JP2002512978A5 - - Google Patents
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- Publication number
- JP2002512978A5 JP2002512978A5 JP2000545568A JP2000545568A JP2002512978A5 JP 2002512978 A5 JP2002512978 A5 JP 2002512978A5 JP 2000545568 A JP2000545568 A JP 2000545568A JP 2000545568 A JP2000545568 A JP 2000545568A JP 2002512978 A5 JP2002512978 A5 JP 2002512978A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotine
- solution
- human
- nicotine solution
- therapeutically effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 234
- 229960002715 nicotine Drugs 0.000 description 234
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 234
- 239000000243 solution Substances 0.000 description 124
- 238000000034 method Methods 0.000 description 68
- 230000036765 blood level Effects 0.000 description 26
- 239000000203 mixture Substances 0.000 description 22
- 208000024891 symptom Diseases 0.000 description 22
- 210000002438 upper gastrointestinal tract Anatomy 0.000 description 22
- 239000000796 flavoring agent Substances 0.000 description 16
- 235000019634 flavors Nutrition 0.000 description 16
- 230000004060 metabolic process Effects 0.000 description 16
- 230000000391 smoking effect Effects 0.000 description 15
- 241000282412 Homo Species 0.000 description 14
- 239000008280 blood Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 13
- 208000024827 Alzheimer disease Diseases 0.000 description 12
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 description 12
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 12
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 12
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 description 12
- 239000000843 powder Substances 0.000 description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 230000002378 acidificating effect Effects 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 8
- 235000013405 beer Nutrition 0.000 description 8
- 235000016213 coffee Nutrition 0.000 description 8
- 235000013353 coffee beverage Nutrition 0.000 description 8
- 230000035622 drinking Effects 0.000 description 8
- 235000015203 fruit juice Nutrition 0.000 description 8
- 235000013336 milk Nutrition 0.000 description 8
- 239000008267 milk Substances 0.000 description 8
- 210000004080 milk Anatomy 0.000 description 8
- 235000000346 sugar Nutrition 0.000 description 8
- 230000005945 translocation Effects 0.000 description 8
- 235000015041 whisky Nutrition 0.000 description 8
- 235000014101 wine Nutrition 0.000 description 8
- 230000002440 hepatic effect Effects 0.000 description 7
- 210000003240 portal vein Anatomy 0.000 description 7
- 230000036470 plasma concentration Effects 0.000 description 6
- 239000003929 acidic solution Substances 0.000 description 4
- 210000001198 duodenum Anatomy 0.000 description 4
- 210000003238 esophagus Anatomy 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 230000009747 swallowing Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 3
- 229910002091 carbon monoxide Inorganic materials 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000005586 smoking cessation Effects 0.000 description 3
- 206010009900 Colitis ulcerative Diseases 0.000 description 2
- 206010012335 Dependence Diseases 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 2
- 235000019788 craving Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 235000019505 tobacco product Nutrition 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/070,263 US6211194B1 (en) | 1998-04-30 | 1998-04-30 | Solution containing nicotine |
| US09/070,263 | 1998-04-30 | ||
| PCT/US1999/008752 WO1999055371A1 (en) | 1998-04-30 | 1999-04-21 | Solution containing nicotine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002512978A JP2002512978A (ja) | 2002-05-08 |
| JP2002512978A5 true JP2002512978A5 (enExample) | 2006-06-15 |
Family
ID=22094213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000545568A Pending JP2002512978A (ja) | 1998-04-30 | 1999-04-21 | ニコチン含有溶液 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6211194B1 (enExample) |
| EP (1) | EP1073466A4 (enExample) |
| JP (1) | JP2002512978A (enExample) |
| AU (1) | AU745292B2 (enExample) |
| CA (1) | CA2330644A1 (enExample) |
| NZ (1) | NZ507845A (enExample) |
| WO (1) | WO1999055371A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268386B1 (en) * | 1998-06-25 | 2001-07-31 | Marshall Anlauf Thompson | Nicotine beverage |
| US6358060B2 (en) * | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| US20020098264A1 (en) * | 1998-11-27 | 2002-07-25 | Cherukuri Subraman R. | Medicated chewing gum delivery system for nicotine |
| JP2004512907A (ja) * | 2000-11-03 | 2004-04-30 | リカバリー ファーマシューティカルズ インコーポレーティッド | 禁煙用の装置および方法 |
| US20050131031A1 (en) * | 2001-12-10 | 2005-06-16 | Thompson Marshall A. | Method of producing a nicotine composition |
| US20030108592A1 (en) * | 2001-12-10 | 2003-06-12 | Thompson Marshall Anlauf | Method of producing a nicotine composition |
| US20060204598A1 (en) * | 2001-12-10 | 2006-09-14 | Thompson Marshall A | Nicotine-alternative compositions and methods of producing such compositions |
| US20060105023A1 (en) * | 2001-12-10 | 2006-05-18 | Knight Joseph R | Treatment of neurological disorders with nicotine |
| EP1461037B1 (en) * | 2001-12-10 | 2007-08-01 | Joseph Robert Knight | Process for preparation of a beverage treated with a nicotine containing substance |
| US20100160376A1 (en) * | 2001-12-10 | 2010-06-24 | Marshall Anlauf Thompson | Nicotine-alternative compositions and methods of producing such compositions |
| SE0104388D0 (sv) * | 2001-12-27 | 2001-12-27 | Pharmacia Ab | New formulation and use and manufacture thereof |
| US7767698B2 (en) * | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
| US20040002520A1 (en) * | 2002-07-01 | 2004-01-01 | Soderlund Patrick L. | Composition and method for cessation of Nicotine cravings |
| DK1803443T3 (en) * | 2002-12-20 | 2019-02-25 | Niconovum Ab | Nicotine-containing particulate material with a crystalline cellulose |
| US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| CN104397869B (zh) | 2003-11-07 | 2016-06-08 | 美国无烟烟草有限责任公司 | 烟草组合物 |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| US7766018B2 (en) | 2004-09-30 | 2010-08-03 | Smoke-Break, Inc. | Device and composition for reducing the incidence of tobacco smoking |
| JP2008528028A (ja) * | 2005-01-27 | 2008-07-31 | マーシャル アンラーフ トンプソン | ニコチン組成物の製造方法 |
| US8642016B2 (en) * | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| AU2006348180A1 (en) * | 2006-09-13 | 2008-03-20 | Warner Chilcott Company, Llc | Methods of treatment for ulcerative colitis |
| US20100048519A1 (en) * | 2006-09-13 | 2010-02-25 | Chyon-Hwa Yeh | Methods of treatment for ulcerative colitis using aminosalicylate |
| ES2521494T3 (es) * | 2007-04-02 | 2014-11-12 | Parkinson's Institute | Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos |
| EP2706854A4 (en) * | 2011-05-09 | 2014-12-03 | Envivo Pharmaceuticals Inc | TREATMENT OF COGNITIVE DISORDERS BY CERTAIN AGONISTS OF THE ALPHA-7 NICOTINIC RECEPTOR IN COMBINATION WITH NICOTINE |
| US20130017259A1 (en) | 2011-07-06 | 2013-01-17 | The Parkinson's Institute | Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients |
| KR102705152B1 (ko) | 2013-05-06 | 2024-09-09 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 염 제제 및 그 방법 |
| KR102957402B1 (ko) | 2013-12-05 | 2026-04-24 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 액제 및 그 방법 |
| WO2016123406A1 (en) | 2015-01-28 | 2016-08-04 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| EP3267875A4 (en) | 2015-03-12 | 2018-12-05 | Chrono Therapeutics Inc. | Craving input and support system |
| US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
| WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| CA3101966A1 (en) | 2018-05-29 | 2019-12-05 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| US20210255202A1 (en) | 2018-06-13 | 2021-08-19 | Michael R. D'Andrea | Methods and dosing regimens for preventing or delaying onset of alzheimer's disease and other forms of dementia and mild congnitive impairment |
| EP3807260B1 (en) | 2018-06-15 | 2024-09-18 | R. J. Reynolds Tobacco Company | Purification of nicotine |
| US12397141B2 (en) | 2018-11-16 | 2025-08-26 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
| BR102020002169A2 (pt) * | 2020-01-31 | 2021-08-10 | Bruno Ghizoni Da Silva Comércio De Produtos E Serviços Inovadores-Me | Bebida estimulante |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR899037A (fr) | 1942-06-17 | 1945-05-15 | Metallguss & Presswerk H Diehl | Alliage de zinc ductile |
| US3870794A (en) * | 1974-02-20 | 1975-03-11 | Foundation For Behavioral Rese | Treatment of certain emotional disorders with nicotine compounds |
| GB2142822B (en) | 1983-06-29 | 1987-02-11 | Alec Stanley Walter Shaw | Nicotine lozenges |
| GB8317576D0 (en) | 1983-06-29 | 1983-08-03 | Shaw A S W | Consumer tobacco products |
| DE3639418A1 (de) | 1986-11-18 | 1988-06-09 | Forschungsgesellschaft Rauchen | Nikotinhaltiges mittel |
| EP0395683A4 (en) * | 1987-11-19 | 1991-01-30 | Indaus International Pty Ltd | Nicotine compositions |
| JP2695247B2 (ja) * | 1988-06-13 | 1997-12-24 | ビーエーエスエフ・ケー・アンド・エフ・コーポレイシヨン | コレスチルアミンを含有する食用の焼いた組成物 |
| US5026555A (en) * | 1988-10-28 | 1991-06-25 | Warner-Lambert Co. | Method for preparing an anion exchange resin delivery system |
| SE8904295D0 (sv) | 1989-12-21 | 1989-12-21 | Pharmacia Ab | Smoking substitute |
| US5147654A (en) * | 1990-07-23 | 1992-09-15 | Alza Corporation | Oral osmotic device for delivering nicotine |
| US5135753A (en) * | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| US5326570A (en) * | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
| US5780051A (en) * | 1992-04-02 | 1998-07-14 | Dynagen, Inc. | Methods and articles of manufacture for nicotine cessation and monitoring nicotine use |
| US5596007A (en) * | 1992-05-18 | 1997-01-21 | Pharmaco Behavioral Associates, Inc. | Therapeutic method to alleviate the craving associated with cessation of tobacco with cotinine |
| US5383478A (en) | 1993-01-12 | 1995-01-24 | Duke University | Low tar and low nicotine cigarette adapted to provide enhanced smoking satisfaction |
| IT1266565B1 (it) | 1993-07-22 | 1997-01-09 | Ct Lab Farm Srl | Composizioni farmaceutiche a rilascio controllato a base di uno o piu' sali farmaceuticamente accettabili dell'acido gamma-idrossi-butirrico. |
| US5549906A (en) | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| JP3188073B2 (ja) * | 1993-09-28 | 2001-07-16 | 武田薬品工業株式会社 | 飲用液組成物 |
| CN1089834A (zh) * | 1993-10-14 | 1994-07-27 | 王子芸 | 戒烟口胶的配方及加工工艺 |
| US5810018A (en) * | 1994-12-29 | 1998-09-22 | Monte; Woodrow C. | Method, composition and apparatus for reducing the incidence of cigarette smoking |
-
1998
- 1998-04-30 US US09/070,263 patent/US6211194B1/en not_active Expired - Lifetime
-
1999
- 1999-04-21 WO PCT/US1999/008752 patent/WO1999055371A1/en not_active Ceased
- 1999-04-21 CA CA002330644A patent/CA2330644A1/en not_active Abandoned
- 1999-04-21 EP EP99919947A patent/EP1073466A4/en not_active Ceased
- 1999-04-21 JP JP2000545568A patent/JP2002512978A/ja active Pending
- 1999-04-21 AU AU37547/99A patent/AU745292B2/en not_active Ceased
- 1999-04-21 NZ NZ507845A patent/NZ507845A/en not_active IP Right Cessation
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