JP2002503223A - 複数の活性分子を供与する分子 - Google Patents
複数の活性分子を供与する分子Info
- Publication number
- JP2002503223A JP2002503223A JP54407498A JP54407498A JP2002503223A JP 2002503223 A JP2002503223 A JP 2002503223A JP 54407498 A JP54407498 A JP 54407498A JP 54407498 A JP54407498 A JP 54407498A JP 2002503223 A JP2002503223 A JP 2002503223A
- Authority
- JP
- Japan
- Prior art keywords
- group
- multivalent
- donor
- poly
- framework
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00756—Compositions, e.g. coatings, crystals, formulations
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4378197P | 1997-04-11 | 1997-04-11 | |
US4382697P | 1997-04-14 | 1997-04-14 | |
US60/043,781 | 1997-04-14 | ||
US60/043,826 | 1997-04-14 | ||
PCT/US1998/007171 WO1998046270A2 (fr) | 1997-04-11 | 1998-04-09 | Molecules presentant une pluralite de groupes fonctionnels actifs |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002503223A true JP2002503223A (ja) | 2002-01-29 |
Family
ID=26720814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54407498A Pending JP2002503223A (ja) | 1997-04-11 | 1998-04-09 | 複数の活性分子を供与する分子 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0973551A2 (fr) |
JP (1) | JP2002503223A (fr) |
KR (1) | KR20010006280A (fr) |
CN (1) | CN1269013A (fr) |
AU (1) | AU743028B2 (fr) |
BR (1) | BR9808521A (fr) |
CA (1) | CA2286692A1 (fr) |
WO (1) | WO1998046270A2 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1079859B1 (fr) | 1998-05-22 | 2010-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Molecules bifonctionnelles et therapies basees sur celles-ci |
JP3468149B2 (ja) * | 1999-02-19 | 2003-11-17 | 松下電器産業株式会社 | 微細物体の操作装置および操作方法 |
EP1177029B1 (fr) * | 1999-05-10 | 2004-03-17 | Glaxo Group Limited | Station de travail haute capacite de criblage de formes cristallines et son utilisation |
US6887842B1 (en) | 1999-11-19 | 2005-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug |
AU2044001A (en) | 1999-11-19 | 2001-05-30 | Board Of Trustees Of The Leland Stanford Junior University | Targeted bifunctional molecules and therapies based thereon |
US7220552B1 (en) | 1999-11-19 | 2007-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
KR100543171B1 (ko) * | 2002-05-31 | 2006-01-20 | 한국과학기술원 | 분자수준에서 배향성을 조절하면서 항체 단분자막을 제조하는 방법 |
EP1802349A1 (fr) * | 2004-10-13 | 2007-07-04 | Ilypsa, Inc. | Preparations pharmaceutiques comprenant un oligosaccharide complexant les toxines et une particule polymere |
EP1951279B1 (fr) | 2005-10-08 | 2017-04-12 | Apellis Pharmaceuticals, Inc. | Compstatine et analogues de celle-ci pour des troubles de la vue |
HUE026001T2 (en) | 2007-02-05 | 2016-04-28 | Apellis Pharmaceuticals Inc | Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system |
EP2139524A1 (fr) * | 2007-03-23 | 2010-01-06 | The Governors of the University of Alberta | Polymères hétérobifonctionnels multivalents et leurs procédés d'utilisation |
WO2009032605A2 (fr) * | 2007-08-27 | 2009-03-12 | Massachusetts Institute Of Technology | Inhibiteurs du virus de la grippe couplés à un polymère bifonctionnel |
JP6522337B2 (ja) | 2011-05-11 | 2019-05-29 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. | 細胞反応性、長時間作用型または標的化コンプスタチン類似体およびその使用 |
JP6618682B2 (ja) | 2011-06-22 | 2019-12-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. | 補体阻害剤による慢性障害の治療方法 |
SI3660033T1 (sl) | 2012-11-15 | 2021-09-30 | Apellis Pharmaceuticals, Inc. | Analogi kompstatina z dolgotrajnim delovanjem in sorodni sestavki in postopki |
US20160010077A1 (en) * | 2013-02-28 | 2016-01-14 | The University Of Southern Mississippi | Covalent Attachment of Bacteriophages (Phages) to Polymeric Surfaces |
CA3001128A1 (fr) | 2015-10-07 | 2017-04-13 | Apellis Pharmaceuticals, Inc. | Utilisation d'un analogue de compstatin a action prolongee pour le traitement d'un trouble oculaire medie par un complement |
US11564995B2 (en) | 2018-10-29 | 2023-01-31 | Wisconsin Alumni Research Foundation | Peptide-nanoparticle conjugates |
KR20210084552A (ko) | 2018-10-29 | 2021-07-07 | 위스콘신 얼럼나이 리서어치 화운데이션 | 향상된 암 면역요법을 위한 면역관문 억제제와 복합체화된 덴드리틱 폴리머 |
WO2021087021A1 (fr) | 2019-10-29 | 2021-05-06 | Wisconsin Alumni Research Foundation | Conjugués peptide-nanoparticule |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE463314B (sv) * | 1989-03-01 | 1990-11-05 | Biocarb Ab | Sampolymerer av en n-acylerad glykosylamin och en amid, n-akryloyl-eller metakryloylglykosylaminer samt foerfarande foer framstaellning av dessa |
DE19640791A1 (de) * | 1996-10-02 | 1998-04-16 | Syntesome Ges Fuer Medizinisch | Glycokonjugate als Inhibitoren der viralen Zelladhäsion |
-
1998
- 1998-04-09 BR BR9808521-2A patent/BR9808521A/pt not_active IP Right Cessation
- 1998-04-09 WO PCT/US1998/007171 patent/WO1998046270A2/fr not_active Application Discontinuation
- 1998-04-09 JP JP54407498A patent/JP2002503223A/ja active Pending
- 1998-04-09 CN CN98804085A patent/CN1269013A/zh active Pending
- 1998-04-09 KR KR1019997009364A patent/KR20010006280A/ko not_active Application Discontinuation
- 1998-04-09 AU AU71069/98A patent/AU743028B2/en not_active Ceased
- 1998-04-09 CA CA002286692A patent/CA2286692A1/fr not_active Abandoned
- 1998-04-09 EP EP98918079A patent/EP0973551A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR20010006280A (ko) | 2001-01-26 |
EP0973551A2 (fr) | 2000-01-26 |
CN1269013A (zh) | 2000-10-04 |
CA2286692A1 (fr) | 1998-10-22 |
AU7106998A (en) | 1998-11-11 |
WO1998046270A2 (fr) | 1998-10-22 |
WO1998046270A3 (fr) | 1999-01-07 |
AU743028B2 (en) | 2002-01-17 |
BR9808521A (pt) | 2000-05-23 |
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