KR20160054868A - Air actuated pump divice for delivering drug and cartridge-way or wristwatch type infusion pump having same - Google Patents

Abstract

The present invention relates to an air actuated pump device for delivering a drug, comprising: a chamber capable of containing a certain amount of the drug; a housing which includes an air hole for introducing air in and out of the chamber, and a suction port and a discharge port for introducing the drug in and out of the chamber; an elastic body, which is installed inside a chamber of the housing, stays attached to a part of the wall around the air hole, and gets attached to the rest of the wall when expanded by air pressure and returns to the previous position when air pressure is removed; a check valve, installed in the suction port and the discharge port to enable the drug to flow in one direction, wherein the air actuated pump device is configured to deliver the drug according to the air being introduced in or out through the air hole, and has a stable structure that is capable of delivering the drug at a constant rate and is easy to miniaturize.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a pneumatic operation pump device for drug delivery, and a cartridge type or wristwatch type drug injector having the same.

The present invention relates to a drug delivery pump device and a cartridge-type or wristwatch-type drug injection device having the drug delivery device, and more particularly, to a pump device with a stable structure that is advantageous in miniaturization and can accurately deliver a predetermined amount of drug.

Drug delivery pump devices are used for various purposes in the medical field, for example, in injectors that automatically inject drugs into the body. Drug injectors, especially portable, are very useful for reducing the number of visits to patients who need to administer small doses of medication continuously, and to be able to conduct economic activities through daily life.

A diaphragm pump disclosed in Patent Document 1 is well known as a drug delivery pump device used in a drug injector. However, since the diaphragm is structurally sensitive to an external force and freely vibrates, it is difficult to precisely control the amount of drug delivery, It is not suitable for use.

The pump apparatuses used in the portable drug injector are known as syringe pumps disclosed in Patent Documents 2 and 3, tube compression pumps disclosed in Patent Documents 4 to 8, cylinder pumps disclosed in Patent Document 9, and the like.

The syringe pump is equipped with a syringe filled with a drug, and is used as a motor that converts the motor and rotational power of the motor into linear motion, thereby gradually pushing the plunger of the syringe. The syringe can be supplemented or replaced.

The tube compression pump is a method of squeezing a tube which is a part of the liquid set and is divided into a finger pressure type disclosed in Patent Documents 4 to 6 and a rolling type disclosed in Patent Documents 7 and 8 . The acupressure device has a plurality of cam followers, cams and motors arranged in order to press a straight tube support groove into which the tube connected to the drug bag is inserted and a tube inserted in the tube support groove. When the motor is driven, the cam is rotated, and the cam holes successively interlock with each other at every rotation cycle of the cam to gradually press the tube. The rolling type includes an arcuate support groove in which a tube connected to the drug bag is inserted, a roller arranged at intervals so as to pivot while pressing a tube fitted in the arcuate support groove, a motor for driving the roller, and a complicated gear train. When the motor is driven, the rollers sequentially pressurize the tubes at intervals.

In the cylinder pump disclosed in Patent Document 9, instead of the tube of the rolling-type tube compression pump described above, an annular cylinder for directly pumping a drug is formed. The cylinder directly pumping the drug is provided as a separate operating unit that can be detached from the body in one use. The main body is equipped with a motor and a drive unit having two drive shafts coupled to the coaxial shaft for transmitting the power of the motor. The operating unit has two rotating bodies facing each other on the same axis, and the toroidal cylinder is formed between the two rotating bodies and the casing inner wall. In the annular cylinder, two plungers, which are respectively attached to two rotors, are accommodated. The inlet of the cylinder is connected to the drug pocket and its outlet is connected to the injection mechanism for the human body. When the motor is driven, the first 300 ° section of one rotation cycle is rotated only one side of the coaxial drive shaft, while the other side is not rotated, and both sides of the next 30 ° section are rotated at the same time. Again, the next 300 ° section is reversed, one side is stopped and only the other side is rotated, and the next 30 ° section is rotated simultaneously on both sides. A central angle between the inlet and the outlet is set to 30 °, and the length of each plunger is 15 °. That is, the two plungers meet each other in the 30 ° section, and one of the inlet and the outlet is clogged at the front end and the rear end of the section. Therefore, when the plunger located at the electric potential moves through the 300 [deg.] Range, the clogged inlet is opened, and the drug is introduced into the cylinder and the drug in front of the plunger flows out to the already opened outlet. Injection is possible.

KR 10-0210224 B1 (1999-04-23) KR 10-0478771 B1 (2005-03-16) KR 10-0802068 B1 (2008-01-31) KR 10-0556186 B1 (2006-02-22) KR 10-0561243 B1 (2006-03-22) KR 10-0580586 B1 (2006-05-09) KR 10-1999-0070632 A (1999-09-15) KR 10-0261584 B1 (2000-04-19) KR 10-0948632 B1 (2010-03-12)

The syringe pump described above can finely adjust the amount of drug and has a high precision, but the syringe needs to be replaced frequently because the amount of continuous injection can not be changed at a time. Therefore, the user needs to come to the hospital frequently to change the syringe.

Since the material, diameter, and thickness of the tube used and the rolling tube compression pump described above are different for each manufacturer, an error may occur in controlling the injection amount of the drug under the same driving conditions of the motor, It can be damaged by pressurization or rolling. In this case, risks such as drug contamination and stoppage of injection are inherent.

The above-mentioned cylinder pump is more stable than the above-mentioned tube use, but an operation unit for disposable use is expensive because of the parts requiring precision machining.

In addition, the above-mentioned conventional pumps have been required to be improved as a portable type, such as a structure having a complex structure and a large number of friction elements between the parts, and a large power consumption.

Accordingly, it is an object of the present invention to provide a drug delivery pump device which is advantageous for miniaturization and suitable for a portable drug injector, structurally stable for accurately delivering a drug to a certain amount without errors or errors, And to provide a cartridge-type or wristwatch-type drug injector which has improved handling convenience.

According to an aspect of the present invention, there is provided a drug delivery air pump apparatus for drug delivery comprising a chamber capable of holding a predetermined amount of drug, an air hole for blowing air into and discharging air from the chamber, An elastic body which is mounted in the chamber of the housing and which is in close contact with a part of the wall surface around the air hole and inflated by the air pressure to come in close contact with the other wall surface and to be restored when the air pressure is removed, And a check valve for allowing the drug to flow in one direction, so that the drug is delivered upon injecting or withdrawing air through the air hole.

The cartridge-type medicament injector according to the present invention for achieving the above object comprises a cartridge having a drug storage space and a main body which can be detachably coupled with the cartridge and can be carried together with the cartridge, An air operation pump for delivering the medicament to the external syringe port is mounted and the main body is equipped with an air injector which operates to inject or withdraw air from the air operation pump body and a control circuit for controlling the air injector, The pump body has a chamber in which a predetermined amount of the drug can be confined, a housing having an air hole for blowing air into and out of the chamber, an inlet and an outlet for allowing the drug to enter and exit, and a wall mounted on the chamber of the housing, And is expanded to the air pressure, And a check valve installed on the suction port and the discharge port and allowing the drug to flow in one direction, wherein the pump driver mounted on the main body has a structure in which the main body of the pump main body Wherein the air injector injects air into the air holes, and the pump main body and the air injector are connected or detached according to the detachment of the cartridge and the main body.

In addition, the wristwatch-type drug injector according to the present invention for achieving the above object comprises a cartridge having a drug storage space and a wristwatch-type body that can be worn on the wrist together in a detachable state of the cartridge, The cartridge is provided with an injection needle capable of piercing the human body under the wrist and a pneumatic operation pump device for transferring the medicine stored in the drug storage space to the injection needle. The air operated pump device is equipped with an air injector that operates to inject and withdraw air and its control circuit. The air operated pump device has a chamber capable of holding a predetermined amount of drug, and has an air hole for blowing air into and out of the chamber, A housing having a suction port and a discharge port, A flexible elastic body which is in close contact with a part of a wall surface around the hole and expands by air pressure to be brought into close contact with the other wall surface and restored when the air pressure is removed and a check valve installed in the suction port and the discharge port to flow the drug in one direction And the cartridge is connected to or detached from the air injector when the main body is detached.

In the pneumatic operation pump apparatus according to the present invention, when the elastic body expands, the drug in the chamber is discharged to the outside, and when the elastic body is restored, the chamber is filled with the drug again. As the elastic body expands and restores so as to closely contact the inner wall surface of the chamber, the drug in the chamber is completely discharged and filled with the same amount. In other words, the air pressure can be sufficiently injected to deliver a constant amount of drug at all times.

In the cartridge type or wristwatch type drug infusion device according to the present invention, the main body is used for permanent use, and the cartridge detachable to the main body is easy to use by disposing, and can be safely used without cross contamination due to the patient's blood backflow. Particularly, since the air operation pump device is integrally mounted on the cartridge and used together, the safety of the pump is high because there is no fear of failure due to repeated use of the pump device. Particularly, the wristwatch type can be easily worn because the subcutaneous needle is integrally coupled to the cartridge, and it is not exposed to the outside, thereby contributing to the protection of the individual patient.

1A and 1B are cross-sectional views showing an inoperative state and an operating state of the drug delivery air pump apparatus according to the present invention.
2 is a perspective view showing the overall appearance of a cartridge type drug injector according to a preferred embodiment of the present invention.
FIG. 3 is a perspective view showing a state in which a cartridge is detached from a main body of a cartridge type drug injector according to a preferred embodiment of the present invention.
FIG. 4 is a cross-sectional view showing a state in which a main assembly of a cartridge type drug injector and a cartridge are coupled according to a preferred embodiment of the present invention.
FIG. 5 is a vertical sectional view of a main part showing an arrangement of an air pump apparatus mounted on a cartridge of a cartridge type drug injector according to a preferred embodiment of the present invention. FIG.
6 is a detailed cross-sectional view of the air operated palp apparatus shown in FIG.
7 is a block diagram showing a control circuit incorporated in the main body of the cartridge type drug injector, which is a preferred embodiment according to the present invention.
8A and 8B are perspective views showing the external appearance of a wristwatch type drug injector according to a preferred embodiment of the present invention.
FIG. 9 is a perspective view showing a wear state of a wristwatch-type drug injector according to a preferred embodiment of the present invention.
FIGS. 10A and 10B are side views of main parts showing the use of a needle of a wristwatch type drug injector according to the present invention. FIG.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings illustrate preferred embodiments of a pneumatic actuation pump apparatus for drug delivery according to the present invention, a cartridge system having the same, and a wristwatch medicament injector. The examples of these drawings are for the purpose of helping understanding of the present invention only, and some elements may be exaggerated or omitted. Hereinafter, the present invention will be described in detail with reference to the drawings.

1, the drug delivery air pump apparatus 40 according to the present invention comprises a housing 41, an elastic body 43, a support body 44 and two check valves 48 and 49, And is connected to the air injector 50. The housing 41 forms a chamber 42 of a predetermined size and has an air hole 45, an air inlet 46, and an air outlet 47. The air hole 45 is connected to a separate air injector 50. The air injector 50 is a conventional one operated by electricity and generates air during its operation to blow air into the chamber 42 through the air hole 45 and to open the chamber 42 when not in operation, To be exhausted. As the elastic body 43, for example, a stretchable material such as a silicone rubber plate or a urethane rubber can be used. The elastic member 43 has an edge fixed to the housing 41 and is in close contact with the wall surface 42a around the air hole 45 in the chamber 42 (Fig. 1A) (Fig. 1B) and is restored when air pressure is removed. The support body 44 is for providing the one wall face 42a to which the elastic body 43 closely contacts in a spherical or parabolic shape in a preferable form and can be integrated with the housing 41. [ The check valves 48 and 49 provided in the suction port 46 and the discharge port 47 are for allowing the drug to flow in one direction with respect to the chamber 42.

1A is an inoperative state of the drug delivery air pump apparatus 40, that is, an initial state in which no air is injected. In this state, the elastic body 43 is in close contact with the wall surface 42a of the chamber 42 having the air hole 45, and the chamber 42 is kept charged with the drug introduced through the suction port 46 . In this state, when air is injected through the air hole 45, the air is inflated according to the air pressure to be injected, and is brought into close contact with the other wall surface 42b in the chamber 42 as shown in FIG. 1B, ) Is pushed out to the discharge port (48) entirely without remaining. When the air is exhausted in the state of FIG. 1B, the expanded elastic body 43 is again restored to the state of FIG. 1A, and the restoring force of the chamber 42 is filled with the drug again. In this way, the process of restoring the elastic body 43 after the expansion is repeated according to the air injection, thereby transferring the drug. Particularly, the elastic body 43 is expanded or restored by closely contacting the wall surfaces 42a and 42b, It can always be delivered in the same amount.

1, the inlet port 46 and the outlet port 47 may be provided as one port. In this case, a T-type branch pipe may be used for installing the two check valves 48 and 49. [

The cartridge type drug injector according to the present invention comprises a main body 1 and a cartridge 2 as shown in Fig. 2, and additionally, a necklace string 3 is provided. That is, the main body 1 can easily carry the necklace string 3 by hanging the necklace string 3 on the neck and hanging the necklace string 3 on the neck.

The main body 10 is provided with a transparent window 5 on its front surface and includes a power switch 7 disposed on the bottom of the front of the window 5 and a mode switch (8) and a bolus switch (9) which is hooked on the opposite side surface. Here, a screen of the display device 6 is provided with a user interface in which information necessary for use or diagnosis, such as a drug injection state, an injection amount, a bolus injection amount, a battery remaining amount, etc., is displayed in real time. The power switch 7 is used, for example, to turn on and off the main power source by pressing and holding it for a long time, and to start and stop the drug infusion operation by pressing the main power switch short. The mode switch 8 is a swing operation type for selecting a predetermined operation mode according to the patient state or the drug type. And a bolus switch 9 is used to temporarily increase the amount of drug injected by the patient himself when urgent. This bolus switch 9 is provided in the form of a clip 10 as a preferred form and is connected to a coil-shaped electric wire 11 drawn out from the inside of the main body 1. That is, the electric wire 11 is elongated to be hung on an inner collar of the patient's upper face, and can be quickly and conveniently operated in emergency.

The cartridge 2 stores the medicament and can be connected to a known external scanning mechanism not shown through a tube connector 12 pulled laterally. The body of the cartridge (2) is transparent so that the medicines stored therein can be seen, and a scale (13) is provided on the body so that the amount of the drug can be measured.

3, the cartridge 2 is detachably mountable to the main body 1. For this purpose, the main body 1 is provided with a support portion 14 and a socket 15, and the cartridge 2 is provided with left and right And a stepped portion 16 is formed along the upper surface, and a plug 17 is provided at a lower portion of the body. 5), and at the same time, the rear half portion of the step portion 16 of the body of the cartridge 2 is inserted into the socket 15 of the main body 1, The left and right support pieces 14a and 14b of the support part 14 of the main body 1 are engaged with the main body 1 of the cartridge 2 as shown in Fig. So that the cartridge 2 is prevented from unintentionally rocking or falling off. The socket 15 of the main body 1 and the plug 17 of the cartridge 2 are formed with connection holes 18 and 19 for connecting the air operation pump device and the air injector to be described later at corresponding positions. The plug 17 of the cartridge 2 is separately molded and integrally fixed to the lower part of the body.

On the other hand, the half-rings 21 and 22 formed on one side of the support of the body 1 and the corresponding side of the body of the cartridge 2 form one ring when engaged, (See FIG. 3).

Reference numeral 23 in FIG. 3 denotes a lead-out guide groove of the above-described tube connector 12, and reference numeral 24 denotes a drug injection hole.

Referring to Fig. 5, the circuit board 25 is incorporated in the main body 1 described above. The circuit board 25 is provided with the air injector 50 necessary for the air pump apparatus 40 integrally mounted on the cartridge 2 and the components of the control circuit thereof such as the circuit shown in Fig. 8, 10 and the connection terminal 18, or is connected by wiring.

The control circuit mounted on the circuit board 25 incorporated in the main body 1 described above can be variously configured according to the driving source of the pump mechanism integrally mounted on the cartridge 2 described above, Fig.

In Fig. 6, reference numeral 31 denotes a power supply battery. The battery 31 may be any type of primary battery or secondary battery, but a flat, coin-shaped battery such as a mercury battery is preferable for miniaturization. The control unit 32 is programmed to instruct the operation and stop of the piezoelectric pump package 28 described above according to the conditions input through the input unit 34 using the processing mechanism of the microcomputer and output the display information in real time. Program routines can be created and loaded at the normal skill level, so a detailed description thereof will be omitted for convenience. The power supply unit 33 is used to supply and manage the power required for the circuit parts such as the control unit 32 from the power supply of the battery 31. For example, a well-known PMIC (power management IC) can be used. The input unit 34 inputs the signals of the power switch 7, the mode switch 8 and the bolus switch 9 to the control unit 32. The display unit 35 displays the real-time display information outputted therefrom in accordance with the instruction of the control unit 32 on the display unit 6 described above. The boosting portion 36 is for boosting the voltage of the battery 31 to the voltage required for the operation of the above-described piezoelectric pump package 28, and can use, for example, a well-known booster and a flyback converter . The driving unit 37 interrupts the voltage applied through the voltage step-up unit 36 according to the command of the control unit 32 to drive the air injector 50 described above. Each of these parts of the control circuit is well known in the field of driving the piezoelectric element, and can be easily implemented, so that further detailed description will be omitted for the sake of convenience.

1, the suction port 46 is connected to the drug storage space 26 of the cartridge 2 or the drug pocket 29 accommodated in the cartridge 2, And the discharge port 47 is connected to the human-side tube connector 12. Preferably, the suction port 46 is connected through a separate infusion check valve 51 to allow the medicine to be replenished through the above-described drug infusion hole 24. [

8A and 8B, the wrist-watch-type drug injector according to the present invention comprises a wrist-watch-like body 60 and a cartridge 70 detachably coupled to the body 60. The main body 60 is provided with the indicator 61 and the above described air injector and its control circuit are mounted in the main body 60. The cartridge 70 is provided with the air operation pump device 71 as described above, Respectively. 9 and 10, the cartridge 70 can also be attached together with a subcutaneous injection needle 72 which can be pierced directly onto the skin of the user's body in a wearing state and a needle actuator 73 for projecting and unloading the needle have. Reference numerals 62, 63, and 64 of the main body 60 are respectively a power button, a needle operation button, and a function setting button.

1: main body, 2: cartridge, 3: neck line, 4: collar, 5; Window, 6: indicator, 7: power switch, 8: mode switch, 9: bolus switch, 10: wire, 11: clip, 12: tube connector, 13; Scale, 14; And a tube insertion hole for injecting the drug into the tube insertion hole, wherein the tube insertion hole is formed in the tube insertion hole. A circuit board 26 a drug storage space 27 a mechanical chamber 28 a piezoelectric pump package 28a a suction port 28b a discharge port 28c an injection port 29 a drug bag 30 a tube 31 battery The present invention relates to a piezoelectric actuator and a method of manufacturing the same and a piezoelectric actuator using the piezoelectric actuator according to the present invention. A piezoelectric actuator plate 44 is formed on the chamber forming plate 45 and a tube forming plate 46 is fixed to the chamber 50. The check valve 48 is connected to the chamber 49 through the suction port 50,

Claims (3)

A housing having a chamber in which a predetermined amount of the drug can be confined and having an air hole for blowing and removing air into and out of the chamber, an inlet and an outlet for allowing the drug to enter and exit, and a housing mounted in the chamber of the housing, An elastic body having elasticity which is expanded by the air pressure and is brought into close contact with the other wall surface and is restored when the air pressure is removed, and a check valve installed at the suction port and the discharge port to flow the drug in one direction, Is configured to deliver the drug upon injection or withdrawal of the drug.
The cartridge is provided with a cartridge having a drug storage space and a main body that can be detachably coupled with the cartridge in a combined state, and the cartridge is equipped with an air operation pump for delivering the drug stored in the drug storage space to an external syringe port And the main body is equipped with an air injector that operates to inject air into or out of the air actuating pump body and a control circuit for controlling the air injector. The air actuating pump body has a chamber capable of holding a certain amount of drug, And a housing having a suction port and a discharge port for inserting and withdrawing the medicine, and a housing mounted in the chamber of the housing and being in close contact with a part of the wall surface around the air hole, An elastic body having elasticity to be restored when the air pressure is removed, And a check valve installed at the suction port and the discharge port to flow the drug in one direction, wherein the pump driver mounted on the main body is an air injector for injecting air into the air holes of the pump main body, Is connected or detached according to the detachment of the cartridge and the main body.
A cartridge having a drug storage space, and a wristwatch-type body that can be worn on the wrist together with the cartridge detachably coupled to the wrist, wherein the cartridge is provided with an injection needle And an air operation pump device for transferring the drug stored in the drug storage space to the injection needle. The main body is equipped with an air injector and its control circuit which operate to inject and withdraw air from the air operation pump device The air operated pump device having a chamber capable of holding a predetermined amount of medicament and having an air hole for blowing and removing air into and out of the chamber, a suction port for discharging the medicine and a discharge port, and a housing mounted in the chamber of the housing The air bubbles are brought into close contact with a part of the wall surface around the air hole, An elastic body having elasticity to be brought into close contact with the wall surface and to be restored when the air pressure is removed; and a check valve installed at the suction port and the discharge port to flow the drug in one direction, wherein when the cartridge is detached from the main body, Or separate from each other.

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