CN101259301A - Digitalization pulsed-release electronic capsule - Google Patents
Digitalization pulsed-release electronic capsule Download PDFInfo
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- CN101259301A CN101259301A CNA2008100695664A CN200810069566A CN101259301A CN 101259301 A CN101259301 A CN 101259301A CN A2008100695664 A CNA2008100695664 A CN A2008100695664A CN 200810069566 A CN200810069566 A CN 200810069566A CN 101259301 A CN101259301 A CN 101259301A
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Abstract
A digital pulse electronic capsule for drug release relates to an oral drug delivery system. The digital pulse electronic capsule for drug release of the invention comprises a shell, a power supply, a starting switch, a digital pulse generating circuit and an array-type drug release device. The array-type release device comprises a drug release driver array and a drug storage bin array, while the drug release driver array consists of a plurality of drug release micro-actuators; the drug storage bin array consists of a plurality of micro drug storage bins. The digital pulse generating circuit generates a pulse electrical signal with specific strength according to preset frequency and intervals, and exerts the pulse electric signals respectively on a plurality of drug release micro-actuators in the array drug release device according to the preset time sequence and triggers the drug release micro-actuators to work, thus releasing the drug out of the micro drug storage bins. The invention provides an oral drug delivery system that can set drug delivery time according to the individual difference of the patients to release drugs for a plurality of times, which is not affected by the individual difference of the digestive tract environment.
Description
Technical field:
The present invention relates to a kind of oral administration device, be used for digestive tract h substance, as medicine, food, label etc. at animal or human's body.
Background technology:
In recent years, because the development of chronobiology and chronopharmacology, finder's multiple physical signs, as blood pressure, blood glucose, the content of adrenocortical hormone and other various hormones all has daily rhythmicity in the blood, find that simultaneously some disease also demonstrates the rhythmicity characteristics, as angina pectoris, gastric acid secretion, migraine, epilepsy, all there is the day and night fluctuation phenomenon in Arthritis and Rheumatisms etc., the outbreak of the dyspnea of asthmatic patient present the daytime-change night, a large amount of clinical observations find that be the high-incidence season of asthma morning, the myocardial infarction morbidity also has analogue, on the other hand, the circadian rhythm that studies show that disease has caused also that curative object giving drugs into nose is moving and has learned and the variation round the clock of pharmacodynamics.For above-mentioned treatment of diseases with rhythmicity, ideal medicine should meet the following conditions: (1) convenience.Preferably in a long time, in 24 hours, only need an oral medicine.(2) can discharge medicine in the relevant particular point in time of disease rule, to obtain best therapeutic effect, wherein can repeatedly discharge medicine according to particular time interval is the necessary technology requirement.
Prior art, slow releasing preparation can be kept uniform and stable blood drug level for a long time, makes people only to need an oral medicine in 24 hours in the long period scope, has reduced the number of times of taking medicine, and makes things convenient for patient's daily life.But slow releasing preparation can not pulsed discharge medicine in the relevant special time of disease rule, have regular disease treatment aspect for angina pectoris, asthma etc., and curative effect is slightly poor.
Can be after the current Orally taken pulsed preparation based on biomaterial enters in the human body through one section predefined time lag stripping again, utilize the time lag technology to respond the disease of patient rhythm and pace of moving things, but, although current Orally taken pulsed drug-supplying system has had higher time control accuracy, but be faced with the severe challenge of individuation difference merely based on the Orally taken pulsed drug-supplying system of biomaterial technology, the subject matter that exists is: (1) has different time lag characteristics with a kind of pulsed release preparation in different patient's bodies.Its main cause is that there is individual variation in different patients, the influence factor comprises inherited genetic factors, physiologic factor, pathological factor, eating patterns, micro ecology of gastrointestinal tract environment, gastrointestinal tract dynamia feature or the like, cause in different patient's bodies, having the time lag of different time, thereby can't respond the life rhythm of patient disease exactly with a kind of pulsed release preparation.(2) with a kind of disease, different patients have different life rhythms, therefore same preparation differs greatly in the intravital curative effect of different patients, Orally taken pulsed preparation towards manufacturing in enormous quantities is difficult to accurately respond life rhythm, press for and a kind ofly can respond the patient individual difference, can preset the oral administration system of drug release time easily.For example, the interior catecholamine levels of body increased when the hyperpietic woke up morning, the easiest going wrong, generally speaking, best administration time is about 3 of mornings, but a lot of patients are because of factors such as work and rest rule difference, body constitution differences, the time phase difference that catecholamine levels increases in its body is very big, according to the pulsatile release tablets of this statistical law development in use, part patient is because of the pulse release of the wrong time of medicine, increased the toleration of patient, reduced the therapeutic effect of this medicine on the contrary medicine.In the oral administration system field, merely accurately respond life rhythm, the tangible problem of individual variation based on the biomaterial technology and towards being difficult to of existing of the Orally taken pulsed preparation of manufacturing in enormous quantities, under personalized medicine (Personality Medicine) development trend, pressing issues in the oral administration system have been become.
Summary of the invention:
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of and can set specified time interval according to the patient individual difference, can repeatedly discharge medicine, precise control, be not subjected to that the digestive tract environment individual variation influences oral administration system.
Technical scheme of the present invention is as described below:
Digitalization pulsed-release electronic capsule, comprise shell, power supply, starting switch, digitized pulse generating circuit and array medicine-feeder, described array medicine-feeder comprises a release drive array and a medicine holding bin array, the release drive array comprises N release microdrive, the medicine holding bin array comprises N miniature medicine holding bin, wherein N is more than or equal to 2 and less than 1000 natural number, each release microdrive and a miniature medicine holding bin constitute a miniature release unit, miniature medicine holding bin is used for encapsulation medicine to be discharged, each release microdrive has circuit with the digitized pulse generating circuit and is connected, the digitized pulse generating circuit is according to predefined frequency, produce the pulse electrical signal of certain strength at interval, and put on pulse electrical signal on each release microdrive in the array medicine-feeder respectively and trigger the work of release microdrive according to predetermined sequential, drug release is gone out miniature medicine holding bin.
Release microdrive in the described array medicine-feeder can be a little chemical propeller, this little chemical propeller comprises lighter, propellant storehouse, propellant, described miniature medicine holding bin comprises a piston, and piston is encapsulated between propellant storehouse and the miniature medicine holding bin.Release microdrive in the described array medicine-feeder also can be a micromechanics propeller, this micromechanics propeller comprises slight fever resistance, Microspring, spring fixator, spring fixator is connected by the low melting point adhesive securement with slight fever resistance or is fixedly connected by low melting point polymerization line, spring is in compressive state, described miniature medicine holding bin comprises a piston, and piston is encapsulated between spring fixator and the miniature medicine holding bin.Described digitized pulse generating circuit comprises an one chip microcomputer or a miniature special IC.Described starting switch is the magnetic switch that is in closure state under the normal condition.
Work process of the present invention and principle are:
Digitalization pulsed-release electronic capsule loads medicine to be discharged, and before swallowing, the starting switch of digitalization pulsed-release electronic capsule is in off-state, and digitized pulse generating circuit access failure power supply is in off-mode.Digitalization pulsed-release electronic capsule is swallowed and is entered after the digestive tract of human body or animal body, because starting switch closure, the work of digitized pulse generating circuit, according to predefined frequency, produce the pulse electrical signal of certain strength at interval, and pulse electrical signal is put on respectively on each release microdrive in the array medicine-feeder according to predetermined sequential, trigger the work of release microdrive, drug release is gone out miniature medicine holding bin, medicine enters blood circulation by the digestive tract of human body or animal, thereby in human body or animal body, produce the blood drug level of specific rule, reach predetermined therapeutic effect.
The present invention compared with prior art has following technique effect:
(1) can set the interval that discharges medicine according to the patient individual difference.Digitalization pulsed-release electronic capsule of the present invention comprises the digitized pulse generating circuit, this circuit can be according to patient's needs, by circuit hardware setting or software setting, come the interval of control drug release by the impulse circuit signal of setting specific interval, thus better response patient's individual variation.
(2) can repeatedly discharge medicine.The present invention has adopted the array medicine-feeder, can repeatedly discharge medicine, thereby has realized the pulse drug release, can reach optimum curative effect repeatedly discharging medicine according to the patient disease rhythm and pace of moving things.
(3) precise control, not influenced by the digestive tract environment individual variation.Because the present invention adopts the digitized pulse generating circuit that is closed in the capsule shell to come the time of control drug release, except the advantage of precise control with electronic circuit, and not influenced by the digestive tract environment individual variation, avoided the shortcoming of the traditional individuation obvious difference that utilizes characteristics such as pharmaceutical preparation degradation in vivo, dissolving, disintegrate.
Description of drawings:
Fig. 1 is the composition sketch map of digitalization pulsed-release electronic capsule of the present invention.
Fig. 2 is the outside drawing with digitalization pulsed-release electronic capsule of 4 miniature medicine holding bins of the present invention.
Fig. 3 is the outside drawing with digitalization pulsed-release electronic capsule of 9 miniature medicine holding bins of the present invention.
Fig. 4 is the outside drawing with digitalization pulsed-release electronic capsule of 16 miniature medicine holding bins of the present invention.
Fig. 5 is the outside drawing with digitalization pulsed-release electronic capsule of 25 miniature medicine holding bins of the present invention.
Fig. 6 is the array medicine-feeder structural representation that comprises little chemical propeller of the present invention.
Fig. 7 is drug release process (in the release) sketch map that comprises the array medicine-feeder of little chemical propeller of the present invention.
Fig. 8 is drug release process (release is finished) sketch map that comprises the array medicine-feeder of little chemical propeller of the present invention.
Fig. 9 is a kind of release pulse signal generating process and the corresponding plasma concentration curve figure that comprises the digitalization pulsed-release electronic capsule of 4 miniature medicine holding bins of the present invention.
Figure 10 is a kind of structural representation that comprises the angle of rake array medicine-feeder of micromechanics of the present invention.
Figure 11 is a kind of structural representation that comprises the angle of rake array medicine-feeder of micromechanics of the present invention.
Figure 12 is drug release process (in the release) sketch map that comprises the angle of rake array medicine-feeder of micromechanics of the present invention.
Figure 13 is drug release process (release is finished) sketch map that comprises the angle of rake array medicine-feeder of micromechanics of the present invention.
Figure 14 is the outside drawing with digitalization pulsed-release electronic capsule of 6 miniature medicine holding bins of the present invention.
Figure 15 is a kind of release pulse signal generating process and the corresponding plasma concentration curve figure that comprises the digitalization pulsed-release electronic capsule of 6 miniature medicine holding bins of the present invention.
In Fig. 1 to Figure 15:
The 1-shell, the 2-starting switch, the 3-power supply, 4-digitized pulse generating circuit, 5-array medicine-feeder,
6-release drive array, 7-medicine holding bin array, 8-release driver, the miniature medicine holding bin of 9-,
The little chemical propeller of 10-, the 11-lighter, 12-propellant storehouse, the 13-propellant, the 14-piston,
The departing seal head of 15-, 16-medicine to be discharged, 17-micromechanics propeller, 18-slight fever resistance,
The 19-Microspring, 20-spring fixator, 21-low melting point polymerization line, 22-diaphragm seal
The specific embodiment:
Embodiment 1:
The digitalization pulsed-release electronic capsule of present embodiment, as shown in Figure 1, comprise shell 1, starting switch 2, power supply 3, digitized pulse generating circuit 4 and array medicine-feeder 5, described array medicine-feeder comprise a release drive array 6 and a medicine holding bin array 7, and the release drive array comprises N release microdrive 8, the medicine holding bin array comprises N miniature medicine holding bin 9, according to actual needs with process conditions permissions, N can be for more than or equal to 2 and less than 1000 natural number, in the present embodiment, the value of N is preferably N=4,6,9,16,25, respectively as Fig. 2, Figure 14, Fig. 3, Fig. 4, shown in Figure 5.
Each release microdrive 8 and a miniature medicine holding bin 9 constitute a miniature release unit, miniature medicine holding bin 9 is used for encapsulation and waits to discharge medicine 16, each release microdrive 8 has circuit with digitized pulse generating circuit 4 and is connected, digitized pulse generating circuit 4 produces the pulse electrical signal of certain strength according to predefined frequency, interval, and put on pulse electrical signal on each release microdrive 8 in the array medicine-feeder 5 respectively and trigger the work of release microdrive according to predetermined sequential, drug release is gone out miniature medicine holding bin 9.
In the present embodiment, release microdrive 8 is a little chemical propeller 10, as shown in Figure 6.This little chemical propeller 10 comprises lighter 11, propellant storehouse 12, propellant 13, described miniature medicine holding bin 9 comprises a piston 14, piston is encapsulated between propellant storehouse 12 and the miniature medicine holding bin 9, the other end of miniature medicine holding bin 9 is departing seal heads 15, departing seal head 15 generally is made by the medical plastic with good biocompatibility, as silicone rubber, also can form for degradable other biological material, the frictional force of the inwall of departing seal head 15 and miniature medicine holding bin 9 is generally between 0.2-5 newton, can guarantee sealing, can under suitable propulsive force, break away from again.Miniature medicine holding bin 9 also comprises the structure that prevents that piston breaks away from.
The processing technique of this little chemical propeller 10 can be with reference to the processing technique that is used for the miniature micro-thruster of micro-nano, and its rapidoprint can carry out on silica-based, also can carry out on polymer or metal, and wherein little propellant can be the chemical propellant of routine.Lighter 11 in the present embodiment can be a miniature heating resistor, pulse signal can be a pulse voltage signal, this pulse voltage signal makes miniature heating resistor temperature raise fast, thereby light propellant, propellant actuated piston 14 travels forward, the pressure that produces forces departing seal head 15 to break away from, and then medicine breaks away from medicine holding bin 9 and discharges.Its work process such as Fig. 7, shown in Figure 8, wherein Fig. 7 is that one of them release driver is just at the work process sketch map of release, Fig. 8 is the sketch map that one of them release driver has been finished drug release process, treating in the sketch map discharges medicine 16 and is liquid preparation, in implementation process, also can be powder formulation or microparticle preparation or Formulation.
The length of the digitalization pulsed-release electronic capsule of present embodiment is between 20-40mm, and diameter is between 6-15mm, and preferred sizes is that length is 28mm, diameter 10mm.Capsule shell 1 is for medical plastic is made, as Merlon.Digitized pulse generating circuit in the present embodiment comprises an one chip microcomputer or a miniature special IC, and the size of single-chip microcomputer satisfies capsular size and energy expenditure requirement.Described starting switch is the magnetic switch that is in closure state under the normal condition, before capsule is swallowed, magnetic switch is near a permanent magnet, the magnetic field that this permanent magnet produces makes magnetic switch disconnect, thereby make the circuit of digitalization pulsed-release electronic capsule disconnect, after swallowing, the magnetic switch closure, circuit turn-on, digitized pulse generating circuit 4 is started working.
Fig. 9 is a kind of release pulse signal generating process and the corresponding plasma concentration curve sketch map of the digitalization pulsed-release electronic capsule that comprises 4 miniature medicine holding bins of present embodiment.Digitalization pulsed-release electronic capsule 6 hours after swallowing, 12 hours, 18 hours, sent the release pulse signal in 24 hours respectively, medicine is at above-mentioned time point, respectively by discharging in the different miniature medicine holding bins, medicine enters blood circulation by digestive tract, produces corresponding plasma concentration curve, respectively 6 hours after swallowing, 12 hours, 18 hours, near the interval 24 hours produced 4 blood drug level peak values, thereby realizes specific therapeutic effect, as shown in Figure 9, can adjust corresponding plasma concentration curve by the interval of adjusting the release pulse signal.
Embodiment 2:
The digitalization pulsed-release electronic capsule of present embodiment, basic structure and embodiment 1 are similar, as shown in Figure 1, comprise shell 1, starting switch 2, power supply 3, digitized pulse generating circuit 4 and array medicine-feeder 5, described array medicine-feeder comprises a release drive array 6 and a medicine holding bin array 7, the release drive array comprises N release microdrive 8, and the medicine holding bin array comprises N miniature medicine holding bin 9, permits with process conditions according to actual needs, N can be for more than or equal to 2 and less than 1000 natural number, in the present embodiment, the value of N is preferably N=4, and 6,9,16,25, respectively as Fig. 2, Figure 14, Fig. 3, Fig. 4, shown in Figure 5.
Each release microdrive 8 and a miniature medicine holding bin 9 constitute a miniature release unit, miniature medicine holding bin 9 is used for encapsulation and waits to discharge medicine 16, each release microdrive 8 has circuit with digitized pulse generating circuit 4 and is connected, digitized pulse generating circuit 4 produces the pulse electrical signal of certain strength according to predefined frequency, interval, and put on pulse electrical signal on each release microdrive 8 in the array medicine-feeder 5 respectively and trigger the work of release microdrive according to predetermined sequential, drug release is gone out miniature medicine holding bin 9.
In the present embodiment, release microdrive 8 is a micromechanics propeller 17, and is as Figure 10, shown in Figure 11.This micromechanics propeller 17 comprises slight fever resistance 18, Microspring 19, spring fixator 20, spring fixator 20 is connected by the low melting point adhesive securement with slight fever resistance 18 or is fixedly connected by low melting point polymerization line 21, Microspring 19 is in compressive state, described miniature medicine holding bin 9 comprises a piston 14, piston 14 is encapsulated between spring fixator 20 and the miniature medicine holding bin 9, the sealing of the other end of miniature medicine holding bin 9, can be with departing seal head 15 sealings that utilize among the embodiment 1, also can be by diaphragm seal 22 sealings, diaphragm seal 22 is made for medical plastic or other polymer with good biocompatibility, and its thickness is between 0.05mm-0.3mm.Miniature medicine holding bin 9 also comprises the structure that prevents that piston breaks away from.
The processing technique of this micromechanics propeller 10 can be carried out with the accurate micromachined technology of routine.The pulse signal that digitized pulse generating circuit 4 produces in the present embodiment can be a pulse voltage signal, this pulse voltage signal makes slight fever resistance 18 temperature raise fast, thereby make that bonding agent is softening or make 21 fusing of low melting point polymerization line, the Microspring 19 that is in compressive state is released also, and driven plunger 14 travels forward, the pressure that produces forces diaphragm seal 22 to break, and then medicine breaks away from medicine holding bin 9 and discharges.Its work process as shown in Figure 12 and Figure 13, wherein Figure 12 be one of them release driver just at the work process sketch map of release, Figure 13 is the sketch map that one of them release driver has been finished drug release process.Treating in the sketch map discharges medicine 16 and is liquid preparation, in implementation process, also can be powder formulation or microparticle preparation or Formulation.
The length of the digitalization pulsed-release electronic capsule of present embodiment is between 20-40mm, and diameter is between 6-15mm, and preferred sizes is that length is 29mm, diameter 11mm.Capsule shell 1 is for medical plastic is made, as makrolon material.Digitized pulse generating circuit in the present embodiment comprises an one chip microcomputer or a miniature special IC, and the size of single-chip microcomputer satisfies capsular size and energy expenditure requirement.Described starting switch is the magnetic switch that is in closure state under the normal condition, before capsule is swallowed, magnetic switch is near a permanent magnet, the magnetic field that this permanent magnet produces makes magnetic switch disconnect, thereby make the circuit of digitalization pulsed-release electronic capsule disconnect, after swallowing, the magnetic switch closure, circuit turn-on, digitized pulse generating circuit 4 is started working.
Figure 15 is a kind of release pulse signal generating process and the corresponding about concentration curve of blood of the digitalization pulsed-release electronic capsule that comprises 6 miniature medicine holding bins of present embodiment.Digitalization pulsed-release electronic capsule 6 hours after swallowing, 12 hours, 14 hours, 16 hours, 18 hours, sent the release pulse signal in 24 hours, medicine is at above-mentioned time point, respectively by discharging in the different miniature medicine holding bins, medicine enters blood circulation by digestive tract, produce corresponding plasma concentration curve, 6 hours after swallowing respectively, 12 hours, 14 hours, 16 hours, 18 hours, near the interval 24 hours produced 6 blood drug level peak values, thereby realize specific therapeutic effect, and carry out drug release 4 times between after swallowing 12 hours and 18 hours, and its interval has only 2 hours, thus after swallowing 12 hours and 18 hours have formed a relatively large blood drug level zone near the interval, play specific therapeutic effect, thereby this embodiment explanation can obtain specific plasma concentration curve by the interval of adjusting the release pulse signal, thereby realizes personalized treatment, has the advantage that traditional oral formulations does not have.
Claims (7)
1. digitalization pulsed-release electronic capsule, comprise shell, power supply, starting switch, it is characterized in that described digitalization pulsed-release electronic capsule comprises digitized pulse generating circuit and array medicine-feeder, described array medicine-feeder comprises a release drive array and a medicine holding bin array, the release drive array comprises N release microdrive, the medicine holding bin array comprises N miniature medicine holding bin, wherein N is more than or equal to 2 and less than 1000 natural number, each release microdrive and a miniature medicine holding bin constitute a miniature release unit, miniature medicine holding bin is used for encapsulation medicine to be discharged, each release microdrive has circuit with the digitized pulse generating circuit and is connected, the digitized pulse generating circuit is according to predefined frequency, produce the pulse electrical signal of certain strength at interval, and put on pulse electrical signal on each release microdrive in the array medicine-feeder respectively and trigger the work of release microdrive according to predetermined sequential, drug release is gone out miniature medicine holding bin.
2. digitalization pulsed-release electronic capsule according to claim 1 is characterized in that: the release microdrive in the described array medicine-feeder is a little chemical propeller, and this little chemical propeller comprises lighter, propellant storehouse, propellant.
3. digitalization pulsed-release electronic capsule according to claim 2 is characterized in that: described miniature medicine holding bin comprises a piston, and piston is encapsulated between propellant storehouse and the miniature medicine holding bin.
4. digitalization pulsed-release electronic capsule according to claim 1, it is characterized in that: the release microdrive in the described array medicine-feeder is a micromechanics propeller, this micromechanics propeller comprises slight fever resistance, Microspring, spring fixator, spring fixator is connected by the low melting point adhesive securement with slight fever resistance or is fixedly connected by low melting point polymerization line, and Microspring is in compressive state.
5. digitalization pulsed-release electronic capsule according to claim 4 is characterized in that: described miniature medicine holding bin comprises a piston, and piston is encapsulated between spring fixator and the miniature medicine holding bin.
6. digitalization pulsed-release electronic capsule according to claim 1 is characterized in that: the digitized pulse generating circuit comprises an one chip microcomputer or a miniature special IC.
7. digitalization pulsed-release electronic capsule according to claim 1 is characterized in that: described starting switch is the magnetic switch that is in closure state under the normal condition.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100695664A CN101259301A (en) | 2008-04-18 | 2008-04-18 | Digitalization pulsed-release electronic capsule |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100695664A CN101259301A (en) | 2008-04-18 | 2008-04-18 | Digitalization pulsed-release electronic capsule |
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| CN101259301A true CN101259301A (en) | 2008-09-10 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102240981A (en) * | 2011-07-12 | 2011-11-16 | 天津市中环天佳电子有限公司 | Sandblasting position controlling device |
| CN103418075A (en) * | 2012-05-21 | 2013-12-04 | 国际商业机器公司 | Method and system dispensing drugs from a companion diagnostic linked smart pill |
| EP3508081B1 (en) | 2010-08-24 | 2021-07-21 | JT International S.A. | Inhalation device including substance usage controls |
| CN113545734A (en) * | 2021-08-31 | 2021-10-26 | 武汉大学 | Magnetic control dual-drive medicine applying capsule robot |
| CN113576374A (en) * | 2021-08-31 | 2021-11-02 | 武汉大学 | Plate spring driven magnetic control medicine applying capsule robot |
| CN113576373A (en) * | 2021-08-31 | 2021-11-02 | 武汉大学 | Magnetic control micro-needle puncture medicine applying capsule |
-
2008
- 2008-04-18 CN CNA2008100695664A patent/CN101259301A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3508081B1 (en) | 2010-08-24 | 2021-07-21 | JT International S.A. | Inhalation device including substance usage controls |
| CN102240981A (en) * | 2011-07-12 | 2011-11-16 | 天津市中环天佳电子有限公司 | Sandblasting position controlling device |
| CN103418075A (en) * | 2012-05-21 | 2013-12-04 | 国际商业机器公司 | Method and system dispensing drugs from a companion diagnostic linked smart pill |
| US10251553B2 (en) | 2012-05-21 | 2019-04-09 | International Business Machines Corporation | Dispensing drugs from a companion diagnostic linked smart pill |
| US10264972B2 (en) | 2012-05-21 | 2019-04-23 | International Business Machines Corporation | Dispensing drugs from a companion diagnostic linked smart pill |
| CN113545734A (en) * | 2021-08-31 | 2021-10-26 | 武汉大学 | Magnetic control dual-drive medicine applying capsule robot |
| CN113576374A (en) * | 2021-08-31 | 2021-11-02 | 武汉大学 | Plate spring driven magnetic control medicine applying capsule robot |
| CN113576373A (en) * | 2021-08-31 | 2021-11-02 | 武汉大学 | Magnetic control micro-needle puncture medicine applying capsule |
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