CA2286692A1 - Molecules presentant une pluralite de groupes fonctionnels actifs - Google Patents
Molecules presentant une pluralite de groupes fonctionnels actifs Download PDFInfo
- Publication number
- CA2286692A1 CA2286692A1 CA002286692A CA2286692A CA2286692A1 CA 2286692 A1 CA2286692 A1 CA 2286692A1 CA 002286692 A CA002286692 A CA 002286692A CA 2286692 A CA2286692 A CA 2286692A CA 2286692 A1 CA2286692 A1 CA 2286692A1
- Authority
- CA
- Canada
- Prior art keywords
- groups
- polyvalent
- group
- polyvalent presenter
- presenter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00756—Compositions, e.g. coatings, crystals, formulations
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Crystallography & Structural Chemistry (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne des compositions polyvalentes permettant de présenter de façon polyvalente un agent thérapeutique. Ces compositions pharmaceutiques contiennent un agent de présentation polyvalent. Selon une réalisation, l'agent de présentation est formulé comme (Y)-(X-A)¿n?, Y étant un squelette, X une liaison directe ou un lien, A un groupe fonctionnel à fonction de présentation, et n un entier supérieur à 10 choisi de façon que les groupes à fonction de présentation puissent entrer en interaction avec une pluralité de sites cibles de liaison. La composition peut également comporter un vecteur pharmaceutiquement acceptable. Selon une autre réalisation, l'agent de présentation peut constituer lui-même son propre vecteur pharmaceutiquement acceptable. L'invention concerne également le traitement d'affections ou d'états. Ce traitement consiste en l'administration à un sujet d'une pluralité de groupes A de façon que le traitement se produise. Le traitement se produit du fait de l'interaction d'un agent de présentation polyvalent avec une pluralité de sites cibles de liaison B. Sous d'autres aspects, l'invention concerne, d'une part des agents de présentation polyvalents emballés avec un mode d'emploi destiné aux traitements considérés, et d'autre part des procédés de conception, d'agents de présentation polyvalent convenant particulièrement dans le cadre des procédés et traitements de l'invention. Les agents de présentation polyvalents de l'invention assurent une liaison spécifique, ce qui est relativement avantageux. En outre, ces agents de présentation polyvalents permettent des interactions positives et négatives.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4378197P | 1997-04-11 | 1997-04-11 | |
US60/043,781 | 1997-04-11 | ||
US4382697P | 1997-04-14 | 1997-04-14 | |
US60/043,826 | 1997-04-14 | ||
PCT/US1998/007171 WO1998046270A2 (fr) | 1997-04-11 | 1998-04-09 | Molecules presentant une pluralite de groupes fonctionnels actifs |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2286692A1 true CA2286692A1 (fr) | 1998-10-22 |
Family
ID=26720814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002286692A Abandoned CA2286692A1 (fr) | 1997-04-11 | 1998-04-09 | Molecules presentant une pluralite de groupes fonctionnels actifs |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0973551A2 (fr) |
JP (1) | JP2002503223A (fr) |
KR (1) | KR20010006280A (fr) |
CN (1) | CN1269013A (fr) |
AU (1) | AU743028B2 (fr) |
BR (1) | BR9808521A (fr) |
CA (1) | CA2286692A1 (fr) |
WO (1) | WO1998046270A2 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2347027T3 (es) | 1998-05-22 | 2010-10-22 | The Board Of Trustees Of The Leland Stanford Junior University | Moleculas bifuncionales y terapias basadas en las mismas. |
JP3468149B2 (ja) * | 1999-02-19 | 2003-11-17 | 松下電器産業株式会社 | 微細物体の操作装置および操作方法 |
ATE261754T1 (de) * | 1999-05-10 | 2004-04-15 | Glaxo Group Ltd | Kristallform-screening-gerät für hohen durchsatz und dessen gebrauch |
US7498025B1 (en) | 1999-11-19 | 2009-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Targeted bifunctional molecules and therapies based thereon |
US7220552B1 (en) | 1999-11-19 | 2007-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
US6887842B1 (en) | 1999-11-19 | 2005-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug |
EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
KR100543171B1 (ko) * | 2002-05-31 | 2006-01-20 | 한국과학기술원 | 분자수준에서 배향성을 조절하면서 항체 단분자막을 제조하는 방법 |
CA2583666A1 (fr) * | 2004-10-13 | 2006-04-27 | Ilypsa, Inc. | Preparations pharmaceutiques comprenant un oligosaccharide complexant les toxines et une particule polymere |
BRPI0617186A2 (pt) | 2005-10-08 | 2011-07-19 | Potentia Pharmaceuticals Inc | uso de análogo de compstatina, implante ocular, micropartìcula ou nanopartìcula, composição, composto multivalente, ácido nucléico, vetor de expressão, célula hospedeira recombinante, proteìna de fusão e método de produção e teste |
PL2148691T3 (pl) | 2007-02-05 | 2015-12-31 | Apellis Pharmaceuticals Inc | Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego |
EP2139524A1 (fr) * | 2007-03-23 | 2010-01-06 | The Governors of the University of Alberta | Polymères hétérobifonctionnels multivalents et leurs procédés d'utilisation |
WO2009032605A2 (fr) * | 2007-08-27 | 2009-03-12 | Massachusetts Institute Of Technology | Inhibiteurs du virus de la grippe couplés à un polymère bifonctionnel |
DK2707384T3 (da) | 2011-05-11 | 2022-06-07 | Apellis Pharmaceuticals Inc | Cellereaktiv, langtidsvirkende eller målrettede compstatinanaloger og anvendelser deraf |
MX363606B (es) | 2011-06-22 | 2019-03-28 | Apellis Pharmaceuticals Inc | Uso de inhibidores del complemento en trastornos crónicos. |
JP2016505527A (ja) | 2012-11-15 | 2016-02-25 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. | 細胞反応性、長時間作用型または標的化コンプスタチン類似体ならびに関係する組成物および方法 |
WO2014134297A1 (fr) * | 2013-02-28 | 2014-09-04 | The University Of Southern Mississippi | Liaison covalente de bactériophages à des surfaces polymères |
EP4349363A2 (fr) | 2015-10-07 | 2024-04-10 | Apellis Pharmaceuticals, Inc. | Régimes posologiques |
US11564995B2 (en) | 2018-10-29 | 2023-01-31 | Wisconsin Alumni Research Foundation | Peptide-nanoparticle conjugates |
AU2019369299A1 (en) | 2018-10-29 | 2021-05-20 | Wisconsin Alumni Research Foundation | Dendritic polymers complexed with immune checkpoint inhibitors for enhanced cancer immunotherapy |
JP2023500602A (ja) | 2019-10-29 | 2023-01-10 | ウィスコンシン アルムニ リサーチ ファンデイション | ペプチド-ナノ粒子コンジュゲート 〔関連出願の相互参照〕 本出願は、2019年10月29日に出願されたpct/us2019/058463の一部継続出願であり、2019年10月29日に出願された米国仮出願第62/927,293号の優先権を主張し、その全体が参照により本明細書に組み込まれる。 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE463314B (sv) * | 1989-03-01 | 1990-11-05 | Biocarb Ab | Sampolymerer av en n-acylerad glykosylamin och en amid, n-akryloyl-eller metakryloylglykosylaminer samt foerfarande foer framstaellning av dessa |
DE19640791A1 (de) * | 1996-10-02 | 1998-04-16 | Syntesome Ges Fuer Medizinisch | Glycokonjugate als Inhibitoren der viralen Zelladhäsion |
-
1998
- 1998-04-09 EP EP98918079A patent/EP0973551A2/fr not_active Withdrawn
- 1998-04-09 CN CN98804085A patent/CN1269013A/zh active Pending
- 1998-04-09 BR BR9808521-2A patent/BR9808521A/pt not_active IP Right Cessation
- 1998-04-09 AU AU71069/98A patent/AU743028B2/en not_active Ceased
- 1998-04-09 KR KR1019997009364A patent/KR20010006280A/ko not_active Application Discontinuation
- 1998-04-09 CA CA002286692A patent/CA2286692A1/fr not_active Abandoned
- 1998-04-09 JP JP54407498A patent/JP2002503223A/ja active Pending
- 1998-04-09 WO PCT/US1998/007171 patent/WO1998046270A2/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU7106998A (en) | 1998-11-11 |
KR20010006280A (ko) | 2001-01-26 |
WO1998046270A2 (fr) | 1998-10-22 |
AU743028B2 (en) | 2002-01-17 |
BR9808521A (pt) | 2000-05-23 |
WO1998046270A3 (fr) | 1999-01-07 |
CN1269013A (zh) | 2000-10-04 |
JP2002503223A (ja) | 2002-01-29 |
EP0973551A2 (fr) | 2000-01-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU743028B2 (en) | Molecules presenting a multitude of active moieties | |
Percec et al. | Modular synthesis of amphiphilic Janus glycodendrimers and their self-assembly into glycodendrimersomes and other complex architectures with bioactivity to biomedically relevant lectins | |
Roy | Syntheses and some applications of chemically defined multivalent glycoconjugates | |
Werz et al. | Carbohydrates as the next frontier in pharmaceutical research | |
Zanini et al. | Synthesis of new α-thiosialodendrimers and their binding properties to the sialic acid specific lectin from Limax flavus | |
Wu et al. | “Sweet” architecture-dependent uptake of glycocalyx-mimicking nanoparticles based on biodegradable aliphatic polyesters by macrophages | |
Roy | Recent developments in the rational design of multivalent glycoconjugates | |
Kensinger et al. | Synthesis of novel, multivalent glycodendrimers as ligands for HIV-1 gp120 | |
Gomez-Garcia et al. | Probing carbohydrate-lectin recognition in heterogeneous environments with monodisperse cyclodextrin-based glycoclusters | |
Rillahan et al. | On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7 | |
Matsushita et al. | Artificial Golgi apparatus: globular protein-like dendrimer facilitates fully automated enzymatic glycan synthesis | |
AU754331B2 (en) | Treatment of bacterial infections | |
JPH09509979A (ja) | ポリマー抱合マロン酸誘導体並びに薬剤および診断剤としてのそれらの使用 | |
Gao et al. | Exploring and controlling the polymorphism in supramolecular assemblies of carbohydrates and proteins | |
Hartweg et al. | Synthetic glycomacromolecules of defined valency, absolute configuration, and topology distinguish between human lectins | |
WO1998047002A2 (fr) | Bibliotheques combinatoires de presentation polyvalente et leurs utilisations | |
Bruehl et al. | Polymerized liposome assemblies: bifunctional macromolecular selectin inhibitors mimicking physiological selectin ligands | |
JP2010521526A (ja) | 多価ヘテロ二官能性ポリマーおよびその使用方法 | |
Eissa et al. | Glycopolymer conjugates | |
Hoyos et al. | Synthesis of glycodendrimers with antiviral and antibacterial activity | |
Nagao et al. | Synthesis of various glycopolymers bearing sialyllactose and the effect of their molecular mobility on interaction with the influenza virus | |
Leyden et al. | Synthesis of bivalent lactosides based on terephthalamide, N, N′-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins | |
Neuhaus et al. | Asymmetrically branched precision glycooligomers targeting langerin | |
Bi et al. | Dynamic glycopeptide dendrimers: Synthesis and their controllable self-assembly into varied glyco-nanostructures for the biomimicry of glycans | |
US20040248801A1 (en) | Methods and reagents for regulation of cellular responses in biological systems |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |