IL130572A0 - Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) - Google Patents

Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Info

Publication number
IL130572A0
IL130572A0 IL13057298A IL13057298A IL130572A0 IL 130572 A0 IL130572 A0 IL 130572A0 IL 13057298 A IL13057298 A IL 13057298A IL 13057298 A IL13057298 A IL 13057298A IL 130572 A0 IL130572 A0 IL 130572A0
Authority
IL
Israel
Prior art keywords
terbenzimidazoles
useful
topoisomerase inhibitors
medical therapy
therapy
Prior art date
Application number
IL13057298A
Other languages
English (en)
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of IL130572A0 publication Critical patent/IL130572A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13057298A 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) IL130572A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/786,629 US5770617A (en) 1996-03-20 1997-01-21 Terbenzimidazoles useful as antifungal agents
PCT/US1998/001005 WO1998031673A1 (en) 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Publications (1)

Publication Number Publication Date
IL130572A0 true IL130572A0 (en) 2000-06-01

Family

ID=25139154

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13057298A IL130572A0 (en) 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Country Status (10)

Country Link
US (1) US5770617A (enExample)
EP (1) EP0960103A1 (enExample)
JP (1) JP2002513399A (enExample)
KR (1) KR20000070359A (enExample)
AU (1) AU746663B2 (enExample)
CA (1) CA2278452A1 (enExample)
IL (1) IL130572A0 (enExample)
NZ (1) NZ336606A (enExample)
PL (1) PL334662A1 (enExample)
WO (1) WO1998031673A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1299358A (zh) * 1997-12-31 2001-06-13 新泽西州州立大学(拉特格斯) 杂环拓扑异构酶毒性剂
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
WO2000076556A2 (en) * 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
JP2004536034A (ja) 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
AU2002363658B2 (en) * 2001-11-14 2008-09-11 Rutgers, The State University Solubilized topoisomerase poisons
CA2467279A1 (en) * 2001-11-14 2003-06-26 Edmond J. Lavoie Solubilized topoisomerase poison agents
ATE405568T1 (de) * 2001-11-14 2008-09-15 Univ Rutgers Cytotoxische mittel
DE60225943T2 (de) * 2001-11-14 2009-01-29 Rutgers, The State University Topoisomerase-giftmittel
EP1458416A1 (en) 2001-12-13 2004-09-22 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
AU2003268075A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
US6989387B2 (en) * 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
AU2003290818A1 (en) * 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
JP5773888B2 (ja) 2009-03-06 2015-09-02 ラットガーズ，ザ・ステート・ユニバーシティ・オブ・ニュージャージー 癌治療に用いられるメチレンジオキシベンゾ［ｉ］フェナントリジン誘導体
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
CA2801274C (en) * 2010-06-01 2021-06-15 Summit Corporation Plc Compounds for the treatment of clostridium difficile-associated disease
US9920014B2 (en) 2013-09-19 2018-03-20 The Florida International University Board Of Trustees Selective inhibition of bacterial topoisomerase I
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
CA3011672C (en) 2016-01-23 2022-11-01 Vibha Tandon Broad spectrum antibacterial activity of bisbenzimidazoles targeting topoisomerase ia
EP3442979A4 (en) 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey topoisomerase poisons
JP7267563B2 (ja) 2017-06-27 2023-05-02 株式会社Kyulux 発光材料、化合物、遅延蛍光体および発光素子
WO2019004254A1 (ja) 2017-06-27 2019-01-03 株式会社Ｋｙｕｌｕｘ 発光材料、化合物、遅延蛍光体および発光素子

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2221248A1 (en) * 1995-05-17 1996-11-21 Leroy Fong Liu Tribenzimidazoles useful as topoisomerase i inhibitors
US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles

Also Published As

Publication number Publication date
NZ336606A (en) 2001-04-27
PL334662A1 (en) 2000-03-13
JP2002513399A (ja) 2002-05-08
AU746663B2 (en) 2002-05-02
CA2278452A1 (en) 1998-07-23
AU6132798A (en) 1998-08-07
US5770617A (en) 1998-06-23
EP0960103A1 (en) 1999-12-01
KR20000070359A (ko) 2000-11-25
WO1998031673A1 (en) 1998-07-23

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