JP2002186672A - Medical capsule device - Google Patents

Medical capsule device

Info

Publication number
JP2002186672A
JP2002186672A JP2001303724A JP2001303724A JP2002186672A JP 2002186672 A JP2002186672 A JP 2002186672A JP 2001303724 A JP2001303724 A JP 2001303724A JP 2001303724 A JP2001303724 A JP 2001303724A JP 2002186672 A JP2002186672 A JP 2002186672A
Authority
JP
Japan
Prior art keywords
capsule
capsule device
medical capsule
bellows
timer switch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001303724A
Other languages
Japanese (ja)
Inventor
Yuichi Ikeda
裕一 池田
Hitoshi Mizuno
均 水野
Masahiro Kudo
正宏 工藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Optical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Optical Co Ltd filed Critical Olympus Optical Co Ltd
Priority to JP2001303724A priority Critical patent/JP2002186672A/en
Publication of JP2002186672A publication Critical patent/JP2002186672A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/073Intestinal transmitters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0204Operational features of power management
    • A61B2560/0214Operational features of power management of power generation or supply

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROBLEM TO BE SOLVED: To provide a medical capsule device capable of controlling the start of the operation of a function for electrical drive by mounting a timer switch on the capsule. SOLUTION: The medical capsule device is made to pass through a coelomoduct for the purpose of carrying out an examination, curing or treatment. The capsule 56, provided with a compact battery 59, the timer switch 61 and an electric circuit, is characterized as follows: the timer switch 61 enables a voltage from the compact battery 59 to be applied to the electric circuit after a lapse of set time.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【0001】[0001]

【発明の属する技術分野】この発明は、体腔内の部位を
直接的に観察し、診断や治療を行う医療用カプセル装置
に関する。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical capsule device for directly observing a site in a body cavity and performing diagnosis and treatment.

【0002】[0002]

【従来の技術】医療用カプセル装置は、患者の口腔から
体腔内に挿入する内視鏡とは異なり、患者が飲み込むこ
とにより、体外装置と無線的に接続されているため、患
者に与える苦痛を大きく軽減できることで注目されてい
る。
2. Description of the Related Art Unlike an endoscope which is inserted into a body cavity from an oral cavity of a patient, a medical capsule device is wirelessly connected to an extracorporeal device by swallowing the patient, thereby reducing the pain given to the patient. It is noted that it can be greatly reduced.

【0003】従来、例えば、特公昭63−62216
(特開昭57−156736号)公報に示すように、医
療用カプセル装置は、薬液を投与したり、体液、組織を
採取する機能を持っており、体腔内において薬液を投与
し、また体液、組織を採取することができるようになっ
ている。
Conventionally, for example, Japanese Patent Publication No. 63-62216
As disclosed in Japanese Patent Application Laid-Open No. 57-156736, a medical capsule device has a function of administering a drug solution, collecting a body fluid and a tissue, and administering a drug solution in a body cavity. Tissue can be collected.

【0004】また、特願平4−224180号に示すよ
うに、前述した機能に加えてカプセル本体にセンサやマ
ニピュレータを設け、患部等を積極的にセンシング・処
置することができるものも提案されている。
Further, as shown in Japanese Patent Application No. 4-224180, in addition to the above-mentioned functions, a capsule body is provided with a sensor and a manipulator so that an affected part or the like can be positively sensed and treated. I have.

【0005】[0005]

【発明が解決しようとする課題】しかしながら、従来の
医療用カプセル装置において、カプセルに搭載した薬剤
投与機能やセンサなどの機能の駆動タイミングをタイマ
ー等で簡便にコントロールする工夫が無かった。
However, in the conventional medical capsule device, there has been no device for simply controlling the drive timing of the drug administration function and the function of the sensor and the like mounted on the capsule with a timer or the like.

【0006】この発明は、前記事情に着目してなされた
もので、その目的とするところは、体腔内の所望の部位
およびタイミングで種々の機能を稼動開始できる医療用
カプセル装置を提供することにある。
The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a medical capsule device capable of starting operation of various functions at a desired site and timing in a body cavity. is there.

【0007】[0007]

【課題を解決するための手段】この発明は前記目的を達
成するために、体腔内を通過させて検査、治療又は処置
を行う医療用カプセル装置において、電源手段と、タイ
マースイッチと、電気回路とを設け、設定時間経過後、
上記タイマースイッチが上記電源手段からの電圧を上記
電気回路に印加可能にすることを特徴とする。
In order to achieve the above object, the present invention provides a medical capsule device for performing examination, treatment or treatment by passing through a body cavity, comprising a power supply means, a timer switch, and an electric circuit. After the set time elapses,
The timer switch enables a voltage from the power supply means to be applied to the electric circuit.

【0008】[0008]

【作用】カプセルにタイマースイッチを設け、電気的に
駆動させる機能の稼動開始をコントロールできる。これ
によって、体腔内の所望の部位およびタイミングで種々
の手段を機能させることができる。
A timer switch is provided on the capsule to control the start of operation of the function to be electrically driven. This allows various means to function at desired locations and timing within the body cavity.

【0009】[0009]

【発明の実施の形態】以下、この発明の各実施の形態を
図面に基づいて説明する。
Embodiments of the present invention will be described below with reference to the drawings.

【0010】図1(a)(b)は第1の実施形態を示
す。図1(a)に示すように、カプセル31を構成する
容器32内には伸縮性のバルーン33と通常は収縮状態
にあるベローズ34が設けられている。バルーン33の
内部には目的とする消化管内の患部で放出させる薬剤3
5が充填され、リザーバとしての役割を果たしている。
FIGS. 1A and 1B show a first embodiment. As shown in FIG. 1A, an elastic balloon 33 and a bellows 34 which is normally in a contracted state are provided in a container 32 constituting a capsule 31. Inside the balloon 33, a drug 3 to be released at the target diseased part in the digestive tract
5 is filled and serves as a reservoir.

【0011】バルーン33の一端は容器32の連通孔3
6と接続され、内外を連通している。一方、ベローズ3
4の一端も容器32の連通孔37と接続され、連通孔3
7には消化管内の消化液で選択的に溶解する溶解膜38
が設けられている。また、連通孔37にはカプセル31
の外部からベローズ34内のみに溶液が浸入してくるよ
うに逆止弁39が設けられている。また、ベローズ34
の内腔には消化管内の消化液と化学反応を起こして気体
(ガス)を発生する化学物質40が充填されている。
One end of the balloon 33 is connected to the communication hole 3 of the container 32.
6 and communicates inside and outside. On the other hand, bellows 3
4 is also connected to the communication hole 37 of the container 32,
7 is a dissolving membrane 38 which selectively dissolves in digestive juice in the digestive tract.
Is provided. Further, the capsule 31 is provided in the communication hole 37.
A check valve 39 is provided so that the solution enters only into the bellows 34 from outside. Bellows 34
Is filled with a chemical substance 40 which generates a gas by causing a chemical reaction with digestive fluid in the digestive tract.

【0012】このように構成されたカプセル31を胃内
で選択的に薬剤を放出する場合について説明すると、前
記溶解膜38を胃液で消化されるゼラチン等で構成し、
またベローズ34の内腔に設ける化学物質40を胃液
(酸)と反応してガスを発生する物質とする。前記化学
物質40としては、K,Ca,Na,Mg,A1,Zn
等の金属あるいはCaCO等が用いられる。
A description will be given of a case where the capsule 31 having the above-described structure selectively releases a drug in the stomach. The dissolving membrane 38 is formed of gelatin or the like digested by gastric juice.
The chemical substance 40 provided in the inner cavity of the bellows 34 is a substance which reacts with gastric juice (acid) to generate gas. As the chemical substance 40, K, Ca, Na, Mg, A1, Zn
Or a metal such as CaCO 3 .

【0013】患者がカプセル31を飲み込むと、胃液等
の消化液41で溶解膜38が溶解し、図1(b)に示す
ように、胃液が逆止弁39を介してペローズ34の内腔
に浸入する。そして、カプセル31内の化学物質40と
化学反応を起こし、水素ガス、二酸化炭素ガス等のガス
42が発生する。ガス42の発生に伴いベローズ34は
伸張し、バルーン33を押圧するため、バルーン33の
内腔に充填された薬剤35は連通孔36を介して胃内に
放出される。
When the patient swallows the capsule 31, the dissolving membrane 38 dissolves in the digestive fluid 41 such as gastric juice and the like, and as shown in FIG. Penetrate. Then, a chemical reaction occurs with the chemical substance 40 in the capsule 31, and a gas 42 such as a hydrogen gas and a carbon dioxide gas is generated. As the gas 42 is generated, the bellows 34 expands and presses the balloon 33, so that the medicine 35 filled in the lumen of the balloon 33 is released into the stomach through the communication hole 36.

【0014】一方、腸内で薬剤放出をさせる場合は、溶
解膜38を腸液で消化される脂肪酸膜とする。また、ベ
ローズ34の内腔の化学物質40を腸液と化学反応を起
こしてガスを発生するAl,Zn,Si,NHCl
等とする。
On the other hand, when the drug is to be released in the intestine, the dissolving film 38 is made of a fatty acid film digested by intestinal fluid. Further, Al, Zn, Si, NH 4 Cl, which generates a gas by causing a chemical reaction of the chemical substance 40 in the lumen of the bellows 34 with intestinal fluid.
And so on.

【0015】そして、患者がカプセル31を飲み込み、
カプセル31が腸内に到達すると、腸液により脂肪酸膜
からなる溶解膜38が溶解する。そして、腸液が逆止弁
39を介してベローズ34の内腔に浸入する。そして、
カプセル31内の化学物質40と化学反応を起こし、水
素ガス、アンモニアガス等のガス42が発生し、ベロー
ズ34は伸張し、バルーン33を押圧するため、バルー
ン33の内腔に充填された薬剤35は連通孔36を介し
て腸内に放出される。
Then, the patient swallows the capsule 31,
When the capsule 31 reaches the intestine, the dissolving film 38 composed of a fatty acid film is dissolved by the intestinal fluid. Then, the intestinal fluid enters the lumen of the bellows 34 via the check valve 39. And
A chemical reaction occurs with a chemical substance 40 in the capsule 31, and a gas 42 such as hydrogen gas or ammonia gas is generated. The bellows 34 expands and presses the balloon 33. Is released into the intestine through the communication hole 36.

【0016】このように構成したカプセルは、ベローズ
内腔に消化液(胃液、腸液)と反応してガスを発生する
化学物質を設けたため、従来のX線造影装置でカプセル
の位置を検出する必要はなく、また体外に大掛かりな超
音波や磁気発生手段を設ける必要もなく、体腔内の目的
とする患部で選択的に薬剤を放出させることができる。
In the capsule constructed as described above, a chemical substance which generates gas by reacting with digestive fluids (gastric fluid and intestinal fluid) is provided in the inner space of the bellows. In addition, there is no need to provide a large-scale ultrasonic or magnetic generating means outside the body, and the medicine can be selectively released at a target diseased part in a body cavity.

【0017】図2(a)(b)は第2の実施形態を示
し、第1の実施形態と同一構成部分については同一番号
を付して説明を省略する。図2(a)に示すように、カ
プセル43の容器44の側面には凹部45が設けられ、
この凹部45は連通孔46を介して容器44の内外を連
通している。凹部45には消化液で溶解する溶解膜38
が取付けられている。ベローズ34の内腔にはガスを吸
着した吸着剤47が設けられている。この吸着剤47と
しては、例えばV,Mn,Cr,Co等が用いられる。
また、容器44内のベローズ34の周囲は消化液と化学
反応を起こして発熱する化学物質48が設けられてい
る。
FIGS. 2A and 2B show a second embodiment. The same components as those in the first embodiment are denoted by the same reference numerals and description thereof is omitted. As shown in FIG. 2A, a concave portion 45 is provided on a side surface of the container 44 of the capsule 43,
The recess 45 communicates with the inside and outside of the container 44 via the communication hole 46. The dissolving film 38 that dissolves in the digestive fluid is
Is installed. An adsorbent 47 that adsorbs gas is provided in the inner cavity of the bellows 34. As the adsorbent 47, for example, V, Mn, Cr, Co, or the like is used.
Around the bellows 34 in the container 44, a chemical substance 48 that generates a chemical reaction with the digestive juice by causing a chemical reaction is provided.

【0018】このように構成したカプセル43を胃内で
選択的に薬剤を放出する場合について説明すると、前記
溶解膜38を胃液で消化されるゼラチン等で構成し、ま
たベローズ34の周囲の化学物質48を胃液(酸)と反
応して発熱するアルカリ、NaOH等とする。
A description will be given of a case where the capsule 43 thus constructed is selectively released in the stomach. The dissolving membrane 38 is made of gelatin or the like digested by gastric juice, and a chemical substance around the bellows 34 is used. 48 is alkali, NaOH or the like which generates heat by reacting with gastric juice (acid).

【0019】患者がカプセル43を飲み込むと、胃液等
の消化液41で溶解膜38が溶解し、図2(b)に示す
ように、連通孔46を介して胃液が容器44内に浸入す
る。そして、消化液41とベローズ34の周囲に設けら
れた化学物質48とが化学反応を起こして発熱する。こ
の発熱により吸着剤47に吸着されていたガス49が解
離放出され、ベローズ34は伸張し、バルーン33を押
圧するため、バルーン33の内腔に充填された薬剤35
は連通孔36を介して胃内に放出される。
When the patient swallows the capsule 43, the dissolving membrane 38 is dissolved by the digestive fluid 41 such as gastric fluid, and the gastric fluid infiltrates into the container 44 through the communication hole 46 as shown in FIG. Then, the digestive juice 41 and the chemical substance 48 provided around the bellows 34 cause a chemical reaction to generate heat. The gas 49 adsorbed by the adsorbent 47 is dissociated and released by this heat generation, and the bellows 34 expands and presses the balloon 33.
Is released into the stomach through the communication hole 36.

【0020】一方、腸内で薬剤放出をさせる場合は、溶
解膜38を腸液で消化される脂肪酸膜とし、ベローズ3
4の周囲に設ける化学物質48を腸液と化学反応を起こ
して発熱するHCl,CHCOOH等の酸性物質と
すれば、前述と同様に腸内において選択的に薬剤が放出
されることになる。したがって、第1の実施形態と同様
の効果が得られる。
On the other hand, when the drug is to be released in the intestine, the dissolving film 38 is made of a fatty acid film digested by intestinal fluid, and the bellows 3 is used.
If the chemical substance 48 provided around 4 is made of an acidic substance such as HCl or CH 3 COOH which generates a chemical reaction with intestinal fluid by generating a chemical reaction, the drug is selectively released in the intestine as described above. Therefore, the same effect as in the first embodiment can be obtained.

【0021】図3(a)(b)は第3の実施形態を示
し、第1,2の実施形態と同一構成部分については同一
番号を付して説明を省略する。図3(a)に示すよう
に、カプセル50の容器51の内部に設けられたベロー
ズ34の内壁には白金担持したTiO粒子52が接
着等により固定して設けられ、ベローズ34の内腔には
電解液53が充填されている。
FIGS. 3A and 3B show a third embodiment. The same components as those in the first and second embodiments are denoted by the same reference numerals and description thereof is omitted. As shown in FIG. 3A, TiO 2 particles 52 carrying platinum are fixed on the inner wall of the bellows 34 provided inside the container 51 of the capsule 50 by bonding or the like. Is filled with an electrolyte 53.

【0022】ベローズ34は透光性を有する材料で形成
されている。ベローズ34の周囲には腸液等の消化液4
1と反応して発光する化学物質54が設けられている。
この化学物質54としては、例えば過酸化水素あるいは
次亜塩素酸塩とルミノールの混合物が用いられる。
The bellows 34 is formed of a light-transmitting material. Around digestive fluid 4 such as intestinal juice around bellows 34
A chemical substance 54 that emits light in response to 1 is provided.
As the chemical substance 54, for example, hydrogen peroxide or a mixture of hypochlorite and luminol is used.

【0023】このように構成したカプセル50を腸内で
選択的に薬剤を放出する場合について説明すると、患者
がカプセル50を飲み込み、腸内に到達すると、脂肪酸
膜からなる溶解膜38が溶解し、図3(b)に示すよう
に、連通孔46を介して腸液が容器51内に浸入する。
そして、腸液とルミノール、過酸化水素水(次亜塩素酸
塩)からなる化学物質54が化学反応を起こし、350
〜600nmの発光を起こす。
A description will be given of a case in which the capsule 50 thus configured selectively releases a drug in the intestine. When a patient swallows the capsule 50 and reaches the intestine, the dissolving film 38 composed of a fatty acid film is dissolved. As shown in FIG. 3B, intestinal fluid enters the container 51 through the communication hole 46.
Then, the chemical substance 54 composed of intestinal fluid, luminol, and hydrogen peroxide (hypochlorite) causes a chemical reaction,
Emit の 600 nm emission.

【0024】この光は透光性のベローズ34内のTi0
2粒子52に届き、光電気分解によりH,O
ス55が発生する。そして、ベローズ34は伸張し、バ
ルーン33を押圧するため、バルーン33の内腔に充填
された薬剤35は連通孔36を介して腸内に放出され
る。したがって、第1,2の実施形態と同様の効果が得
られる。
This light is transmitted through the Ti0 in the translucent bellows 34.
The H 2 and O 2 gas 55 is generated by the photoelectrolysis. Then, since the bellows 34 expands and presses the balloon 33, the medicine 35 filled in the lumen of the balloon 33 is released into the intestine through the communication hole 36. Therefore, effects similar to those of the first and second embodiments can be obtained.

【0025】図4(a)(b)は第4の実施形態を示
し、第1〜3の実施形態と同一構成部分については同一
番号を付して説明を省略する。図4(a)に示すよう
に、カプセル56の容器57の内部に設けられたベロー
ズ34の内腔には電解液溶液58が充填されている。電
解液溶液58としては水に塩化ナトリウム、塩化銅(I
I)硫酸銅(II)等の電解質を溶解したものが用いら
れる。
FIGS. 4A and 4B show a fourth embodiment, in which the same components as those in the first to third embodiments are denoted by the same reference numerals and description thereof is omitted. As shown in FIG. 4A, the inner space of the bellows 34 provided inside the container 57 of the capsule 56 is filled with an electrolyte solution 58. As the electrolyte solution 58, sodium chloride, copper chloride (I
I) A solution in which an electrolyte such as copper (II) sulfate is dissolved is used.

【0026】また、ベローズ34の端部には小型バッテ
リー59と、これに接続された一対の電極60が設けら
れている。一対の電極60は電解質溶液58に浸漬され
ている。また、カプセル56の外周にはタイマースイッ
チ61が設けられ、設定時間経過後、電極60間に小型
バッテリー59の電圧を印加可能となっている。
At the end of the bellows 34, a small battery 59 and a pair of electrodes 60 connected thereto are provided. The pair of electrodes 60 is immersed in the electrolyte solution 58. A timer switch 61 is provided on the outer periphery of the capsule 56 so that a voltage of the small battery 59 can be applied between the electrodes 60 after a lapse of a set time.

【0027】このように構成したカプセル56を胃内、
腸内で選択的に薬剤を放出する場合について説明する
と、まず、タイマースイッチ61を操作してタイマーの
設定時間をカプセル56が胃あるいは腸に到達する時間
にする。そして、タイマースイッチ61をオンにし、患
者がカプセル56を飲み込む。タイマーは設定時間にな
ると、スイッチオンとなり、小型バッテリー59の電圧
が一対の電極60間に印加される。
The capsule 56 constructed as described above is inserted into the stomach,
The case where the medicine is selectively released in the intestine will be described. First, the timer switch 61 is operated to set the timer to the time required for the capsule 56 to reach the stomach or intestine. Then, the timer switch 61 is turned on, and the patient swallows the capsule 56. When the timer reaches a set time, the timer is turned on, and the voltage of the small battery 59 is applied between the pair of electrodes 60.

【0028】電圧が印加されることで、電解質溶液58
は電気分解を起こし、H,O ガス55が発生す
る。そして、ベローズ34は伸張し、バルーン33を押
圧するため、バルーン33の内腔に充填された薬剤35
は連通孔36を介して胃内または腸内に放出される。し
たがって、第1〜3の実施形態と同様の効果が得られ
る。
When a voltage is applied, the electrolyte solution 58
Causes electrolysis and H2, O2 Gas 55 is generated
You. Then, the bellows 34 expands and pushes the balloon 33.
The medicine 35 filled in the lumen of the balloon 33 for pressurization
Is released into the stomach or intestine through the communication hole 36. I
Therefore, the same effect as in the first to third embodiments can be obtained.
You.

【0029】[0029]

【発明の効果】以上説明したように、この発明によれ
ば、カプセルにタイマースイッチを設けたことによっ
て、電気的に駆動させる機能の稼動開始をコントロール
できる。よって、体腔内の所望の部位およびタイミング
で種々の手段を機能させることができる。
As described above, according to the present invention, the operation start of the function to be electrically driven can be controlled by providing the timer switch on the capsule. Therefore, various means can be made to function at a desired site and timing in the body cavity.

【図面の簡単な説明】[Brief description of the drawings]

【図1】この発明の第1の実施形態を示し、カプセルの
縦断側面図。
FIG. 1 shows a first embodiment of the present invention, and is a longitudinal side view of a capsule.

【図2】この発明の第2の実施形態を示し、カプセルの
縦断側面図。
FIG. 2 is a longitudinal sectional side view of a capsule according to the second embodiment of the present invention.

【図3】この発明の第3の実施形態を示し、カプセルの
縦断側面図。
FIG. 3 is a longitudinal sectional side view of a capsule, showing a third embodiment of the present invention.

【図4】この発明の第4の実施形態を示し、カプセルの
縦断側面図。
FIG. 4 is a longitudinal sectional side view of a capsule according to a fourth embodiment of the present invention.

【符号の説明】[Explanation of symbols]

33…バルーン 35…薬剤 56…カプセル 59…小型バッテリー 61…タイマースイッチ 33 ... Balloon 35 ... Drug 56 ... Capsule 59 ... Small battery 61 ... Timer switch

───────────────────────────────────────────────────── フロントページの続き (72)発明者 工藤 正宏 東京都渋谷区幡ヶ谷2丁目43番2号 オリ ンパス光学工業株式会社内 Fターム(参考) 4C038 CC01 CC05 4C066 AA02 AA05 BB08 CC01 CC09 CC10 EE03 HH30 KK17 QQ76 QQ85 4C076 AA53 AA95 BB21 DD21 FF31 FF54 FF68  ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Masahiro Kudo 2-43-2, Hatagaya, Shibuya-ku, Tokyo Olympus Optical Co., Ltd. F-term (reference) 4C038 CC01 CC05 4C066 AA02 AA05 BB08 CC01 CC09 CC10 EE03 HH30 KK17 QQ76 QQ85 4C076 AA53 AA95 BB21 DD21 FF31 FF54 FF68

Claims (4)

【特許請求の範囲】[Claims] 【請求項1】 体腔管路内を通過させて検査、治療又は
処置を行う医療用カプセル装置において、 電源手段と、タイマースイッチと、電気回路とを設け、
設定時間経過後、上記タイマースイッチが上記電源手段
からの電圧を上記電気回路に印加可能にすることを特徴
とする医療用カプセル装置。
1. A medical capsule device for performing examination, treatment or treatment by passing through a body cavity channel, comprising a power supply means, a timer switch, and an electric circuit,
A medical capsule device, wherein after a set time has elapsed, the timer switch enables the voltage from the power supply means to be applied to the electric circuit.
【請求項2】 上記電源がバッテリーであることを特徴
とする請求項1の医療用カプセル装置。
2. The medical capsule device according to claim 1, wherein said power source is a battery.
【請求項3】 薬剤収納部と薬剤放出手段とを設け、上
記電気回路が薬剤放出手段駆動回路である請求項1の医
療用カプセル装置。
3. The medical capsule device according to claim 1, further comprising a medicine storing section and a medicine releasing means, wherein the electric circuit is a medicine releasing means driving circuit.
【請求項4】 上記薬剤放出手段が電極と電解質溶液と
電解質溶液を収納したバルーンとからなり、電解質溶液
が電極によって電気分解され、発生したガスによってバ
ルーンを拡張させることを特徴とする請求項3の医療用
カプセル装置。
4. The method according to claim 3, wherein the drug releasing means comprises an electrode, an electrolyte solution and a balloon containing the electrolyte solution, wherein the electrolyte solution is electrolyzed by the electrode and the balloon is expanded by generated gas. Medical capsule device.
JP2001303724A 2001-09-28 2001-09-28 Medical capsule device Pending JP2002186672A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2001303724A JP2002186672A (en) 2001-09-28 2001-09-28 Medical capsule device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001303724A JP2002186672A (en) 2001-09-28 2001-09-28 Medical capsule device

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP25988293A Division JP3279409B2 (en) 1993-10-18 1993-10-18 Medical capsule device

Publications (1)

Publication Number Publication Date
JP2002186672A true JP2002186672A (en) 2002-07-02

Family

ID=19123768

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001303724A Pending JP2002186672A (en) 2001-09-28 2001-09-28 Medical capsule device

Country Status (1)

Country Link
JP (1) JP2002186672A (en)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005023102A1 (en) * 2003-09-08 2005-03-17 Olympus Corporation In-subject introducing device and wireless in-subject information capturing system
JP2006509574A (en) * 2002-12-16 2006-03-23 ギブン イメージング リミテッド Apparatus, system, and method for selective actuation of in-vivo sensors
JP2006334141A (en) * 2005-06-02 2006-12-14 Konica Minolta Medical & Graphic Inc Capsule endoscope
WO2007129655A1 (en) * 2006-05-05 2007-11-15 Olympus Medical Systems Corp. Medical capsule
JP2007536377A (en) * 2004-05-03 2007-12-13 イー−ピル ファーマ リミティド Delivery of active ingredients in the gastrointestinal tract
US8021356B2 (en) 2003-09-29 2011-09-20 Olympus Corporation Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system
US8062287B2 (en) 2005-12-22 2011-11-22 Koninklijke Philips Electronics N V Device for controlled release of chemical molecules
JP2013501569A (en) * 2009-08-12 2013-01-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Chemical delivery device with compressible chemical reservoir
US8517928B2 (en) 2004-08-04 2013-08-27 Olympus Corporation Capsule-type endoscope
JP2014510107A (en) * 2011-03-24 2014-04-24 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ Swallowable medical capsule
US8945010B2 (en) 2009-12-23 2015-02-03 Covidien Lp Method of evaluating constipation using an ingestible capsule
JP2015186590A (en) * 2009-12-24 2015-10-29 インキューブ ラブズ, エルエルシー Swallowable drug delivery device and drug delivery method
US9757548B2 (en) 2009-12-24 2017-09-12 Rani Therapeutics, Llc Method for delivering a therapeutic agent into the wall of the small intestine
US9757514B2 (en) 2010-12-23 2017-09-12 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9808510B2 (en) 2011-06-29 2017-11-07 Rani Therapeutics, Llc Method for delivering gonadotropin releasing hormone into a lumen of the intestinal tract
US9814763B2 (en) 2010-12-23 2017-11-14 Incube Labs, Llc Method for delivery of somatostatin into a lumen of the intestinal tract
US9844505B2 (en) 2010-12-23 2017-12-19 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9844655B2 (en) 2010-12-23 2017-12-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9907747B2 (en) 2010-12-23 2018-03-06 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9956178B2 (en) 2010-12-23 2018-05-01 Rani Therapeutics, Llc Methods for delivering insulin preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9987487B2 (en) 2009-08-03 2018-06-05 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US10004783B2 (en) 2010-12-23 2018-06-26 Rani Therapeutics, Llc Method for delivering pramlintide into a lumen of the intestinal tract using a swallowable drug delivery device
US10029080B2 (en) 2010-12-23 2018-07-24 Rani Therapeutics, Llc Method for delivering exenatide into a lumen of the intestinal tract using a swallowable drug delivery device
US10350163B2 (en) 2010-12-23 2019-07-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10487145B2 (en) 2010-12-23 2019-11-26 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10752681B2 (en) 2010-12-23 2020-08-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
CN113769249A (en) * 2021-09-10 2021-12-10 安翰科技(武汉)股份有限公司 Drug delivery capsule

Cited By (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006509574A (en) * 2002-12-16 2006-03-23 ギブン イメージング リミテッド Apparatus, system, and method for selective actuation of in-vivo sensors
US8216130B2 (en) 2002-12-16 2012-07-10 Given Imaging Ltd. Device, system and method for selective activation of in vivo sensors
WO2005023102A1 (en) * 2003-09-08 2005-03-17 Olympus Corporation In-subject introducing device and wireless in-subject information capturing system
US8021356B2 (en) 2003-09-29 2011-09-20 Olympus Corporation Capsule medication administration system, medication administration method using capsule medication administration system, control method for capsule medication administration system
JP2007536377A (en) * 2004-05-03 2007-12-13 イー−ピル ファーマ リミティド Delivery of active ingredients in the gastrointestinal tract
US8517928B2 (en) 2004-08-04 2013-08-27 Olympus Corporation Capsule-type endoscope
JP2006334141A (en) * 2005-06-02 2006-12-14 Konica Minolta Medical & Graphic Inc Capsule endoscope
US8062287B2 (en) 2005-12-22 2011-11-22 Koninklijke Philips Electronics N V Device for controlled release of chemical molecules
WO2007129655A1 (en) * 2006-05-05 2007-11-15 Olympus Medical Systems Corp. Medical capsule
EP2052757A4 (en) * 2006-05-05 2009-12-02 Olympus Medical Systems Corp Medical capsule
JP5091125B2 (en) * 2006-05-05 2012-12-05 オリンパスメディカルシステムズ株式会社 Medical capsule
EP2052757A1 (en) * 2006-05-05 2009-04-29 Olympus Medical Systems Corp. Medical capsule
JP2013031673A (en) * 2006-05-05 2013-02-14 Olympus Medical Systems Corp Medical capsule
US11872396B2 (en) 2009-08-03 2024-01-16 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US11439817B2 (en) 2009-08-03 2022-09-13 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US9987487B2 (en) 2009-08-03 2018-06-05 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
JP2013501569A (en) * 2009-08-12 2013-01-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Chemical delivery device with compressible chemical reservoir
US8945010B2 (en) 2009-12-23 2015-02-03 Covidien Lp Method of evaluating constipation using an ingestible capsule
US11253686B2 (en) 2009-12-24 2022-02-22 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US9757548B2 (en) 2009-12-24 2017-09-12 Rani Therapeutics, Llc Method for delivering a therapeutic agent into the wall of the small intestine
US11376405B2 (en) 2009-12-24 2022-07-05 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US11338118B2 (en) 2009-12-24 2022-05-24 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US10179228B2 (en) 2009-12-24 2019-01-15 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US10987499B2 (en) 2009-12-24 2021-04-27 Rani Therapeutics, Llc Swallowable drug delivery device and method of delivery
US10603475B2 (en) 2009-12-24 2020-03-31 Rani Therapeutics, Llc Swallowable drug delivery device and methods of drug delivery
US10596359B2 (en) 2009-12-24 2020-03-24 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10493253B2 (en) 2009-12-24 2019-12-03 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
JP2017014274A (en) * 2009-12-24 2017-01-19 インキューブ ラブズ, エルエルシー Swallowable Drug Delivery Device and Drug Delivery Method
JP2015186590A (en) * 2009-12-24 2015-10-29 インキューブ ラブズ, エルエルシー Swallowable drug delivery device and drug delivery method
US10252039B2 (en) 2009-12-24 2019-04-09 Rani Therapeutics, Llc Therapeutic agent preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10039908B2 (en) 2009-12-24 2018-08-07 Rani Therapeutics, Llc Swallowable drug delivery device and method of delivery
US10335463B2 (en) 2010-12-23 2019-07-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10967050B2 (en) 2010-12-23 2021-04-06 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10300010B2 (en) 2010-12-23 2019-05-28 Rani Therapeutics, Llc Methods for delivering entanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10307579B2 (en) 2010-12-23 2019-06-04 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10314891B2 (en) 2010-12-23 2019-06-11 Rani Therapeutics, Llc Method for delivering pramlintide into a lumen of the intestinal tract using a swallowable drug delivery device
US10314892B2 (en) 2010-12-23 2019-06-11 Rani Therapeutics, Llc Method of delivering a somatostatin compound into a lumen of the intestinal tract using a swallowable drug delivery device
US10322167B2 (en) 2010-12-23 2019-06-18 Rani Therapeutics, Llc Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device
US10004783B2 (en) 2010-12-23 2018-06-26 Rani Therapeutics, Llc Method for delivering pramlintide into a lumen of the intestinal tract using a swallowable drug delivery device
US10350163B2 (en) 2010-12-23 2019-07-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10478396B2 (en) 2010-12-23 2019-11-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10487145B2 (en) 2010-12-23 2019-11-26 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9956178B2 (en) 2010-12-23 2018-05-01 Rani Therapeutics, Llc Methods for delivering insulin preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10548850B2 (en) 2010-12-23 2020-02-04 Rani Therapeutics, Llc Therapeutic composition comprising insulin prepared for delivery into an intestinal tract
US9907747B2 (en) 2010-12-23 2018-03-06 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10632251B2 (en) 2010-12-23 2020-04-28 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US10752681B2 (en) 2010-12-23 2020-08-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10864254B2 (en) 2010-12-23 2020-12-15 Rani Therapeutics, Llc Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device
US10874840B2 (en) 2010-12-23 2020-12-29 Rani Therapeutics, Llc Preparation comprising exanatide for delivery into a lumen of the intestinal tract
US10888517B2 (en) 2010-12-23 2021-01-12 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10926073B2 (en) 2010-12-23 2021-02-23 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US10953077B2 (en) 2010-12-23 2021-03-23 Rani Therapeutics, Llc Method of delivering a somatostatin compound into a lumen of the intestinal tract using a swallowable drug delivery device
US10029080B2 (en) 2010-12-23 2018-07-24 Rani Therapeutics, Llc Method for delivering exenatide into a lumen of the intestinal tract using a swallowable drug delivery device
US10980749B2 (en) 2010-12-23 2021-04-20 Rani Therapeutics, Llc Therapeutic preparation comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9844655B2 (en) 2010-12-23 2017-12-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11844867B2 (en) 2010-12-23 2023-12-19 Rani Therapeutics, Llc Method of delivering insulin into a lumen of the intestinal tract using a swallowable drug delivery device
US11229684B2 (en) 2010-12-23 2022-01-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9844505B2 (en) 2010-12-23 2017-12-19 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US11304895B2 (en) 2010-12-23 2022-04-19 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9814763B2 (en) 2010-12-23 2017-11-14 Incube Labs, Llc Method for delivery of somatostatin into a lumen of the intestinal tract
US11813314B2 (en) 2010-12-23 2023-11-14 Rani Therapeutics, Llc Method of delivering a somatostatin compound into a lumen of the intestinal tract using a swallowable drug delivery device
US11419812B2 (en) 2010-12-23 2022-08-23 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US9757514B2 (en) 2010-12-23 2017-09-12 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US11555068B2 (en) 2010-12-23 2023-01-17 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11814427B2 (en) 2010-12-23 2023-11-14 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11638690B2 (en) 2010-12-23 2023-05-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US11654182B2 (en) 2010-12-23 2023-05-23 Rani Therapeutics, Llc Method of delivering gonadotropin releasing hormone or an analogue thereof into a lumen of the intestinal tract using a swallowable drug delivery device
US11684761B2 (en) 2010-12-23 2023-06-27 Rani Therapeutics, Llc Preparation comprising exanatide for delivery into a lumen of the intestinal tract
US11806504B2 (en) 2010-12-23 2023-11-07 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US11771879B2 (en) 2010-12-23 2023-10-03 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
JP2014510107A (en) * 2011-03-24 2014-04-24 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ Swallowable medical capsule
US9808510B2 (en) 2011-06-29 2017-11-07 Rani Therapeutics, Llc Method for delivering gonadotropin releasing hormone into a lumen of the intestinal tract
CN113769249B (en) * 2021-09-10 2023-08-04 安翰科技(武汉)股份有限公司 Drug delivery capsule
WO2023036296A1 (en) * 2021-09-10 2023-03-16 安翰科技(武汉)股份有限公司 Drug administration capsule
CN113769249A (en) * 2021-09-10 2021-12-10 安翰科技(武汉)股份有限公司 Drug delivery capsule

Similar Documents

Publication Publication Date Title
JP2002186672A (en) Medical capsule device
JP3279409B2 (en) Medical capsule device
JP3957272B2 (en) Capsule medical device
US7226442B2 (en) Microchip reservoir devices using wireless transmission of power and data
JP4231657B2 (en) Capsule medical device
US5217449A (en) Medical capsule and apparatus for activating the same
JP4674038B2 (en) In vivo sensing device
WO2004066903B1 (en) Active drug delivery in the gastrointestinal tract
JP4520126B2 (en) Capsule type medical device system
WO2005063111A1 (en) Capsule device for medical use
KR20070065357A (en) Capsule type medical device
WO2005023102A1 (en) In-subject introducing device and wireless in-subject information capturing system
JP2008526419A (en) Electronically controlled ingestible capsule for sampling fluid in the digestive tract
EP0460327B1 (en) Medical capsule and apparatus for activating the same
JP2003325440A (en) Capsule medical treatment device
JP2005103123A (en) Internal observation apparatus
JP2020513276A (en) Implantable system
JP2005192820A (en) Capsule type medical device
WO2006070472A1 (en) Introduction aiding apparatus for encapsulated medical device
JP2003135387A (en) Capsule type medical apparatus
JP7097888B2 (en) Embeddable system
Nakamura et al. Swallowable sensing device for long-term gastrointestinal tract monitoring
JPS58194809A (en) Capsule for applying drug into digestive tract
JPH0236848A (en) Medical capsule
JP2006102361A (en) Intracorporeal medical treatment apparatus

Legal Events

Date Code Title Description
A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20040706