CA2286098C - Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods - Google Patents
Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods Download PDFInfo
- Publication number
- CA2286098C CA2286098C CA002286098A CA2286098A CA2286098C CA 2286098 C CA2286098 C CA 2286098C CA 002286098 A CA002286098 A CA 002286098A CA 2286098 A CA2286098 A CA 2286098A CA 2286098 C CA2286098 C CA 2286098C
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- CA
- Canada
- Prior art keywords
- protein
- human
- leu
- ser
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000000034 method Methods 0.000 title claims abstract description 27
- 101001063991 Homo sapiens Leptin Proteins 0.000 title claims description 64
- 102000049953 human LEP Human genes 0.000 title claims description 64
- 239000000203 mixture Substances 0.000 title abstract description 46
- 239000000725 suspension Substances 0.000 claims abstract description 91
- 102000016267 Leptin Human genes 0.000 claims abstract description 49
- 108010092277 Leptin Proteins 0.000 claims abstract description 49
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 11
- 235000018102 proteins Nutrition 0.000 claims description 52
- 102000004169 proteins and genes Human genes 0.000 claims description 52
- 108090000623 proteins and genes Proteins 0.000 claims description 52
- 235000001014 amino acid Nutrition 0.000 claims description 31
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 23
- 150000001413 amino acids Chemical group 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 229940039781 leptin Drugs 0.000 claims description 14
- 210000004369 blood Anatomy 0.000 claims description 13
- 239000008280 blood Substances 0.000 claims description 13
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 13
- 230000001376 precipitating effect Effects 0.000 claims description 11
- 108060003951 Immunoglobulin Proteins 0.000 claims description 10
- 102000018358 immunoglobulin Human genes 0.000 claims description 10
- 150000002632 lipids Chemical class 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 239000011701 zinc Substances 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 229910052725 zinc Inorganic materials 0.000 claims description 8
- 235000004279 alanine Nutrition 0.000 claims description 7
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 5
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- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 4
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- 150000003839 salts Chemical class 0.000 claims description 4
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- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims description 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 2
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- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 5
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
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- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 15
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- 238000002347 injection Methods 0.000 description 10
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- SBANPBVRHYIMRR-UHFFFAOYSA-N Leu-Ser-Pro Natural products CC(C)CC(N)C(=O)NC(CO)C(=O)N1CCCC1C(O)=O SBANPBVRHYIMRR-UHFFFAOYSA-N 0.000 description 8
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- IHCXPSYCHXFXKT-DCAQKATOSA-N Pro-Arg-Glu Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(O)=O IHCXPSYCHXFXKT-DCAQKATOSA-N 0.000 description 7
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84397197A | 1997-04-17 | 1997-04-17 | |
| US08/843,971 | 1997-04-17 | ||
| US09/059,467 US20020019352A1 (en) | 1997-04-17 | 1998-04-14 | Stable, active, human ob protein compositions and methods |
| US09/059,467 | 1998-04-14 | ||
| PCT/US1998/007828 WO1998046257A1 (en) | 1997-04-17 | 1998-04-16 | Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2286098A1 CA2286098A1 (en) | 1998-10-22 |
| CA2286098C true CA2286098C (en) | 2009-07-07 |
Family
ID=26738785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002286098A Expired - Fee Related CA2286098C (en) | 1997-04-17 | 1998-04-16 | Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0977583B1 (https=) |
| JP (1) | JP4086908B2 (https=) |
| CN (1) | CN1202862C (https=) |
| AT (1) | ATE223229T1 (https=) |
| AU (1) | AU7132798A (https=) |
| CA (1) | CA2286098C (https=) |
| DE (1) | DE69807679T2 (https=) |
| ES (1) | ES2183351T3 (https=) |
| HU (1) | HU226175B1 (https=) |
| IL (1) | IL132380A0 (https=) |
| WO (1) | WO1998046257A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030040467A1 (en) | 1998-06-15 | 2003-02-27 | Mary Ann Pelleymounter | Ig/ob fusions and uses thereof. |
| WO1997018833A1 (en) * | 1995-11-22 | 1997-05-29 | Amgen Inc. | Methods of increasing lean tissue mass using ob protein compositions |
| US6936439B2 (en) | 1995-11-22 | 2005-08-30 | Amgen Inc. | OB fusion protein compositions and methods |
| EP1489100B1 (en) | 1997-12-08 | 2016-06-15 | Merck Patent GmbH | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| PT1783222E (pt) | 1998-10-23 | 2012-07-26 | Kirin Amgen Inc | Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| WO2000024418A1 (en) * | 1998-10-27 | 2000-05-04 | Eli Lilly And Company | Prevention of muscle mass loss with leptin receptor ligands |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| JP4793971B2 (ja) | 1999-08-09 | 2011-10-12 | メルク パテント ゲーエムベーハー | 複合サイトカイン−抗体複合体 |
| EP1228214A2 (en) | 1999-11-12 | 2002-08-07 | MERCK PATENT GmbH | Erythropoietin forms with improved properties |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| US20020090646A1 (en) * | 2000-05-03 | 2002-07-11 | Amgen Inc. | Calcitonin-related molecules |
| AU5943201A (en) * | 2000-05-03 | 2001-11-12 | Amgen Inc | Modified peptides as therapeutic agents |
| DE60129695T2 (de) | 2000-06-29 | 2008-06-05 | Merck Patent Gmbh | Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| KR20030067755A (ko) * | 2001-01-18 | 2003-08-14 | 메르크 파텐트 게엠베하 | 글루코세레브로시다제 활성을 갖는 이관능성 융합 단백질 |
| AU2002248571B2 (en) | 2001-03-07 | 2007-01-18 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| PT1383785E (pt) | 2001-05-03 | 2011-06-28 | Merck Patent Gmbh | Anticorpo recombinante específico de tumores e utilização deste |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| CA2485166A1 (en) | 2002-05-21 | 2003-12-04 | Amgen Inc. | Substituted pyrimidinone and pyridinone compounds |
| CN100432105C (zh) | 2002-12-17 | 2008-11-12 | 默克专利有限公司 | 与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合 |
| CA2551915C (en) | 2003-12-30 | 2015-06-23 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Il-7 fusion proteins |
| JP2008504008A (ja) | 2003-12-31 | 2008-02-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改良された薬物動態を有するＦｃ−エリスロポエチン融合タンパク質 |
| AU2005203962C1 (en) | 2004-01-05 | 2012-11-08 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| EA011879B1 (ru) | 2004-09-24 | 2009-06-30 | Эмджин Инк. | МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ |
| CN101072793B (zh) | 2004-12-09 | 2012-06-20 | 默克专利有限公司 | 具有降低的免疫原性的il-7变体 |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US8642543B2 (en) | 2005-09-07 | 2014-02-04 | Neurotez, Inc. | Methods for treating progressive cognitive disorders related to neurofibrillary tangles |
| US8227408B2 (en) | 2005-09-07 | 2012-07-24 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
| US8716220B2 (en) | 2005-09-07 | 2014-05-06 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| WO2009149379A2 (en) | 2008-06-05 | 2009-12-10 | Regents Of The University Of Michigan | Use of leptin for the treatment of fatty liver diseases and conditions |
| EP2421896A1 (en) | 2009-04-22 | 2012-02-29 | Merck Patent GmbH | Antibody fusion proteins with modified fcrn binding sites |
| TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| RU2650646C2 (ru) | 2012-09-27 | 2018-04-16 | Дзе Чилдрен'З Медикал Сентер Корпорейшн | Соединения, предназначенные для лечения ожирения, и способы их применения |
| SI3074033T1 (sl) | 2013-11-26 | 2019-03-29 | The Children's Medical Center Corporation | Spojine za zdravljenje debelosti in postopki njihove uporabe |
| US20170209408A1 (en) | 2014-04-03 | 2017-07-27 | The Children's Medical Center Corporation | Hsp90 inhibitors for the treatment of obesity and methods of use thereof |
| CN107207607B (zh) | 2014-12-19 | 2021-05-04 | 中外制药株式会社 | 抗-c5抗体及使用方法 |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| TWI693940B (zh) | 2016-08-05 | 2020-05-21 | 日商中外製藥股份有限公司 | Ｉｌ-８相關疾病之治療用或預防用組成物 |
| CA3036551A1 (en) | 2016-09-12 | 2018-03-15 | Aegerion Pharmaceuticals, Inc. | Methods of detecting anti-leptin neutralizing antibodies |
| JP7191833B2 (ja) | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559208A (en) * | 1995-01-31 | 1996-09-24 | Eli Lilly And Company | Anti-obesity proteins |
| GB9511935D0 (en) * | 1995-06-13 | 1995-08-09 | Smithkline Beecham Plc | Novel compound |
| AU1520097A (en) * | 1995-12-27 | 1997-07-28 | Genentech Inc. | Ob protein derivatives having prolonged half-life |
| WO1998028427A1 (en) * | 1996-12-20 | 1998-07-02 | Amgen Inc. | Ob fusion protein compositions and methods |
-
1998
- 1998-04-16 CN CNB988042258A patent/CN1202862C/zh not_active Expired - Fee Related
- 1998-04-16 JP JP54433898A patent/JP4086908B2/ja not_active Expired - Lifetime
- 1998-04-16 ES ES98918399T patent/ES2183351T3/es not_active Expired - Lifetime
- 1998-04-16 AU AU71327/98A patent/AU7132798A/en not_active Abandoned
- 1998-04-16 IL IL13238098A patent/IL132380A0/xx active IP Right Grant
- 1998-04-16 WO PCT/US1998/007828 patent/WO1998046257A1/en not_active Ceased
- 1998-04-16 EP EP98918399A patent/EP0977583B1/en not_active Expired - Lifetime
- 1998-04-16 HU HU0002831A patent/HU226175B1/hu not_active IP Right Cessation
- 1998-04-16 CA CA002286098A patent/CA2286098C/en not_active Expired - Fee Related
- 1998-04-16 DE DE69807679T patent/DE69807679T2/de not_active Expired - Lifetime
- 1998-04-16 AT AT98918399T patent/ATE223229T1/de active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0977583A1 (en) | 2000-02-09 |
| ES2183351T3 (es) | 2003-03-16 |
| CA2286098A1 (en) | 1998-10-22 |
| DE69807679D1 (de) | 2002-10-10 |
| JP4086908B2 (ja) | 2008-05-14 |
| HUP0002831A3 (en) | 2005-11-28 |
| WO1998046257A1 (en) | 1998-10-22 |
| IL132380A0 (en) | 2001-03-19 |
| EP0977583B1 (en) | 2002-09-04 |
| HU226175B1 (en) | 2008-06-30 |
| WO1998046257A8 (en) | 2000-01-27 |
| ATE223229T1 (de) | 2002-09-15 |
| CN1274289A (zh) | 2000-11-22 |
| HUP0002831A2 (hu) | 2000-12-28 |
| CN1202862C (zh) | 2005-05-25 |
| HK1023513A1 (en) | 2000-09-15 |
| AU7132798A (en) | 1998-11-11 |
| DE69807679T2 (de) | 2003-07-31 |
| JP2002512612A (ja) | 2002-04-23 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150416 |