CN100438937C - Mini medicine releasing device - Google Patents
Mini medicine releasing device Download PDFInfo
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- CN100438937C CN100438937C CNB02128122XA CN02128122A CN100438937C CN 100438937 C CN100438937 C CN 100438937C CN B02128122X A CNB02128122X A CN B02128122XA CN 02128122 A CN02128122 A CN 02128122A CN 100438937 C CN100438937 C CN 100438937C
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- Prior art keywords
- drug release
- magnetic switch
- release device
- micropump
- medicine
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention discloses a miniature medicine release device which is composed of a shell body with biocompatibility, a permanent magnet, a power supply magnetic switch circuit and a minipump, wherein the shell body is provided with a medicine release port, and the surface of the shell body is smooth; the permanent magnet is encapsulated and fixed to the region of one end in the shell body; the power supply magnetic switch circuit is encapsulated and fixed to the region of the other end in the shell body; the minipump is encapsulated and fixed between the two regions, medicine is filled into the chamber of the minipump, and the release opening is sealed by a valve. The present invention has the advantages of tiny volume, convenient swallow and smooth surface, and does not injure the digestive tract. The outer shell of the device is made from biocompatible material, so that the present invention can not induce adverse reaction, and is used more safely. The permanent magnet in the device can exactly measure the position where miniature medicine is released in vivo by a monitor. The medicine is exactly and rapidly released in a particular place by a trigger control device.
Description
Technical field
The present invention relates to a kind of miniature drug release device, particularly relate to a kind of miniature drug release device that can fix a point to discharge medicine in vivo.
Background technology
To disease particularly in the process of intestinal tract disease treatment, often some medicine is absorbed by the focus zone, has not only caused the waste of medicine, has reduced therapeutic effect, also may cause the untoward reaction of other organ at oral drugs.Therefore, wish to have a kind of volume small, in adorn required medicine, swallow easily, the no show appointed place is in sealing state, arrive behind the appointed place under outer signals triggers can rapid delivery of pharmaceuticals device.Existing people has proposed the method and apparatus that several localities in vivo discharge medicines, and its major defect is: the device that discharges medicine is the response external triggering signal fast and effectively, the device that is provided as Japan's the 5549853rd patent.This device makes its response circuit conducting after accepting triggering signal, make an easy heating-wire heating by electric current, by the heat energy other static line that fuses, just can impel drug release device to discharge medicine.Because said method can not guarantee that static line is fused easily, even static line is finally fused, also can produce a uncertain time difference, promptly outer triggering signal and drug release device begin to discharge the time difference between the medicine.Second problem is energy supply and consumption problem.Some medicament release device, energy dissipation is big, generally just starts working after assembling is finished, and not only wastes energy, and face and cause device after shelving a period of time is because of energy expenditure can not be used.
Summary of the invention
The objective of the invention is to: at the problem that present drug release device exists, provide small, the interior powder charge thing of a kind of volume, sealing tightly, swallow easily, the miniature drug release device of safe in utilization, precise control, the rapid delivery of pharmaceuticals of can only fixing a point.
The objective of the invention is to realize by the enforcement following technical proposals:
A kind of miniature drug release device, by have biocompatibility, have the drug release port, ganoid housing unit constitutes, it is characterized in that: also include: encapsulation is fixed on the permanent magnet in this housing intracavity one end regions, encapsulation is fixed on power supply magnetic switch circuit in this housing intracavity other end zone, and encapsulation be fixed on zone between above-mentioned two zones, be loaded with the micropump assembly that medicine, unidirectional micro valve face housing drug release port in the chamber.
Its additional technical feature is:
1. described encapsulation is fixed on the power supply magnetic switch circuit in this housing intracavity one end regions, is made of minicell and magnetic switch; One end of magnetic switch connects the positive pole of minicell, and the other end connects the micropump power input, and the negative pole of minicell connects the micropump power output end, thereby constitutes power supply magnetic switch circuit.
2. the magnetic switch in the described power supply magnetic switch circuit, form by the intravital two elasticity magneto sensors of the magnetic switch insulation shell that is contained in a leaded outlet in two ends, each end of two elasticity magneto sensors is separately fixed on the inwall of magnetic switch insulation shell, wherein a slice elasticity magneto sensor is connected on the positive pole of minicell by the lead outlet that lead passes magnetic switch insulation shell one end, and another sheet elasticity magneto sensor is connected on the micropump power input by the lead outlet that lead passes the magnetic switch insulation shell other end.
The magnetic switch insulation shell of two elasticity magneto sensors is housed in the 3. described cavity, is to be fixed on the inwall of miniature drug release device housing by being arranged on its spring all around.
4. the described micropump that is encapsulated in miniature drug release device housing stage casing, its top surface layer is the plate with power supply input, outfan, one sealing coat is arranged below the plate, cavity is provided with the chamber of splendid attire medicine, in the side of this chamber by sealing coat, locular wall is the deformable film locular wall, and containing medicine chamber bottom has the chamber medicine delivery outlet that is sealed, docked with device drug release port by unidirectional micro valve.
5. the described unidirectional micro valve that is contained on the chamber medicine delivery outlet of containing the medicine chamber is the unidirectional micro valve of outwards opening.
6. the described micropump that is encapsulated in the drug release device housing, the pump housing surface and the drug release device housing seal of its drug release port peripheral region.
7. the unidirectional micro valve of described micropump, its width is less than the degree of depth of medicine release port passage on the drug release device.
The invention has the advantages that: volume is small can conveniently be swallowed; Smooth dysphagia and the damage digestive tract of can not causing of surface curvature; Device case can not cause untoward reaction by having the biocompatible materials manufacturing, and is safer in making it to use; Be encapsulated in the permanent magnet in the drug release device housing, can detect the position of miniature drug release device in the body accurately by the exterior monitoring device; Be encapsulated in the operating circuit of forming by micropump, power supply and magnetic switch in the drug release device housing, can realize that locality in vivo discharges medicine quickly and accurately effectively by triggering the signal control device of drug release.
Description of drawings
Fig. 1 is the miniature drug release device profile of the present invention
Fig. 2 is the micropump section of structure
Fig. 3 is the magnetic switch structure chart
Fig. 4 is for triggering the signal control device structural representation of drug release
Labelling among the figure: 1 is miniature drug release device housing, and 2 is permanent magnet, and 3 is micropump, 4 is plate, 5 is sealing coat, and 6 for containing the medicine chamber, and 7 is the deformable film locular wall, 8 is unidirectional micro valve, 9 is the drug release port, and 10 is chamber medicine delivery outlet, and 11 is minicell, 12 is magnetic switch, 13 is fixing spring, 14,15 is the elasticity magneto sensor, and 16 is the power input on the micropump end face pole plate, 17 is the power output end on the micropump end face pole plate, 18 is the horseshoe type spiral winding, and 19 is battery, and 20 is the micropump outer surface around the drug release port, 21,22 is lead, and 23 is the insulation shell of magnetic switch.
The specific embodiment
A kind of miniature drug release device system, form by miniature drug release device and the signal control device that matches in order to trigger drug release, wherein: miniature drug release device, its device case 1 is to make by having biocompatible materials, housing 1 smooth surface has a drug release port 9; Intracavity one end regions device stationary permanent magnet 2 at device case 1; Be provided with by minicell 11 and two power supply magnetic switch circuit that elasticity magneto sensor 14,15 is formed in the other end zone of this housing intracavity; A slice elasticity magneto sensor 14 in the circuit in the magnetic switch 12, the positive pole that connects minicell 11 by lead 21, another sheet elasticity magneto sensor 15 connects on the power input 16 of micropump 3 end face top crowns 4 by lead 22, the negative pole of minicell 11 then connects the power output end 17 of micropump 3 end face top crowns 4 by lead, formed the circuit of effective control micropump 3 work; Be encapsulated in the micropump 3 in zone, drug release device housing 1 stage casing, its top surface layer is the plate 4 with power input 16 and power output end 17, one sealing coat 5 is arranged below this plate 4, be provided with in the drug release device cavity and contain medicine chamber 6, leaning on a side room wall of sealing coat 5 at this chamber is deformable film locular wall 7, and containing medicine chamber 6 bottoms has the chamber medicine delivery outlet 10 that is sealed, docked with device drug release port 9 by unidirectional micro valve 8; The peripheral region of drug release port 9 and drug release device housing 1 tight seal, and the width of the unidirectional micro valve 8 of micropump 3 is less than the channel depth of drug release port 9, damage digestive tract when preventing this valve opening.
Shown in Figure 1, this miniature drug release device comprises: the housing 1 of an ellipsoidal structure, it is to make by having biocompatible materials, can not cause untoward reaction in vivo, a permanent magnet 2 that is fixed on magnet area, this magnet area is by being bolted on the miniature drug release device inner walls; With silica gel the surface around this pump drug release port 9 is bonded at and makes its sealing on the device case wall, the minicell 11 and the spring 13 that is used for pushing down self-contained battery that comprise two joint 1.5V in the battery area, battery area is the power supply magnetic switch by being bolted on the miniature drug release device inner walls on the right of battery area.Miniature drug release device volume shown in Figure 1 is small, can directly swallow, and can also be excreted by anus at last.
Power supply magnetic switch shown in Figure 3 can be a magnetosensitive switch, also can be other components and parts with said function.It is fixed between releasing device inner walls and the battery area by spring 13, it comprises 14,15 and two leads 21,22 of two elasticity magneto sensors, the lead 21 1 ends other end that links to each other with elasticity magneto sensor 14 links to each other with anode, and the power input 16 that an end of lead 22 links to each other with elasticity magneto sensor 15 on the plate 4 of the other end and micropump 3 links to each other.Connect the negative pole of set of cells 11 and the power output end 17 on the micropump plate with a lead, thereby set of cells 11, micropump 3 and power supply magnetic switch 12 constitute the micropump operating circuit.14,15 pairs of magnetic directions of elasticity magneto sensor in the on and off switch 12 are very responsive.Do not having under the magnetic field force effect, two magneto sensors 14,15 will keep released state because of the effect of self elastic force, and at this moment set of cells 11, and the circuit that power supply magnetic switch 12 and micropump 3 constitute is in off state, so miniature air pump inoperative does not produce any energy expenditure.Behind certain specific part in this miniature drug release device arrival organism, affected area for example, the operator just can utilize the signal control device of external trigger drug release to provide a triggering signal, spiral winding in the signal control device produces magnetic field, two elasticity magneto sensors will phase adhesive under the effect of high-intensity magnetic field direction power, make 12 conductings of power supply magnetic switch, micropump is started working and is carried out drug release, the intact signal control device of closing drug release of drug release.So the present invention is consumed energy low.
Fig. 2 is an electrostatic micropump that utilizes micro fabrication to make.Micropump 3 is fixed in the drug release device housing, make and keep sealing between the drug release port circumferential surface position of pump and drug release device housing, prevent that medicine from flowing out hourglass and going in the medicine releasing device housing, the unidirectional micro valve 8 and the drug release port 9 of micropump 3 connect, to guarantee the outflow of medicine.This micropump mainly comprise have power input 16,4, one sealing coats 5 of a plate of outfan 17, one deck deformable film 7 is used for the chamber 6 of powder charge, one-way cock 8.Wherein distortion up or down can take place in deformable film 7 under the effect of voltage, the check valve on the micropump, and it can only be opened to the direction of drug release port 9.Chamber 6 among Fig. 2 is used for the splendid attire required liquid medicine of curing the disease, and this medicine is poured into to chamber 6 by the unidirectional micro valve 8 on the micropump.The effect of plate 4 is actually for input voltage being added on the deformable film 7, and this deformable film 7 can adopt the bimetallic film preparation, also can adopt the niti-shaped memorial alloy film preparation, the cavity of micropump silicon materials processing and fabricating.
Fig. 4 is the drug release signal control device of described drug release device.Spiral winding 18 is a horseshoe type.It adopts battery powered, can carry, can also be movable freely after patient swallows miniature drug release device.When this miniature drug release device arrives intravital certain locality, the affected area of small intestinal for example, the switch that patient or doctor just can press above this device makes this flip flop equipment energising, the spiral winding 18 energising backs of this device produce magnetic field then, and two elasticity magneto sensors on the power supply magnetic switch 12 are connected.Deformable film 7 on the micropump has obtained required voltage, under the effect of this voltage, deformable film 7 is bent downwardly deformation, chamber 6 volume-diminished pressure are increased, unidirectional micro valve 8 is opened downwards, and the medicine in the chamber 6 is just by beyond the chamber process medicine delivery outlet 10 outflow drug release ports 9.
Claims (8)
1, a kind of miniature drug release device, by have biocompatibility, have the drug release port, ganoid housing (1) assembly constitutes, it is characterized in that: also include: encapsulation is fixed on the permanent magnet (2) in this housing intracavity one end regions, encapsulation is fixed on power supply magnetic switch circuit in this housing intracavity other end zone, and encapsulation be fixed on zone between above-mentioned two zones, be loaded with micropump (3) assembly that medicine, unidirectional micro valve (8) face housing drug release port (9) in the chamber (6).
2, according to the described miniature drug release device of claim 1, it is characterized in that: described encapsulation is fixed on the power supply magnetic switch circuit in this housing intracavity one end regions, is made of minicell (11) and magnetic switch (12); One end of magnetic switch (12) connects the positive pole of minicell (11), and the other end connects micropump (3) power input (16), and the negative pole of minicell (11) connects micropump power output end (17), thereby constitutes power supply magnetic switch circuit.
3, according to the described miniature drug release device of claim 2, it is characterized in that: the magnetic switch (12) in the described power supply magnetic switch circuit, be by two elasticity magneto sensors (14 in the magnetic switch insulation shell (23) that is contained in a leaded outlet in two ends, 15) form, elasticity magneto sensor (14,15) each end is separately fixed on the inwall of magnetic switch insulation shell (23), wherein a slice elasticity magneto sensor (14) is connected on the positive pole of minicell (11) by the lead outlet that a lead (21) passes magnetic switch insulation shell (23) one ends, and another sheet elasticity magneto sensor (15) is connected on the power input (16) of micropump (3) by the lead outlet that another lead (22) passes magnetic switch insulation shell (23) other end.
4, according to the described miniature drug release device of claim 3, it is characterized in that: the described magnetic switch insulation shell (23) of elasticity magneto sensor (14,15) is housed in the cavity, is to be fixed on the inwall of miniature drug release device housing (1) by being arranged on its spring (13) all around.
5, according to the described miniature drug release device of claim 1, it is characterized in that: the described micropump (3) that is encapsulated in miniature drug release device housing (1) stage casing, its top surface layer is for having power input (16), the plate (4) of outfan (17), one sealing coat (5) is arranged below the plate, cavity is provided with the described chamber (6) of splendid attire medicine, in the side of this chamber by sealing coat (5), locular wall is deformable film locular wall (7), and the chamber medicine delivery outlet (10) that is sealed and docked with drug release port (9) by described unidirectional micro valve (8) is arranged at described chamber (6) bottom.
6, according to the described miniature drug release device of claim 5, it is characterized in that: the unidirectional micro valve (8) on the described chamber medicine delivery outlet (10) that is contained in chamber (6) is the unidirectional micro valve of outwards opening.
7, according to the described miniature drug release device of claim 1, it is characterized in that: be encapsulated in the micropump (3) in the miniature drug release device housing (1), the pump housing surface of its drug release port (9) peripheral region and miniature drug release device housing (1) sealing.
8, according to the described miniature drug release device of claim 1, it is characterized in that: the unidirectional micro valve (8) of described micropump, its width is less than the degree of depth of medicine release port (9) passage on the miniature drug release device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02128122XA CN100438937C (en) | 2002-12-30 | 2002-12-30 | Mini medicine releasing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB02128122XA CN100438937C (en) | 2002-12-30 | 2002-12-30 | Mini medicine releasing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1425477A CN1425477A (en) | 2003-06-25 |
| CN100438937C true CN100438937C (en) | 2008-12-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB02128122XA Expired - Fee Related CN100438937C (en) | 2002-12-30 | 2002-12-30 | Mini medicine releasing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100438937C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100376299C (en) * | 2005-08-19 | 2008-03-26 | 华南理工大学 | Chemical reaction gas pressure type microcapsule medicine release method and apparatus thereof |
| GB201220974D0 (en) | 2012-11-22 | 2013-01-02 | Cefai Joseph J | Micro valve |
| CN108671370A (en) * | 2018-06-20 | 2018-10-19 | 南京林业大学 | The insulin closed loop controlled release mechanisms of biological fuel cell driving |
| CN109621169B (en) * | 2019-01-09 | 2021-06-08 | 李红岩 | Observation therapeutic instrument for obstetrical department |
| CN110215570A (en) * | 2019-04-19 | 2019-09-10 | 吴银洪 | Full automatic solid sensor body inner injector with mutual exclusion tension stability |
| CN112968532B (en) * | 2021-02-05 | 2022-09-27 | 浙江大学台州研究院 | Wireless magnetic resistance actuator based on magnetic resonance coupling |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5170801A (en) * | 1990-10-02 | 1992-12-15 | Glaxo Inc. | Medical capsule device actuated by radio-frequency (rf) signal |
| US5217449A (en) * | 1990-12-11 | 1993-06-08 | Miyarisan Kabushiki Kaisha | Medical capsule and apparatus for activating the same |
| JP2000023980A (en) * | 1998-07-08 | 2000-01-25 | Olympus Optical Co Ltd | Ultrasonograph |
| US20020055734A1 (en) * | 1999-12-21 | 2002-05-09 | Houzego Peter J. | Ingestible device |
| US20020114715A1 (en) * | 2001-02-20 | 2002-08-22 | Korea Advanced Institute Of Science And Technology | Micropump driven by movement of liquid drop induced by continuous electrowetting |
| GB2374149A (en) * | 2000-11-08 | 2002-10-09 | Hewlett Packard Co | A swallowable internal drug dispensing capsule with memory |
-
2002
- 2002-12-30 CN CNB02128122XA patent/CN100438937C/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5170801A (en) * | 1990-10-02 | 1992-12-15 | Glaxo Inc. | Medical capsule device actuated by radio-frequency (rf) signal |
| US5217449A (en) * | 1990-12-11 | 1993-06-08 | Miyarisan Kabushiki Kaisha | Medical capsule and apparatus for activating the same |
| JP2000023980A (en) * | 1998-07-08 | 2000-01-25 | Olympus Optical Co Ltd | Ultrasonograph |
| US20020055734A1 (en) * | 1999-12-21 | 2002-05-09 | Houzego Peter J. | Ingestible device |
| GB2374149A (en) * | 2000-11-08 | 2002-10-09 | Hewlett Packard Co | A swallowable internal drug dispensing capsule with memory |
| US20020114715A1 (en) * | 2001-02-20 | 2002-08-22 | Korea Advanced Institute Of Science And Technology | Micropump driven by movement of liquid drop induced by continuous electrowetting |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1425477A (en) | 2003-06-25 |
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Granted publication date: 20081203 Termination date: 20100201 |