CN113769249B - Drug delivery capsule - Google Patents
Drug delivery capsule Download PDFInfo
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- CN113769249B CN113769249B CN202111060451.0A CN202111060451A CN113769249B CN 113769249 B CN113769249 B CN 113769249B CN 202111060451 A CN202111060451 A CN 202111060451A CN 113769249 B CN113769249 B CN 113769249B
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- Prior art keywords
- drug delivery
- medicine
- administration
- capsule
- drug
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a drug delivery capsule which is provided with a shell with a drug bin, a soft capsule arranged in the drug bin, a drug delivery channel communicated with the soft capsule and the outside of the shell, and a drug delivery control module arranged in the shell; the drug delivery control module is used for filling fluid into the drug bin so as to squeeze the soft bag. Compared with the prior art, the embodiment of the invention adopts a replacement mode for drug delivery, and the drug delivery control module pumps the external fluids such as gas, liquid and the like of the drug delivery capsule into the drug bin where the soft capsule is positioned so as to occupy the space of the drug bin, thereby extruding the drug from the soft capsule; the administration control module can control the administration amount by controlling the amount of fluid entering the medicine bin, and further realize the administration speed by controlling the speed of the fluid entering the medicine bin, and further realize the administration control.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a drug delivery capsule.
Background
The controlled release of the drug can improve the therapeutic effect of the drug, reduce side effects, and especially for difficult-to-reach digestive tract sections, the capsule administration scheme is more and more concerned, and the drug has the advantages of no damage, no pain, wide coverage, accurate controlled release of the drug and the like.
There are some capsule drug delivery devices, such as InteliCap, which use a micro motor to convert rotary motion into linear motion through a transmission mechanism, so as to push a piston to push out the drug in a drug cartridge. This design has a high release control capability: multiple administrations can be performed and the drug flow rate is controllable. However, the device has relatively complex mechanical structure, high power consumption and no camera shooting function, and can only roughly distinguish the digestive tract region through the pH sensor, so that more accurate drug release can not be performed, such as drug administration in focus regions of bleeding, ulcer and the like.
Paper Therapeutic Capsule Endoscopy Opportunities and Challenges discloses a capsule device using a spring as the power for drug delivery. Under normal state, the spring is in compression state, and is fixed by fusible yarn, and medicine is filled in the medicine bin. When the drug administration instruction is sent, the heating device blows out the fuse wire, the spring is released, and the piston is pushed to spray out the drug. The design structure is relatively simple, but has no camera shooting function and cannot accurately administer medicine. Meanwhile, the scheme can only be used for one-time administration, and the flow rate cannot be controlled. Similar designs are numerous, such as those disclosed in Progenity, U.S. Pat. No. 3,182,1A 1.
The scheme based on the micro motor, the magnetic drive and the like has strong controllability, such as multiple dosing and adjustable flow rate. However, their structure is generally complex and the drug loading is small. While solutions based on springs, compressed air, chemical gas production reactions, etc. are relatively simple in structure, but have low controllability and can be administered only once. Meanwhile, the scheme of compressed air and a compression spring has the problem that equipment fails due to material aging, such as slow release of a spring, air leakage and the like.
In view of the above, it is necessary to provide a safe and reliable drug delivery capsule with high controllability.
Disclosure of Invention
The invention aims to provide a drug delivery capsule, which solves the defects in the prior art, is delivered in a replacement mode, and pumps the external air, liquid and other fluids of the drug delivery capsule into a drug cabin of a soft capsule to occupy the space of the drug cabin through a drug delivery control module, so that the drug is extruded from the soft capsule, and the drug delivery control can be conveniently realized.
The invention provides a drug delivery capsule which is provided with a shell with a drug bin, a soft capsule arranged in the drug bin, a drug delivery channel communicated with the soft capsule and the outside of the shell, and a drug delivery control module arranged in the shell; the drug delivery control module is used for filling fluid into the drug bin so as to squeeze the soft bag.
Further, still have equipment chamber and separation in the casing equipment chamber with the separator in medicine storehouse, the control module that doses sets up equipment intracavity and includes the pump body, the entry and the casing external intercommunication of pump body, the export of pump body communicates to the medicine storehouse.
Furthermore, the drug administration control module is also provided with a pump inlet channel which is communicated with the inlet of the pump body and the outside of the shell, and a filtering unit which is arranged on the pump inlet channel.
Further, the filtering unit is provided with a plurality of air inlets arranged on the shell, the size of the air inlets is smaller than that of the inlet of the pump body, and the pump inlet channel is also provided with a connecting channel for communicating the air inlets with the inlet of the pump body.
Further, the pump body is arranged on the partition, a connecting hole for communicating the medicine bin with the equipment cavity is formed in the partition, and an inlet of the pump body is communicated with the connecting hole.
Further, the administration capsule is further provided with an imaging module arranged in the equipment cavity, and the administration channel comprises an administration outlet arranged on the shell; the drug delivery outlet is arranged in an image acquisition area of the imaging module.
Further, the drug delivery capsule is arranged in an extending mode along the length direction, and the soft capsule and the imaging module are oppositely arranged at two sides of the shell in the length direction; the drug delivery outlet is arranged on one side of the shell far away from the soft bag; the administration channel is also provided with an administration inlet arranged on the soft bag and a connecting pipe communicated with the administration inlet and the administration outlet.
Further, the imaging module comprises a camera arranged in the equipment cavity and a light supplementing lamp arranged beside the camera.
Further, a magnetic unit is arranged in the equipment cavity.
Further, a soft rubber filling plug is further arranged on the shell, and part of the soft rubber filling plug extends into the soft bag.
Compared with the prior art, the invention adopts a replacement mode for drug delivery, and pumps the external fluids such as gas, liquid and the like of the drug delivery capsule into the drug bin of the soft capsule through the drug delivery control module so as to occupy the space of the drug bin, thereby extruding the drug from the soft capsule; the administration control module can control the administration amount by controlling the amount of fluid entering the medicine bin, and further realize the administration speed by controlling the speed of the fluid entering the medicine bin, and further realize the administration control.
Drawings
FIG. 1 is a state diagram of a drug delivery capsule disclosed in an embodiment of the present invention prior to administration;
FIG. 2 is a state diagram of a drug delivery capsule according to an embodiment of the present invention after administration;
FIG. 3 is a schematic view showing the installation structure of a filter unit in a drug delivery capsule according to an embodiment of the present invention;
reference numerals illustrate: 1-shell, 10-medicine bin, 11-soft capsule, 12-equipment cavity, 121-module accommodating cavity, 122-installation cavity, 13-partition piece, 14-first shell, 15-second shell, 16-inlet port, 17-connecting channel, 18-medicine filling soft rubber plug, 2-medicine feeding channel, 21-medicine feeding outlet, 22-medicine feeding inlet, 23-connecting pipe, 3-medicine feeding control module, 31-pump body, 4-control module, 41-battery unit, 42-electric control unit, 5-imaging module, 51-module circuit board, 52-camera, 53-light filling lamp.
Detailed Description
The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the invention.
Embodiments of the invention: a medicine delivering capsule is disclosed, which has medicine cabin for storing medicine, and the medicine is stored in the medicine cabin and then delivered to digestive tract area when reaching medicine delivering area, and the medicine is delivered to focus area.
Specifically, as shown in fig. 1, the drug delivery capsule disclosed in the present invention comprises: the medicine box comprises a shell 1 with a medicine bin 10, a soft bag 11 arranged in the medicine bin 10, a medicine feeding channel 2 which is communicated with the soft bag 11 and the outside of the shell 1, and a medicine feeding control module 3 arranged in the shell 1; the administration control module 3 is used for filling the medicine bin 10 with fluid so as to squeeze the soft capsule 1.
As shown in fig. 2, the soft capsule 11 is used for storing medicine, and the shape of the soft capsule 11 is changeable, that is, the soft capsule 11 can be compressed by extrusion under the action of external force, and when the soft capsule 11 is compressed by extrusion of external force, the medicine stored in the soft capsule 11 can be controlled to be released to the outside of the shell 1 through the medicine delivery channel 2, that is, released to the medicine delivery area in the human body. It can be understood that the release degree of the medicine stored in the soft bag 11 can be controlled by changing the extrusion compression degree of the soft bag 11, and the release rate of the medicine at the source in the soft bag 11 can also be controlled by changing the extrusion compression rate of the soft bag 11, so that the control of the medicine release process is realized by the arrangement of the structure.
In order to conveniently control the extrusion and compression of the soft capsule 11, the embodiment is provided with the administration control module 3, the administration control module 3 fills the fluid into the medicine bin 10, and the fluid occupies the space in the medicine bin 10 after filling the fluid, so that the space of the soft capsule 11 is compressed, the soft capsule 11 is extruded, and the medicine is released from the soft capsule 11 through the administration channel 2. It will be appreciated that the fluid filled into the drug delivery control module 3 into the drug reservoir 10 may be digestive fluid or other fluids in the human body, or may be gas or a mixture of gas and liquid in the human body.
In this embodiment, the medicine in the soft bag 11 is not directly sucked by using a pump, and then the soft bag 11 is pumped out, but the medicine compartment 10 where the soft bag 11 is positioned is occupied by external air, liquid and other fluids in a 'replacement' mode, so that the medicine is extruded from the soft bag 11. The reason for this is that some drugs are relatively viscous or are suspended liquids containing fine particles, and if the pump body is used to pump directly from the bladder 11, excessive viscosity of the liquid or excessive particle size of the substance may cause jamming of the pump body. In the scheme disclosed by the embodiment, the medicine is prevented from directly flowing through the pump body, the effectiveness of the equipment is improved, and the flexibility of medicine use is improved.
The administration control module 3 can control the administration amount by controlling the amount of fluid entering the medicine compartment 10, and can control the administration speed by controlling the speed of fluid entering the medicine compartment 10, and can further control the administration.
In order to conveniently realize the control of fluid entering the medicine compartment 10, the casing 1 is also provided with an equipment cavity 12 and a partition piece 13 for separating the equipment cavity 12 from the medicine compartment 10, the medicine feeding control module 3 is arranged in the equipment cavity 12 and comprises a pump body 31, an inlet of the pump body 31 is communicated with the outside of the casing, and an outlet of the pump body 31 is communicated with the medicine compartment 10.
The device cavity 12 is internally used for installing control equipment, the partition piece 13 divides the cavity in the shell 1 into two parts of the device cavity 12 and the drug bin 10, the device cavity 12 is internally provided with a control module 4 besides the drug administration control module 3, the control module 4 comprises a battery unit 41 and an electric control unit 42, the electric control unit 42 specifically comprises a circuit board for controlling the operation of the drug administration control module 3, a microprocessor and a wireless communication module, the microprocessor and the wireless communication module are arranged on the circuit board, the battery unit 41 supplies power for the drug administration control module 3, the electric control unit 42 and the wireless communication module, the wireless communication module is used for communicating with a control center outside a human body and receiving instructions of the communication center, and the microprocessor controls the operation or closing of the drug administration control module 3 after receiving the instructions, and the specific microprocessor controls the stopping or operation of the pump body 31. In this embodiment, the pump body 31 is a micro pump, such as a booster pump, which has low power consumption, small volume, safe use, long service life, controllable flow rate, and can realize multiple drug release. In order to conveniently realize the connection between the pump body 31 and the electric control unit 42, the electric control unit 42 and the pump body 31 are in installation fit through a plug-in assembly.
Further, the device cavity 12 is further internally provided with an imaging module 5, the imaging module 5 is electrically connected with the battery unit 41, the imaging module 5 is used for obtaining an image or image of the drug delivery capsule after entering the human body, whether the drug delivery capsule reaches a specified alimentary canal area or not can be judged by the imaging module 5, or a focus area is identified by the imaging module 5, and after the drug delivery capsule reaches the specified area or the focus is identified, the release of the drug in the soft capsule 11 is controlled, so that the device has the capability of visual drug delivery, and the more accurate controlled release of the drug can be realized. For example, when treating peptic ulcer, the ulcer can be accurately found through the imaging module 5, and when the administration capsule is close to the surface of the ulcer, the drug release is controlled to spray the drug to the ulcer area, so that the gel drug is convenient to attach, and the curative effect is improved.
Further, in order to conveniently control the movement of the administration capsule in the alimentary canal, a magnetic unit is further provided in the device cavity 12, and the magnetic unit is arranged in the administration capsule and can control the movement of the administration capsule in the human body by using an external magnetic field, thereby better controlling the position of the administration capsule in the human body.
The housing 1 is biocompatible and is not corroded by the digestive juice, and may be transparent or opaque as needed. Because the imaging module 5 is arranged, the part of the shell 1 corresponding to the image acquisition area of the imaging module 5 is transparent, so that the acquisition of the image of the imaging module 5 is conveniently realized. The image acquisition area of the imaging module 5 is the range and area of the image that can be shot by the imaging module 5.
The imaging module 5 in this embodiment includes an internal module circuit board 51 disposed in the equipment chamber 12, a camera 52 disposed on the module circuit board 51, and a light supplementing lamp 53 disposed beside the camera 52. The module circuit board 51 is electrically connected to the battery unit 41, and the battery unit 41 supplies power to the imaging module 5.
The module circuit board 51 is adapted to the cross-sectional shape of the housing 1, the module circuit board 51 divides the device cavity 12 into two parts, namely a module accommodating cavity 121 and a mounting cavity 122, the battery unit 41 and the administration control module 3 are arranged in the mounting cavity 122, and the module accommodating cavity 121 is used for accommodating the imaging module 5; the module accommodating chambers 121 are disposed on two sides of the mounting chamber 122 opposite to the medicine compartment 10.
It should be noted that the imaging module 5 may have no module circuit board 51, and in another embodiment, a partition board is disposed in the device cavity 12 to divide the device cavity 12 into two parts, namely a module accommodating cavity 121 and a mounting cavity 122, and the imaging module 5 is disposed in the module accommodating cavity 121. The camera 52 and the light supplementing lamp 53 are directly installed and fixed on the partition board and are respectively electrically connected with the battery unit 41, and meanwhile, the camera 52 and the light supplementing lamp 53 are respectively electrically connected with the electric control unit 42.
For conveniently realizing the installation and fixation of the imaging module 5, the housing 1 generally includes a first housing 14 and a second housing 15, the second housing 15 is detachably installed and fixed on the first housing 14, the installation cavity 122 is disposed in the first housing 14, the module accommodating cavity 121 is disposed in the second housing 15, and the module accommodating cavity 121 is formed between the second housing 15 and the module circuit board 51. The second housing 15 has a hemispherical structure, and the second housing 15 is a transparent housing, so as to conveniently obtain an image of the outside of the housing.
In this embodiment, the administration control module 3 further has a pump inlet passage communicating the inlet of the pump body 31 with the outside of the housing 1 and a filter unit provided on the pump inlet passage. The arrangement of the filtering unit can be carried out on the fluid entering the pump body 31, so that the impurity mixed in the fluid is prevented from entering the pump body and further blocking the pump body.
Specifically, as shown in fig. 3, the filtering unit includes a plurality of air intake holes 16 disposed on the housing 1, and the size of the air intake holes 16 is smaller than the size of the inlet of the pump body 31, and the pump intake passage further has a connection passage 17 that communicates the air intake holes 16 with the inlet of the pump body 31. Setting the size of the air intake hole 16 smaller than the size of the inlet of the pump body 31 can effectively block the entry of impurities of larger particles into the pump body 31 through the inlet of the pump body 31, thereby causing clogging of the pump body 31.
In this embodiment, the pump body 31 is disposed on the partition member 13 for better space saving, and the partition member 13 is provided with a connection hole for communicating the medicine compartment 10 with the equipment chamber 12, and an inlet of the pump body 31 is communicated with the connection hole. The inlet of the pump body 31 is directly exposed to the drug cartridge 10 to conveniently realize the controlled release of the fluid into the drug cartridge 10.
The administration channel 2 comprises an administration outlet 21 provided on the housing 1; the administration outlet 21 is arranged in the image acquisition area of the imaging module 5. In the present embodiment, the administration port 21 is provided on the second housing 15.
In this embodiment, the drug delivery capsule is extended along the length direction, and the soft capsule 11 and the imaging module 5 are oppositely arranged at two sides of the housing 1 along the length direction; the drug delivery outlet 21 is arranged on one side of the shell 1 far from the soft bag 11; the administration channel 2 further has an administration inlet 22 provided on the soft bag 11 and a connection pipe 23 connecting the administration inlet 22 and the administration outlet 21, and the connection pipe 23 is a hose. The administration outlet 21 is arranged in the image acquisition area of the imaging module 5, so that the administration condition can be directly observed by the imaging module 5, and the administration control can be better realized.
It should be noted that the drug delivery outlet 21 is disposed on the housing 1 at a position away from the air inlet hole 16, and this structure can prevent the drug from the drug delivery outlet 21 from being directly inhaled from the air inlet hole 16, so that the drug cannot be applied to the human body.
For conveniently adding medicine into the soft capsule 11, the shell 1 is also provided with a medicine filling soft rubber plug 18, and part of the medicine filling soft rubber plug 18 extends into the soft capsule 11. The drug is injected into the soft capsule 11 from the syringe by penetrating the drug-filled soft capsule 18 through the syringe needle and finally extending into the soft capsule 11 when the drug is filled into the soft capsule 11, and the drug-filled soft capsule 18 has a resetting capability after the needle of the syringe is pulled out to re-block the needle hole of the drug-filled soft capsule 18 penetrated by the syringe.
Before use, a user pierces the drug-loading soft rubber plug 18 by using an injector, injects the drug into the soft capsule 11, then takes the drug-loading soft rubber plug for a patient, can control the drug-releasing capsule to enter a formulated area through an external magnetic field, judges whether the drug-releasing capsule reaches a specified digestive tract area or recognizes a focus through the imaging module 5, and can send a drug-releasing instruction after reaching the specified digestive tract area or recognizing the focus to control the pump body 31 of the drug-loading capsule to work. The gas and liquid fluid in the alimentary canal enters the inlet of the pump body 31 after being filtered by the filtering unit, and is pumped into the medicine bin 10 through the pump body 31, and the fluid in the alimentary canal extrudes the soft bag 111 to spray the medicine through the medicine outlet 21.
It should be noted that, the start, stop and flow rate of the pump body 31 can be controlled by the control module, and the micro pump can be turned off and on at any time and the working frequency can be adjusted according to the requirement, so as to achieve the purposes of releasing medicine for multiple times and adjusting the flow rate of medicine.
While the foregoing is directed to embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow.
Claims (10)
1. A dosing capsule, comprising: the medicine box comprises a shell provided with a medicine bin, a soft bag arranged in the medicine bin, a medicine feeding channel communicated with the soft bag and the outside of the shell, and a medicine feeding control module arranged in the shell; the drug delivery control module is used for filling fluid into the drug bin so as to squeeze the soft bag; the medicine feeding control module is arranged in the equipment cavity and comprises a pump body, an inlet of the pump body is communicated with the outside of the shell, and an outlet of the pump body is communicated to the medicine bin;
the medicine feeding control module fills fluid into the medicine bin, and the fluid occupies the space in the medicine bin after filling the fluid, so that the space of the soft bag is compressed, the soft bag is extruded, and the medicine is released from the soft bag through the medicine feeding channel;
the fluid filled into the medicine bin by the medicine feeding control module comes from a human body.
2. The drug delivery capsule of claim 1, wherein: the drug administration control module is also provided with a pump inlet channel communicated with the inlet of the pump body and the outside of the shell, and a filter unit arranged on the pump inlet channel.
3. The drug delivery capsule of claim 2, wherein: the filtering unit is provided with a plurality of air inlets arranged on the shell, the size of the air inlets is smaller than that of the inlet of the pump body, and the pump inlet channel is also provided with a connecting channel which is communicated with the air inlets and the inlet of the pump body.
4. The drug delivery capsule of claim 1, wherein: the pump body is arranged on the partition, a connecting hole for communicating the medicine bin with the equipment cavity is formed in the partition, and an inlet of the pump body is communicated with the connecting hole.
5. A dosing capsule according to claim 3, wherein: the administration capsule is also provided with an imaging module arranged in the equipment cavity, and the administration channel comprises an administration outlet arranged on the shell; the drug delivery outlet is arranged in an image acquisition area of the imaging module.
6. The drug delivery capsule of claim 5, wherein: the drug delivery capsules are arranged in an extending mode along the length direction, and the soft capsules and the imaging module are oppositely arranged on two sides of the shell in the length direction; the drug delivery outlet is arranged on one side of the shell far away from the soft bag; the administration channel is also provided with an administration inlet arranged on the soft bag and a connecting pipe communicated with the administration inlet and the administration outlet.
7. The drug delivery capsule of claim 6, wherein: the medicine outlet is arranged on the shell at a position far away from the air inlet hole;
the air inlet hole is arranged at the middle position of the administration capsule in the length direction.
8. The drug delivery capsule of claim 6, wherein: the imaging module comprises a camera arranged in the equipment cavity and a light supplementing lamp arranged beside the camera.
9. The drug delivery capsule of claim 1, wherein: the device cavity also has a magnetic unit therein.
10. The drug delivery capsule of claim 1, wherein: the shell is also provided with a soft rubber plug for charging, and part of the soft rubber plug for charging extends into the soft capsule.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111060451.0A CN113769249B (en) | 2021-09-10 | 2021-09-10 | Drug delivery capsule |
| PCT/CN2022/118123 WO2023036296A1 (en) | 2021-09-10 | 2022-09-09 | Drug administration capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111060451.0A CN113769249B (en) | 2021-09-10 | 2021-09-10 | Drug delivery capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113769249A CN113769249A (en) | 2021-12-10 |
| CN113769249B true CN113769249B (en) | 2023-08-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111060451.0A Active CN113769249B (en) | 2021-09-10 | 2021-09-10 | Drug delivery capsule |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN113769249B (en) |
| WO (1) | WO2023036296A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113769249B (en) * | 2021-09-10 | 2023-08-04 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
| CN114376980A (en) * | 2022-01-14 | 2022-04-22 | 安翰科技(武汉)股份有限公司 | Medicine applying capsule |
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| WO2023036296A1 (en) | 2023-03-16 |
| CN113769249A (en) | 2021-12-10 |
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