JP2002500180A5 - - Google Patents
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- Publication number
- JP2002500180A5 JP2002500180A5 JP2000527235A JP2000527235A JP2002500180A5 JP 2002500180 A5 JP2002500180 A5 JP 2002500180A5 JP 2000527235 A JP2000527235 A JP 2000527235A JP 2000527235 A JP2000527235 A JP 2000527235A JP 2002500180 A5 JP2002500180 A5 JP 2002500180A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- disorder
- disulfiram
- medical device
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- AUZONCFQVSMFAP-UHFFFAOYSA-N disulfiram Chemical compound CCN(CC)C(=S)SSC(=S)N(CC)CC AUZONCFQVSMFAP-UHFFFAOYSA-N 0.000 description 30
- 239000008194 pharmaceutical composition Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 16
- 229960002563 disulfiram Drugs 0.000 description 15
- 206010028980 Neoplasm Diseases 0.000 description 12
- 230000033115 angiogenesis Effects 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 208000035475 disorder Diseases 0.000 description 8
- 208000026106 cerebrovascular disease Diseases 0.000 description 6
- 230000000926 neurological effect Effects 0.000 description 6
- 208000023178 Musculoskeletal disease Diseases 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 208000022211 Arteriovenous Malformations Diseases 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 206010012689 Diabetic retinopathy Diseases 0.000 description 3
- 208000010412 Glaucoma Diseases 0.000 description 3
- 206010018691 Granuloma Diseases 0.000 description 3
- 208000031220 Hemophilia Diseases 0.000 description 3
- 208000009292 Hemophilia A Diseases 0.000 description 3
- 206010029113 Neovascularisation Diseases 0.000 description 3
- 206010039710 Scleroderma Diseases 0.000 description 3
- 230000005744 arteriovenous malformation Effects 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 210000002808 connective tissue Anatomy 0.000 description 3
- 208000018631 connective tissue disease Diseases 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 210000003238 esophagus Anatomy 0.000 description 3
- 201000011066 hemangioma Diseases 0.000 description 3
- 201000001371 inclusion conjunctivitis Diseases 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 210000000867 larynx Anatomy 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 201000003142 neovascular glaucoma Diseases 0.000 description 3
- 230000000399 orthopedic effect Effects 0.000 description 3
- 210000001672 ovary Anatomy 0.000 description 3
- 210000000496 pancreas Anatomy 0.000 description 3
- 210000002307 prostate Anatomy 0.000 description 3
- 230000001698 pyrogenic effect Effects 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 210000001685 thyroid gland Anatomy 0.000 description 3
- 206010044325 trachoma Diseases 0.000 description 3
- 210000003708 urethra Anatomy 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 2
- 208000009129 Ear Neoplasms Diseases 0.000 description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 description 2
- 206010046458 Urethral neoplasms Diseases 0.000 description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 208000014829 head and neck neoplasm Diseases 0.000 description 2
- 230000001969 hypertrophic effect Effects 0.000 description 2
- 206010023841 laryngeal neoplasm Diseases 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 208000026037 malignant tumor of neck Diseases 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 201000001514 prostate carcinoma Diseases 0.000 description 2
- 201000000498 stomach carcinoma Diseases 0.000 description 2
- 206010046766 uterine cancer Diseases 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12289298A IL122892A0 (en) | 1998-01-11 | 1998-01-11 | Pharmaceutical compositions comprising a thiocarbamate |
| IL122892 | 1998-01-11 | ||
| PCT/IL1999/000017 WO1999034784A2 (en) | 1998-01-11 | 1999-01-11 | Pharmaceutical compositions comprising disulfiram for inhibiting angiogenesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002500180A JP2002500180A (ja) | 2002-01-08 |
| JP2002500180A5 true JP2002500180A5 (https=) | 2006-02-23 |
Family
ID=11071076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000527235A Pending JP2002500180A (ja) | 1998-01-11 | 1999-01-11 | ジスルフィラムで構成される医薬品組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6288110B1 (https=) |
| EP (1) | EP1047416B1 (https=) |
| JP (1) | JP2002500180A (https=) |
| AT (1) | ATE401879T1 (https=) |
| AU (1) | AU1888599A (https=) |
| DE (1) | DE69939155D1 (https=) |
| DK (1) | DK1047416T3 (https=) |
| IL (1) | IL122892A0 (https=) |
| WO (1) | WO1999034784A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548540B2 (en) | 1998-09-08 | 2003-04-15 | Charlotte-Mecklenburg Hospital Authority | Method of treating cancer using dithiocarbamate derivatives |
| US7816403B2 (en) * | 1998-09-08 | 2010-10-19 | University Of Utah Research Foundation | Method of inhibiting ATF/CREB and cancer cell growth and pharmaceutical compositions for same |
| US6589987B2 (en) | 1998-09-08 | 2003-07-08 | Charlotte-Mecklenburg Hospital Authority | Method of treating cancer using tetraethyl thiuram disulfide |
| US6706759B1 (en) | 1998-09-08 | 2004-03-16 | Charlotte-Mecklenburg Hospital Authority | Method of treating cancer using dithiocarbamate derivatives |
| WO2002056823A2 (en) * | 2001-01-18 | 2002-07-25 | Arnold Hoffman | Redox therapy for tumors |
| US20040157837A1 (en) * | 2002-11-07 | 2004-08-12 | Serbedzija George N. | Combinations for the treatment of fungal infections |
| EP2345412A1 (en) * | 2005-12-02 | 2011-07-20 | The Johns Hopkins University | Use of high-dose oxazaphosphorine drugs for treating immune disorders |
| WO2008034076A2 (en) | 2006-09-15 | 2008-03-20 | The Johns Hopkins University | Cyclophosphamide in combination with immune therapeutics |
| WO2008034071A2 (en) | 2006-09-15 | 2008-03-20 | The Johns Hopkins University | Method of identifying patients suitable for high-dose cyclophosphamide treatment |
| WO2008034074A2 (en) | 2006-09-15 | 2008-03-20 | The Johns Hopkins University | Cyclosphosphamide in combination with anti-idiotypic vaccines |
| US20100099757A1 (en) * | 2006-12-04 | 2010-04-22 | Yossef Israeli-Shalev | Disulfiram doses and treatment regimen suitable for treatment of angiogenesis-dependent disorders |
| WO2009067699A2 (en) * | 2007-11-21 | 2009-05-28 | Accentia Biopharmaceuticals, Inc. | Methods for providing a system of care for an oxazaphosphorine drug regimen |
| US9026372B2 (en) * | 2007-11-21 | 2015-05-05 | Accentia Biopharmaceuticals, Inc. | Methods for providing a system of care for a high-dose oxazaphosphorine drug regimen |
| WO2012028311A1 (en) * | 2010-08-31 | 2012-03-08 | Avidal Vascular Gmbh | Compositions comprising a taxane for coating medical devices |
| JP6206939B2 (ja) * | 2011-10-11 | 2017-10-04 | 国立大学法人 千葉大学 | 肝がん幹細胞阻害剤 |
| WO2014152207A1 (en) | 2013-03-15 | 2014-09-25 | Mylan Laboratories, Inc. | Hot melt granulation formulations of poorly water-soluble active agents |
| WO2015120254A1 (en) * | 2014-02-06 | 2015-08-13 | Texas Tech University System | Disulfiram compositions and treatments for brain tumors |
| GB201407806D0 (en) * | 2014-05-02 | 2014-06-18 | Ucl Business Plc | Treatment of fibrosis |
| GB201519643D0 (en) * | 2015-11-06 | 2015-12-23 | Univ Wolverhampton | Disulfiram formulation |
| WO2017177947A1 (zh) | 2016-04-13 | 2017-10-19 | 诺马（北京）科技有限公司 | 局部注射双硫仑制剂治疗胸腹膜癌症的方法 |
| EP3311843A1 (en) | 2016-10-13 | 2018-04-25 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Compositions comprising dithiocarbamate and cyclodextrin |
| JP7193146B2 (ja) | 2017-03-17 | 2022-12-20 | 国立大学法人大阪大学 | 光受容感度の抑制又は低減剤 |
| CA3103432A1 (en) * | 2018-06-27 | 2020-01-02 | Children's Medical Center Corporation | Compounds for inhibition of inflammation |
| US11311538B2 (en) | 2018-07-13 | 2022-04-26 | Yale University | Compositions and methods for targeting cancers |
| EP3693740A1 (en) | 2019-02-07 | 2020-08-12 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Improved dithiocarmabate based compounds, therapies and diagnostics |
| KR20210049403A (ko) * | 2019-10-25 | 2021-05-06 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 조성물 |
| AU2021254780A1 (en) * | 2020-04-16 | 2022-10-20 | Atossa Therapeutics, Inc. | Compositions and methods to reduce the infectivity of a virus |
| US12070468B2 (en) * | 2020-05-14 | 2024-08-27 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for the treatment and prevention of vascular malformations |
| WO2021231814A1 (en) * | 2020-05-14 | 2021-11-18 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for the treatment and prevention of vascular malformations |
| US11065214B1 (en) * | 2020-09-18 | 2021-07-20 | Spring Discovery, Inc. | Combination therapies with disulfiram |
| WO2022061171A1 (en) * | 2020-09-18 | 2022-03-24 | Spring Discovery, Inc. | Combination therapies with disulfiram |
| CN114376997B (zh) * | 2021-10-10 | 2023-04-28 | 深圳市人民医院 | 一种新型IRE1a抑制剂紫草素及与双硫仑协同抗肿瘤组合方式 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0284879A3 (en) * | 1987-03-17 | 1990-10-17 | Merrell Dow Pharmaceuticals Inc. | Method of inhibiting interleukin-1 release |
| US4870101A (en) * | 1987-03-17 | 1989-09-26 | Merrell Dow Pharmaceuticals Inc. | Method of inhibiting interleukin-1 release |
| US5807884A (en) * | 1992-10-30 | 1998-09-15 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
-
1998
- 1998-01-11 IL IL12289298A patent/IL122892A0/xx unknown
-
1999
- 1999-01-11 US US09/582,995 patent/US6288110B1/en not_active Expired - Lifetime
- 1999-01-11 JP JP2000527235A patent/JP2002500180A/ja active Pending
- 1999-01-11 EP EP99900280A patent/EP1047416B1/en not_active Expired - Lifetime
- 1999-01-11 AT AT99900280T patent/ATE401879T1/de not_active IP Right Cessation
- 1999-01-11 DK DK99900280T patent/DK1047416T3/da active
- 1999-01-11 AU AU18885/99A patent/AU1888599A/en not_active Abandoned
- 1999-01-11 DE DE69939155T patent/DE69939155D1/de not_active Expired - Lifetime
- 1999-01-11 WO PCT/IL1999/000017 patent/WO1999034784A2/en not_active Ceased
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