|
US20030040467A1
(en)
|
1998-06-15 |
2003-02-27 |
Mary Ann Pelleymounter |
Ig/ob fusions and uses thereof.
|
|
WO1997018833A1
(en)
*
|
1995-11-22 |
1997-05-29 |
Amgen Inc. |
Methods of increasing lean tissue mass using ob protein compositions
|
|
US6936439B2
(en)
|
1995-11-22 |
2005-08-30 |
Amgen Inc. |
OB fusion protein compositions and methods
|
|
EP1489100B1
(en)
|
1997-12-08 |
2016-06-15 |
Merck Patent GmbH |
Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation
|
|
US7488590B2
(en)
|
1998-10-23 |
2009-02-10 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
PT1783222E
(pt)
|
1998-10-23 |
2012-07-26 |
Kirin Amgen Inc |
Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética
|
|
US6660843B1
(en)
*
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
WO2000024418A1
(en)
*
|
1998-10-27 |
2000-05-04 |
Eli Lilly And Company |
Prevention of muscle mass loss with leptin receptor ligands
|
|
US7067110B1
(en)
|
1999-07-21 |
2006-06-27 |
Emd Lexigen Research Center Corp. |
Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
JP4793971B2
(ja)
|
1999-08-09 |
2011-10-12 |
メルク パテント ゲーエムベーハー |
複合サイトカイン−抗体複合体
|
|
EP1228214A2
(en)
|
1999-11-12 |
2002-08-07 |
MERCK PATENT GmbH |
Erythropoietin forms with improved properties
|
|
HUP0204475A2
(en)
|
2000-02-11 |
2003-04-28 |
Merck Patent Gmbh |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
US20020090646A1
(en)
*
|
2000-05-03 |
2002-07-11 |
Amgen Inc. |
Calcitonin-related molecules
|
|
AU5943201A
(en)
*
|
2000-05-03 |
2001-11-12 |
Amgen Inc |
Modified peptides as therapeutic agents
|
|
DE60129695T2
(de)
|
2000-06-29 |
2008-06-05 |
Merck Patent Gmbh |
Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme
|
|
KR20030067755A
(ko)
*
|
2001-01-18 |
2003-08-14 |
메르크 파텐트 게엠베하 |
글루코세레브로시다제 활성을 갖는 이관능성 융합 단백질
|
|
AU2002248571B2
(en)
|
2001-03-07 |
2007-01-18 |
Merck Patent Gmbh |
Expression technology for proteins containing a hybrid isotype antibody moiety
|
|
WO2002079415A2
(en)
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
PT1383785E
(pt)
|
2001-05-03 |
2011-06-28 |
Merck Patent Gmbh |
Anticorpo recombinante específico de tumores e utilização deste
|
|
PT1454138E
(pt)
|
2001-12-04 |
2012-03-28 |
Merck Patent Gmbh |
Imunocitoquinas com seletividade modulada
|
|
CA2485166A1
(en)
|
2002-05-21 |
2003-12-04 |
Amgen Inc. |
Substituted pyrimidinone and pyridinone compounds
|
|
CN100432105C
(zh)
|
2002-12-17 |
2008-11-12 |
默克专利有限公司 |
与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合
|
|
CA2551915C
(en)
|
2003-12-30 |
2015-06-23 |
Merck Patent Gesellschaft Mit Beschraenkter Haftung |
Il-7 fusion proteins
|
|
JP2008504008A
(ja)
|
2003-12-31 |
2008-02-14 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
改良された薬物動態を有するFc−エリスロポエチン融合タンパク質
|
|
AU2005203962C1
(en)
|
2004-01-05 |
2012-11-08 |
Antisoma Research Limited |
Interleukin-12 targeted to oncofoetal fibronectin
|
|
EA011879B1
(ru)
|
2004-09-24 |
2009-06-30 |
Эмджин Инк. |
МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ
|
|
CN101072793B
(zh)
|
2004-12-09 |
2012-06-20 |
默克专利有限公司 |
具有降低的免疫原性的il-7变体
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
US8642543B2
(en)
|
2005-09-07 |
2014-02-04 |
Neurotez, Inc. |
Methods for treating progressive cognitive disorders related to neurofibrillary tangles
|
|
US8227408B2
(en)
|
2005-09-07 |
2012-07-24 |
Neurotez, Inc. |
Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
|
|
US8716220B2
(en)
|
2005-09-07 |
2014-05-06 |
Nikolaos Tezapsidis |
Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta
|
|
KR102057826B1
(ko)
|
2008-04-11 |
2019-12-20 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
WO2009149379A2
(en)
|
2008-06-05 |
2009-12-10 |
Regents Of The University Of Michigan |
Use of leptin for the treatment of fatty liver diseases and conditions
|
|
EP2421896A1
(en)
|
2009-04-22 |
2012-02-29 |
Merck Patent GmbH |
Antibody fusion proteins with modified fcrn binding sites
|
|
TWI812066B
(zh)
|
2010-11-30 |
2023-08-11 |
日商中外製藥股份有限公司 |
具有鈣依存性的抗原結合能力之抗體
|
|
CN112812184A
(zh)
|
2011-02-25 |
2021-05-18 |
中外制药株式会社 |
FcγRIIb特异性Fc抗体
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
RU2650646C2
(ru)
|
2012-09-27 |
2018-04-16 |
Дзе Чилдрен'З Медикал Сентер Корпорейшн |
Соединения, предназначенные для лечения ожирения, и способы их применения
|
|
SI3074033T1
(sl)
|
2013-11-26 |
2019-03-29 |
The Children's Medical Center Corporation |
Spojine za zdravljenje debelosti in postopki njihove uporabe
|
|
US20170209408A1
(en)
|
2014-04-03 |
2017-07-27 |
The Children's Medical Center Corporation |
Hsp90 inhibitors for the treatment of obesity and methods of use thereof
|
|
CN107207607B
(zh)
|
2014-12-19 |
2021-05-04 |
中外制药株式会社 |
抗-c5抗体及使用方法
|
|
KR101860280B1
(ko)
|
2014-12-19 |
2018-05-21 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
|
|
CN114773470A
(zh)
|
2015-02-05 |
2022-07-22 |
中外制药株式会社 |
包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用
|
|
US11359009B2
(en)
|
2015-12-25 |
2022-06-14 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies and methods of use
|
|
TWI693940B
(zh)
|
2016-08-05 |
2020-05-21 |
日商中外製藥股份有限公司 |
Il-8相關疾病之治療用或預防用組成物
|
|
CA3036551A1
(en)
|
2016-09-12 |
2018-03-15 |
Aegerion Pharmaceuticals, Inc. |
Methods of detecting anti-leptin neutralizing antibodies
|
|
JP7191833B2
(ja)
|
2017-01-30 |
2022-12-19 |
中外製薬株式会社 |
抗スクレロスチン抗体およびその使用
|