JP2002506034A5 - - Google Patents

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Publication number
JP2002506034A5
JP2002506034A5 JP2000535346A JP2000535346A JP2002506034A5 JP 2002506034 A5 JP2002506034 A5 JP 2002506034A5 JP 2000535346 A JP2000535346 A JP 2000535346A JP 2000535346 A JP2000535346 A JP 2000535346A JP 2002506034 A5 JP2002506034 A5 JP 2002506034A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000535346A
Other languages
Japanese (ja)
Other versions
JP2002506034A (ja
JP3877961B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP1999/001496 external-priority patent/WO1999045931A1/en
Publication of JP2002506034A publication Critical patent/JP2002506034A/ja
Publication of JP2002506034A5 publication Critical patent/JP2002506034A5/ja
Application granted granted Critical
Publication of JP3877961B2 publication Critical patent/JP3877961B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2000535346A 1998-03-11 1999-03-10 Cns疾患の治療におけるエピアロプレグナノロン Expired - Fee Related JP3877961B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3786998A 1998-03-11 1998-03-11
US09/037,869 1998-03-11
PCT/EP1999/001496 WO1999045931A1 (en) 1998-03-11 1999-03-10 Epiallopregnanolone in the treatment of cns disorders

Publications (3)

Publication Number Publication Date
JP2002506034A JP2002506034A (ja) 2002-02-26
JP2002506034A5 true JP2002506034A5 (https=) 2005-11-17
JP3877961B2 JP3877961B2 (ja) 2007-02-07

Family

ID=21896803

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000535346A Expired - Fee Related JP3877961B2 (ja) 1998-03-11 1999-03-10 Cns疾患の治療におけるエピアロプレグナノロン

Country Status (9)

Country Link
US (1) US6455516B1 (https=)
EP (1) EP1063999B1 (https=)
JP (1) JP3877961B2 (https=)
CN (1) CN1270718C (https=)
AT (1) ATE307592T1 (https=)
AU (1) AU756001B2 (https=)
CA (1) CA2321728C (https=)
DE (1) DE69927960T2 (https=)
WO (1) WO1999045931A1 (https=)

Families Citing this family (34)

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US20020072509A1 (en) * 2000-10-11 2002-06-13 Stein Donald Gerald Methods for the treatment of a traumatic central nervous system injury
SE0104423D0 (sv) 2001-12-27 2001-12-27 Umecrine Ab Pregnane steroids and their use in the treatment of CNS disorders
RU2413516C2 (ru) * 2004-11-18 2011-03-10 Умекрин Аб Гамк-стероидные антагонисты и их применение в лечении нарушений цнс
WO2006054938A1 (en) * 2004-11-18 2006-05-26 Umecrine Ab Gaba-steroid antagonists and their use for the treatment of cns disorders
DE102006003508A1 (de) * 2006-01-24 2007-07-26 Grünenthal GmbH Arzneimittel umfassend eine Hormonkombination
DE102006003509A1 (de) * 2006-01-24 2007-07-26 Grünenthal GmbH Kontrazeptivum
US20070203216A1 (en) * 2006-02-14 2007-08-30 Bjarke Ebert Method of treating inflammatory diseases
DK2097437T3 (en) 2006-11-21 2015-06-29 Umecrine Cognition Ab THE USE OF PREGNANCY AND ANDROSTANOSTEROIDS FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CNS DISEASES
WO2008154579A1 (en) * 2007-06-11 2008-12-18 University Of Southern California Allopregnanolone in a method for enhancing neurological function (alzheimer disease)
US20100204192A1 (en) 2007-06-11 2010-08-12 University Of Sourthern California Agents, compositions and methods for enhancing neurological function
US20090048288A1 (en) * 2007-08-13 2009-02-19 H. Lundbeck A/S Method of treating stress-mediated depression
HUE027298T2 (en) * 2010-01-14 2016-10-28 Asarina Pharma Ab Pharmaceutical composition containing developed storage and dissolution properties containing 3-beta-hydroxy-5-alpha-pregnan-20-one
AU2012260955B2 (en) * 2011-05-20 2017-08-17 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antagonists of CB1 receptor.
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
SG10201606063RA (en) * 2012-01-23 2016-09-29 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
US20140050789A1 (en) 2012-08-13 2014-02-20 The Regents Of The University Of California Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids
MX2015002252A (es) 2012-08-21 2015-07-21 Sage Therapeutics Inc Metodos para tratar epilepsia o estado de epilepsia.
AU2013351190B2 (en) 2012-11-28 2018-03-29 Alienor Farma 3-(4'-substituted)-benzyl-ether derivatives of pregnenolone
DK2925327T3 (da) * 2012-11-30 2024-03-25 Univ California Allopregnanolon til behandling, reduktion eller lindring af symptomer på fødselsdepression
AU2015212606B2 (en) 2014-01-29 2019-11-21 Umecrine Cognition Ab Steroid compound for use in the treatment of hepatic encephalopathy
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016082789A1 (en) * 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
AR103384A1 (es) 2015-01-12 2017-05-03 Umecrine Cognition Ab 3a-ETINILO, 3b-HIDROXI, 5a-PREGNAN-20-OXIMA COMO MODULADOR DE GABA
HK1258616A1 (zh) 2016-03-08 2019-11-15 Sage Therapeutics, Inc. 神经活性类固醇、组合物、及其用途
US10278977B2 (en) 2016-06-06 2019-05-07 Umecrine Cognition Ab Methods for treating hypersomnolence
DK3565528T3 (da) * 2017-01-09 2025-05-26 Relmada Therapeutics Inc Injicerbare suspensioner
EP3579842A4 (en) 2017-02-10 2020-12-23 Asarina Pharma AB 3-BETA-HYDROXY-5-ALPHA-PRÉGNAN-20-ONE FOR USE IN THE TREATMENT OF ESSENTIAL TREMMENTS
JP7179739B2 (ja) * 2017-02-10 2022-11-29 アサリナ ファーマ アーベー 医学的治療における使用のための3-β-ヒドロキシ-5-α-プレグナン-20-オン
WO2019075362A1 (en) * 2017-10-12 2019-04-18 Sage Therapeutics, Inc. METHOD OF TREATING CENTRAL NERVOUS SYSTEM DISORDERS WITH NEUROSTEROIDS AND GABAERGIC COMPOUNDS
MX2020010219A (es) 2018-04-05 2020-11-09 Asarina Pharma Aps Antagonistas de gaba-a para tratar trastornos por abstinencia de sustancia.
KR20240050372A (ko) 2021-09-14 2024-04-18 난징 미노바 파마슈티컬 컴퍼니, 리미티드 수용성 알로프레그나놀론 유도체 및 이의 제조 방법과 용도
EP4429669A1 (en) 2021-11-10 2024-09-18 Umecrine AB Steroid as a modulator of gabaa receptor
US20250387409A1 (en) 2021-11-10 2025-12-25 Umecrine Cognition Ab 3-beta-hydroxy-3-alpha-ethyl steroids for modulation of the alpha-3 subtype of the gabaa receptor
WO2023083978A1 (en) 2021-11-10 2023-05-19 Umecrine Ab 3.alpha.-substituted 3.beta.-hydroxy 17-oximated androstane compound for modulation of the alpha-3 subtype of the gaba-a receptor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
US5120723A (en) 1987-08-25 1992-06-09 University Of Southern California Method, compositions, and compounds for modulating brain excitability
WO1995005826A1 (en) * 1993-08-20 1995-03-02 Jackson Meyer B Method for regulating neuropeptide hormone secretion
US5939545A (en) * 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
FI972202L (fi) * 1994-11-23 1997-07-17 Cocensys Inc Androstaanit ja pregnaanit GABA-reseptoreiden allosteeriseen muunteluun
WO1998050042A1 (en) * 1997-05-02 1998-11-12 American Home Products Corporation Pregnan-3-ol-20-ones

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