IL143229A0 - Method for producing optically active 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives - Google Patents

Method for producing optically active 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives

Info

Publication number
IL143229A0
IL143229A0 IL14322999A IL14322999A IL143229A0 IL 143229 A0 IL143229 A0 IL 143229A0 IL 14322999 A IL14322999 A IL 14322999A IL 14322999 A IL14322999 A IL 14322999A IL 143229 A0 IL143229 A0 IL 143229A0
Authority
IL
Israel
Prior art keywords
cyclopent
hydroxymethyl
amino
optically active
ene derivatives
Prior art date
Application number
IL14322999A
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of IL143229A0 publication Critical patent/IL143229A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Abstract

The invention discloses a new method for producing enantiomer-enriched 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives of the general formulae (I) and (II) in which R1 is hydrogen or a possibly substituted C1-8 alkyl radical, aryl radical or cycloalkyl radical and R2 is acyl. According to said method a racemic 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivative of general formula (III), in which R1 has the meaning given above, is converted using a hydrolase and in the presence of an acylation agent
IL14322999A 1998-12-23 1999-12-23 Method for producing optically active 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives IL143229A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98124570 1998-12-23
US14599999P 1999-07-29 1999-07-29
PCT/EP1999/010382 WO2000039324A2 (en) 1998-12-23 1999-12-23 Method for producing optically active 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives

Publications (1)

Publication Number Publication Date
IL143229A0 true IL143229A0 (en) 2002-04-21

Family

ID=26149931

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14322999A IL143229A0 (en) 1998-12-23 1999-12-23 Method for producing optically active 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives

Country Status (20)

Country Link
US (1) US6524844B2 (en)
EP (1) EP1141374B1 (en)
JP (1) JP4633934B2 (en)
KR (1) KR100685195B1 (en)
CN (1) CN1189569C (en)
AT (1) ATE253125T1 (en)
AU (1) AU2102600A (en)
CA (1) CA2354382C (en)
CZ (1) CZ301107B6 (en)
DE (1) DE59907569D1 (en)
DK (1) DK1141374T3 (en)
ES (1) ES2211216T3 (en)
HU (1) HUP0104547A3 (en)
IL (1) IL143229A0 (en)
MX (1) MXPA01006428A (en)
NO (1) NO326058B1 (en)
PL (1) PL196857B1 (en)
PT (1) PT1141374E (en)
SK (1) SK285795B6 (en)
WO (1) WO2000039324A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2354382C (en) * 1998-12-23 2010-09-07 Lonza Ag Process for preparing optically active 1-amino-4-(hydroxymethyl) cyclopent-2-ene derivatives
GB0306267D0 (en) 2003-03-19 2003-04-23 Ineos Fluor Ltd Process
WO2006117057A1 (en) * 2005-05-02 2006-11-09 Dsm Fine Chemicals Austria Nfg Gmbh & Co Kg Process for preparing enantiomerically enriched e-(2s)- and (2r)-alkyl-5-halopent-4-enecarboxylic acids or their esters

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2756790B2 (en) * 1988-07-18 1998-05-25 富士薬品工業株式会社 Method for producing optically active cyclopentenol derivative
GB9108376D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Cyclopentenes
WO1997045529A1 (en) * 1996-05-30 1997-12-04 Lonza Ag Process for the preparation of amino alcohols and derivatives thereof
SK285229B6 (en) * 1997-05-13 2006-09-07 Lonza Ag Process for the preparation of a (1R, 4S)- or (1S, 4R)-1-amino-4- (hydroxymethyl)-2-cyclopentene derivative and an enantiomer of a (1R,4S)-N-butyryl-1-amino-4-(hydroxymethyl)-2-cyclopenten
SK284594B6 (en) * 1997-11-27 2005-07-01 Lonza Ag Process for the preparation of aminoalcohol derivatives and their salts
CA2354382C (en) * 1998-12-23 2010-09-07 Lonza Ag Process for preparing optically active 1-amino-4-(hydroxymethyl) cyclopent-2-ene derivatives

Also Published As

Publication number Publication date
DE59907569D1 (en) 2003-12-04
US6524844B2 (en) 2003-02-25
PL196857B1 (en) 2008-02-29
WO2000039324A3 (en) 2000-09-21
EP1141374B1 (en) 2003-10-29
MXPA01006428A (en) 2002-06-21
HUP0104547A2 (en) 2002-03-28
PT1141374E (en) 2004-03-31
PL349388A1 (en) 2002-07-15
CZ20012168A3 (en) 2001-11-14
NO20013037L (en) 2001-06-19
WO2000039324A2 (en) 2000-07-06
AU2102600A (en) 2000-07-31
ATE253125T1 (en) 2003-11-15
CA2354382A1 (en) 2000-07-06
CZ301107B6 (en) 2009-11-11
DK1141374T3 (en) 2004-02-16
SK8812001A3 (en) 2002-01-07
CA2354382C (en) 2010-09-07
US20020042108A1 (en) 2002-04-11
ES2211216T3 (en) 2004-07-01
CN1352695A (en) 2002-06-05
KR20010099861A (en) 2001-11-09
EP1141374A2 (en) 2001-10-10
NO20013037D0 (en) 2001-06-19
NO326058B1 (en) 2008-09-08
KR100685195B1 (en) 2007-02-22
JP2003520018A (en) 2003-07-02
HUP0104547A3 (en) 2003-12-29
CN1189569C (en) 2005-02-16
JP4633934B2 (en) 2011-02-16
SK285795B6 (en) 2007-08-02

Similar Documents

Publication Publication Date Title
HK1070103A1 (en) Process for the preparation of (1s,4r)-or (1r,4s)-1-amino-4-(hydroxymethyl)-2-cyclopentene, its derivatives or salts thereof
DE69928821D1 (en) RESOLUTION OF TRANS-2 (ALKOXYCARBONYLETHYL) LACTAMEN, USEFUL IN THE SYNTHESIS OF 1- (4-FLUOROPHENYL) -3 (R) -3 (S) -HYDROXY-3- (4-FLUORO-PHENYL) PROPYL] -4 (S) - (4-hydroxyphenyl) -2-azetidinone
ATE211732T1 (en) N-BENZYLPIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES
ES2155995T3 (en) 4-PHENYLPIPERIDINE COMPOUNDS.
DE69516866D1 (en) STEREOCHEMICAL WORDMAN DERIVATIVES
ES2260933T3 (en) DERIVATIVES OF THE ACID OF TIAZOLINA.
FI955498A (en) Nipecotinic acid derivatives as anticoagulants
ES2188134T3 (en) CICLOHEXANDIOL DERIVATIVES.
PL349388A1 (en) Method for producing optically active 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives
EA199901098A1 (en) NEW METHOD
MA24197A1 (en) NEW FUNGARRESTINES
DE69306570D1 (en) METHOD FOR PRODUCING RIBONUCLEOTIDE REDUCTASE INHIBITORS
YU1500A (en) Method for preparing alkyloxy furanone derivatives, compounds obtained by said method and use of said compounds
ES2140552T3 (en) INDOL DERIVATIVES AS INHIBITORS OF 5-ALPHA-REDUCTASE-1.
ATE195115T1 (en) METHOD FOR PRODUCING 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALINE DERIVATIVES
HUP0003361A2 (en) Carbonyldiimidazoles, their ester derivatives and method for their production
DK0459449T3 (en) Furano (2,3-F) isoindoles as aldose reductase inhibitors
ES8700693A1 (en) Novel alpha-D-mannosidase inhibitor.
AU2148899A (en) 15-methyl-cyclopropanosteroids and method for the production thereof
SU1266156A1 (en) 7-MORFOLINOCUMRINES AS DYES FOR LASER TECHNOLOGY
MY132489A (en) New 2-(3h)-oxazolone derivatives

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed