CO4950616A1 - Acidos bifenil butiricos y sus derivados como inhibidores de metaloproteinasas de matriz - Google Patents

Acidos bifenil butiricos y sus derivados como inhibidores de metaloproteinasas de matriz

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Publication number
CO4950616A1
CO4950616A1 CO97051086A CO97051086A CO4950616A1 CO 4950616 A1 CO4950616 A1 CO 4950616A1 CO 97051086 A CO97051086 A CO 97051086A CO 97051086 A CO97051086 A CO 97051086A CO 4950616 A1 CO4950616 A1 CO 4950616A1
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Colombia
Prior art keywords
previously defined
different
same
hydrogen
previously
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CO97051086A
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English (en)
Inventor
Claude Forsey Purchase Jr
Bruce David Roth
Andrew David White
Gerald P Schielke
Lary Craswell Walker
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Warner Lambert Co
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Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CO4950616A1 publication Critical patent/CO4950616A1/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/64—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
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    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
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    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen
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    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
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    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
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  • Communicable Diseases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto de la Fórmula Icaracterizado porque donde R y R1 son iguales o diferentes y sonhidrógeno,alquilo,halógeno,nitro,ciano,trifluorometil,OCF3 ,OCF2 H,OCF2 F,-OR6 donde R6 es hidrógeno, oalquilo, oarilo, oarilalquilo, oheteroarilo, o-N-R6 donde R6 y R6a son iguales o diferentes y son oe6a como fueron definidos anteriormente para R6 ,O|-O-C-R6 donde R6 es como definimos anteriormente,O|-NH-C-R6 donde R6 es como definimos anteriormente,O|-S-C-R6 donde R6 es como definimos anteriormente,-SR6 donde R6 es como definimos anteriormente,O|-C-R6 donde R6 es como definimos anteriormente, - 2 --CH2 -OR6 donde R6 es como definimos anteriormente,-CH2 -N-R6 donde R6 y R6a son iguales o diferentes | R6a y son como hemos definido anteriormente para R6 , O |-C-N-Ra donde R6 y R6a son iguales o diferentes y oe R6a son como hemos definido anteriormente para R6 , O |-S-R6 donde R6 es como definimos anteriormente, O |-S-R6 donde R6 es como definimos anteriormente, | Ocicloalquilo, oheteroalquilo, con la condición de que R y R1 no sonambos hidrógeno;R2 es OR6 tal como definimos anteriormente, oN-R6 donde R6 y R6a son iguales o diferentes y son|R6a como definimos anteriormente para R6 ;R3 , R3a , R4 y R4a son iguales o diferentes y sonhidrógeno,flúor,alquilo,-(CH2 )n -arilo donde n es un entero entre 1 y 6,-(CH2 )n -heteroarilo donde n es tal como definimos anteriormente, -(CH2 )n -heteroarilo donde n es tal como definimosanteriormente,-(CH2 )n -cicloalquilo donde n es tal como definimosanteriormente, -(CH2 )p -X-(CH2 )q -arilo donde X es O, SO, SO2 , o NH y p y q son cada uno cero o un entero entre 1 y 6, y la suma de p+q no es mayor que seis,-(CH2 )p -X-(CH2 )q -heteroarilo donde X, p y q son como hemos definido anteriormente, o-(CH2 )n -R7 donde R7 esN-ftalimido,N-2,3-naftilimido,-OR6 donde R6 es como hemos definido anteriormente,-N-R6 donde R6 y R6a o iguales, o bien diferentes, | R6ay son ambos como definimos anteriormente para R6 ,-SR6 donde R6 es como definimos anteriormente,O |-S-R6 donde R6 es como definimos anteriormente,O |-S-R6 donde R6 es como definimos anteriormente, |O O |O-C-R6 donde R6 es como definimos anteriormente, O |N-C-R6 donde R6 y R6a son iguales o diferentes y|R6a son como definimos anteriormente para R6 , O |-S-C-R6 donde R6 es como definimos anteriormente,O ½AND#8209;CAND#8209;R6 donde R6 es como definimos anteriormente,O½AND#8209;CAND#8209;OR6 donde R6 es como definimos anteriormente, O ½AND#8209;CAND#8209;NAND#8209;R6 donde R6 y R6a son iguales o diferentes y ½ R6a son como definimos anteriormente para Ra , y n es como definimos anteriormente,R5 es OH, SH, u OR5n donde R5a es alquilo, arilalquilo, cicloalquilo, o aciloximetilo, con la condición de que R3 , R3a , R4 y R4a son hidrógeno o al menos uno de R3 , R3a , R4 y R4a sean flúor;y sus isómeros correspondientes; o su salfarmacéuticamente aceptable.
CO97051086A 1996-09-04 1997-09-03 Acidos bifenil butiricos y sus derivados como inhibidores de metaloproteinasas de matriz CO4950616A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2581496P 1996-09-04 1996-09-04
US2713896P 1996-10-02 1996-10-02
US5490597P 1997-08-06 1997-08-06

Publications (1)

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CO4950616A1 true CO4950616A1 (es) 2000-09-01

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CO97051086A CO4950616A1 (es) 1996-09-04 1997-09-03 Acidos bifenil butiricos y sus derivados como inhibidores de metaloproteinasas de matriz

Country Status (9)

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US (2) US6239288B1 (es)
EP (1) EP0927156A1 (es)
JP (1) JP2002514179A (es)
AR (1) AR009723A1 (es)
AU (1) AU4159197A (es)
CO (1) CO4950616A1 (es)
HR (1) HRP970475A2 (es)
PE (1) PE109498A1 (es)
WO (1) WO1998009940A1 (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0927156A1 (en) * 1996-09-04 1999-07-07 Warner-Lambert Company Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
BR9714385A (pt) * 1996-12-09 2000-05-16 Warner Lambert Co Método para tratamento e prevenção de deficiência cardìaca e dilatação ventricular
US6399612B1 (en) 1997-10-06 2002-06-04 Warner-Lambert Company Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
US6169103B1 (en) 1998-03-03 2001-01-02 Warner-Lambert Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
KR20010101325A (ko) 1998-12-30 2001-11-14 빌프리더 하이더 치환된 4-비아릴부티르산 유도체 및 5-비아릴펜탄산유도체의 호흡기 질환 치료용 매트릭스 메탈로프로테아제저해제로서의 용도
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
MXPA02009311A (es) 2000-03-21 2003-03-12 Procter & Gamble Inhibidores de las metaloproteasas n-sustituidas que contienen cadenas laterales heterociclicas.
IL151250A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Difluorobutyric acid metalloprotease inhibitors
WO2001070682A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
KR100405913B1 (ko) * 2000-04-25 2003-11-14 삼성전자주식회사 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체
CN1366518A (zh) * 2000-04-25 2002-08-28 三星电子株式会社 作为基质金属蛋白酶抑制剂的联苯基丁酸衍生物
KR100405914B1 (ko) * 2000-04-25 2003-11-15 삼성전자주식회사 메트릭스 메탈로프로테이나제의 저해제로서의 비페닐부티릭산 유도체
DE10047118A1 (de) * 2000-09-22 2002-04-11 Bayer Ag Verfahren zur Herstellung von Ketocarbonsäurederivaten
DE10113604A1 (de) * 2001-03-20 2002-10-24 Ibfb Gmbh Privates Inst Fuer B Verfahren zur Spaltung des humanen Wachstumshormons GH
WO2003006006A1 (en) * 2001-07-09 2003-01-23 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
WO2003053912A1 (en) * 2001-12-20 2003-07-03 Bristol-Myers Squibb Company α-(N-SULPHONAMIDO)ACETAMIDE DERIVATIVES AS β-AMYLOID INHIBITORS
CA2490409A1 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian ch1 deleted mimetibodies, compositions, methods and uses
US6734579B1 (en) * 2002-07-24 2004-05-11 Apple Computer, Inc. System and method for activating a first device from a second device
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
GB0312654D0 (en) * 2003-06-03 2003-07-09 Glaxo Group Ltd Therapeutically useful compounds
GB0314488D0 (en) * 2003-06-20 2003-07-23 Glaxo Group Ltd Therapeutically useful compounds
EP1833472A2 (en) * 2004-12-31 2007-09-19 Aventis Pharmaceuticals Inc. Use of certain biphenyl compounds for protection of neurons and oligodendrocytes in the treatment of multiple sclerosis (ms)
EP1856063B1 (en) * 2005-02-22 2012-01-25 Ranbaxy Laboratories Limited 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases
US7414142B2 (en) 2005-09-19 2008-08-19 Wyeth 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators
US7319152B2 (en) 2005-09-19 2008-01-15 Wyeth 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators
JP4936512B2 (ja) * 2006-02-24 2012-05-23 公立大学法人大阪府立大学 光解裂性環状化合物
EA016567B1 (ru) 2006-08-22 2012-05-30 Ранбакси Лабораториз Лимитед Ингибиторы матриксных металлопротеиназ
WO2010011302A1 (en) * 2008-07-22 2010-01-28 Chdi, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MX339096B (es) * 2008-12-23 2016-05-11 Aquilus Pharmaceuticals Inc Compuestos inhibidores de metaloproteasa a base de feniletiniltiofeno y su uso en el tratamiento del dolor y otras enfermedades.
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
NZ596304A (en) 2009-05-28 2014-01-31 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
BR112014004845A2 (pt) 2011-08-30 2017-04-04 Chdi Foundation Inc pelo menos uma entidade química; pelo menos um composto; composição farmacêutica; uso de uma quantidade terapeuticamente eficaz de pelo menos uma entidade química; composição farmacêutica embalada
PT2750677T (pt) 2011-08-30 2017-07-03 Chdi Foundation Inc Inibidores de quinurenina-3-monooxigenase, composições farmacêuticas e métodos de utilização dos mesmos
WO2014083229A1 (es) 2012-11-28 2014-06-05 Administración General De La Comunidad Autónoma De Euskadi Uso de inhibidores de metaloproteasas en el tratamiento de enfermedades hepáticas poliquísticas
EP2956445A1 (en) 2013-02-14 2015-12-23 Novartis AG Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy
LT2956464T (lt) 2013-02-14 2018-07-10 Novartis Ag Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai
CA2944614A1 (en) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases
WO2015150362A2 (de) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft Chirale 2,5-disubstituierte cyclopentancarbonsäure-derivate und ihre verwendung
WO2015150363A1 (de) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung
UA120856C2 (uk) 2014-07-17 2020-02-25 Кхді Фаундейшн, Інк. Способи та композиції для лікування розладів, пов'язаних з віл
FR3035105A1 (fr) 2015-04-16 2016-10-21 Metabrain Res Derives utiles dans le traitement de l'atrophie musculaire
CN109422645A (zh) * 2017-09-04 2019-03-05 任洁 芬布芬体内代谢产物及衍生物作为糖尿病相关靶点调节剂的用途
CN109422644A (zh) * 2017-09-04 2019-03-05 任洁 芬布芬体内代谢产物及衍生物的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182061A (en) * 1961-03-20 1965-05-04 Warner Lambert Pharmaceutical 5-[4-(p-hydroxyphenoxy)phenyl]-5-oxo-3-methylvaleric acid
US3997589A (en) * 1971-03-17 1976-12-14 Boehringer Ingelheim Gmbh 4-(2'-Fluoro-4-biphenylylr-4-oxo-butyric acid and esters and salts thereof
NL7203400A (es) * 1971-03-17 1972-09-19
BE790085A (fr) * 1971-10-15 1973-04-13 Thomae Gmbh Dr K Nouveaux 4-(4-biphenylyl)-butanols
FR2524463A1 (fr) * 1982-04-05 1983-10-07 Fabre Sa Pierre Obtention du metbufene par synthese malonique
US5192753A (en) * 1991-04-23 1993-03-09 Mcgeer Patrick L Anti-rheumatoid arthritic drugs in the treatment of dementia
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
US5886022A (en) * 1995-06-05 1999-03-23 Bayer Corporation Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors
EP0927156A1 (en) * 1996-09-04 1999-07-07 Warner-Lambert Company Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

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WO1998009940A1 (en) 1998-03-12
US6307089B2 (en) 2001-10-23
EP0927156A1 (en) 1999-07-07
JP2002514179A (ja) 2002-05-14
PE109498A1 (es) 1999-01-15
US6239288B1 (en) 2001-05-29
HRP970475A2 (en) 1998-08-31
US20010000513A1 (en) 2001-04-26
AU4159197A (en) 1998-03-26
AR009723A1 (es) 2000-05-03

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