WO2022186548A1

WO2022186548A1 - Driving control mechanism and drug injection apparatus using same

Info

Publication number: WO2022186548A1
Application number: PCT/KR2022/002737
Authority: WO
Inventors: 박철
Original assignee: 주식회사 바리센
Priority date: 2021-03-02
Filing date: 2022-02-24
Publication date: 2022-09-09
Also published as: KR102336073B1

Abstract

A driving control mechanism of the present invention comprises: a base unit having a base plate and a plurality of protruding parts, wherein whether the protruding parts protrude is controlled according to a control signal; a rotation unit having a disc-shaped rotating plate and a plurality of catching protrusions that are arranged at predetermined intervals along the circumferential direction of the rotating plate and prevent rotation of the rotating plate by contacting the protruding parts when the protruding parts protrude, wherein the rotation unit is rotatably coupled to the base unit; a power unit positioned between the base unit and the rotation unit so as to provide a driving force to rotate the rotation unit; and a control unit for controlling the protruding parts or the protruding parts and the power unit.

Description

Drive control mechanism and drug injection device using the same

The present invention relates to a drive control mechanism and a drug injection device using the same, and more particularly, to a drive control mechanism controlled so that the operation can be reliably repeated, and a drug that can be periodically injected using the drive control mechanism It is about the injection device.

In general, one of the methods of injecting drugs into the human body in the medical field is injection. These injections include intramuscular injection, intravenous injection, and subcutaneous injection, all of which inject a drug solution by inserting a needle into the body. If the drug is to be supplied periodically, the skin must be pierced with a needle each time, and the patient continues to feel discomfort and pain.

In particular, in the case of a diabetic patient who needs to supply insulin periodically, an insulin pump is used to solve the above inconvenience.

A general insulin pump is usually worn on a belt or clothes, and when a needle is inserted into the lower abdomen or thigh and then the pump is operated, a certain amount of insulin is continuously injected automatically over several days.

However, in such an insulin pump, the needle inserted into the skin and the pump located on the belt/clothes are connected by a soft pipe, so insulin pump users must put the pump in a waterproof pack when bathing or swimming to prevent water from permeating, There are many inconveniences, such as having to attach a waterproof tape to the injection site.

Recent insulin pumps are sold in the form of wearables that can be attached to the forearm or the like as the pump and the needle are integrated and miniaturized.

When expressing the amount of insulin, it is expressed as “unit”, and 1 unit is 1/24 mg of pure insulin, that is, 24 units are equivalent to 1 mg of insulin.

This unit of insulin is also used to indicate the concentration of insulin in the injection solution. 80 units of insulin injection means that 1 milliliter (1 cc) of the injection contains 80 units of insulin. For example, if you are prescribed 40 units of insulin per day, you need to inject 0.5 cc, which is 1/2 of 1 cc of 80 units of insulin injection, and if you are 20 units, you need to inject 0.25 cc. However, if you purchase 40 units of insulin instead of 80 units, you need to inject 1 cc for 40 units and 0.5 cc for 20 units. Usually, patients are prescribed to inject several to tens of units of insulin per day.

100 units of insulin injection, which has recently started to be distributed, is relatively easy to calculate the dose as 1 milliliter is made up of 100 units, but it is necessary to control the injection amount very accurately.

Therefore, the drive system used in the insulin pump must be able to control the amount of injected insulin very precisely.

Examples of such a wearable insulin pump include the Omnipod system of Insulet corp. of the United States, and the eopatch of Eoflow of Korea.

The omnipod system allows a certain amount of insulin to be injected into the drive system through a shape memory alloy as disclosed in US Patent No. 6,656,158, and the IOPatch uses a drive system by an electroosmotic pump as disclosed in Korean Patent Registration No. 10-1910932. are using

However, the conventional product has a complicated structure for such precise control, so there are many factors that can cause failure. Also, the injection amount controlled by one operation signal is too small, so the energy required for driving is excessively consumed, resulting in a large capacity. And there is a problem that requires a battery having a size or is unsuitable for long-term use.

In addition, in the prior art, since the driving force is directly related to the injection amount, there is a possibility that a problem such as excessive injection due to a malfunction of the driving source may occur, and countermeasures to prevent this may occur.

The present invention provides a driving control mechanism that can be reliably driven and repeated, and as a drug injection device (for example, an insulin pump) using such a drive control mechanism, consumes less electricity and adopts a small battery. The purpose is to enable long-term use and to precisely control the amount of drug injection without using an expensive motor.

The drive control mechanism of the present invention,

a base part having a base plate and a plurality of protrusions whose protrusions are controlled according to the control signal;

A disc-shaped rotating plate, and a plurality of engaging projections arranged at regular intervals along the circumferential direction of the rotating plate to prevent rotation of the rotating plate in contact with the protruding portion when the protruding portion is protruded, and rotatably to the base portion a rotating unit coupled thereto;

a power unit positioned between the base unit and the rotating unit to provide a driving force to rotate the rotating unit;

a control unit for controlling the protrusion or the protrusion and the power unit; characterized by being made.

Preferably, the power unit generates a driving force by an elastic force of the elastic member or generates a driving force by a motor operated by electricity.

When the rotating plate is stationary, at least one of the protrusions is in contact with the locking jaw, and the rest is maintained in a state spaced apart from the locking jaw,

It is preferable that the rotating plate rotates when the protrusion in contact with the locking jaw moves so that the contact is released, but the protrusion, which was spaced apart from the locking jaw, comes into contact with the locking jaw to stop the rotation.

If the width of the locking jaw is t, the distance between the locking jaws is x, the radius of the projections is r, the number of projections is n, and the distance between the projections is y,

y > t,

The distance z = r + k(x+t)/n (where k is 0, ..., n-1, n is a natural number) from the stopping jaw to the center of the projection. it is preferable

The protrusion includes a protruding end, a spring elastically supporting the protruding end toward the rotating plate to a position where the protruding end can be caught by the locking jaw of the rotating plate, a guide portion guiding the protruding end and the spring, and the protruding end of the rotating plate. It is preferable to have a driving unit that moves to a position where it is not caught on the clasp.

It is also preferable that the protrusion is made by a protruding end and a shape memory alloy operation unit or a piezo linear motor for moving the protruding end.

It is preferable that the protruding end portion and the driving portion are formed in the form of permanent magnets and electromagnets.

It is also preferable that the locking protrusion is formed by a member between the slits arranged at regular intervals along the circumferential direction on the rotating plate.

It is also preferable that a gear is provided between the power unit and the rotating unit.

The drug injection device of the present invention,

In the drug injection device driven by the drive control mechanism, and having an injection unit for injecting a chemical solution according to the rotation of the rotating unit,

The injection part includes a piston part that is moved by the amount of rotation of the rotating part determined by the contact between the protrusion and the protrusion according to the operation control of the protrusion of the controller, and a cylinder part coupled to the piston part and fixed to the base plate and storing the chemical therein; , including a needle part in which the chemical liquid inside the cylinder part is discharged according to the movement of the piston part; characterized in that

It is preferable that the piston part and the cylinder part consist of a spiral structure.

It is preferable that the piston part consists of a piston for pushing the chemical solution inside the cylinder part, and a wire-type push bar connecting the piston and the rotating plate.

It is preferable that the rotating unit and the injection unit are formed as an integral module, and can be disassembled from the power unit and the fixed unit or coupled to the power unit and the fixed unit.

It is preferable that the rotating unit, the injection unit, and the power unit are formed as an integral module, and can be disassembled from the fixed unit or coupled to the fixed unit.

Preferably, the control unit receives a control signal from an external device to control the drug injection device.

The external device is preferably a blood glucose meter.

The present invention provides a drive control mechanism that can be reliably and repeatedly driven, and as a drug injection device (eg, an insulin pump) using such a drive control mechanism, consumes less electricity, and adopts a small battery for a long time. The purpose is to make it possible to use and precisely control the amount of drug injection without using an expensive motor.

The present invention is a drug injection device that can be used as an insulin pump. It consumes less electricity and consumes less power, so it can be used for a long time even with a small battery, and can precisely control the amount of drug injection without using an expensive motor. there is an effect

1 is a perspective view of a drug injection device according to an embodiment of the present invention.

Figure 2 is a plan view showing the form of the base portion of the present invention.

3 is a view showing the structure of the present invention protrusion.

Figure 4 is a perspective view showing the structure under the rotating part of the drug injection device according to an embodiment of the present invention.

5 is a side view of the drug injection device according to an embodiment of the present invention.

6 and 7 are diagrams for explaining the operation relationship of an embodiment of the present invention.

8 is a view for explaining the size and positional relationship of the locking jaw and the protrusion of the present invention.

9 and 10 are views showing the shape of the locking jaw and the protrusion according to another embodiment of the present invention.

11 is a view showing the shape of the rotating plate and the protrusion of another embodiment of the present invention.

12 is a view showing the shape of the injection unit according to another embodiment of the present invention.

13 is a view showing a form including the case of the drug injection device of the present invention.

** Description of reference numbers **

100: base 110: base plate 120: control unit 125: power supply

130: protrusion 131: protruding end 132: spring 133: guide 134: driving unit

200: rotating part 210: rotating plate 230: locking jaw 260: switch 300: power unit

400: injection part 410: piston part 420: cylinder part 430: needle part

500,600 : Case

Hereinafter, the present invention will be described in more detail with reference to the drawings according to embodiments thereof.

1 to 3 are diagrams for explaining the structure of the drug injection device according to an embodiment of the present invention.

The drug injection device of the present invention is located between the base part 100, the rotating part 200 that is rotatably mounted to the base part 100, and the base part 100 and the rotating part 200, and the rotating part ( It consists of a power unit 300 that provides power to rotate 200 , and an injection unit 400 that injects a chemical solution according to the rotation of the rotating unit 200 .

The drive control mechanism of the present invention has a configuration in which the injection part is removed from the drug injection device using the same, and since the specific configuration can be understood through the embodiment of the drug injection device, a separate description will be omitted.

The base unit 100 is a base plate 100, a control unit 120 (not shown in FIGS. 1, 4, 5) for controlling the operation of the drug injection device, and whether the protrusion is controlled by the control unit 120 It is made to include a plurality of protrusions (130-1,2).

The rotating part 200 is in contact with the rotating plate 210 on a circular plate, and when the protruding parts 130-1,2 are protruded, to prevent the movement of the rotating plate 210 and follow the circumferential direction of the rotating plate 210 . It is made to include a plurality of locking jaws 230 arranged at regular intervals.

The base plate 100 is equipped with a control unit 120 made of various ICs or electronic components to control the driving of the projection 120 as shown in FIG. 2 , and the control unit 120 and the projection 120 are the power supply unit ( 125) is supplied and operated. The power supply unit 125 is a part of the control unit 120 , and as will be described below, when the power unit 300 is a motor, power is also supplied to the power unit 300 .

As shown in FIG. 3 , the protrusion 130 includes the protruding end 131 and the protruding end 131 to a position where the protruding end 131 can be caught by the locking jaw 230 of the rotating plate 210 . A spring 132 for elastically supporting the 210 side, a guide 133 for guiding the protruding end 131 and the spring 132 , and a locking protrusion 230 for the protruding end 131 of the rotating plate 210 . ) consists of a driving unit 134 that moves to a position where it is not caught.

The protrusion 130 has the protruding end 131 in the form of a permanent magnet and the driving unit 134 in the form of an electromagnet, so that the control unit can control the driving of the protrusion 130 .

The relationship between the protrusion 130 and the locking jaw 230 is not limited to the embodiment to be described later, and when the driving unit 134 does not operate, any It doesn't matter if it's in the form.

In addition, the protrusion may be made by a shape memory alloy operating unit or a piezo linear motor that moves between the protruding end and a position to catch the protruding end on the engaging jaw and a position not to catch the protruding portion. The shape-memory alloy operation part prevents it from being caught on the locking jaw when it is restored to the memorized shape, and the unrestored shape is operated by being caught on the locking jaw by deformation that is stretched by its own elasticity.

The power unit 300 of the present invention is made by a wound spiral spring, and the rotating plate rotates with the rotational force generated when the spiral spring is unwound. The power unit 300 may be made by a motor, and as will be described later, it is possible to reliably control the amount of rotation without using an expensive stepping motor that can be controlled to rotate by a predetermined angle. In addition, it goes without saying that a power transmission system by a gear or the like may be installed between the power unit 300 and the rotating unit 200 , and such a power transmission system is included in the power unit 300 .

In addition, the power unit may use a motor operated by electricity, and the motor operated by electricity is a rotary ultrasonic motor disclosed in Korean Patent No. 1040474, or a piezo vibration motor and a motor using a shape memory alloy to generate rotational force. Any of the available known motors are applicable.

The rotary plate 210 is connected to the piston 410 of the injection unit 400 , and the amount of movement of the piston 410 is proportional to the amount of rotation of the rotary plate 210 . A cylinder part 420 is installed on the base plate 110 , and a chemical solution (insulin) is stored in the cylinder part 420 . The piston unit 410 is composed of a piston 410-1 that pushes the chemical solution inside the cylinder unit, and a wire-shaped push rod 410-2 connecting the piston and the rotating plate. (See FIG. 11 ) Cylinder 420 One end of the piston unit 410 enters, the other end is provided with a needle unit 430 installed through the base plate (110).

Next, an operating relationship in which the amount of rotation of the rotating plate rotated by the power unit 300 is controlled by the protrusion and the locking jaw will be described.

Although the arrangement of the protrusion and the locking protrusion is arranged along the circumferential direction of the rotating plate as shown in FIG. 6, it will be developed and described in a straight line form as shown in FIG. 7 for better understanding. 7(a)-(d) is an expanded view of FIGS. 6(a)-(d).

As shown in FIG. 7 , the rotating part 200 is provided with a total of 12 (i to xii) locking jaws 230 . Of the two protrusions 130-1.2, the left protrusion 130-1 is hooked on the locking jaw iii, and the right protrusion 130-2 is positioned between the locking jaw ix and the locking jaw x.

When the rotating unit 200 is to be moved to the right by the rotational force transmitted from the power unit 300 (in FIG. 1, the rotating unit 200 rotates counterclockwise), the left protrusion 130-1 is caught by the clasp iii. Impossible to move (See Fig. 6(a), Fig. 7(a))

At this time, if the control unit moves the protruding end 131 of the protrusion 130-1 downward so as not to be caught on the locking jaw iii, the rotating part 200 is movable so that the locking jaw iii moves upwards of the protrusion 130-1. It passes through (see FIGS. 6(b) and 7(b)), and the protrusion 130-1 is positioned between the locking jaw ii and the locking jaw iii. (See FIGS. 6(c) and 7(c)) ) At this time, the protruding end 131 of the left protrusion 130-1 moves upward by the elastic force of the spring 132 without being controlled by the controller.

While the rotating part 200 continues to move, when the locking jaw ix is caught on the right protrusion 130-2, the rotating part 200 stops moving (rotating). (See Fig. 6(d), Fig. 7(d))

In this order, the movement of one step is completed.

In the next step, the protruding end 131 of the right protrusion 130-2 moves downward so that the locking jaw ix exceeds the protrusion 130-2, and the rotary plate 210 moves (rotates), and the left protrusion 130-1 ) is caught on the locking jaw ii, and another stage of movement occurs, and in this way, the movement of the rotating plate is controlled.

As shown in the shape shown in Figure 8, when the width of the locking jaw is t, the distance between the locking jaws is x, the radius of the protrusions is r, the number of the protrusions is n, and the distance between the protrusions is y,

y > t,

The distance z = r + k(x+t)/n (where k is 0, ..., n-1, n is a natural number) from the stopping jaw to the center of the protrusion is made so that the stopping jaws are arranged respectively. If it loses, the movement of one step is made with a displacement by (x+t)/n.

According to the above movement of the rotating plate, the piston of the drug injection unit moves in the cylinder by a certain amount to allow the drug solution to be discharged to the needle unit.

Although it has been described in this embodiment that a certain amount of the chemical is injected by the locking jaw, it will be possible to sequentially inject different amounts of the chemical solution by adjusting the position of the locking jaw.

Since the protrusion of the present invention moves downward only when electricity is supplied by the control unit, if there is no control, it is supported upward by the spring and suppresses the rotating part from rotating, so that unintentional injection of the chemical can be reliably prevented. do.

In addition, at the moment when one protruding end is released from the locking jaw, the rotating plate is rotated by the power unit, and the other protruding end is caught by the locking jaw, and the rotating plate stops rotating. Accordingly, the electricity required for injecting a certain unit of the chemical is made possible in a very small amount.

Two or more protrusions may be installed according to the above conditions.

In addition, it is also possible to install two or more at the same position of the protrusion as shown in FIG. 9, and it is also possible to install all the protrusions between two adjacent locking protrusions as shown in FIG.

Although the present embodiment has been described as a protrusion that moves up and down at a position perpendicular to the rotating plate 210 , it will be possible to install the protrusion so as to protrude toward the center of the rotating plate 210 as shown in FIG. 11 . In this case, the locking jaw is provided in a radially protruding form along the circumferential surface of the rotating plate, not formed by a slit as shown in FIG. 1 .

Displacement is generated in the injection unit shown in FIG. 4 by an amount by which the rotating plate 210 rotates by about 1/3, but when manufactured in a spiral structure as shown in FIG. 12, the generated displacement may be increased.

13 shows that the rotating unit 200 and the injection unit 400 are formed as an integral module, and can be disassembled or combined from the power unit 300 and the fixed unit 100 . Accordingly, it is possible not only to recycle the power unit and the fixing unit, but also to change the input capacity by adjusting the distance between the stopping jaw and the stopping jaw.

As shown in FIG. 13, the chemical injection device of the present invention is used in a form in which the rotating part 200 and the injection part 400, the power part 300 and the fixed part 100 are embedded in each

case

500 and 600, and , according to this form, it is possible to use it as a wearable device attached to the user's forearm or abdomen with a belt or tape.

The case 600 is provided with a switch 260 that can send a signal to the control unit to operate the protrusion, the user may manually command the injection of the chemical to the control unit.

In addition, it is preferable that the control unit is controlled to inject a drug (insulin) in conjunction with a blood glucose meter disclosed in Korean Patent Application No. 10-2021-0052192 or No. 10-2021-0061323 of the present applicant or other known blood glucose meters. In this case, of course, a communication function capable of communicating with an external device should be further added to the control unit.

The drive control mechanism of the present invention can be used for devices that require a drive controller to be repeatedly driven, for example, in a medical device such as an insulin pump, consume less electricity, and can be used for a long time by adopting a small battery and it is possible to precisely control the amount of drug injection without using an expensive motor.

Claims

a base part having a base plate and a plurality of protrusions whose protrusions are controlled according to the control signal;

A disc-shaped rotating plate, and a plurality of engaging projections arranged at regular intervals along the circumferential direction of the rotating plate to prevent rotation of the rotating plate by contacting the protruding portion when the protruding portion is protruded, and rotatably coupled to the base a rotating part that becomes;

a power unit positioned between the base unit and the rotating unit to provide a driving force to rotate the rotating unit;

a control unit for controlling the protrusion or the protrusion and the power unit; A drive control mechanism, characterized in that made.
The method of claim 1,

The power unit generates a driving force by the elastic force of the elastic member, or generates a driving force by a motor operated by electricity.
The method of claim 1,

When the rotating plate is stationary, at least one of the protrusions is in contact with the locking jaw, and the rest is maintained in a state spaced apart from the locking jaw,

The rotating plate rotates when the protrusion in contact with the locking jaw moves to release the contact, but the protrusion spaced apart from the locking jaw comes into contact with the locking jaw to stop the rotation.
The method of claim 1,

If the width of the locking jaw is t, the distance between the locking jaws is x, the radius of the projections is r, the number of projections is n, and the distance between the projections is y,

y > t,

The distance z = r + k(x+t)/n (where k is 0, ..., n-1, n is a natural number) from the stopping jaw to the center of the projection. A drive control mechanism, characterized in that.
The method of claim 1,

The protrusion includes a protruding end, a spring elastically supporting the protruding end toward the rotating plate to a position where the protruding end can be caught by the locking jaw of the rotating plate, a guide portion guiding the protruding end and the spring, and the protruding end of the rotating plate. A drive control mechanism comprising a driving unit that moves to a position where it is not caught on the locking jaw.
6. The method of claim 5,

The driving control mechanism, characterized in that the protruding end and the driving part is made in the form of a permanent magnet and an electromagnet.
The method of claim 1,

The protruding portion is a driving control mechanism, characterized in that made by a protruding end and a shape memory alloy operation unit or a piezo linear motor for moving the protruding end.
The method of claim 1,

The locking projection is a drive control mechanism, characterized in that formed by a member between the slits arranged at regular intervals along the circumferential direction on the rotating plate.
The method of claim 1,

A drive control mechanism, characterized in that a gear is installed between the power unit and the rotating unit.
[Claim 10] In the drug injection device driven by the drive control mechanism of any one of claims 1 to 9, the drug injection device having an injection unit for injecting a chemical solution according to the rotation of the rotating unit,

The injection part includes a piston part that is moved by the amount of rotation of the rotating part determined by the contact between the protrusion and the protrusion according to the operation control of the protrusion of the controller, and a cylinder part coupled to the piston part and fixed to the base plate and storing the chemical therein; , Drug injection device, characterized in that it comprises a needle part in which the chemical liquid inside the cylinder part is released according to the movement of the piston part.
11. The method of claim 10,

The piston part and the cylinder part drug injection device, characterized in that made of a spiral structure.
11. The method of claim 10,

The piston part is a drug injection device, characterized in that consisting of a piston that pushes the chemical solution inside the cylinder, and a wire-shaped push bar connecting the piston and the rotating plate.
11. The method of claim 10,

The rotating unit and the injection unit are formed as an integral module, and the drug injection device, characterized in that it can be disassembled from the power unit and the fixed unit or coupled to the power unit and the fixed unit.
11. The method of claim 10,

The rotating part, the injection part, and the power part are formed as an integral module, and the drug injection device, characterized in that it can be disassembled from the fixed part or coupled to the fixed part.
11. The method of claim 10,

The control unit receives a control signal from an external device to control the drug injection device, characterized in that the drug injection device.
11. The method of claim 10,

The external device is a drug injection device, characterized in that the blood glucose meter.