JP2002514179A5 - - Google Patents

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Publication number
JP2002514179A5
JP2002514179A5 JP1998512706A JP51270698A JP2002514179A5 JP 2002514179 A5 JP2002514179 A5 JP 2002514179A5 JP 1998512706 A JP1998512706 A JP 1998512706A JP 51270698 A JP51270698 A JP 51270698A JP 2002514179 A5 JP2002514179 A5 JP 2002514179A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP1998512706A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002514179A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/014852 external-priority patent/WO1998009940A1/en
Publication of JP2002514179A publication Critical patent/JP2002514179A/ja
Publication of JP2002514179A5 publication Critical patent/JP2002514179A5/ja
Abandoned legal-status Critical Current

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JP51270698A 1996-09-04 1997-08-22 マトリックスメタロプロテイナーゼの阻害剤としてのビフェニル酪酸およびその誘導体 Abandoned JP2002514179A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US2581496P 1996-09-04 1996-09-04
US60/025,814 1996-09-04
US2713896P 1996-10-02 1996-10-02
US60/027,138 1996-10-02
US5490597P 1997-08-06 1997-08-06
US60/054,905 1997-08-06
PCT/US1997/014852 WO1998009940A1 (en) 1996-09-04 1997-08-22 Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

Publications (2)

Publication Number Publication Date
JP2002514179A JP2002514179A (ja) 2002-05-14
JP2002514179A5 true JP2002514179A5 (https=) 2005-04-07

Family

ID=27362627

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51270698A Abandoned JP2002514179A (ja) 1996-09-04 1997-08-22 マトリックスメタロプロテイナーゼの阻害剤としてのビフェニル酪酸およびその誘導体

Country Status (9)

Country Link
US (2) US6239288B1 (https=)
EP (1) EP0927156A1 (https=)
JP (1) JP2002514179A (https=)
AR (1) AR009723A1 (https=)
AU (1) AU4159197A (https=)
CO (1) CO4950616A1 (https=)
HR (1) HRP970475A2 (https=)
PE (1) PE109498A1 (https=)
WO (1) WO1998009940A1 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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AU4159197A (en) * 1996-09-04 1998-03-26 Warner-Lambert Company Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
KR20000057444A (ko) * 1996-12-09 2000-09-15 로즈 암스트롱, 크리스틴 에이. 트러트웨인 심기능부전 및 심실확장의 치료 및 예방 방법
US6399612B1 (en) 1997-10-06 2002-06-04 Warner-Lambert Company Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
US6169103B1 (en) 1998-03-03 2001-01-02 Warner-Lambert Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
CN1337932A (zh) * 1998-12-30 2002-02-27 拜尔公司 取代的4-联芳基丁酸和5-联芳基戊酸衍生物作为治疗呼吸疾病的基质金属蛋白酶抑制剂的用途
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
WO2001070682A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
WO2001070693A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Difluorobutyric acid derivatives and their use as metalloprotease inhibitors
NZ520657A (en) * 2000-03-21 2004-11-26 Procter & Gamble Heterocyclic side chain containing, N-substituted metalloprotease inhibitors
KR100405914B1 (ko) * 2000-04-25 2003-11-15 삼성전자주식회사 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체
WO2001083445A1 (en) * 2000-04-25 2001-11-08 Samsung Electronics Co., Ltd. Biphenyl butyric acid derivative as a matrix metalloproteinase inhibitor
KR100405913B1 (ko) * 2000-04-25 2003-11-14 삼성전자주식회사 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체
DE10047118A1 (de) * 2000-09-22 2002-04-11 Bayer Ag Verfahren zur Herstellung von Ketocarbonsäurederivaten
DE10113604A1 (de) * 2001-03-20 2002-10-24 Ibfb Gmbh Privates Inst Fuer B Verfahren zur Spaltung des humanen Wachstumshormons GH
WO2003006006A1 (en) * 2001-07-09 2003-01-23 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
CA2471099C (en) * 2001-12-20 2011-04-12 Bristol-Myers Squibb Company .alpha.-(n-sulphonamido)acetamide derivatives as .beta.-amyloid inhibitors
CA2490409A1 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian ch1 deleted mimetibodies, compositions, methods and uses
US6734579B1 (en) * 2002-07-24 2004-05-11 Apple Computer, Inc. System and method for activating a first device from a second device
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
GB0312654D0 (en) 2003-06-03 2003-07-09 Glaxo Group Ltd Therapeutically useful compounds
GB0314488D0 (en) * 2003-06-20 2003-07-23 Glaxo Group Ltd Therapeutically useful compounds
CN101087597A (zh) * 2004-12-31 2007-12-12 安万特药物公司 某些联苯基化合物在治疗多发性硬化症(ms)中保护神经元和少突胶质细胞的用途
AP2413A (en) 2005-02-22 2012-06-01 Ranbaxy Lab Ltd 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other disease.
US7319152B2 (en) 2005-09-19 2008-01-15 Wyeth 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators
US7414142B2 (en) 2005-09-19 2008-08-19 Wyeth 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators
JP4936512B2 (ja) * 2006-02-24 2012-05-23 公立大学法人大阪府立大学 光解裂性環状化合物
PL2074093T3 (pl) 2006-08-22 2013-03-29 Sun Pharmaceutical Ind Ltd Sposób przygotowywania inhibitorów metaloproteinazy macierzy i chiralnego środka wspomagającego
WO2010011302A1 (en) * 2008-07-22 2010-01-28 Chdi, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US8765953B2 (en) * 2008-12-23 2014-07-01 Aquilus Pharmaceuticals, Inc. Compounds and methods for the treatment of pain and other diseases
SG176009A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
JP5466759B2 (ja) 2009-05-28 2014-04-09 ノバルティス アーゲー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
KR20140072037A (ko) 2011-08-30 2014-06-12 씨에이치디아이 파운데이션, 인코포레이티드 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법
SI2750677T1 (sl) 2011-08-30 2017-10-30 Chdi Foundation, Inc. Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe
WO2014083229A1 (es) 2012-11-28 2014-06-05 Administración General De La Comunidad Autónoma De Euskadi Uso de inhibidores de metaloproteasas en el tratamiento de enfermedades hepáticas poliquísticas
TR201808541T4 (tr) 2013-02-14 2018-07-23 Novartis Ag Nep (nötr endopeptidaz) inhibitörleri olarak ikame edilmiş bisfenil butanoik fosfonik asit türevleri.
JP6301371B2 (ja) 2013-02-14 2018-04-11 ノバルティス アーゲー インビボ効力が改善されたnep阻害剤としての置換ビスフェニルブタン酸誘導体
US20170022171A1 (en) 2014-04-03 2017-01-26 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentanecarboxylic acids and their use
US20170119776A1 (en) 2014-04-03 2017-05-04 Bayer Pharma Aktiengesellschaft Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof
CA2944614A1 (en) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases
AU2015289492B2 (en) 2014-07-17 2020-02-20 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders
FR3035105A1 (fr) 2015-04-16 2016-10-21 Metabrain Res Derives utiles dans le traitement de l'atrophie musculaire
CN109422644A (zh) * 2017-09-04 2019-03-05 任洁 芬布芬体内代谢产物及衍生物的用途
CN109422645A (zh) * 2017-09-04 2019-03-05 任洁 芬布芬体内代谢产物及衍生物作为糖尿病相关靶点调节剂的用途

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US3182061A (en) * 1961-03-20 1965-05-04 Warner Lambert Pharmaceutical 5-[4-(p-hydroxyphenoxy)phenyl]-5-oxo-3-methylvaleric acid
US3997589A (en) * 1971-03-17 1976-12-14 Boehringer Ingelheim Gmbh 4-(2'-Fluoro-4-biphenylylr-4-oxo-butyric acid and esters and salts thereof
NL7203400A (https=) * 1971-03-17 1972-09-19
BE790085A (fr) * 1971-10-15 1973-04-13 Thomae Gmbh Dr K Nouveaux 4-(4-biphenylyl)-butanols
FR2524463A1 (fr) * 1982-04-05 1983-10-07 Fabre Sa Pierre Obtention du metbufene par synthese malonique
US5192753A (en) * 1991-04-23 1993-03-09 Mcgeer Patrick L Anti-rheumatoid arthritic drugs in the treatment of dementia
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
US5886022A (en) * 1995-06-05 1999-03-23 Bayer Corporation Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors
AU4159197A (en) * 1996-09-04 1998-03-26 Warner-Lambert Company Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

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