CN106730284A - Microcapsules formula gastrointestinal drug discharges system - Google Patents
Microcapsules formula gastrointestinal drug discharges system Download PDFInfo
- Publication number
- CN106730284A CN106730284A CN201611044016.8A CN201611044016A CN106730284A CN 106730284 A CN106730284 A CN 106730284A CN 201611044016 A CN201611044016 A CN 201611044016A CN 106730284 A CN106730284 A CN 106730284A
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- Prior art keywords
- shell
- memory polymer
- drug release
- shape
- drive device
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0266—Shape memory materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/1053—Stomach
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Anesthesiology (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
A kind of microcapsules formula gastrointestinal drug discharges system, including shell, stationary barrier in shell, drug release drive device, active clapboard and medicine storing bag are set in sequence in from left to right, and it is arranged on the shedding motion on shell right side, the drug release drive device is at least one twisted plate being made by shape memory polymer composite material, and the original shape of twisted plate is straight panel.Simple structure of the present invention, the reliability of system is high, is capable of achieving the repeatedly release of medicine, you can by once swallowing, and realizes the administration functions of the different parts in intestines and stomach, drastically increases the utilization rate of system.
Description
Technical field
The present invention relates to drug delivery system, system is discharged more particularly, to a kind of microcapsules formula gastrointestinal drug.
Background technology
At present, China human mortality distribution is just stepping into the aging stage.Counted according to Ministry of Civil Affairs, to year ends 2015, China 60
Year above elderly population reached 2.21 hundred million.Epidemiology is more based on chronic disease, wherein intestines and stomach class disease be performance compared with
It is prominent one kind.Simultaneously as the quickening of rhythm of life and the increase of everyday stress, also cause chronic digestible tract disease
The incidence of disease is improved year by year.Current intestines and stomach class chronic disease needs to carry out long-term treatment by drug administration mostly, but due to medicine
The residence time is too short in vivo for thing, or as a result may reach diseased region because the influence of hydrochloric acid in gastric juice etc. causes degraded in stomach
Medicine only sub-fraction or medicine fail to reach diseased region, so as to reduce the curative effect of medicine, therefore common drug treatment
Do not get a desired effect.Therefore, if treatment can be directly administered in intestines and stomach affected area, medicine can both be strengthened
Absorb, realize efficiently treatment, can reduce dosage again and reduce the toxic and side effect of medicine.
Dietzel etc. has made capsule doser using magnetic material, and the device is made up of left and right two parts.Work as glue
When capsule is by intestines and stomach, capsule sealing is kept by magnetic force.When capsule reaches diseased region, make capsule left by external magnetic field
Right two parts are separated, so as to liquid be discharged.The apparatus structure is simple, there is provided drugloading rate higher, and total drugloading rate is
0.34mL, it primary disadvantage is that cannot discharge, and can only realize once discharging completely to some solid powder medicines.Lee
Do not possess autokinetic movement control ability Deng for existing capsule endoscope, passively can only be moved with the wriggling of enteron aisle
Defect, devises a kind of combined micro drive mechanism, and its drive part is made using dimethione (PDMS), by electricity
Heating expands PDMS, so that lead agency is moved.Although effectively, its heating-up temperature is too high for the structure, more than 100 DEG C,
Cannot be used for human body.SmartPill companies of the U.S. have developed a wireless intestines and stomach device for detecting performance, and the device orally enters
PH value, pressure and the temperature of intestines and stomach can be tested after intestines and stomach, and related data is wirelessly transmitted to external reception device, but
It does not have administration functions.The propositions such as Liang Hao based on MEMS (micro-electro mechanical
Systems, MEMS) technology internal drug delivery system.Its operation principle is：By using button cell as the energy, micro- electricity
Machine as driving source, worm drive as drug delivery methods mechanism, and by gastrointestinal peristalsis as microcapsules in vivo before
Capable power.Whole micro mechanism diameter 11mm, 35mm long, are made up of, each cabin powerhouse dome, medicine propelling module and control circuit cabin
The parts such as difference discharge source, transmission mechanism and motor.Close-packed arrays between three cabins.Micro machine can drive screw rod once rotating
Synchronized rotation.With the rotation of micro machine, larger axial thrust can be produced with less torque, make the work coordinated with screw rod
Plug is travelled forward, and the medicament in storehouse is transported forward under thrust, so as to discharge.It is micro- that flourish east equality devises a kind of intestines and stomach
Type pill, is capable of achieving the insoluble drug release of intestines and stomach.The basic process of drug release is：Minipill is entered in the way of swallowing from oral cavity
Enter human body, enter back into small intestine.When needing to discharge the diseased region of medicine in minipill arrival patient's body, positioned at external control
System transmitting unit processed can launch actuating signal, and internal reception device after action command is received, connect by remote control switch
Power supply, magnetic control means work, starts pressed gas device, discharges pressed gas, and liquid medicine storage device is squeezed gas pressure
Pressure is deformed upon, and liquid is extruded by check valve.There is certain negative pressure in the minipill, therefore in an initial condition,
Liquid will not flow out.Zeng Zhaowang etc. exists according to Faraday's electromagnetic induction principle, proposition using between magnet and magnet coil
Repulsion as driving force, realize insoluble drug release.The medicament capsule structure is by shell, medicine drive mechanism, power supply and timing
A few part compositions such as device.After energization, permanent magnet will be subject to magnet coil to produce the repulsive force in magnetic field, and then promote medicine,
Medicine is released under thrust.
To sum up state, the gastrointestinal drug release system of research and development at present has following deficiencies：(1) drive device construction is relatively multiple
Miscellaneous, reliability is relatively low；(2) can be only done single administration process, it is impossible to realize the multiple release of medicine.
The content of the invention
The purpose of the present invention, exactly in order to solve the above problems, there is provided a kind of simple structure and multiple dosing mistake can be realized
The microcapsules formula gastrointestinal drug release system of journey.
In order to achieve the above object, present invention employs following technical scheme：
A kind of microcapsules formula gastrointestinal drug discharges system, including shell, and consolidating in shell is set in sequence in from left to right
Determine dividing plate, drug release drive device, active clapboard and medicine storing bag, and the shedding motion on shell right side is arranged on, it is described to release
Medicine drive device is at least one twisted plate being made by shape memory polymer composite material, the original shape of twisted plate
It is straight panel.
Described shedding motion is magnetic switch door, by magnetic-adsorption on shell right side, the shell right-hand member
Contain magnetic material in face.
Described shape memory polymer composite material is, with shape-memory polymer as matrix, reinforcement to be added wherein
It is prepared from；The shape-memory polymer matrix is thermotropic shape-memory polymer, and the reinforcement is fibre reinforcement
Or reinforced particulate.
The thermotropic shape-memory polymer is selected from the one kind in PU, PLGA or PLMC.
The system drug release basic process be：Minipill enters the intestines and stomach of human body from oral cavity in the way of swallowing.When
When needing insoluble drug release, drug release drive device is heated by way of in-vitro high-energy amount focuses on ultrasound, and release the drug and drive
Device is made by shape memory polymer composite material, and its original shape is tabular, its shape recovery temperature always
40 DEG C can be set in.When focusing on Ultrasonic Heating temperature and reaching 40 DEG C, drug release drive device will be gradually extensive by present bending
It is again initial straight panel shape, so as to promote the dividing plate being connected with medicine storing bag to travel forward.
The shedding motion on shell end face is arranged on for a magnetic devices, by magnetic-adsorption on shell end face.Releasing
It is higher than between shedding motion and shell when it promotes the thrust that dividing plate travels forward in the shape recovery process of medicine drive device
During magnetic force, shedding motion will be opened, so as to realize insoluble drug release.
Insoluble drug release such as to be stopped, can closing extracorporeal ultrasound device, that is, stop entering shape memory polymer composite material
Row heating, causes shape memory polymer composite material to stop shape and recovers, and the dividing plate being connected with medicine storing bag stops travelling forward.
In the presence of no thrust, magnetic shedding motion will be closed, so as to realize stopping insoluble drug release.Using said process, can be real
Show medicine is repeated several times release.
The beneficial effects of the invention are as follows：The simple structure of package unit, only by shell, dividing plate, drug release drive device, drug storage
Capsule and shedding motion etc. are constituted.Parts are fewer, and the reliability of whole system is higher.And relative to existing insoluble drug release
For system, the repeatedly release of the achievable medicine of the present invention, you can by once swallowing, realize the difference portion in intestines and stomach
The administration functions of position, drastically increase the utilization rate of system.
Brief description of the drawings
Fig. 1 is structural front view of the invention；
Fig. 2 is the top view of Fig. 1；
Fig. 3 is the right view of Fig. 1；
Fig. 4 is dimensional structure diagram of the invention；
Fig. 5 is the schematic diagram in drug release process；
Fig. 6 is the schematic diagram after insoluble drug release is finished.
Specific embodiment
The present invention is further illustrated with embodiment below in conjunction with the accompanying drawings.
As shown in Figures 1 to 6, microcapsules formula gastrointestinal drug release system of the invention, including shell 1, from left to right
It is set in sequence in stationary barrier 2 in shell, drug release drive device 3, active clapboard 4 and medicine storing bag 5, and to be arranged on shell right
Shedding motion 6 on end face, drug release drive device therein is made at least by shape memory polymer composite material
A piece twisted plate, the original shape of twisted plate is straight panel.
Patient makes minipill enter the intestines and stomach of human body from oral cavity in the way of swallowing.When insoluble drug release is needed, lead to
The mode for crossing in-vitro high-energy amount focusing ultrasound is heated to drug release drive device 3, and the drive device 3 that releases the drug is by shape memory
What polymer composites were made, its original shape is tabular always, and its shape recovery temperature can be set in 40 DEG C.When poly-
When burnt Ultrasonic Heating temperature reaches 40 DEG C, drug release drive device 3 will gradually revert to initial straight panel shape by present bending,
So as to promote the active clapboard 4 being connected with medicine storing bag 4 to travel forward.
It is magnetic switch door to be arranged on the shedding motion 6 on the end face of shell 1, by magnetic-adsorption on shell end face.
It is higher than shedding motion 6 when it promotes the thrust that active clapboard 4 travels forward in the shape recovery process of drug release drive device 3
During with magnetic force between shell 1, shedding motion 6 will be opened, so as to realize insoluble drug release.
Insoluble drug release such as to be stopped, can closing extracorporeal ultrasound device, that is, stop entering shape memory polymer composite material
Row heating, cause shape memory polymer composite material stop shape recover, the active clapboard 4 being connected with medicine storing bag 5 stop to
Preceding motion.In the presence of no thrust, magnetic shedding motion 6 will be closed, so as to realize stopping insoluble drug release.Using above-mentioned mistake
Journey, be capable of achieving medicine is repeated several times release.
Claims (4)
1. a kind of microcapsules formula gastrointestinal drug discharges system, it is characterised in that：Including shell, it is set in sequence in from left to right outer
Stationary barrier, drug release drive device, active clapboard and medicine storing bag in shell, and it is arranged on the opening dress on shell right side
Put, the drug release drive device is at least one twisted plate being made by shape memory polymer composite material, twisted plate
Original shape be straight panel.
2. microcapsules formula gastrointestinal drug according to claim 1 discharges system, it is characterised in that described shedding motion
It is magnetic switch door, by magnetic-adsorption on shell right side, magnetic material is contained in the shell right side.
3. microcapsules formula gastrointestinal drug according to claim 1 discharges system, it is characterised in that described shape memory
Polymer composites are, with shape-memory polymer as matrix, reinforcement to be added wherein and is prepared from；The shape memory
Polymeric matrix is thermotropic shape-memory polymer, and the reinforcement is fibre reinforcement or reinforced particulate.
4. microcapsules formula gastrointestinal drug according to claim 1 discharges system, it is characterised in that the thermotropic shape
Memory polymer is selected from the one kind in PU, PLGA or PLMC.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611044016.8A CN106730284A (en) | 2016-11-24 | 2016-11-24 | Microcapsules formula gastrointestinal drug discharges system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611044016.8A CN106730284A (en) | 2016-11-24 | 2016-11-24 | Microcapsules formula gastrointestinal drug discharges system |
Publications (1)
| Publication Number | Publication Date |
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| CN106730284A true CN106730284A (en) | 2017-05-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201611044016.8A Pending CN106730284A (en) | 2016-11-24 | 2016-11-24 | Microcapsules formula gastrointestinal drug discharges system |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111227769A (en) * | 2020-01-20 | 2020-06-05 | 张源一 | Endoscopic capsule, camera shooting mechanism thereof and medicine discharging control method |
| CN111760177A (en) * | 2020-06-16 | 2020-10-13 | 杭州电子科技大学 | Microcapsule injection type magnetic control robot for targeted drug delivery and control method thereof |
| CN111939444A (en) * | 2020-08-25 | 2020-11-17 | 东北电力大学 | Micro-nano robot for targeted drug delivery |
| US11179341B2 (en) | 2017-05-17 | 2021-11-23 | Massachusetts Institute Of Technology | Self-righting articles |
| CN113769249A (en) * | 2021-09-10 | 2021-12-10 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
| US11202903B2 (en) | 2018-05-17 | 2021-12-21 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| US11541216B2 (en) | 2019-11-21 | 2023-01-03 | Massachusetts Institute Of Technology | Methods for manufacturing tissue interfacing components |
| US11541016B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
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| CN100998904A (en) * | 2006-12-19 | 2007-07-18 | 重庆大学 | Slow release type remote controlled electronic capsule |
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Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11541016B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US12064520B2 (en) | 2017-05-17 | 2024-08-20 | Massachusetts Institute Of Technology | Components with high API loading |
| US12036324B2 (en) | 2017-05-17 | 2024-07-16 | Massachusetts Institute Of Technology | Self-righting systems and related components and methods |
| US11179341B2 (en) | 2017-05-17 | 2021-11-23 | Massachusetts Institute Of Technology | Self-righting articles |
| US11712421B2 (en) | 2017-05-17 | 2023-08-01 | Massachusetts Institute Of Technology | Self-actuating articles |
| US11607390B2 (en) | 2017-05-17 | 2023-03-21 | Massachusetts Institute Of Technology | Self-righting systems and related components and methods |
| US11207272B2 (en) | 2017-05-17 | 2021-12-28 | Massachusetts Institute Of Technology | Tissue anchoring articles |
| US11311489B2 (en) | 2017-05-17 | 2022-04-26 | Massachusetts Institute Of Technology | Components with high API loading |
| US11369574B2 (en) | 2017-05-17 | 2022-06-28 | Massachusetts Institute Of Technology | Self-righting systems and related components and methods |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US11202903B2 (en) | 2018-05-17 | 2021-12-21 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| US12059562B2 (en) | 2018-05-17 | 2024-08-13 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
| US11541216B2 (en) | 2019-11-21 | 2023-01-03 | Massachusetts Institute Of Technology | Methods for manufacturing tissue interfacing components |
| CN111227769A (en) * | 2020-01-20 | 2020-06-05 | 张源一 | Endoscopic capsule, camera shooting mechanism thereof and medicine discharging control method |
| CN111760177A (en) * | 2020-06-16 | 2020-10-13 | 杭州电子科技大学 | Microcapsule injection type magnetic control robot for targeted drug delivery and control method thereof |
| CN111939444A (en) * | 2020-08-25 | 2020-11-17 | 东北电力大学 | Micro-nano robot for targeted drug delivery |
| WO2023036296A1 (en) * | 2021-09-10 | 2023-03-16 | 安翰科技(武汉)股份有限公司 | Drug administration capsule |
| CN113769249A (en) * | 2021-09-10 | 2021-12-10 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
| CN113769249B (en) * | 2021-09-10 | 2023-08-04 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
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Application publication date: 20170531 |
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