CN1951338A - Alimentary tract drug release remote controlled capsule system - Google Patents
Alimentary tract drug release remote controlled capsule system Download PDFInfo
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- CN1951338A CN1951338A CN 200610095210 CN200610095210A CN1951338A CN 1951338 A CN1951338 A CN 1951338A CN 200610095210 CN200610095210 CN 200610095210 CN 200610095210 A CN200610095210 A CN 200610095210A CN 1951338 A CN1951338 A CN 1951338A
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Abstract
The invention relates to an enteron remote-control drug release capsule system. Wherein, it comprises external remote controller and electric capsule; the electric capsule comprises frame, remote-control circuit, spring, piston, positioning mark resource, and drug release channel; the remote-control circuit has electromagnetic couple unit, without energy storage unit; the couple unit comprises couple antenna, resonance circuit; the external remote controller comprises a high-frequency electromagnetic field generator; the couple antenna couples the electromagnetic energy generated by said high-frequency electromagnetic field generator, to obtain the resonance voltage via the resonance circuit; said resonance voltage is generated by micro heating resistance and other circuits of electric capsule. The invention has small volume and high safety.
Description
Technical field:
The present invention relates to a kind of alimentary tract drug release remote controlled capsule system, be used for digestive tract remote control h substance, as medicine, food, label etc. at animal or human's body.
Background technology:
Drug release remote controlled capsule system is a kind of drug delivery system based on the micromechanics electronic technology, can be by external remote control, the control medicine has excellent application value in gastral release time and off-position aspect clinical treatment, the medicine digestive tract Absorption Study.A kind of digestive tract medicine fixed point releasing device is disclosed in Chinese patent CN200410040809.3, comprise external remote-control gear and the electronic capsule that can swallow, electronic capsule comprises shell, battery, the remote control circuit module, spring, piston, medicine holding bin, the drug release passage mechanism, the telltale mark source, it is characterized in that piston, cavity between outer casing inner wall and the drug release passage mechanism constitutes medicine holding bin, the remote control circuit module comprises a miniature heating resistor, low-melting polymer line is fixed on a end in the electronic capsule shell with piston, spring be in compressive state and be restrained to piston and the remote control circuit module between, polymer line contacts with miniature heating resistor, the remote control circuit module is connected circuit after receiving the remote signal of external remote-control gear emission, miniature heating resistor temperature under the power supply effect raises rapidly, the fusing polymer line, the spring that is in compressive state obtains discharging, piston under the driving of spring to the other end motion of electronic capsule, the drug release passage mechanism is opened under the pressure effect that the piston motion produces, and the medicine in the medicine holding bin discharges by the drug release passage mechanism that has been opened.
There are following two shortcomings in foregoing invention: one is the energy employing button cell of electronic capsule, battery exists chronic power consumption phenomenon, therefore, after the encapsulated, the power consumption meeting of battery causes reliability decrease, button cell contains harmful composition in addition, in case capsule is revealed, can cause potential injury to human body, in addition, because technology limitation, the volume of button cell is bigger, has occupied bigger space, cause the capsule volume big, be difficult to swallow, perhaps cause the medicine holding bin volume less, be difficult to enough medicines of packing into.The another one shortcoming is, after triggering capsule and discharging the medicine action, whether medicine successfully discharges, and lacks authorization information, and the manipulation in vitro personnel can't know whether and successfully trigger drug release.
Summary of the invention:
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of structure to simplify list, high security, have the digestive tract medicine fixed point releasing device that triggers deictic function.
Technical scheme of the present invention is: alimentary tract drug release remote controlled capsule system comprises external remote control unit and electronic capsule, electronic capsule comprises shell, the remote control circuit module, spring, piston, the telltale mark source, the drug release passage mechanism, its piston, cavity between outer casing inner wall and the drug release passage mechanism constitutes medicine holding bin, the remote control circuit module comprises a miniature heating resistor, low-melting polymer line is fixed on a end in the electronic capsule shell with piston, spring be in compressive state and be restrained to piston and the remote control circuit module between, polymer line contacts with miniature heating resistor.The remote control circuit module comprises the electromagnetic energy coupling unit, and do not comprise the energy-storage units that has stored electric energy, the electromagnetic energy coupling unit comprises coupled antenna, resonance circuit, external remote control unit comprises an electromagnetic field of high frequency generating means, the energy of electromagnetic field that coupled antenna coupling electromagnetic field of high frequency generating means is produced, and by resonance circuit acquisition resonance potential, this resonance potential is other components power supplies in miniature heating resistor and the electronic capsule.
Comprise a microcircuit switching mechanism, a miniature radio-frequency generation circuit in the remote control circuit module, its circuit structure is: the microcircuit switching mechanism with constitute series circuit with miniature heating resistor, electromagnetic energy coupling unit after miniature radio-frequency generation circuit is in parallel; When microcircuit switching mechanism closing of circuit, miniature radio-frequency generation circuit is supplied with because of the electric energy that the closed short circuit of microcircuit switch can't obtain the electromagnetic energy coupling unit, and the electromagnetic energy coupling unit is only to miniature heating resistor power supply; When microcircuit switching mechanism circuit disconnects, miniature radio-frequency generation circuit, miniature heating resistor and electromagnetic energy coupling unit are connected in series, circuit turn-on, the electromagnetic energy coupling unit is to miniature heating resistor and miniature radio-frequency generation circuit supply, miniature radio-frequency generation circuit is to external electromagnetic signals, and the frequency of electromagnetic wave signal is greater than 100KHZ.
The microcircuit switching mechanism comprises a thin footpath lead that can disconnect under mechanical pulling force effect, concrete structure is: between 2 in the microcircuit switching mechanism circuit, utilize diameter between 0.01～0.1mm, the thin footpath wire coupling of length between 0.5mm～3mm, the two ends of a nylon wire are fixed on the piston, form a ring, thin footpath lead passes in the ring of nylon wire formation, when piston is in a fixed position, the wire circuit conducting of thin footpath is the closure state of described microcircuit switching mechanism; When piston during to an end motion, the motion of piston pulling nylon wire, nylon wire produces pressure to thin footpath lead, and thin footpath lead ruptures under pressure, and circuit disconnects, and is the off-state of described microcircuit switching mechanism.
The microcircuit switching mechanism comprises a miniature magnetic switch, and this miniature magnetic switch is a normally open, switch closure under the effect of static magnetic field; The piston of electronic capsule is the permanent magnet material making or has embedded permanent magnet that in piston when piston was fixed on remote control circuit module one end, the static magnetic field in the piston made and miniature magnetic switch closure is the closure state of described microcircuit switching mechanism; When piston during to an end motion, field decay, miniature magnetic switch circuit disconnects, and is the off-state of described microcircuit switching mechanism.
Work process of the present invention is: the volunteer, after perhaps the patient swallows electronic capsule, utilize the radioscopy machine, B ultrasonic, existing armarium such as ECT, the perhaps special-purpose position of locating and tracking system monitoring electronic capsule in digestive tract, when arriving the appointed area, the electromagnetic field of high frequency launched in external remote control unit, be arranged in the energy of electromagnetic field that the coupled antenna coupling electromagnetic field of high frequency generating means of the electronic capsule of digestive tract is produced, and by resonance circuit acquisition resonance potential, this resonance potential is other component power supplies in miniature heating resistor and the electronic capsule, miniature heating resistor is under the power supply effect, temperature raises rapidly and the fusing polymer line, piston the compression spring driving under to the other end motion of electronic capsule, under the pressure effect that the piston motion produces, sealing-plug comes off, and the medicine in the medicine holding bin discharges by the drug release passage mechanism that has been opened.Meanwhile, when piston moves, piston make the microcircuit switching mechanism be in closure state originally become off-state, the conducting of miniature radio-frequency generation circuit to an end motion, miniature radio-frequency generation circuit is indicated the carrying out of drug release action to external electromagnetic signals.
The present invention compared with prior art has following technique effect:
1, structure is simplified, high security.The present invention compares with the conventional art scheme, utilizes coupling body external electromagnetic field energy to obtain power supply, has omitted battery, has not only saved the space effectively, makes structure simplify more, and avoided the potential injury of battery leakage to human body that safety is higher.
2, improve reliability, and had the deictic function after the drug release action is carried out.The present invention program has avoided battery to exist chronic power consumption phenomenon, and the reliability of control has obtained further raising.Simultaneously, on behalf of the drug release action, piston successfully triggered to an end motion, and the motion of piston has caused the miniature radio-frequency circuit to external electromagnetic signals, and this electromagnetic wave signal has indicated the success of drug release action to carry out.
Description of drawings:
Fig. 1 is a system of the present invention composition diagram.
Fig. 2 is that coupled antenna is the electronic capsule structural representation of solenoid type.
Fig. 3 is that coupled antenna is the remote control circuit modular circuit sketch map of solenoid type.
Fig. 4 is that coupled antenna is the electronic capsule structural representation of multilayer planar spiral winding formula.
Fig. 5 is a multilayer planar spiral winding formula antenna structure view.
Fig. 6 is that coupled antenna is the remote control circuit modular circuit sketch map of multilayer planar spiral winding formula.
Fig. 7 is that coupled antenna is the electronic capsule structural representation of multilayer planar spiral winding formula and solenoid type combination.
Fig. 8 is that coupled antenna is the remote control circuit modular circuit sketch map of multilayer planar spiral winding formula and solenoid type combination.
Fig. 9 is the remote control circuit modular circuit sketch map that contains microcircuit switching mechanism and miniature radio-frequency generation circuit.
Figure 10 is that the microcircuit switching mechanism is in the remote control circuit modular circuit sketch map under the closing of circuit state.
Figure 11 is that the microcircuit switching mechanism is in the remote control circuit modular circuit sketch map under the circuit off-state.
Figure 12 is a kind of electronic capsule structural representation with microcircuit switching mechanism.
Figure 13 is a kind of structural representation of microcircuit switching mechanism.
Figure 14 is a kind of electronic capsule structural representation with microcircuit switching mechanism.
Figure 15 is a kind of structural representation of microcircuit switching mechanism.
In Fig. 1 to Figure 15:
The external remote control unit of 1-, 2-electronic capsule, 3-remote control circuit module, the miniature heating resistor of 4-, the 5-polymer line, 6-spring, 7-piston, 8-telltale mark source, the 9-shell, 10-drug release passage mechanism, 11-sealing-plug, 12-solenoid type coupled antenna, the 13-medicinal liquid, 14-resonance circuit, 15-multilayer planar helix ring type coupled aerial, the 16-planar spiral winding, 17-contactor mechanism, 18-miniature radio-frequency generation circuit, the thin footpath of 19-lead, 20-nylon wire, the miniature magnetic switch of 21-
The specific embodiment:
A kind of alimentary tract drug release remote controlled capsule system, comprise external remote control unit [1] and electronic capsule [2], electronic capsule [2] comprises shell [9], remote control circuit module [3], spring [6], piston [7], telltale mark source [8], drug release passage mechanism [10], its piston, cavity between outer casing inner wall and the drug release passage mechanism constitutes medicine holding bin, remote control circuit module [3] comprises a miniature heating resistor [4], a low-melting polymer line [5] is fixed on the interior end of electronic capsule shell with piston [7], spring [6] be in compressive state and be restrained to piston [7] and remote control circuit module [3] between, polymer line [5] contacts with miniature heating resistor [4].Drug release passage mechanism [10] is a manhole, utilizes sealing-plug [11] sealing.Telltale mark source [8] is permanent magnet or is the medical radioactive tracer; For conserve space, telltale mark source [8] can be embedded into or be encapsulated among the piston [7].
Remote control circuit module [3] in the electronic capsule [2] comprises the electromagnetic energy coupling unit, and do not comprise the energy-storage units that has stored electric energy, the electromagnetic energy coupling unit comprises coupled antenna [12,15], resonance circuit [14], external remote control unit comprises an electromagnetic field of high frequency generating means, coupled antenna [12,15] energy of electromagnetic field that produced of coupling electromagnetic field of high frequency generating means, and by resonance circuit [14] acquisition resonance potential, this resonance potential is other components power supplies in miniature heating resistor [4] and the electronic capsule.
Included coupled antenna in the remote control circuit module, its structure can be solenoid type coupled antenna [12], antenna is wrapped between the inwall and outer wall of shell, and antenna material is copper enamel-covered wire or silver-plated enamel-covered wire or multiply enamel-covered wire, and antenna diameter is between 0.05mm to 0.3mm.The structure of coupled antenna also can be multilayer planar helix ring type coupled aerial [15], connect or compose in parallel by multilayer planar spiral winding [16], mutually insulated is isolated between the helix ring layer, its isolated material is insullac or magnetic media material, the thickness of helix ring layer can be processed multilayer planar helix ring type coupled aerial [15] by LTCC (low temperature co-fired multi-layer ceramics) technology between 0.05mm to 0.3mm.The structure of coupled antenna also can connecting or combination in parallel for solenoid type antenna [12] and multilayer planar spiral winding formula antenna [15].
Comprise a microcircuit switching mechanism [17], a miniature radio-frequency generation circuit [18] in the remote control circuit module [3], its circuit structure is: microcircuit switching mechanism [17] back in parallel with miniature radio-frequency generation circuit [18] constitutes series circuit with miniature heating resistor [4], electromagnetic energy coupling unit; When microcircuit switching mechanism [17] closing of circuit, miniature radio-frequency generation circuit [18] is because of the closed short circuit of microcircuit switch [17] and the circuit disconnection of electromagnetic energy coupling unit, and the electromagnetic energy coupling unit is only to miniature heating resistor power supply; When microcircuit switching mechanism [17] circuit disconnects, miniature radio-frequency generation circuit [18], miniature heating resistor [4] are connected in series with the electromagnetic energy coupling unit, circuit turn-on, the electromagnetic energy coupling unit is to miniature heating resistor [4] and miniature radio-frequency generation circuit [18] power supply, miniature radio-frequency generation circuit [18] is to external electromagnetic signals, and the frequency of electromagnetic wave signal is greater than 100KHZ.
Microcircuit switching mechanism [17] can be following structure: microcircuit switching mechanism [17] comprises a thin footpath lead that can disconnect under mechanical pulling force effect, concrete structure is: between 2 in the microcircuit switching mechanism circuit, utilize diameter between 0.01-0.1mm, length connects at the thin footpath of 0.5mm-3mm lead [19], the two ends of a nylon wire [20] are fixed on the piston [7], form a ring, thin footpath lead [19] passes in the ring of nylon wire [20] formation, when piston [7] when being in a fixed position, thin footpath lead [19] circuit turn-on is the closure state of described microcircuit switching mechanism [17]; When piston [7] during to an end motion, piston [7] pulling nylon wire [20] produces pressure to thin footpath lead [19], and thin footpath lead [19] rupture under pressure, and the circuit disconnection is the off-state of described microcircuit switching mechanism [17].
Microcircuit switching mechanism [17] also can be following structure: microcircuit switching mechanism [17] comprises a miniature magnetic switch [21], and this miniature magnetic switch is a normally open, switch closure under the effect of static magnetic field; Permanent magnet [8] is made or embedded to piston [7] for permanent magnet material in piston, when piston [7] is fixed on remote control circuit module [3] one ends, static magnetic field in the piston [7] makes and miniature magnetic switch [21] closure is the closure state of described microcircuit switching mechanism [17]; When piston [7] during to an end motion, field decay, miniature magnetic switch [21] circuit disconnects, and is the off-state of described microcircuit switching mechanism [17].
Work process of the present invention is: the volunteer, after perhaps the patient swallows electronic capsule [2], utilize the radioscopy machine, B ultrasonic, existing armarium such as ECT, the perhaps special-purpose position of locating and tracking system monitoring electronic capsule [2] in digestive tract, when arriving the appointed area, the electromagnetic field of high frequency launched in external remote control unit [1], be arranged in the coupled antenna [12 of the electronic capsule [2] of digestive tract, 15] energy of electromagnetic field that produced of coupling electromagnetic field of high frequency generating means, and by resonance circuit [14] acquisition resonance potential, this resonance potential is other component power supplies in miniature heating resistor [4] and the electronic capsule, miniature heating resistor [4] is under the power supply effect, temperature raises rapidly and fusing polymer line [5], piston [7] the compression spring [6] driving under to the other end motion of electronic capsule, under the pressure effect that the piston motion produces, the drug release passage mechanism is opened, and the medicine in the medicine holding bin discharges by the drug release passage mechanism that has been opened.Meanwhile, when piston moves, piston make the microcircuit switching mechanism [17] be in closure state originally become off-state to an end motion, miniature radio-frequency generation circuit [18] circuit turn-on, miniature radio-frequency generation circuit [18] is to external electromagnetic signals.
Fig. 1 is that the system of present embodiment forms, and system comprises external remote control unit [1] and electronic capsule [2].The size of electronic capsule is generally: diameter is less than 12mm, and length is generally less than 35mm.
Fig. 2 is a kind of structure chart of the electronic capsule of present embodiment, electronic capsule [2] comprises shell [9], remote control circuit module [3], spring [6], piston [7], telltale mark source [8], drug release passage mechanism [10], cavity between its piston, outer casing inner wall and the drug release passage mechanism constitutes medicine holding bin, in medicinal liquid [13] the encapsulation medicine holding bin.Telltale mark source [8] is a permanent magnet, and for conserve space, telltale mark source [8] are embedded in the piston [7].Remote control circuit module [3] comprises a miniature heating resistor [4], a low-melting polymer line [5] is fixed on the interior end of electronic capsule shell with piston [7], spring [6] be in compressive state and be restrained to piston [7] and remote control circuit module [3] between, polymer line [5] contacts with miniature heating resistor [4].Remote control circuit module [3] in the electronic capsule [2] comprises the electromagnetic energy coupling unit, and do not comprise the energy-storage units that has stored electric energy, the electromagnetic energy coupling unit comprises coupled antenna [12,15], resonance circuit [14], external remote control unit comprises an electromagnetic field of high frequency generating means, the energy of electromagnetic field that coupled antenna [12] coupling electromagnetic field of high frequency generating means is produced, and by resonance circuit [14] acquisition resonance potential, this resonance potential is other components power supplies in miniature heating resistor [4] and the electronic capsule.Included coupled antenna in the remote control circuit module, its structure can be solenoid type coupled antenna [12], provided the structure of coupled antenna among Fig. 2, coupled antenna is wrapped between the inwall and outer wall of shell, antenna material is copper enamel-covered wire or silver-plated enamel-covered wire or multiply enamel-covered wire, and antenna diameter is between 0.05mm to 0.3mm.
It is the remote control circuit modular circuit sketch map of solenoid type that Fig. 3 has provided coupled antenna.The energy of electromagnetic field that solenoid type coupled antenna [12] coupling electromagnetic field of high frequency generating means is produced, and by resonance circuit [14] acquisition resonance potential, this resonance potential is other components power supplies in miniature heating resistor [4] and the electronic capsule.
Fig. 4 is that coupled antenna is the electronic capsule structural representation of multilayer planar spiral winding formula.Other structures are identical with Fig. 2, and difference is that coupled antenna is a multilayer planar helix ring type coupled aerial [15].
Fig. 5 is a multilayer planar spiral winding formula antenna structure view.Multilayer planar helix ring type coupled aerial [15] is connected by multilayer planar spiral winding [16] or is composed in parallel, mutually insulated is isolated between the helix ring layer, its isolated material is insullac or magnetic media material, the thickness of helix ring layer can be processed multilayer planar helix ring type coupled aerial [15] by LTCC (low temperature co-fired multi-layer ceramics) technology between 0.05mm to 0.3mm.
Fig. 6 is that coupled antenna is the remote control circuit modular circuit sketch map of multilayer planar spiral winding formula.The energy of electromagnetic field that multilayer planar helix ring type coupled aerial [15] coupling electromagnetic field of high frequency generating means is produced, and by resonance circuit [14] acquisition resonance potential, this resonance potential is other components power supplies in miniature heating resistor [4] and the electronic capsule.
Fig. 7 is that coupled antenna is the electronic capsule structural representation of multilayer planar spiral winding formula and solenoid type combination.The structure of coupled antenna also can solenoid type antenna [12] and the connecting or combination in parallel of multilayer planar spiral winding formula antenna [15].
Fig. 8 is that coupled antenna is the remote control circuit modular circuit sketch map of multilayer planar spiral winding formula and solenoid type combination.Solenoid type antenna [12] is connected or combination in parallel with multilayer planar spiral winding formula antenna [15], the energy of electromagnetic field that coupling electromagnetic field of high frequency generating means is produced, and by resonance circuit [14] acquisition resonance potential, this resonance potential is other components power supplies in miniature heating resistor [4] and the electronic capsule.
Fig. 9 is the remote control circuit modular circuit sketch map that contains contactor mechanism and miniature radio-frequency generation circuit.Comprise a microcircuit switching mechanism [17], a miniature radio-frequency generation circuit [18] in the remote control circuit module [3], its circuit structure is: microcircuit switching mechanism [17] back in parallel with miniature radio-frequency generation circuit [18] constitutes series circuit with miniature heating resistor [4], electromagnetic energy coupling unit; When microcircuit switching mechanism [17] closing of circuit, miniature radio-frequency generation circuit [18] is because of the closed short circuit of microcircuit switch [17] and the circuit disconnection of electromagnetic energy coupling unit, and the electromagnetic energy coupling unit is only to miniature heating resistor power supply; When microcircuit switching mechanism [17] circuit disconnects, miniature radio-frequency generation circuit [18], miniature heating resistor [4] are connected in series with the electromagnetic energy coupling unit, circuit turn-on, the electromagnetic energy coupling unit is to miniature heating resistor [4] and miniature radio-frequency generation circuit [18] power supply, miniature radio-frequency generation circuit [18] is to external electromagnetic signals, and the frequency of electromagnetic wave signal is greater than 100KHZ.
Figure 10 is that contactor mechanism is in the remote control circuit modular circuit sketch map under the closing of circuit state.Microcircuit switching mechanism [17] closing of circuit, miniature radio-frequency generation circuit [18] are because of the closed short circuit of microcircuit switch [17] and the circuit disconnection of electromagnetic energy coupling unit, and the electromagnetic energy coupling unit is only to miniature heating resistor power supply.
Figure 11 is that the microcircuit switching mechanism is in the remote control circuit modular circuit sketch map under the circuit off-state.Microcircuit switching mechanism [17] circuit disconnects, miniature radio-frequency generation circuit [18], miniature heating resistor [4] are connected in series with the electromagnetic energy coupling unit, circuit turn-on, the electromagnetic energy coupling unit is to miniature heating resistor [4] and miniature radio-frequency generation circuit [18] power supply, miniature radio-frequency generation circuit [18] is to external electromagnetic signals, and the frequency of electromagnetic wave signal is greater than 100KHZ.
Figure 12 is a kind of electronic capsule structural representation with microcircuit switching mechanism.The structure of microcircuit switching mechanism [17] is: between 2 in the circuit, utilize diameter between 0.01 ~ 0.1mm, length connects at the thin footpath of 0.5mm ~ 3mm lead [19], the two ends of a nylon wire [20] are fixed on the piston [7], form a ring, thin footpath lead [19] passes in the ring that nylon wire [20] constitutes, when piston [7] when being in a fixed position, thin footpath lead [19] circuit turn-on is the closure state of described microcircuit switching mechanism [17]; When piston [7] during to an end motion, piston [7] pulling nylon wire [20] produces pressure to thin footpath lead [19], and thin footpath lead [19] rupture under pressure, and the circuit disconnection is the off-state of described microcircuit switching mechanism [17].
Figure 13 is a kind of structural representation of microcircuit switching mechanism, the part of the microcircuit switching mechanism among Figure 12 has been awarded amplified explanation.
Figure 14 is a kind of electronic capsule structural representation with microcircuit switching mechanism; Microcircuit switching mechanism [17] also can be a miniature magnetic switch [21], this miniature magnetic switch [21] is a normally open, permanent magnet [8] is made or embedded to piston [7] for permanent magnet material in piston, when piston [7] is fixed on remote control circuit module [3] one ends, static magnetic field in the piston [7] makes and miniature magnetic switch [21] closure is the closure state of described microcircuit switching mechanism [17]; When piston [7] during to an end motion, field decay, miniature magnetic switch [21] circuit disconnects, and is the off-state of described microcircuit switching mechanism [17].
Figure 15 is a kind of structural representation of microcircuit switching mechanism; Part to the contactor mechanism among Figure 14 has awarded the amplification explanation.
Claims (7)
1. alimentary tract drug release remote controlled capsule system, comprise external remote control unit and electronic capsule, electronic capsule comprises shell, remote control circuit module, spring, piston, telltale mark source, drug release passage mechanism, cavity between its piston, outer casing inner wall and the drug release passage mechanism constitutes medicine holding bin, the remote control circuit module comprises a miniature heating resistor, low-melting polymer line is fixed on a end in the electronic capsule shell with piston, spring be in compressive state and be restrained to piston and the remote control circuit module between, polymer line contacts with miniature heating resistor; It is characterized in that the remote control circuit module in the electronic capsule comprises the electromagnetic energy coupling unit, and do not comprise the energy-storage units that has stored electric energy, the electromagnetic energy coupling unit comprises coupled antenna, resonance circuit, external remote control unit comprises an electromagnetic field of high frequency generating means, the energy of electromagnetic field that coupled antenna coupling electromagnetic field of high frequency generating means is produced, and by resonance circuit acquisition resonance potential, this resonance potential is other components power supplies in miniature heating resistor and the electronic capsule.
2. alimentary tract drug release remote controlled capsule system according to claim 1, it is characterized in that coupled antenna included in the remote control circuit module, its structure is a solenoid type, this solenoid type coupled antenna is wrapped between the inwall and outer wall of shell, antenna material is copper enamel-covered wire or silver-plated enamel-covered wire or multiply enamel-covered wire, and antenna diameter is between 0.05mm to 0.3mm.
3. alimentary tract drug release remote controlled capsule system according to claim 1, it is characterized in that coupled antenna included in the remote control circuit module, its structure is a multilayer planar spiral winding formula, this multilayer planar helix ring type coupled aerial is connected by the multilayer planar spiral winding or is composed in parallel, mutually insulated is isolated between the layer of spiral winding and the layer, its isolated material is insullac or magnetic media material, and the thickness of helix ring layer is between 0.05mm to 0.3mm.
4. alimentary tract drug release remote controlled capsule system according to claim 1 is characterized in that coupled antenna included in the remote control circuit module, and its structure is the solenoid type coupled antenna and the connecting or combination in parallel of multilayer planar helix ring type coupled aerial.
5. alimentary tract drug release remote controlled capsule system according to claim 1, it is characterized in that comprising in the remote control circuit module microcircuit switching mechanism, a miniature radio-frequency generation circuit, its circuit structure is: the microcircuit switching mechanism with constitute series circuit with miniature heating resistor, electromagnetic energy coupling unit after miniature radio-frequency generation circuit is in parallel; When microcircuit switching mechanism closing of circuit, miniature radio-frequency generation circuit is supplied with because of the electric energy that the closed short circuit of microcircuit switch can't obtain the electromagnetic energy coupling unit, and the electromagnetic energy coupling unit is only to miniature heating resistor power supply; When microcircuit switching mechanism circuit disconnects, miniature radio-frequency generation circuit, miniature heating resistor and electromagnetic energy coupling unit are connected in series, circuit turn-on, the electromagnetic energy coupling unit is to miniature heating resistor and miniature radio-frequency generation circuit supply, miniature radio-frequency generation circuit is to external electromagnetic signals, and the frequency of electromagnetic wave signal is greater than 100KHZ.
6. alimentary tract drug release remote controlled capsule system according to claim 5, it is characterized in that the microcircuit switching mechanism comprises a thin footpath lead that can disconnect under mechanical pulling force effect, concrete structure is: between 2 in the microcircuit switching mechanism circuit, utilize diameter between 0.01～0.1mm, the thin footpath wire coupling of length between 0.5mm～3mm, the two ends of a nylon wire are fixed on the piston, form a ring, thin footpath lead passes in the ring of nylon wire formation, when piston is in a fixed position, the wire circuit conducting of thin footpath is the closure state of described microcircuit switching mechanism; When piston during to an end motion, the motion of piston pulling nylon wire, nylon wire produces pressure to thin footpath lead, and thin footpath lead ruptures under pressure, and circuit disconnects, and is the off-state of described microcircuit switching mechanism.
7. alimentary tract drug release remote controlled capsule system according to claim 5 is characterized in that the microcircuit switching mechanism comprises a miniature magnetic switch, and this miniature magnetic switch is a normally open, switch closure under the effect of static magnetic field; The piston of electronic capsule is the permanent magnet material making or has embedded permanent magnet that in piston when piston was fixed on remote control circuit module one end, the static magnetic field in the piston made and miniature magnetic switch closure is the closure state of described microcircuit switching mechanism; When piston during to an end motion, field decay, miniature magnetic switch circuit disconnects, and is the off-state of described microcircuit switching mechanism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610095210A CN100588378C (en) | 2006-11-16 | 2006-11-16 | Alimentary tract drug release remote controlled capsule system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610095210A CN100588378C (en) | 2006-11-16 | 2006-11-16 | Alimentary tract drug release remote controlled capsule system |
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| CN1951338A true CN1951338A (en) | 2007-04-25 |
| CN100588378C CN100588378C (en) | 2010-02-10 |
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Cited By (5)
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| CN102697565A (en) * | 2012-07-03 | 2012-10-03 | 重庆大学 | In-vivo tracking and positioning method of remote control delivery capsule based on scintiscan |
| CN106581842A (en) * | 2016-12-12 | 2017-04-26 | 东莞市广信知识产权服务有限公司 | Electromagnetic induction heating circuit |
| CN113576374A (en) * | 2021-08-31 | 2021-11-02 | 武汉大学 | Plate spring driven magnetic control medicine applying capsule robot |
| CN113576373A (en) * | 2021-08-31 | 2021-11-02 | 武汉大学 | Magnetic control micro-needle puncture medicine applying capsule |
| EP4091538A1 (en) * | 2016-09-09 | 2022-11-23 | Biora Therapeutics, Inc. | Electromechanical ingestible device for delivery of a dispensable substance |
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| US10045713B2 (en) | 2012-08-16 | 2018-08-14 | Rock West Medical Devices, Llc | System and methods for triggering a radiofrequency transceiver in the human body |
| WO2014028902A1 (en) | 2012-08-16 | 2014-02-20 | Rock West Solutions, Inc. | System and methods for locating a radiofrequency transceiver in the human body |
| US10945635B2 (en) | 2013-10-22 | 2021-03-16 | Rock West Medical Devices, Llc | Nearly isotropic dipole antenna system |
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2006
- 2006-11-16 CN CN200610095210A patent/CN100588378C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102697565A (en) * | 2012-07-03 | 2012-10-03 | 重庆大学 | In-vivo tracking and positioning method of remote control delivery capsule based on scintiscan |
| EP4091538A1 (en) * | 2016-09-09 | 2022-11-23 | Biora Therapeutics, Inc. | Electromechanical ingestible device for delivery of a dispensable substance |
| US11793420B2 (en) | 2016-09-09 | 2023-10-24 | Biora Therapeutics, Inc. | Ingestible device for delivery of a dispensable substance |
| CN106581842A (en) * | 2016-12-12 | 2017-04-26 | 东莞市广信知识产权服务有限公司 | Electromagnetic induction heating circuit |
| CN113576374A (en) * | 2021-08-31 | 2021-11-02 | 武汉大学 | Plate spring driven magnetic control medicine applying capsule robot |
| CN113576373A (en) * | 2021-08-31 | 2021-11-02 | 武汉大学 | Magnetic control micro-needle puncture medicine applying capsule |
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| Publication number | Publication date |
|---|---|
| CN100588378C (en) | 2010-02-10 |
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