2002-12-12 Exelixis, Inc. Gfats as modifiers of the p53 pathway and methods of use
CA2454514A1 (en) * 2001-08-06 2003-02-20 Exelixis, Inc. Sphks as modifiers of the p53 pathway and methods of use
CA2460806A1 (en) * 2001-12-13 2003-06-26 Exelixis, Inc. Taojiks as modifiers of the beta-catenin pathway and methods of use
WO2004012817A2 (en) * 2002-07-31 2004-02-12 Kylix B.V. Use of genes identified to be involved in tumor development for the development of anti-cancer drugs
US7282479B2 (en) * 2003-03-31 2007-10-16 Ttc Co., Ltd. Hyperthermia agent for malignant tumor comprising cytokine and magnetic fine particles
EP1514558A1 (en) * 2003-09-15 2005-03-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Use of MARKK or MARKK antagonists for the treatment of pathologies characterised by increased or reduced phosphorylation of MARK or tau protein
AU2006262324A1 (en) * 2005-06-20 2007-01-04 Exelixis, Inc. GALK1s as modifiers of the PTEN/AKT pathway and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000539A2 (en) * 1996-07-03 1998-01-08 Chiron Corporation (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002699A1 (en) * 1997-07-08 1999-01-21 Cadus Pharmaceutical Corporation Kds protein kinase molecules and uses related thereto
US6165461A (en) 1998-04-14 2000-12-26 Board Of Regents, University Of Texas System Tao protein kinases and methods of use therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000539A2 (en) * 1996-07-03 1998-01-08 Chiron Corporation (mitogen-activated protein kinase) kinase-3 (mkk3) interacting protein (mip)

Also Published As

Publication number Publication date
JP2002515223A (ja) 2002-05-28
WO1999053076A9 (en) 2001-03-15
EP1071787A1 (en) 2001-01-31
WO1999053076A1 (en) 1999-10-21
CA2325824A1 (en) 1999-10-21
AU3560599A (en) 1999-11-01
AU758731B2 (en) 2003-03-27
US6586242B1 (en) 2003-07-01
US6165461A (en) 2000-12-26
BR9909679A (pt) 2000-12-19
CN1303435A (zh) 2001-07-11

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Granted publication date: 20080312