JP2002510690A5 - - Google Patents
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- Publication number
- JP2002510690A5 JP2002510690A5 JP2000542323A JP2000542323A JP2002510690A5 JP 2002510690 A5 JP2002510690 A5 JP 2002510690A5 JP 2000542323 A JP2000542323 A JP 2000542323A JP 2000542323 A JP2000542323 A JP 2000542323A JP 2002510690 A5 JP2002510690 A5 JP 2002510690A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridyl
- tricyclo
- aza
- hydrogen
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 12
- 239000001257 hydrogen Substances 0.000 description 12
- 239000008194 pharmaceutical composition Substances 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 3
- INDYXBQOPZTSTJ-UHFFFAOYSA-N 2-pyridin-3-yl-1-azatricyclo[3.3.1.13,7]decane Chemical compound C1C(C2)CC3CC1CN2C3C1=CC=CN=C1 INDYXBQOPZTSTJ-UHFFFAOYSA-N 0.000 description 2
- BVLWZZNUQSYJOG-UHFFFAOYSA-N BrC1=CN=CC(C2N3CC4CC(C3)CC2C4)=C1 Chemical compound BrC1=CN=CC(C2N3CC4CC(C3)CC2C4)=C1 BVLWZZNUQSYJOG-UHFFFAOYSA-N 0.000 description 2
- KWBCVUZLCMSFAL-UHFFFAOYSA-N C1C(CO)(C2=O)CC3CC2CN1C3C1=CC=CN=C1 Chemical compound C1C(CO)(C2=O)CC3CC2CN1C3C1=CC=CN=C1 KWBCVUZLCMSFAL-UHFFFAOYSA-N 0.000 description 2
- ADMGCHXOTILZAP-UHFFFAOYSA-N CC(C)OC1=CN=CC(C2N3CC4CC(C3)CC2C4)=C1 Chemical compound CC(C)OC1=CN=CC(C2N3CC4CC(C3)CC2C4)=C1 ADMGCHXOTILZAP-UHFFFAOYSA-N 0.000 description 2
- WTTLLKAMZRPQQS-UHFFFAOYSA-N CCOC1=CN=CC(C2N3CC4CC(C3)CC2C4)=C1 Chemical compound CCOC1=CN=CC(C2N3CC4CC(C3)CC2C4)=C1 WTTLLKAMZRPQQS-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- NRJLFPGRQMOVIQ-UHFFFAOYSA-N NC1=CN=CC(C2N3CC4CC(C3)CC2C4)=C1 Chemical compound NC1=CN=CC(C2N3CC4CC(C3)CC2C4)=C1 NRJLFPGRQMOVIQ-UHFFFAOYSA-N 0.000 description 2
- VODCVOLSDCFBLD-UHFFFAOYSA-N OC1C(C2)CC3CC1CN2C3C1=CC=CN=C1 Chemical compound OC1C(C2)CC3CC1CN2C3C1=CC=CN=C1 VODCVOLSDCFBLD-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000003957 neurotransmitter release Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/053,937 US6057446A (en) | 1998-04-02 | 1998-04-02 | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
| US09/054,175 | 1998-04-02 | ||
| US09/054,175 US5952339A (en) | 1998-04-02 | 1998-04-02 | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
| US09/053,937 | 1998-04-02 | ||
| PCT/US1999/004728 WO1999051602A1 (en) | 1998-04-02 | 1999-03-03 | Azatricyclo[3.3.1.1] decane derivatives and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002510690A JP2002510690A (ja) | 2002-04-09 |
| JP2002510690A5 true JP2002510690A5 (enExample) | 2006-05-11 |
Family
ID=26732410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000542323A Pending JP2002510690A (ja) | 1998-04-02 | 1999-03-03 | アザトリシクロ［３．３．１．１］デカン誘導体とそれらを含有する薬剤組成物 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1068208B1 (enExample) |
| JP (1) | JP2002510690A (enExample) |
| KR (1) | KR100591805B1 (enExample) |
| AT (1) | ATE240331T1 (enExample) |
| AU (1) | AU2892999A (enExample) |
| BR (1) | BR9907172A (enExample) |
| CA (1) | CA2317567A1 (enExample) |
| DE (1) | DE69907894T2 (enExample) |
| DK (1) | DK1068208T3 (enExample) |
| ES (1) | ES2199561T3 (enExample) |
| MX (1) | MXPA00009634A (enExample) |
| PT (1) | PT1068208E (enExample) |
| WO (1) | WO1999051602A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6953855B2 (en) | 1998-12-11 | 2005-10-11 | Targacept, Inc. | 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof |
| US6432975B1 (en) * | 1998-12-11 | 2002-08-13 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| MY137020A (en) * | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
| US6809105B2 (en) | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
| WO2001082978A2 (en) * | 2000-05-01 | 2001-11-08 | Targacept, Inc. | Imaging of nicotinic acetylcholine receptor subtypes |
| US7897766B2 (en) | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| EP2069346B1 (en) | 2007-03-23 | 2011-12-21 | Abbott Laboratories | Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof |
| CA2679876A1 (en) * | 2007-03-23 | 2008-10-02 | Abbott Laboratories | 4-substituted azaadamantane derivatives and methods of use thereof |
| SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| CA2809675A1 (en) | 2010-09-23 | 2012-03-29 | Shuang Chen | Monohydrate of an azaadamantane derivative |
| US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL107184A (en) * | 1992-10-09 | 1997-08-14 | Abbott Lab | Heterocyclic ether compounds that enhance cognitive function |
| US5597919A (en) * | 1995-01-06 | 1997-01-28 | Dull; Gary M. | Pyrimidinyl or Pyridinyl alkenyl amine compounds |
| US5585388A (en) * | 1995-04-07 | 1996-12-17 | Sibia Neurosciences, Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
| US5583140A (en) * | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| JP3510937B2 (ja) * | 1995-06-05 | 2004-03-29 | ポリプラスチックス株式会社 | 耐熱性ポリエステルアミドスルフィド樹脂及びその組成物 |
| JPH11508540A (ja) * | 1995-06-29 | 1999-07-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の置換アザ環式またはアザ二環式化合物 |
| JPH11512443A (ja) * | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
-
1999
- 1999-03-03 DK DK99909806T patent/DK1068208T3/da active
- 1999-03-03 JP JP2000542323A patent/JP2002510690A/ja active Pending
- 1999-03-03 MX MXPA00009634A patent/MXPA00009634A/es not_active IP Right Cessation
- 1999-03-03 CA CA002317567A patent/CA2317567A1/en not_active Abandoned
- 1999-03-03 EP EP99909806A patent/EP1068208B1/en not_active Expired - Lifetime
- 1999-03-03 ES ES99909806T patent/ES2199561T3/es not_active Expired - Lifetime
- 1999-03-03 WO PCT/US1999/004728 patent/WO1999051602A1/en not_active Ceased
- 1999-03-03 AU AU28929/99A patent/AU2892999A/en not_active Abandoned
- 1999-03-03 BR BR9907172-0A patent/BR9907172A/pt not_active Application Discontinuation
- 1999-03-03 PT PT99909806T patent/PT1068208E/pt unknown
- 1999-03-03 DE DE69907894T patent/DE69907894T2/de not_active Expired - Fee Related
- 1999-03-03 KR KR1020007008963A patent/KR100591805B1/ko not_active Expired - Fee Related
- 1999-03-03 AT AT99909806T patent/ATE240331T1/de not_active IP Right Cessation
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