KR101347640B1 - Cartridge-way infusion pump - Google Patents

Abstract

The present invention relates to a cartridge mode medicine injection device which automatically injects medicines into a patient, and is formed of a main body (1) and a cartridge (2). The main body (1) and the cartridge (2) are detachable. The cartridge (2) includes a pump device for injecting stored medicines to a syringe device on the outside by being integrated, and the main body (1) includes a control circuit for outputting electric signals to control the operation of the pump device. The main body (1) and the cartridge (2) are combined to each other by electrically connecting the pump device and the control circuit. The cartridge integrated with the pump device is disposable, thus the malfunction caused by repeatedly using the pump device is reduced.

Description

Cartridge-type drug injector {CARTRIDGE-WAY INFUSION PUMP}

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pump injector for automatically injecting drugs into a patient using an electrically operated pump mechanism and a control circuit thereof. In particular, the drug storage passage pump mechanism is integrated into one cartridge, and the main body controls the pump mechanism. The present invention relates to a cartridge type drug injector having a built-in circuit, in which a cartridge can be detached from the main body, and in which the control circuit and the pump mechanism are electrically connected.

Drug injectors that use a pump mechanism to inject painkillers, anticancer drugs, insulin, etc. into a patient, and the pump mechanism is controlled by a microcomputer and automatically injected are well known. These drug injectors are small and portable, so they can be used for injecting drugs not only in hospitals but also outside of hospitals during their daily lives, thereby ensuring their normal economic activity and reducing the number of visits.

Pump mechanisms used in conventional drug injectors include syringe pumps (Patent Documents 1 and 2), tube compression pumps (Patent Documents 3 to 7), cylinder pumps (Patent Document 8), and piezoelectric pumps by the present inventors. (Patent Document 9) is proposed.

The syringe pump has a structure in which a syringe filled with drugs is used to gradually pressurize the plunger of the syringe by using a motor and an electric mechanism that converts the rotational power of the motor into linear motion. Syringes can be supplemented or replaced with medication.

Tube compression pump is a form of squeezing the tube which is a part of the fluid set to be again divided into the finger type (finger presure type) of Patent Documents 3 to 5 and the rolling type proposed in Patent Documents 6 and 7 Can be. The acupressure type has a cam follower, a cam and a motor arranged in order to press the straight tube support groove into which the tube connected to the drug bag is fitted, and the tube inserted into the tube support groove in turn. When the motor is driven, the cam is rotated, and the cam in the tube is pushed out by the cam balls in turn, and the pressure in the tube is gradually pushed out. On the other hand, the rolling type includes an arcuate support groove into which a tube connected to the drug bag is fitted, rollers arranged at intervals to revolve while pushing the tube inserted into the arc support groove, a motor for driving the motor, and a complicated power mechanism. When the motor is driven, the rollers are pushed into the tube at intervals, causing the drug in the tube to be pushed out.

The cylinder pump proposed in the following Patent Document 8 constitutes an annular cylinder that directly pumps a drug instead of the tube of the rolling tube compression pump described above. The cylinder for directly pumping the drug is provided as a separate operating unit that can be detached to the body for single use. The main body is equipped with a drive having a motor and two drive shafts coupled on a coaxial to transmit power of the motor. The operating unit has two rotating bodies facing each other on the same axis, and the annular cylinder is formed between the two rotating bodies and the casing inner wall. The toroidal cylinder accommodates two plungers, each attached to two rotating bodies. The inlet of the cylinder is connected to the drug bag and the outlet is connected to the syringe port for the human body. When the motor is driven, the first 300 ° section of one rotation cycle rotates only one side of the drive shaft on the coaxial axis, and the other side remains unrotated, and the next 30 ° section both sides rotate simultaneously. Again, the next 300 ° section is reversed on one side and rotates only on the other side, while the next 30 ° section is rotated on both sides simultaneously. The central angle between the inlet and the outlet is set to 30 ° and the length of each plunger is 15 ° to the center angle. That is, the two plungers meet each other in the 30 ° section and one of the inlet and the outlet is blocked at the front and rear ends of the section. Thus, when the plunger located at the dislocation moves 300 °, the inlet that is blocked by it opens, allowing the drug to enter the cylinder and at the same time the drug in front of the plunger exits to the already open outlet. Injection is possible.

On the other hand, Patent Document 9 (Korean Patent Registration No. 10-1127126) is based on the present inventors and uses a pump bag connected to a drug bag and a piezoelectric actuator for expanding and contracting the pump bag.

KR 10-0478771 B1 (2005-03-16) KR 10-0802068 B1 (2008-01-31) KR 10-0556186 B1 (2006-02-22) KR 10-0561243 B1 (2006-03-22) KR 10-0580586 B1 (2006-05-09) KR 10-1999-0070632 A (1999-09-15) KR 10-0261584 B1 (2000-04-19) KR 10-0948632 B1 (2010-03-12) KR 10-1127126 B1 (2012-03-08)

In general, the drug injector can be economically improved by making it reusable except for a portion which may be cross-contaminated by blood flow of the patient such as a fluid set. In addition, it is possible to reduce the use error by the medical staff or patients by increasing the handleability, such as installing or replacing the infusion set for the drug injector or setting operating conditions. In addition, of course, there should be no inconvenience in carrying or using the patient.

The above-mentioned syringe pumps of Patent Documents 1 and 2 can finely adjust the amount of the drug and have a very high precision. However, since the amount of continuous injection at a time is small, the syringe must be frequently replaced, and the replacement process is complicated. Do.

The acupressure tube crimping pumps disclosed in the above-mentioned patent documents 3 to 5 and the rolling tube crimping pump disclosed in the above-mentioned patent documents 6 and 7 have the same driving conditions of the motor because the materials, diameters and thicknesses of the tubes used vary from manufacturer to manufacturer. In the drug injection dose control error may occur, and in particular, the tube may be damaged by repeated pressing or rolling, in this case, it is dangerous, such as drug contamination or stop the injection.

Although the cylinder pump proposed in the above-mentioned patent document 8 is more stable than the use of the tube described above, the operation unit used for single use is a component that requires precise processing, and the burden on the patient is very high.

On the other hand, the products according to the above-mentioned conventional techniques are not only inconvenient to carry because they are large in volume, but also have a common problem in that they are noisy during use and cannot guarantee safety, such as a drug injection error due to a failure. It is to use a motor as a driving source of. The motor requires an electric machine composed of many mechanical elements such as a complex gear train or cam, such as decelerating and transmitting the rotational power or converting it into a linear motion. This is because it often causes malfunction due to overload, breakdown and external shock. In addition, the motor and its powertrain are not too loud at first, but as time passes, the noise gradually increases, which may cause stress to the patient, and also increase the risk of an accident. In addition, the motor must be installed with a complex powertrain, as well as the power consumption is large, it is difficult to miniaturize the product, such as the use of a large capacity battery, which will increase the price increase.

The present inventors have provided a drug infusion pump (infusion pump) using a piezoelectric actuator excluding the use of a motor through the pre-registered patent of Patent Document 9 described above to solve the above problems at once. However, the piezoelectric actuator was intended to shrink and expand a separate pump bag connected to the drug bag, and the work of replacing the pump bag for the piezoelectric actuator was still inconvenient and needed to be improved.

Therefore, the main object of the present invention is to integrate the infusion set and pump mechanism for supplying drugs in one cartridge to eliminate the trouble caused by the repeated use of the pump mechanism and at the same time to increase the safety and convenience of handling, furthermore piezoelectric as a pump mechanism By applying an actuator and using a piezoelectric pump designed to be suitable for the cartridge, it is possible to provide a cartridge type drug injector that can be much cheaper, noiseless, and miniaturized by excluding an existing electric motor and its power mechanism.

Cartridge-type drug injector according to the present invention for achieving the above object is made of a cartridge having a drug storage space and the main body that is removable and can be carried together in a combined state, the cartridge is a drug stored in the drug storage space The pump mechanism that operates as an electrical signal to eject the to the external syringe port is integrally mounted, the main body has a built-in control circuit for controlling the operation of the pump mechanism, the cartridge and the main body when the coupling A contact terminal for contacting and electrically connecting the pump mechanism and the control circuit is provided, and as the pump mechanism there is a suction port connected to the drug storage space, a discharge port for connecting the external syringe port, and a piezoelectric Actuators can be used to pump drugs from their suction ports to their discharge ports. A piezoelectric pump package is provided, which is installed at the discharge port of the piezoelectric pump package, operates to open only above the normal discharge pressure of the piezoelectric pump package, and is provided with a check valve having a pressure structure capable of adjusting the operating pressure. It is characterized by.

The connection mechanism provided in the main body is preferably in a form that is protected by a structure that prevents contact with the human body so that a finger or the like does not touch when handled by a medical staff or a patient.
Also preferably, the piezoelectric pump package may be provided with an injection port communicating with the suction port, and may be configured to fill or replenish the drug in the drug storage space through the injection port.

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In the cartridge-type drug injector according to the present invention as described above, the main body is to be used permanently, the cartridge detachable to the main body is easy to use by disposable, it can be used safely without cross contamination by blood backflow of the patient. In particular, the cartridge is equipped with a pump mechanism is integrally mounted and used together, so there is no risk of accidents due to the repeated use of the pump mechanism, the safety is high.

The pump mechanism may be any type of pump including a conventionally known electric motor and its electric mechanism, but by using the above-mentioned piezoelectric pump, there is no cost burden, there is no noise, it provides a comfortable use environment, and miniaturization In addition to improving the portability of the product, it is also effective in improving the reliability of the product by increasing the precision of drug injection by utilizing the constant electro-mechanical characteristics of the piezoelectric element. To meet the various needs of the user.

1 is a stereogram showing the overall appearance of a cartridge type drug injector which is a preferred embodiment according to the present invention.
Figure 2 is a three-dimensional figure showing a state in which the cartridge is separated with respect to the main body of the cartridge type drug injector according to the present invention.
Figure 3 is a cross-sectional view showing a coupling state of the cartridge and the main body of the cartridge type drug injector according to the preferred embodiment of the present invention.
Figure 4 is a partial longitudinal sectional view of the main portion showing the arrangement of the pump mechanism integrated into the cartridge of the cartridge type drug injector which is a preferred embodiment according to the present invention.
5 is a block diagram showing a control circuit embedded in the main body of the cartridge type drug injector according to the preferred embodiment of the present invention.
6 is a cross-sectional view of a package of a piezoelectric pump configured as a pump mechanism integrally mounted to a cartridge of a cartridge type drug injector which is a preferred embodiment according to the present invention.
7 is a cross-sectional view of the drug inhalation operation state of the piezoelectric pump package shown in FIG.
7 is a cross-sectional view of the drug discharge operation state of the piezoelectric pump package shown in FIG.

The accompanying drawings illustrate preferred embodiments of a cartridge type drug injector according to the present invention. Examples of these drawings are only to help the understanding of the present invention to the last, there may be a difference from the actual, such as some components are exaggerated or omitted. Hereinafter, the present invention will be described in detail with reference to the drawings.

The cartridge type drug injector according to the present invention shown in FIG. 1 is composed of a body 1 and a cartridge 2, and additionally a necklace string 3 is provided. That is, the main body 1 can be easily carried by hanging the necklace string 3 on the upper ring portion 4 and hanging the necklace string 3 on the neck.

The main body 10 has a transparent window 5 on the front side, is shown on the display of the indicator 6 inside the window 5, a power switch 7 installed at the lower front side, and a mode switch installed on one side. (8) and a bolus switch 9 on the opposite side are provided. Here, the screen of the indicator 6 is provided with a user interface for displaying information necessary for use or diagnosis in real time, such as, for example, an injection state of the drug, an injection amount, a bolus injection amount, and a battery remaining amount. The power switch 7 is used for, for example, a long press operation to turn on or off the main power, and a short press when the main power is turned on to start and end the drug injection operation. The mode switch 8 is swing-operated to select several preset operating modes according to the patient's condition or drug type. And the bolus switch 9 is used to temporarily increase the amount of drug injection by manipulating the patient himself in an emergency. This bolus switch 9 is provided in the form with a clip 10 as a preferable form, and is connected to the coil-shaped electric wire 11 drawn out from the inside of the main body 1. As shown in FIG. In other words, the wire 11 is elongated to be placed on the inner pocket of the patient's upper garment, etc., so that it can be quickly and conveniently operated in an emergency.

The cartridge 2 stores the drug and may be connected to an externally known syringe port, not shown, through a laterally drawn tube connector 12. The body of the cartridge 2 is transparent so that the drug stored therein is visible, and a scale 13 for marking the amount of drug on the front of the body is indicated.

Referring to FIG. 2, the cartridge 2 is detachable to the main body 1, and for this purpose, the support 1 and the socket 15 are formed in the main body 1, and the left and right sides of the body are formed in the cartridge 2. And the stepped portion 16 is formed along the upper side, the plug 17 is installed in the lower body. That is, the cartridge 2 has a plug 17 fitted into the socket 15 of the main body 1 (see FIG. 4), and at the same time, the latter part of the step 16 of the main body supports the main body 1. The main body 1 is coupled to the main body 1 in a state where it is properly accommodated in (13), and as shown in FIG. 3, both support pieces 14a and 14b on the left and right sides of the main body 1 support 14 are disposed in the cartridge 2 body. By elastically pressing the left and right sides of the cartridge (2) is to be restrained from accidentally swinging or falling off.

The sockets 15 of the main body 1 and the plugs 17 of the cartridge 2 are provided with connection terminals 18 and 19 which are in contact with each other and electrically connected at corresponding positions. The connection terminal 18 provided in the socket 15 of the main body 1 uses a commercially available product, and is fixed to the inside of the main body 1, and a part thereof protrudes through the bottom surface of the socket 15. Several elastic contact pieces (not shown) made of metal are exposed on the protruding portion of the connection terminal 18, and each contact piece is protected by a rib structure 20 positioned between the adjacent ones. This is to prevent contact of the human body, such as a finger. The rib structure 20 is integrally protruded from the support 14 surface and the bottom surface of the socket 14 of the main body 1, which is a plastic injection molding.

The plug 17 of the cartridge 2 is integrally fixedly attached to the lower part of the body as a separate injection molding, and the connection terminal 19 installed therein may use a commercial product, but preferably a cartridge 1 which is an injection molding. Part of the plug 17 is formed in a shape corresponding to the connection terminal 18 provided in the main body 1, and a plurality of metal contact pieces (not shown) are directly inserted into the mold. It will be possible.

On the other hand, half rings (21, 22) formed on one side of the support of the main body (1) and the corresponding side of the body of the cartridge (2), respectively, form one ring at the time of engagement, so that the aforementioned bolus switch (9) It is possible to hang (see Figure 3).

Reference numeral 23 in FIG. 2 denotes a withdrawal guide groove of the tube connector 12 described above, and reference numeral 24 denotes a hole for drug injection.

Referring to FIG. 4, a circuit board 25 is embedded in the aforementioned main body 1. The circuit board 25 is a circuit for controlling the operation of the pump mechanism that is integrally mounted to the cartridge 2, and the components of the circuit as shown in FIG. ) And the connection terminal 18 are mounted directly or connected by wiring. The pump mechanism integrally mounted to the cartridge 2 is operated by receiving the control signal of the control circuit through the connection terminals 18 and 19, and the piezoelectric pump package 28 having the configuration as shown in FIG. It became. The piezoelectric pump package 28 is fixedly mounted in the machine room 27 provided in the plug 17, and the machine room 27 is distinguished from the drug storage space 26 in the cartridge 2 body. The piezoelectric pump package 28 has a suction port 28a, a discharge port 28b and an injection port 28c of the drug. The suction port 28a is connected to the drug storage space 26 directly or with the drug bag 29 housed therein. The discharge port 28b is described above through a tube 30 which is a separate pipe. It is connected to the tube connector 12, and the injection port 28c is adjacent to the above-described drug injection hole 24. In FIG. 4, the solid arrow indicates the drug storage space (2) by the piezoelectric pump package 28. 26 shows the flow of the drug from the outside to the outside, and the flow of the drug injected from the outside into the drug storage space 26.

The control circuit mounted on the circuit board 25 embedded in the above-described main body 1 may be configured in various ways depending on the driving source of the pump mechanism integrally mounted to the cartridge 2 described above. 5 corresponds to the piezoelectric pump package 28 described above.

In Fig. 5, reference numeral 31 denotes a battery for power supply. The battery 31 may use any type of primary or secondary battery, but a coin-like flattened mercury cell is preferable for miniaturization. The control unit 32 is programmed to instruct the operation and stop of the piezoelectric pump package 28 described above according to the conditions input through the input unit 34 using the processing mechanism of the microcomputer and output the display information in real time. Since the program routines can be written and loaded in the usual technical level, the detailed description thereof is omitted for convenience. The power supply unit 33 is for supplying and managing power required for each circuit unit such as the control unit 32 from the battery 31 power source, and may use a well-known power management IC (PMIC). The input unit 34 inputs the signals of the above-described power switch 7, the mode switch 8, and the bolus switch 9 to the controller 32. The display unit 35 displays the real-time display information output therefrom according to the command of the control unit 32 on the display unit 6 described above. The booster 36 is for boosting the voltage of the battery 31 to the voltage required for operating the piezoelectric pump package 28 described above. For example, the booster 36 may use a well-known booster and a flyback converter. . The driver 37 controls the operation of the piezoelectric pump package 28 described above by controlling the voltage applied through the booster 36 according to the command of the controller 32, for example, a pulse signal. For example, a well-known oscillator and a bridge circuit are used. Each part of such a control circuit is already well known in the field of driving a piezoelectric element and can be easily implemented, and thus the detailed description thereof is omitted for convenience.

In the above-described piezoelectric pump package 28, the driving substrate 39, the piezoelectric operation support plate 40, the piezoelectric element 42 and the piezoelectric operation plate made of metal in one housing 38 as shown in FIG. The piezoelectric actuator 41 to which the 43 is bonded, the chamber forming plate 44, and the pipe forming plate 45 are sequentially stacked to form a so-called piezoelectric pump, and the piezoelectric pump 41 is connected to the housing 38 of the piezoelectric pump. As a part, a check valve for directly forming the above-mentioned suction, discharge, and injection ports 28a, 28b, and 28c, and control the flow of drugs in one direction inside the discharge and injection ports 28b and 28c, respectively ( 46,47) are integrally constructed. In this case, the driving substrate 39 is connected to the above-described connection terminal 19 by electrical wiring and is applied as an electric field signal to both surfaces of the piezoelectric element 42 of the piezoelectric actuator 41. The piezoelectric operation support plate 40 fixes and supports both ends of the piezoelectric operation plate 43 of the piezoelectric actuator 41. The chamber forming plate 44 forms a chamber 48 and a suction port 49 and a discharge port 50 for the chamber 48 between the piezoelectric operating plate 43. The suction port 49 and the discharge port 50 of the piezoelectric pump communicate with the suction port 28a and the discharge port 28b described above, respectively, and the opening 48 and the discharge port 50 toward the chamber 48 of the suction port 49. The opening on the opposite side of the chamber 48 opens the drug flow in only one direction, from the inlet 49 to the chamber 48 and from the chamber 48 toward the outlet 50, in the reverse direction. Closed check valves 51 and 52 are provided, respectively. On the other hand, the check valve 47 provided in the discharge port 28b is supported by the support 53 as a pressure structure, and the support 53 is screwed to the housing 38. Support 53 can be tightened or loosened using a driver tool (not shown), thereby adjusting the operating pressure of check valve 47. The reason for this configuration is that in the state where the electric field signal of the piezoelectric actuator 41 is cut off, that is, in the non-operation state, the check valves 51 and 52 provided in the inlet port 49 and the outlet port 50 are used. This is because the pressure of the drug in the storage space 26 may cause a so-called injection error in which the drug flows on its own. That is, the injection error can be prevented by adjusting the operating pressure so that the pressure check valve 47 operates only above the normal discharge pressure by the piezoelectric pump.

The piezoelectric pump configured as described above may continuously eject the drug by repeating the suction operation (Fig. 7) and the discharge operation (Fig. 8) of the drug at every moment when the electric field signal cycle is changed or its phase is reversed. Depending on the input cycle or phase reversal cycle of the drug to be adjusted to a certain amount will be injected into the human body.

Specifically, when the non-inverting electric field signal is applied after the non-operating state of FIG. 6 or the ejection action of FIG. 8, the length of the piezoelectric element 42 of the piezoelectric actuator 41 is extended, and the piezoelectric operating plate 43 is shown in FIG. 7. It is deformed into a convex shape as shown below, and the chamber 48 expands to lower its internal pressure. At this time, the suction force to the chamber 48 on both sides of the suction port 49 and the discharge port 50 acts, but the suction port 49 is opened and the discharge port 50 is closed by the action of the check valves 51 and 52. Therefore, the drug stored in the drug storage space 26 of the cartridge 2 described above is sucked into the chamber 48 via the suction port 28a and the suction port 49, thereby filling the chamber 48 with the drug. .

When the electric field signal applied to the piezoelectric element 42 is blocked or the phase is inverted in the state filled with the drug in the chamber 48, the piezoelectric element 33 and the piezoelectric operation plate of the piezoelectric actuator 41 as shown in FIG. 35) is restored to its original state and the chamber 48 is retracted to increase its internal pressure. At this time, the discharge pressure acts on both sides of the suction port 49 and the discharge port 50, but the suction port 49 is closed by the action of the check valves 51 and 52, and the discharge port 50 is opened. As a result, the drug filled in the chamber 48 is discharged to the discharge port 52, and then injected into the outside, that is, the human body via the aforementioned tube 30 while opening the pressure check valve 47.

After the discharge operation as shown in FIG. 8, when the pressure of the chamber 48 decreases to equilibrate with the outside, the non-operating state, that is, as shown in FIG. 6, is closed.

Meanwhile, the empty drug storage space 26 or the drug bag 29 accommodated therein in the body of the cartridge 2 described above may be filled or supplemented by a drug injected through the injection port 28c. Since the pressure of the drug storage space 26 is lower than the pressure of the chamber 48, there is no fear that the drug injected for filling or replenishment leaks out through the chamber 48.

1: main body, 2: cartridge, 3: necklace cord, 4: hook portion, 5; Window, 6: indicator, 7: power switch, 8: mode switch, 9: bolus switch, 10: wires, 11: clip, 12: tube connector, 13; Graduation, 14; Support, 15: socket, 16: step, 17: plug, 18; 19: connection terminal, 20: rib structure, 21; 22: half ring, 23: tube connector lead-out hole, 24: drug injection hole, 25 : Circuit board, 26: drug storage space, 27: machine room, 28: piezo pump package, 28a: suction port, 28b: discharge port, 28c: injection port, 29: drug bag, 30: tube, 31: battery 32: control part, 33: power supply part, 34: input part, 35: display part, 36: boosting part, 37: driving part, 38: housing, 39: driving substrate, 40: piezoelectric actuating support plate, 41: piezoelectric actuator, 42: piezoelectric Element: 43: piezoelectric actuating plate, 44: chamber forming plate, 45: tube forming plate, 46; 47; 51; 52: check valve, 48: chamber, 49: inlet, 50: outlet, 53: support

Claims (6)

A cartridge having a drug storage space and a main body which is detachable and can be carried together in a combined state, the cartridge having a pump mechanism that operates by an electrical signal to eject a drug stored in the drug storage space to an external syringe hole; Is integrally mounted, and the main body has a built-in control circuit for controlling the operation of the pump mechanism, and the cartridge and the main body come into contact with each other when they are coupled to electrically connect the pump mechanism and the control circuit. A terminal is provided, and as the pump mechanism, there is a suction port connected to the drug storage space, a discharge port for connecting the external syringe port, and a piezoelectric actuator pumps drugs from the suction port to the discharge port. A piezoelectric pump package is provided, and for the discharge of the piezoelectric pump package It is installed in the tree that only works to open more than a normal discharge pressure of the piezoelectric pump, cartridge type infusion pumps, characterized by a configuration provided with a check valve of the pressure type structure which can control the operating pressure. The cartridge type drug injector of claim 1, wherein the contact terminal provided in the main body is protected by a structure that prevents contact with a human body. delete delete delete The method according to claim 1, wherein the piezoelectric pump package is provided with an injection port in communication with the suction port, the cartridge system characterized in that the configuration for filling or replenishing the drug to the drug storage space through the injection port Drug injector.

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