JP2002501044A - カリクレインプロテアーゼ阻害剤としての複素環アミジン - Google Patents

カリクレインプロテアーゼ阻害剤としての複素環アミジン

Info

Publication number
JP2002501044A
JP2002501044A JP2000528535A JP2000528535A JP2002501044A JP 2002501044 A JP2002501044 A JP 2002501044A JP 2000528535 A JP2000528535 A JP 2000528535A JP 2000528535 A JP2000528535 A JP 2000528535A JP 2002501044 A JP2002501044 A JP 2002501044A
Authority
JP
Japan
Prior art keywords
alkyl
hooc
pyridyl
group
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000528535A
Other languages
English (en)
Japanese (ja)
Inventor
バウケ ドリット
ランゲ ウド
マック ヘルムート
ザイツ ヴェルナー
ヴォルフガング ヘフケン ハンス
ホルンベルガー ヴィルフリート
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of JP2002501044A publication Critical patent/JP2002501044A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2000528535A 1998-01-26 1999-01-23 カリクレインプロテアーゼ阻害剤としての複素環アミジン Pending JP2002501044A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19802802.4 1998-01-26
DE19802802 1998-01-26
PCT/EP1999/000435 WO1999037611A1 (de) 1998-01-26 1999-01-23 Heterocyclische amidine als kallikrein protease inhibitoren

Publications (1)

Publication Number Publication Date
JP2002501044A true JP2002501044A (ja) 2002-01-15

Family

ID=7855661

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000528535A Pending JP2002501044A (ja) 1998-01-26 1999-01-23 カリクレインプロテアーゼ阻害剤としての複素環アミジン

Country Status (4)

Country Link
EP (1) EP1049673A1 (de)
JP (1) JP2002501044A (de)
AU (1) AU2424499A (de)
WO (1) WO1999037611A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002502852A (ja) * 1998-02-09 2002-01-29 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼ阻害剤、特にウロキナーゼ阻害剤としてのヘテロアリールアミジン、メチルアミジンおよびグアニジン
JP2002536446A (ja) * 1999-02-09 2002-10-29 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼ阻害剤としての、ヘテロアリールアミジン類、メチルアミジン類およびグアニジン類

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000047461A (ko) * 1998-12-29 2000-07-25 성재갑 트롬빈 억제제
CA2370267A1 (en) 1999-04-09 2000-10-19 Basf Aktiengesellschaft Prodrugs of thrombin inhibitors
TR200102913T2 (tr) * 1999-04-09 2002-01-21 Basf Aktiengesellschaft Tam proteazların düşük moleküler ağırlıklı inhibitörleri.
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
CN1642946A (zh) * 2002-03-22 2005-07-20 株式会社Lg生命科学 (2s)－n－{5－[氨基(亚氨基)甲基]－2－噻吩基}甲基－1－{(2r)－2－[(羧甲基)氨基]3，－二苯基丙酰}－2－吡咯烷甲酰胺的马来酸盐及其制备方法
CN1642947A (zh) * 2002-03-22 2005-07-20 株式会社Lg生命科学 ( 2 S )－N－5－[氨基(亚氨基)甲基]－2－噻吩基甲基－1－( 2 R ) －2－[(羧甲基) 氨基]－3 ,3－二苯基丙酰－2－吡咯烷甲酰胺·nH2O的新晶形
WO2004002985A1 (en) * 2002-06-27 2004-01-08 Lg Life Sciences Ltd. Peptidic thrombin inhibitor compound
EP1736465A4 (de) 2004-03-31 2009-06-17 Ajinomoto Kk Anilinderivative
DE102005035250A1 (de) * 2005-07-25 2007-02-01 Archimica Gmbh Verfahren zur Herstellung von Nitrilen durch Eliminierungsreaktionen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
DE19506610A1 (de) * 1995-02-24 1996-08-29 Basf Ag Thrombininhibitoren
DE19504504A1 (de) * 1995-02-10 1996-08-14 Basf Ag Heterocyclische Thrombininhibitoren
CN1198839C (zh) * 1995-02-17 2005-04-27 艾伯特有限及两合公司 作为凝血酶抑制剂的新的二肽脒类
DE19632773A1 (de) * 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002502852A (ja) * 1998-02-09 2002-01-29 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼ阻害剤、特にウロキナーゼ阻害剤としてのヘテロアリールアミジン、メチルアミジンおよびグアニジン
JP2002536446A (ja) * 1999-02-09 2002-10-29 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼ阻害剤としての、ヘテロアリールアミジン類、メチルアミジン類およびグアニジン類

Also Published As

Publication number Publication date
AU2424499A (en) 1999-08-09
EP1049673A1 (de) 2000-11-08
WO1999037611A1 (de) 1999-07-29

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