IL130572A0 - Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) - Google Patents

Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Info

Publication number
IL130572A0
IL130572A0 IL13057298A IL13057298A IL130572A0 IL 130572 A0 IL130572 A0 IL 130572A0 IL 13057298 A IL13057298 A IL 13057298A IL 13057298 A IL13057298 A IL 13057298A IL 130572 A0 IL130572 A0 IL 130572A0
Authority
IL
Israel
Prior art keywords
terbenzimidazoles
useful
topoisomerase inhibitors
medical therapy
therapy
Prior art date
Application number
IL13057298A
Other languages
English (en)
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of IL130572A0 publication Critical patent/IL130572A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13057298A 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors) IL130572A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/786,629 US5770617A (en) 1996-03-20 1997-01-21 Terbenzimidazoles useful as antifungal agents
PCT/US1998/001005 WO1998031673A1 (en) 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Publications (1)

Publication Number Publication Date
IL130572A0 true IL130572A0 (en) 2000-06-01

Family

ID=25139154

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13057298A IL130572A0 (en) 1997-01-21 1998-01-21 Terbenzimidazoles useful for medical therapy (topoisomerase inhibitors)

Country Status (10)

Country Link
US (1) US5770617A (enExample)
EP (1) EP0960103A1 (enExample)
JP (1) JP2002513399A (enExample)
KR (1) KR20000070359A (enExample)
AU (1) AU746663B2 (enExample)
CA (1) CA2278452A1 (enExample)
IL (1) IL130572A0 (enExample)
NZ (1) NZ336606A (enExample)
PL (1) PL334662A1 (enExample)
WO (1) WO1998031673A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1299358A (zh) 1997-12-31 2001-06-13 新泽西州州立大学(拉特格斯) 杂环拓扑异构酶毒性剂
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
CA2371728C (en) * 1999-06-11 2009-06-02 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
WO2002062398A2 (en) 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
EP1453812B1 (en) * 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxic agents
AU2002364953A1 (en) * 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
AU2002365161B2 (en) * 2001-11-14 2008-07-03 Rutgers, The State University Solubilized topoisomerase poison agents
PT1465625E (pt) * 2001-11-14 2010-03-09 Univ Rutgers Venenos de topoisomerase solubilizados
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
AU2003265406A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
AU2003268075A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
AU2003290818A1 (en) * 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
EP2403856B1 (en) 2009-03-06 2012-12-19 Rutgers, The State University of New Jersey Methylenedioxybenzo [i]phenanthridine derivatives used to treat cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2011151621A1 (en) * 2010-06-01 2011-12-08 Summit Corporation Plc Compounds for the treatment of clostridium difficile associated disease
US9920014B2 (en) 2013-09-19 2018-03-20 The Florida International University Board Of Trustees Selective inhibition of bacterial topoisomerase I
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
WO2017125944A1 (en) * 2016-01-23 2017-07-27 Jawaharlal Nehru University (Jnu) Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase ia and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria
JP2019515025A (ja) 2016-04-04 2019-06-06 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー トポイソメラーゼ毒
JP7267563B2 (ja) 2017-06-27 2023-05-02 株式会社Kyulux 発光材料、化合物、遅延蛍光体および発光素子
WO2019004254A1 (ja) 2017-06-27 2019-01-03 株式会社Ｋｙｕｌｕｘ 発光材料、化合物、遅延蛍光体および発光素子

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900071A3 (en) * 1995-05-17 2002-01-28 Univ Rutgers Tribenzimidazoles useful as topoisomerase i inhibitors, pharmaceutical compositions containing them and their use
US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles

Also Published As

Publication number Publication date
US5770617A (en) 1998-06-23
EP0960103A1 (en) 1999-12-01
NZ336606A (en) 2001-04-27
AU6132798A (en) 1998-08-07
JP2002513399A (ja) 2002-05-08
PL334662A1 (en) 2000-03-13
WO1998031673A1 (en) 1998-07-23
CA2278452A1 (en) 1998-07-23
AU746663B2 (en) 2002-05-02
KR20000070359A (ko) 2000-11-25

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