JP2002513399A - 医学治療に有用なテルベンゾイミダゾール（トポイソメラーゼインヒビター） - Google Patents
医学治療に有用なテルベンゾイミダゾール（トポイソメラーゼインヒビター）Info
- Publication number
- JP2002513399A JP2002513399A JP53462498A JP53462498A JP2002513399A JP 2002513399 A JP2002513399 A JP 2002513399A JP 53462498 A JP53462498 A JP 53462498A JP 53462498 A JP53462498 A JP 53462498A JP 2002513399 A JP2002513399 A JP 2002513399A
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- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- halo
- compound
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 229940095064 tartrate Drugs 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
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- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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- 150000003852 triazoles Chemical class 0.000 description 1
- SYUVAXDZVWPKSI-UHFFFAOYSA-N tributyl(phenyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=CC=C1 SYUVAXDZVWPKSI-UHFFFAOYSA-N 0.000 description 1
- GYUURHMITDQTRU-UHFFFAOYSA-N tributyl(pyridin-2-yl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=CC=N1 GYUURHMITDQTRU-UHFFFAOYSA-N 0.000 description 1
- GZJNLVYEAQGOSJ-UHFFFAOYSA-N tributyl-(4-chlorophenyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=C(Cl)C=C1 GZJNLVYEAQGOSJ-UHFFFAOYSA-N 0.000 description 1
- PIILXFBHQILWPS-UHFFFAOYSA-N tributyltin Chemical class CCCC[Sn](CCCC)CCCC PIILXFBHQILWPS-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- JLEXUIVKURIPFI-UHFFFAOYSA-N tris phosphate Chemical compound OP(O)(O)=O.OCC(N)(CO)CO JLEXUIVKURIPFI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/786,629 US5770617A (en) | 1996-03-20 | 1997-01-21 | Terbenzimidazoles useful as antifungal agents |
| US08/786,629 | 1997-01-21 | ||
| PCT/US1998/001005 WO1998031673A1 (en) | 1997-01-21 | 1998-01-21 | Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002513399A true JP2002513399A (ja) | 2002-05-08 |
| JP2002513399A5 JP2002513399A5 (enExample) | 2005-09-08 |
Family
ID=25139154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53462498A Ceased JP2002513399A (ja) | 1997-01-21 | 1998-01-21 | 医学治療に有用なテルベンゾイミダゾール（トポイソメラーゼインヒビター） |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5770617A (enExample) |
| EP (1) | EP0960103A1 (enExample) |
| JP (1) | JP2002513399A (enExample) |
| KR (1) | KR20000070359A (enExample) |
| AU (1) | AU746663B2 (enExample) |
| CA (1) | CA2278452A1 (enExample) |
| IL (1) | IL130572A0 (enExample) |
| NZ (1) | NZ336606A (enExample) |
| PL (1) | PL334662A1 (enExample) |
| WO (1) | WO1998031673A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013527220A (ja) * | 2010-06-01 | 2013-06-27 | サミット コーポレイション ピーエルシー | クロストリジウム・ディフィシル関連疾患を治療するための化合物 |
| US9763925B2 (en) | 2008-12-02 | 2017-09-19 | Summit Therapeutics Plc | Antibacterial compounds |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299358A (zh) | 1997-12-31 | 2001-06-13 | 新泽西州州立大学(拉特格斯) | 杂环拓扑异构酶毒性剂 |
| IL137351A0 (en) | 1998-02-12 | 2001-07-24 | Univ Rutgers | Heterocyclic topoisomerase poisons |
| CA2371728C (en) * | 1999-06-11 | 2009-06-02 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
| US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| WO2002062398A2 (en) | 2001-01-08 | 2002-08-15 | Neorx Corporation | Radioactively labelled conjugates of phosphonates |
| EP1453812B1 (en) * | 2001-11-14 | 2008-08-20 | Rutgers, The State University | Cytotoxic agents |
| AU2002364953A1 (en) * | 2001-11-14 | 2003-06-17 | Edmond J. Lavoie | Topoisomerase poison agents |
| AU2002365161B2 (en) * | 2001-11-14 | 2008-07-03 | Rutgers, The State University | Solubilized topoisomerase poison agents |
| PT1465625E (pt) * | 2001-11-14 | 2010-03-09 | Univ Rutgers | Venenos de topoisomerase solubilizados |
| WO2003051403A1 (en) | 2001-12-13 | 2003-06-26 | Dow Global Technologies Inc. | Treatment of osteomyelitis with radiopharmaceuticals |
| US6992088B2 (en) * | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| AU2003265406A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted topoisomerase agents |
| AU2003268075A1 (en) * | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| AU2003290818A1 (en) * | 2002-11-12 | 2004-06-03 | Edmond J. Lavoie | Topoisomerase-targeting agents |
| GB0619325D0 (en) | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| EP2403856B1 (en) | 2009-03-06 | 2012-12-19 | Rutgers, The State University of New Jersey | Methylenedioxybenzo [i]phenanthridine derivatives used to treat cancer |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| US9920014B2 (en) | 2013-09-19 | 2018-03-20 | The Florida International University Board Of Trustees | Selective inhibition of bacterial topoisomerase I |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| WO2017125944A1 (en) * | 2016-01-23 | 2017-07-27 | Jawaharlal Nehru University (Jnu) | Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase ia and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria |
| JP2019515025A (ja) | 2016-04-04 | 2019-06-06 | ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー | トポイソメラーゼ毒 |
| JP7267563B2 (ja) | 2017-06-27 | 2023-05-02 | 株式会社Kyulux | 発光材料、化合物、遅延蛍光体および発光素子 |
| WO2019004254A1 (ja) | 2017-06-27 | 2019-01-03 | 株式会社Ｋｙｕｌｕｘ | 発光材料、化合物、遅延蛍光体および発光素子 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9900071A3 (en) * | 1995-05-17 | 2002-01-28 | Univ Rutgers | Tribenzimidazoles useful as topoisomerase i inhibitors, pharmaceutical compositions containing them and their use |
| US5643935A (en) * | 1995-06-07 | 1997-07-01 | The University Of North Carolina At Chapel Hill | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
-
1997
- 1997-01-21 US US08/786,629 patent/US5770617A/en not_active Expired - Lifetime
-
1998
- 1998-01-21 IL IL13057298A patent/IL130572A0/xx unknown
- 1998-01-21 NZ NZ336606A patent/NZ336606A/en unknown
- 1998-01-21 JP JP53462498A patent/JP2002513399A/ja not_active Ceased
- 1998-01-21 PL PL98334662A patent/PL334662A1/xx unknown
- 1998-01-21 CA CA002278452A patent/CA2278452A1/en not_active Abandoned
- 1998-01-21 AU AU61327/98A patent/AU746663B2/en not_active Ceased
- 1998-01-21 WO PCT/US1998/001005 patent/WO1998031673A1/en not_active Ceased
- 1998-01-21 KR KR1019997006592A patent/KR20000070359A/ko not_active Withdrawn
- 1998-01-21 EP EP98905972A patent/EP0960103A1/en not_active Ceased
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9763925B2 (en) | 2008-12-02 | 2017-09-19 | Summit Therapeutics Plc | Antibacterial compounds |
| JP2013527220A (ja) * | 2010-06-01 | 2013-06-27 | サミット コーポレイション ピーエルシー | クロストリジウム・ディフィシル関連疾患を治療するための化合物 |
| JP2015214541A (ja) * | 2010-06-01 | 2015-12-03 | サミット コーポレイション ピーエルシーＳｕｍｍｉｔ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｌｃ | クロストリジウム・ディフィシル関連疾患を治療するための化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US5770617A (en) | 1998-06-23 |
| EP0960103A1 (en) | 1999-12-01 |
| NZ336606A (en) | 2001-04-27 |
| AU6132798A (en) | 1998-08-07 |
| PL334662A1 (en) | 2000-03-13 |
| WO1998031673A1 (en) | 1998-07-23 |
| CA2278452A1 (en) | 1998-07-23 |
| IL130572A0 (en) | 2000-06-01 |
| AU746663B2 (en) | 2002-05-02 |
| KR20000070359A (ko) | 2000-11-25 |
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