JP2002514179A5 - - Google Patents

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Publication number
JP2002514179A5
JP2002514179A5 JP1998512706A JP51270698A JP2002514179A5 JP 2002514179 A5 JP2002514179 A5 JP 2002514179A5 JP 1998512706 A JP1998512706 A JP 1998512706A JP 51270698 A JP51270698 A JP 51270698A JP 2002514179 A5 JP2002514179 A5 JP 2002514179A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP1998512706A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002514179A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/014852 external-priority patent/WO1998009940A1/en
Publication of JP2002514179A publication Critical patent/JP2002514179A/ja
Publication of JP2002514179A5 publication Critical patent/JP2002514179A5/ja
Abandoned legal-status Critical Current

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JP51270698A 1996-09-04 1997-08-22 マトリックスメタロプロテイナーゼの阻害剤としてのビフェニル酪酸およびその誘導体 Abandoned JP2002514179A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US2581496P 1996-09-04 1996-09-04
US2713896P 1996-10-02 1996-10-02
US5490597P 1997-08-06 1997-08-06
US60/054,905 1997-08-06
US60/027,138 1997-08-06
US60/025,814 1997-08-06
PCT/US1997/014852 WO1998009940A1 (en) 1996-09-04 1997-08-22 Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

Publications (2)

Publication Number Publication Date
JP2002514179A JP2002514179A (ja) 2002-05-14
JP2002514179A5 true JP2002514179A5 (https=) 2005-04-07

Family

ID=27362627

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51270698A Abandoned JP2002514179A (ja) 1996-09-04 1997-08-22 マトリックスメタロプロテイナーゼの阻害剤としてのビフェニル酪酸およびその誘導体

Country Status (9)

Country Link
US (2) US6239288B1 (https=)
EP (1) EP0927156A1 (https=)
JP (1) JP2002514179A (https=)
AR (1) AR009723A1 (https=)
AU (1) AU4159197A (https=)
CO (1) CO4950616A1 (https=)
HR (1) HRP970475A2 (https=)
PE (1) PE109498A1 (https=)
WO (1) WO1998009940A1 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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JP2002514179A (ja) * 1996-09-04 2002-05-14 ワーナー―ランバート・コンパニー マトリックスメタロプロテイナーゼの阻害剤としてのビフェニル酪酸およびその誘導体
CA2263886A1 (en) * 1996-12-09 1998-06-18 Warner-Lambert Company Method for treating and preventing heart failure and ventricular dilatation
AU9663798A (en) 1997-10-06 1999-04-27 Warner-Lambert Company Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
US6169103B1 (en) 1998-03-03 2001-01-02 Warner-Lambert Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
KR20010101325A (ko) 1998-12-30 2001-11-14 빌프리더 하이더 치환된 4-비아릴부티르산 유도체 및 5-비아릴펜탄산유도체의 호흡기 질환 치료용 매트릭스 메탈로프로테아제저해제로서의 용도
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
EP1265864A1 (en) * 2000-03-21 2002-12-18 The Procter & Gamble Company Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
IL151250A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Difluorobutyric acid metalloprotease inhibitors
PL357275A1 (en) * 2000-03-21 2004-07-26 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
CN1366518A (zh) * 2000-04-25 2002-08-28 三星电子株式会社 作为基质金属蛋白酶抑制剂的联苯基丁酸衍生物
KR100405914B1 (ko) * 2000-04-25 2003-11-15 삼성전자주식회사 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체
KR100405913B1 (ko) * 2000-04-25 2003-11-14 삼성전자주식회사 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체
DE10047118A1 (de) * 2000-09-22 2002-04-11 Bayer Ag Verfahren zur Herstellung von Ketocarbonsäurederivaten
DE10113604A1 (de) * 2001-03-20 2002-10-24 Ibfb Gmbh Privates Inst Fuer B Verfahren zur Spaltung des humanen Wachstumshormons GH
WO2003006006A1 (en) * 2001-07-09 2003-01-23 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
CN1289469C (zh) * 2001-12-20 2006-12-13 布里斯托尔-迈尔斯斯奎布公司 α-(N-磺酰氨基)乙酰胺衍生物作为β-淀粉样蛋白抑制剂
AU2003280130B2 (en) 2002-06-28 2009-06-11 Centocor, Inc. Mammalian CH1 deleted mimetibodies, compositions, methods and uses
US6734579B1 (en) * 2002-07-24 2004-05-11 Apple Computer, Inc. System and method for activating a first device from a second device
EP2181704B1 (en) 2002-12-30 2015-05-06 Angiotech International Ag Drug delivery from rapid gelling polymer composition
GB0312654D0 (en) 2003-06-03 2003-07-09 Glaxo Group Ltd Therapeutically useful compounds
GB0314488D0 (en) * 2003-06-20 2003-07-23 Glaxo Group Ltd Therapeutically useful compounds
RU2007129149A (ru) * 2004-12-31 2009-02-10 Авентис Фармасьютикалз Инк. (Us) Использование ряда бифенильных соединений для защиты нейронов и олигодендроцитов при лечении рассеянного склероза (рс)
CA2598518C (en) * 2005-02-22 2015-04-21 Ranbaxy Laboratories Limited 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases
US7319152B2 (en) 2005-09-19 2008-01-15 Wyeth 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators
US7414142B2 (en) 2005-09-19 2008-08-19 Wyeth 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators
JP4936512B2 (ja) * 2006-02-24 2012-05-23 公立大学法人大阪府立大学 光解裂性環状化合物
ES2397284T3 (es) 2006-08-22 2013-03-06 Ranbaxy Laboratories Limited Proceso para preparar inhibidores de la metaloproteinasa de la matriz y auxiliares quirales para los mismos
US20110230428A1 (en) * 2008-07-22 2011-09-22 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
KR101682427B1 (ko) * 2008-12-23 2016-12-05 아쿠일루스 파마슈티컬즈, 인코포레이티드 통증 및 기타 질병을 치료하기 위한 화합물 및 방법
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
CN103896796B (zh) 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
MX2014002459A (es) 2011-08-30 2014-04-10 Chdi Foundation Inc Inhibidores de quinurenina-3-monooxigenasa, composiciones farmaceuticas y metodos de uso de los mismos.
SI2750677T1 (sl) 2011-08-30 2017-10-30 Chdi Foundation, Inc. Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe
EP2926808A1 (en) 2012-11-28 2015-10-07 Administración General De La Communidad Autónoma De Euskadi Use of metalloprotease inhibitors for the treatment of polycystic liver diseases
CU24330B1 (es) 2013-02-14 2018-03-13 Novartis Ag Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral)
US9102635B2 (en) 2013-02-14 2015-08-11 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
US20170119776A1 (en) 2014-04-03 2017-05-04 Bayer Pharma Aktiengesellschaft Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof
US20170114049A1 (en) 2014-04-03 2017-04-27 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratory tract diseases
EP3126339A1 (de) 2014-04-03 2017-02-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung
CN106715421A (zh) 2014-07-17 2017-05-24 Chdi基金会股份有限公司 用于治疗hiv相关病症的方法和组合物
FR3035105A1 (fr) * 2015-04-16 2016-10-21 Metabrain Res Derives utiles dans le traitement de l'atrophie musculaire
CN109422644A (zh) * 2017-09-04 2019-03-05 任洁 芬布芬体内代谢产物及衍生物的用途
CN109422645A (zh) * 2017-09-04 2019-03-05 任洁 芬布芬体内代谢产物及衍生物作为糖尿病相关靶点调节剂的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182061A (en) * 1961-03-20 1965-05-04 Warner Lambert Pharmaceutical 5-[4-(p-hydroxyphenoxy)phenyl]-5-oxo-3-methylvaleric acid
US3997589A (en) * 1971-03-17 1976-12-14 Boehringer Ingelheim Gmbh 4-(2'-Fluoro-4-biphenylylr-4-oxo-butyric acid and esters and salts thereof
NL7203400A (https=) * 1971-03-17 1972-09-19
BE790085A (fr) * 1971-10-15 1973-04-13 Thomae Gmbh Dr K Nouveaux 4-(4-biphenylyl)-butanols
FR2524463A1 (fr) * 1982-04-05 1983-10-07 Fabre Sa Pierre Obtention du metbufene par synthese malonique
US5192753A (en) * 1991-04-23 1993-03-09 Mcgeer Patrick L Anti-rheumatoid arthritic drugs in the treatment of dementia
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
US5886022A (en) * 1995-06-05 1999-03-23 Bayer Corporation Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors
JP2002514179A (ja) * 1996-09-04 2002-05-14 ワーナー―ランバート・コンパニー マトリックスメタロプロテイナーゼの阻害剤としてのビフェニル酪酸およびその誘導体

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