|
US6613942B1
(en)
|
1997-07-01 |
2003-09-02 |
Novo Nordisk A/S |
Glucagon antagonists/inverse agonists
|
|
US7045519B2
(en)
|
1998-06-19 |
2006-05-16 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
WO1999065897A1
(en)
*
|
1998-06-19 |
1999-12-23 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
AR023052A1
(es)
*
|
1998-09-25 |
2002-09-04 |
Mitsuharu Yoshimura Milton |
Derivados de pirimidona
|
|
DE69914357T2
(de)
|
1998-11-04 |
2004-11-11 |
Smithkline Beecham Corp. |
Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
|
|
US6350744B1
(en)
*
|
1998-11-20 |
2002-02-26 |
Merck & Co., Inc. |
Compounds having cytokine inhibitory activity
|
|
WO2000040243A1
(en)
|
1999-01-08 |
2000-07-13 |
Smithkline Beecham Corporation |
Novel compounds
|
|
US6503949B1
(en)
|
1999-05-17 |
2003-01-07 |
Noro Nordisk A/S |
Glucagon antagonists/inverse agonists
|
|
US7122666B2
(en)
|
1999-07-21 |
2006-10-17 |
Sankyo Company, Limited |
Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
|
|
GB9927844D0
(en)
|
1999-11-26 |
2000-01-26 |
Glaxo Group Ltd |
Chemical compounds
|
|
US6906067B2
(en)
|
1999-12-28 |
2005-06-14 |
Bristol-Myers Squibb Company |
N-heterocyclic inhibitors of TNF-α expression
|
|
EP1246823A1
(en)
*
|
1999-12-28 |
2002-10-09 |
Pharmacopeia, Inc. |
Pyrimidine and triazine kinase inhibitors
|
|
GB0003224D0
(en)
*
|
2000-02-11 |
2000-04-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
EP1136486A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-[Indanylamino]pyrimidone and 2-[tetrahydronaphthalenylamino]pyrimidone derivatives
|
|
EP1136483A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-[Piperazinyl]pyrimidone derivatives
|
|
EP1136484A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-(Arylalkylamino)pyrimidone derivatives
|
|
EP1136489A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-[Piperidin-1-yl]pyrimidone derivatives
|
|
EP1136493A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives
|
|
EP1136485A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
Aminophenyl pyrimidone derivatives
|
|
AU2001262150A1
(en)
*
|
2000-03-23 |
2001-10-03 |
Mitsubishi Pharma Corporation |
2-(nitrogen-heterocyclic)pyrimidone derivatives
|
|
WO2001070727A1
(en)
*
|
2000-03-23 |
2001-09-27 |
Sanofi-Synthelabo |
2-(arylalkylamino)pyrimidone derivatives and 2-(heteroarylalkylamino)pyrimidone derivatives
|
|
EP1136099A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-(Indolylalkylamino)pyrimidone derivatives as GSK3beta inhibitors
|
|
EP1136491A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-[(Heteroaryl)alkylamino]pyrimidone derivatives
|
|
EP1136482A1
(en)
*
|
2000-03-23 |
2001-09-26 |
Sanofi-Synthelabo |
2-Amino-3-(alkyl)-pyrimidone derivatives as GSK3beta inhibitors
|
|
AU5260601A
(en)
|
2000-04-26 |
2001-11-07 |
Eisai Co Ltd |
Medicinal compositions promoting bowel movement
|
|
CA2781858C
(en)
*
|
2000-05-12 |
2015-03-31 |
Genzyme Corporation |
Modulators of tnf-.alpha. signaling
|
|
US6562807B2
(en)
|
2000-06-23 |
2003-05-13 |
Novo Nordisk A/S |
Glucagon antagonists/inverse agonists
|
|
GB0021494D0
(en)
|
2000-09-01 |
2000-10-18 |
Glaxo Group Ltd |
Chemical comkpounds
|
|
AU9502601A
(en)
*
|
2000-09-06 |
2002-03-22 |
Chiron Corp |
Inhibitors of glycogen synthase kinase 3
|
|
US6670362B2
(en)
|
2000-09-20 |
2003-12-30 |
Pfizer Inc. |
Pyridazine endothelin antagonists
|
|
US6706744B2
(en)
|
2000-11-17 |
2004-03-16 |
Novo Nordisk A/S |
Glucagon antagonists/inverse agonists
|
|
US6821960B2
(en)
|
2000-11-17 |
2004-11-23 |
Noyo Nordisk Pharmaceuticals, Inc. |
Glucagon antagonists/inverse agonists
|
|
WO2002040445A1
(en)
|
2000-11-17 |
2002-05-23 |
Novo Nordisk A/S |
Glucagon antagonists/inverse agonists
|
|
GB0112802D0
(en)
|
2001-05-25 |
2001-07-18 |
Glaxo Group Ltd |
Pyrimidine derivatives
|
|
GB0112810D0
(en)
*
|
2001-05-25 |
2001-07-18 |
Glaxo Group Ltd |
Pyrimidine derivatives
|
|
GB0119477D0
(en)
|
2001-08-09 |
2001-10-03 |
Glaxo Group Ltd |
Pyrimidine derivatives
|
|
CN101274928A
(zh)
*
|
2001-09-21 |
2008-10-01 |
三菱制药株式会社 |
3-取代的-4-嘧啶酮衍生物
|
|
IL160701A0
(en)
|
2001-09-21 |
2004-08-31 |
Mitsubishi Pharma Corp |
3-substituted-4-pyrimidone derivatives
|
|
IL160700A0
(en)
*
|
2001-09-21 |
2004-08-31 |
Mitsubishi Pharma Corp |
3-substituted-4-pyrimidone derivatives
|
|
TWI301834B
(en)
*
|
2001-10-22 |
2008-10-11 |
Eisai R&D Man Co Ltd |
Pyrimidone compound and pharmaceutical composition including the same
|
|
TWI330183B
(https=)
*
|
2001-10-22 |
2010-09-11 |
Eisai R&D Man Co Ltd |
|
|
US6921762B2
(en)
|
2001-11-16 |
2005-07-26 |
Amgen Inc. |
Substituted indolizine-like compounds and methods of use
|
|
US6762318B2
(en)
|
2001-12-03 |
2004-07-13 |
Novo Nordisk A/S |
Glucagon antagonists
|
|
US6881746B2
(en)
|
2001-12-03 |
2005-04-19 |
Novo Nordick A/S |
Glucagon antagonists/inverse agonists
|
|
AR038368A1
(es)
|
2002-02-01 |
2005-01-12 |
Novartis Ag |
Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
|
|
JP4467307B2
(ja)
|
2002-02-22 |
2010-05-26 |
ファルマシア・アンド・アップジョン・カンパニー・エルエルシー |
５−ｈｔ受容体アンタゴニストとしてのピリジルスルホン誘導体
|
|
DE60302221T2
(de)
*
|
2002-02-28 |
2006-08-03 |
Sanofi-Aventis |
Heteroaryl substituierte 2-pyridinyl und 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-onderivate
|
|
AU2003216585A1
(en)
*
|
2002-04-10 |
2003-10-20 |
Orchid Chemicals And Pharmaceuticals Limited |
Pyrimidinedione derivatives useful for the treatment of inflammation and immunological diseases
|
|
JP4606161B2
(ja)
*
|
2002-05-21 |
2011-01-05 |
アムジエン・インコーポレーテツド |
置換複素環式化合物および使用方法
|
|
ES2278170T3
(es)
|
2002-07-09 |
2007-08-01 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG |
Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias.
|
|
ATE325115T1
(de)
|
2002-08-19 |
2006-06-15 |
Glaxo Group Ltd |
Pyrimidinderivate als selektive cox-2-inhibitoren
|
|
GB0221443D0
(en)
|
2002-09-16 |
2002-10-23 |
Glaxo Group Ltd |
Pyridine derivates
|
|
CN1726209B
(zh)
|
2002-12-16 |
2011-04-13 |
三菱制药株式会社 |
3-取代的-4-嘧啶酮衍生物
|
|
US20060058326A1
(en)
*
|
2003-02-06 |
2006-03-16 |
Basf Aktiengesllschaft |
Pyrimidines, methods for the production thereof, and use thereof
|
|
TWI357408B
(en)
|
2003-03-26 |
2012-02-01 |
Mitsubishi Tanabe Pharma Corp |
3-substituted-4-pyrimidone derivatives
|
|
CA2531619A1
(en)
*
|
2003-07-16 |
2005-01-27 |
Neurogen Corporation |
Biaryl piperazinyl-pyridine analogues
|
|
KR20060056377A
(ko)
*
|
2003-08-13 |
2006-05-24 |
카이론 코포레이션 |
Ｇｓｋ-3 억제제 및 그것의 사용
|
|
EP1656366A1
(en)
*
|
2003-08-20 |
2006-05-17 |
Amgen Inc. |
Substituted pyrimdinone derivatives and methods of use
|
|
GB0323137D0
(en)
|
2003-10-03 |
2003-11-05 |
Chang Lisa C W |
2,4,6- Trisubstituted pyrimidines and their different uses
|
|
EP1732541A4
(en)
*
|
2004-04-07 |
2008-03-05 |
Takeda Pharmaceutical |
CYCLIC COMPOUNDS
|
|
US20060035893A1
(en)
|
2004-08-07 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
|
|
MY145822A
(en)
|
2004-08-13 |
2012-04-30 |
Neurogen Corp |
Substituted biaryl piperazinyl-pyridine analogues
|
|
PE20060777A1
(es)
|
2004-12-24 |
2006-10-06 |
Boehringer Ingelheim Int |
Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
|
|
NZ564222A
(en)
*
|
2005-06-14 |
2011-10-28 |
Taigen Biotechnology Co Ltd |
Pyrimidine compounds
|
|
US8193206B2
(en)
|
2005-06-14 |
2012-06-05 |
Taigen Biotechnology Co., Ltd. |
Pyrimidine compounds
|
|
ES2270715B1
(es)
|
2005-07-29 |
2008-04-01 |
Laboratorios Almirall S.A. |
Nuevos derivados de pirazina.
|
|
EP1917244A2
(de)
|
2005-08-24 |
2008-05-07 |
Abbott GmbH & Co. KG |
Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
|
|
ES2274712B1
(es)
|
2005-10-06 |
2008-03-01 |
Laboratorios Almirall S.A. |
Nuevos derivados imidazopiridina.
|
|
EP2079728B1
(en)
|
2006-10-10 |
2013-09-25 |
Amgen Inc. |
N-aryl pyrazole compounds for use against diabetes
|
|
EP1992344A1
(en)
|
2007-05-18 |
2008-11-19 |
Institut Curie |
P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
|
|
BRPI0813629A2
(pt)
*
|
2007-07-26 |
2018-07-10 |
Novartis Ag |
derivados de pirimidina úteis no tratamento de condições inflamatórias ou alérgicas
|
|
DK2268635T3
(en)
|
2008-04-21 |
2015-09-14 |
Taigen Biotechnology Co Ltd |
Heterocyclic Compounds
|
|
US9023834B2
(en)
|
2008-11-13 |
2015-05-05 |
Taigen Biotechnology Co., Ltd. |
Lyophilization formulation
|
|
SG189019A1
(en)
|
2010-10-18 |
2013-05-31 |
Cerenis Therapeutics Holding Sa |
Compounds, compositions and methods useful for cholesterol mobilisation
|
|
GB201106829D0
(en)
|
2011-04-21 |
2011-06-01 |
Proximagen Ltd |
Heterocyclic compounds
|
|
NZ611529A
(en)
|
2010-12-23 |
2015-06-26 |
Pfizer |
Glucagon receptor modulators
|
|
WO2012107850A1
(en)
|
2011-02-08 |
2012-08-16 |
Pfizer Inc. |
Glucagon receptor modulator
|
|
US8927577B2
(en)
|
2011-07-22 |
2015-01-06 |
Pfizer Inc. |
Quinolinyl glucagon receptor modulators
|
|
CN103917529B
(zh)
|
2011-11-11 |
2016-08-17 |
辉瑞大药厂 |
2-硫代嘧啶酮类
|
|
US9902712B2
(en)
|
2013-12-19 |
2018-02-27 |
Sunshine Lake Pharma Co., Ltd. |
Nitrogenous heterocyclic derivatives and their application in drugs
|
|
TWI651310B
(zh)
*
|
2014-02-20 |
2019-02-21 |
日商日本煙草產業股份有限公司 |
三化合物及其醫藥用途
|
|
AU2016257179A1
(en)
|
2015-05-05 |
2017-11-02 |
Pfizer Inc. |
2-thiopyrimidinones
|
|
KR20180037270A
(ko)
|
2015-08-17 |
2018-04-11 |
니뽄 다바코 산교 가부시키가이샤 |
히드록시트리아진 화합물 및 그의 의약 용도
|
|
EP3372589B1
(en)
*
|
2015-10-29 |
2021-10-20 |
ASKA Pharmaceutical Co., Ltd. |
Pyrimidine derivative
|
|
PL3371165T3
(pl)
*
|
2015-11-04 |
2022-05-02 |
Merck Patent Gmbh |
Inhibitor btk do zastosowania w terapii rakowej
|
|
SI3377484T1
(sl)
*
|
2015-11-17 |
2024-02-29 |
Merck Patent Gmbh |
Postopki za zdravljenje multiple skleroze z uporabo pirimidinskih in piridinskih spojin z btk inhibitorno aktivnostjo
|
|
TW201811766A
(zh)
|
2016-08-29 |
2018-04-01 |
瑞士商諾華公司 |
N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途
|
|
EP4058434A1
(en)
|
2019-11-12 |
2022-09-21 |
Genzyme Corporation |
6-membered heteroarylaminosulfonamides for treating diseases and conditions mediated by deficient cftr activity
|
|
EP4626878A1
(en)
|
2022-12-02 |
2025-10-08 |
Neumora Therapeutics, Inc. |
Methods of treating neurological disorders
|