JP2002508320A - スタチン−カルボキシアルキルエーテル配合物 - Google Patents
スタチン−カルボキシアルキルエーテル配合物Info
- Publication number
- JP2002508320A JP2002508320A JP2000538687A JP2000538687A JP2002508320A JP 2002508320 A JP2002508320 A JP 2002508320A JP 2000538687 A JP2000538687 A JP 2000538687A JP 2000538687 A JP2000538687 A JP 2000538687A JP 2002508320 A JP2002508320 A JP 2002508320A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- statin
- pharmaceutical composition
- kit
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims abstract description 75
- -1 carboxyalkyl ether Chemical compound 0.000 claims abstract description 36
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- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 27
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- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 claims description 25
- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 claims description 25
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- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims description 14
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- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims description 11
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims description 11
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- VXDSGTRNDFHIJB-QQPOVDNESA-N [(1s,4ar)-8-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2s)-2-methylbutanoate Chemical compound C([C@H]1CCC[C@@H](C21)OC(=O)[C@@H](C)CC)=CC(C)C2CC[C@@H]1C[C@@H](O)CC(=O)O1 VXDSGTRNDFHIJB-QQPOVDNESA-N 0.000 claims description 11
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Landscapes
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- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6937597P | 1997-12-12 | 1997-12-12 | |
| US60/069,375 | 1997-12-12 | ||
| PCT/US1998/024679 WO1999030704A1 (en) | 1997-12-12 | 1998-11-20 | Statin-carboxyalkylether combinations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508320A true JP2002508320A (ja) | 2002-03-19 |
| JP2002508320A5 JP2002508320A5 (enExample) | 2006-01-19 |
Family
ID=22088573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000538687A Pending JP2002508320A (ja) | 1997-12-12 | 1998-11-20 | スタチン−カルボキシアルキルエーテル配合物 |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1045691B1 (enExample) |
| JP (1) | JP2002508320A (enExample) |
| KR (1) | KR20010033003A (enExample) |
| AR (1) | AR017851A1 (enExample) |
| AT (1) | ATE285762T1 (enExample) |
| AU (1) | AU754089B2 (enExample) |
| BR (1) | BR9813542A (enExample) |
| CA (1) | CA2304612A1 (enExample) |
| CO (1) | CO4970816A1 (enExample) |
| CR (1) | CR5926A (enExample) |
| CU (1) | CU20000140A7 (enExample) |
| DE (1) | DE69828442T2 (enExample) |
| DK (1) | DK1045691T3 (enExample) |
| ES (1) | ES2230733T3 (enExample) |
| GT (1) | GT199800196A (enExample) |
| HN (1) | HN1998000185A (enExample) |
| HU (1) | HUP0004547A3 (enExample) |
| IL (1) | IL135349A0 (enExample) |
| IS (1) | IS2150B (enExample) |
| MY (1) | MY118381A (enExample) |
| NO (1) | NO20002966L (enExample) |
| NZ (1) | NZ503982A (enExample) |
| PA (1) | PA8464601A1 (enExample) |
| PE (1) | PE20000017A1 (enExample) |
| PL (1) | PL341066A1 (enExample) |
| PT (1) | PT1045691E (enExample) |
| SV (1) | SV1998000146A (enExample) |
| UY (1) | UY25299A1 (enExample) |
| WO (1) | WO1999030704A1 (enExample) |
| ZA (1) | ZA9811348B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002525321A (ja) * | 1998-09-30 | 2002-08-13 | ワーナー−ランバート・カンパニー | カテーテルによる血管再生を予防または遅らせる方法 |
| JP2003524582A (ja) * | 1997-12-12 | 2003-08-19 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 抗高脂血症性スタチン−Ｌｐ（ａ）阻害剤配合物 |
| JP2015503588A (ja) * | 2012-01-06 | 2015-02-02 | ミシガン ライフ セラピューティクス リミティッド ライアビリティ カンパニーＭｉｃｈｉｇａｎ Ｌｉｆｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｌｃ | 心血管疾患のリスクを低減する方法 |
| JP2018536710A (ja) * | 2015-11-06 | 2018-12-13 | ジェンファイア・セラピューティクス・インコーポレイテッドＧｅｍｐｈｉｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 混合型脂質異常症の治療 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861555B2 (en) | 2000-01-25 | 2005-03-01 | Warner-Lambert Company | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith |
| US20030105154A1 (en) | 2001-10-24 | 2003-06-05 | Bisgaier Charles Larry | Statin-carboxyalkylether combinations |
| US6562864B1 (en) * | 1999-09-02 | 2003-05-13 | Drake Larson | Catechin multimers as therapeutic drug delivery agents |
| IN191580B (enExample) * | 1999-12-17 | 2003-12-06 | Ranbaxy Lab Ltd | |
| ATE431326T1 (de) | 2000-01-25 | 2009-05-15 | Warner Lambert Co | Calcium-dicarboxylatether, verfahren zu deren herstellung |
| AU2001256278A1 (en) * | 2000-04-18 | 2001-10-30 | Bayer Aktiengesellschaft | Use of cse inhibitors for treating heart failure |
| PL357906A1 (en) * | 2000-04-26 | 2004-08-09 | Warner-Lambert Company | Combination of carboxyalkylethers with antihypertensives and pharmaceutical use |
| US6689807B1 (en) * | 2000-06-08 | 2004-02-10 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | HMG CoA reductase inhibitors for promoting angiogenesis |
| JP4188826B2 (ja) * | 2001-08-16 | 2008-12-03 | テバ ファーマシューティカル インダストリーズ リミティド | カルシウム塩型スタチンの製造方法 |
| KR20040026705A (ko) | 2001-08-16 | 2004-03-31 | 테바 파마슈티컬 인더스트리즈 리미티드 | 스타틴의 칼슘 염 형태의 제조 방법 |
| US20050026979A1 (en) * | 2003-07-31 | 2005-02-03 | Maha Ghazzi | Methods for treating inflammation and inflammation-associated diseases with a statin and ether |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5648387A (en) * | 1995-03-24 | 1997-07-15 | Warner-Lambert Company | Carboxyalkylethers, formulations, and treatment of vascular diseases |
-
1998
- 1998-11-12 NZ NZ503982A patent/NZ503982A/en unknown
- 1998-11-20 PL PL98341066A patent/PL341066A1/xx unknown
- 1998-11-20 KR KR1020007006355A patent/KR20010033003A/ko not_active Ceased
- 1998-11-20 ES ES98960278T patent/ES2230733T3/es not_active Expired - Lifetime
- 1998-11-20 PT PT98960278T patent/PT1045691E/pt unknown
- 1998-11-20 CA CA002304612A patent/CA2304612A1/en not_active Abandoned
- 1998-11-20 EP EP98960278A patent/EP1045691B1/en not_active Expired - Lifetime
- 1998-11-20 HU HU0004547A patent/HUP0004547A3/hu unknown
- 1998-11-20 DE DE69828442T patent/DE69828442T2/de not_active Expired - Lifetime
- 1998-11-20 IL IL13534998A patent/IL135349A0/xx unknown
- 1998-11-20 AT AT98960278T patent/ATE285762T1/de not_active IP Right Cessation
- 1998-11-20 DK DK98960278T patent/DK1045691T3/da active
- 1998-11-20 JP JP2000538687A patent/JP2002508320A/ja active Pending
- 1998-11-20 BR BR9813542-2A patent/BR9813542A/pt not_active Application Discontinuation
- 1998-11-20 WO PCT/US1998/024679 patent/WO1999030704A1/en not_active Ceased
- 1998-11-20 AU AU15915/99A patent/AU754089B2/en not_active Ceased
- 1998-12-09 HN HN1998000185A patent/HN1998000185A/es unknown
- 1998-12-10 ZA ZA9811348A patent/ZA9811348B/xx unknown
- 1998-12-10 MY MYPI98005579A patent/MY118381A/en unknown
- 1998-12-10 CR CR5926A patent/CR5926A/es not_active Application Discontinuation
- 1998-12-11 PE PE1998001207A patent/PE20000017A1/es not_active Application Discontinuation
- 1998-12-11 CO CO98073828A patent/CO4970816A1/es unknown
- 1998-12-11 UY UY25299A patent/UY25299A1/es not_active Application Discontinuation
- 1998-12-11 SV SV1998000146A patent/SV1998000146A/es not_active Application Discontinuation
- 1998-12-11 GT GT199800196A patent/GT199800196A/es unknown
- 1998-12-11 AR ARP980106321A patent/AR017851A1/es unknown
- 1998-12-11 PA PA19988464601A patent/PA8464601A1/es unknown
-
2000
- 2000-04-14 IS IS5445A patent/IS2150B/is unknown
- 2000-06-09 NO NO20002966A patent/NO20002966L/no not_active Application Discontinuation
- 2000-06-09 CU CU20000140A patent/CU20000140A7/es unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003524582A (ja) * | 1997-12-12 | 2003-08-19 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 抗高脂血症性スタチン−Ｌｐ（ａ）阻害剤配合物 |
| JP2002525321A (ja) * | 1998-09-30 | 2002-08-13 | ワーナー−ランバート・カンパニー | カテーテルによる血管再生を予防または遅らせる方法 |
| JP2015503588A (ja) * | 2012-01-06 | 2015-02-02 | ミシガン ライフ セラピューティクス リミティッド ライアビリティ カンパニーＭｉｃｈｉｇａｎ Ｌｉｆｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｌｃ | 心血管疾患のリスクを低減する方法 |
| JP2018104452A (ja) * | 2012-01-06 | 2018-07-05 | ジェムファイア セラピューティクス インクＧｅｍｐｈｉｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 心血管疾患のリスクを低減する方法 |
| JP2018536710A (ja) * | 2015-11-06 | 2018-12-13 | ジェンファイア・セラピューティクス・インコーポレイテッドＧｅｍｐｈｉｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 混合型脂質異常症の治療 |
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