CN1887373A - Timely capsule medicine releasing set for digestive tract - Google Patents
Timely capsule medicine releasing set for digestive tract Download PDFInfo
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- CN1887373A CN1887373A CN 200610054178 CN200610054178A CN1887373A CN 1887373 A CN1887373 A CN 1887373A CN 200610054178 CN200610054178 CN 200610054178 CN 200610054178 A CN200610054178 A CN 200610054178A CN 1887373 A CN1887373 A CN 1887373A
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- capsule
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- medicine
- digestive tract
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Abstract
The present invention is one miniature device capable of being swallowed for releasing medicine and collecting fluid in digestive tract of human body or animal. The miniature device is one sealed capsule with magnetic switch, power source, power source managing and time controlling unit, driving unit, spring and piston. The magnetic switch, the power source, the power source managing and time controlling unit and the driving unit are in the back part inside the capsule shell; the compressed spring and piston are connected through a fuse wire to the heating resistor of the driving unit and in the middle part inside the capsule shell; and the medicine is set in the front part inside the capsule, with the front part being provided with one non-return valve. The medicine releasing time is set during assembling the capsule or before oral taking. The device is used in administrating and sampling, and has high reliability, low power consumption, long stand-by time and simple structure.
Description
Technical field
The present invention relates to a kind of digestive tract micro device of swallowing, relate in particular to regularly drug release device of a kind of digestive tract, the interior Preset Time of realizing of digestive tract that is used in human body or animal discharges medicine.
Background technology
Carrying out timing in digestive tract, to discharge medicinal usage extensive, particularly in the absorption characteristic of research medicine at the digestive tract diverse location, studies gastral metabolism status and relevant biochemical characteristic all has important value.It has established solid foundation for new drug development, provide supplementary means for digestive tract disease detects, so the research of capsule type digestive tract drug release device becomes a focus naturally.
U.S. Pat 4425117 has proposed a kind of device of digestive tract assigned address h substance, and this device is divided into two cells, and a movable mechanism that can move under the pressure effect of compression spring is arranged in first Room, and a pin is arranged in the movable mechanism end; Second cell be around foraminate medicine holding bin, drug pack is implanted in the medicine holding bin in tiny balloons; Be equipped with a fixed dam in this device interposition two cells separated, in the middle of the baffle plate with can be broken by acupuncture at the position of answering.When this device arrives the digestive tract assigned address, trigger release movement by outer signals, movable mechanism moves forward to certain position in the spring pressure effect, and the broken baffle plate of acupuncture also punctures the balloon that medicine is housed, and the medicine that balloon self shrinks the dressing of extruding institute discharges outward.There is following problem in this device: at first, the drug release situation depends on aperture size and the balloon interior pressure that the drug storage balloon in the medicine holding bin centre position is broken by acupuncture, if it is big inadequately that the balloon interior pressure of medicine is housed, then drug releasing rate is slow; The medicine thickness then may cause and can't discharge; Secondly because the passage that medicine discharges in install is the aperture on the shell wall, and be equipped with medicine balloon since good morphotropism these apertures can be blocked; In addition, even can shrink rapidly after balloon punctures, its contractility effect has only guaranteed drug release to medicine holding bin, and medicine discharges the leakage that depends on aperture from medicine holding bin, these apertures can be sealed by the digestive tract material, do not have suitable external pressure medicine just can't come out by small hole leaking.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of release effect of drugs good, the reliability height, energy consumption is low, and the working time is long, timely capsule medicine releasing set for digestive tract simple in structure.
Technical scheme of the present invention is as follows:
This capsule type digestive tract drug release device includes capsule shell, magnetic switch, power supply, power management and timing control unit, driver element and the piston of front end shell and rear end housing formation enclosed cavity after sealing is connected.The sealed rear end enclosure interior that is positioned at of the part of magnetic switch, power supply, power management and timing control unit and driver element wherein, the piston that driver element passes in sealant and the front end shell is connected, the housing inner chamber in piston the place ahead is a containing liquid chamber, and the export-oriented check valve of at least one and medicine holding bin internal communication is set at the front end of front end shell.Piston is fixed on the bottom of front end shell before not being driven.
Described driver element can adopt heating resistor, fuse and spring to form, and the spring of piston and compressive state is fixedly connected on the heating resistor by fuse, with piston fixedly bottom the front end shell.
The capsule release medicine time can be set in the Capsules group process of assembling, also can be set by portable capsule timing control apparatus according to practical situation before oral.
Work process of the present invention is as follows: this microencapsulation carries medicine and enters human body alimentary canal from the oral cavity after external assembling, and sends action command by timing control unit after arriving Preset Time.After driver element is received action command, by the heating resistor fusible fracture of wire that fuses, discharge the mechanical energy of storage in advance, spring (anticorrosive material or have corrosion-inhibiting coating) promotes piston and moves to the capsule top, and then the pressure of containing liquid chamber is strengthened, force export-oriented one-way valve opens, medicine flows out into digestive tract by export-oriented check valve, after the piston arrives cover top portion, spring travel finishes, because the effect of check valve valve block self elastic force is closed check valve automatically, capsule is hedged off from the outer world.
The present invention compared with prior art has following technique effect:
1, the predeterminable time independently discharges medicine, need not extraneous control.
2, simple structure, high reliability.
3, device space availability ratio height.
4, energy consumption is low, and the working time is long, lengthens working hours by the high quality control of power management module, reduces device and carries number of batteries.
Description of drawings
Fig. 1 is the structural representation before the timely capsule medicine releasing set for digestive tract action.
Fig. 2 is the structural representation in the timely capsule medicine releasing set for digestive tract course of action.
Fig. 3 is a structural representation after the action of timely capsule medicine releasing set for digestive tract.
Fig. 4 is the structural representation of the driving mechanism part of timely capsule medicine releasing set for digestive tract.
Fig. 5 is the control principle block diagram of power management and timing control unit.
Wherein: 1, rear end housing 2, magnetic switch 3, power supply 4, power management and timing control unit 5, driver element 6, spring 7, rubber piston 8, containing liquid chamber 9, front end shell 10, export-oriented check valve 11, fuse 12, heating resistor 13, crystal oscillator 14, output signal to driving mechanism 15, electric capacity
The specific embodiment
The present invention is further described below in conjunction with embodiment.
Embodiments of the invention as shown in Figure 1, the bulk shape size is about 11 * 30 millimeters of φ.
Capsule shell of the present invention is tightly connected for 1 two sections by front end shell 9 and rear end housing and forms, and timing controlled mechanism comprises magnetic switch 2, power supply 3, power management and timing control unit 4 and driver element 5.Wherein driver element 5 mainly constitutes (seeing shown in Figure 4) by heating resistor 12, high strength is fusible fracture of wire 11 and spring 6, and power supply 3 is a button cell.Wherein the heating resistor 12 of magnetic switch 2, power supply 3, power management and timing control unit 4 and driver element 5 is sealed in the rear end housing 1, and the fusible fracture of wire 11 of high strength and the spring 6 of piston 7 and driver element 5 then is housed in the front end shell 9.Before the piston motion, piston 7 is fixedly connected on the heating resistor 12 by fusible fracture of wire 11 with the spring 6 of compressive state, be positioned at the front end shell bottom, the housing inner chamber of piston 7 front ends is that medicine holding bin 8 (variable volume) is used for storage of pharmaceutical, piston and inner walls are slidingly matched, and are provided with an export-oriented check valve 10 with medicine holding bin 8 internal communication at the front end of front end shell 9.Before the action, spring 6 is in not release conditions, and piston 7 is fixed in the front end shell bottom, as shown in Figure 2; After arriving Preset Time, power management and timing control unit 4 send action command, discharge mechanical energy by driver element 5 control springs 6, piston 7 travels forward under the effect of spring 6, and the medicine that presets in the medicine holding bin 8 is discharged by export-oriented check valve 10.After piston 7 arrived the capsule tops, spring 6 strokes finished, and the valve block of export-oriented check valve 10 is closed under the effect of self elastic force automatically.Thereafter capsule excretes voluntarily with feces under metabolism, as shown in Figure 3.
The timing controlled mechanism that the present invention adopts can adopt existing sophisticated timing controlled technology to realize, its basic control principle is referring to Fig. 5,13 is crystal oscillators among the figure, the 14th, power management and timing control unit 4 are to the output signal of driver element 5, the 15th, electric capacity, wherein 4 pairs of power supplys 3 of power management and timing control unit are controlled (prolonging the total system working time), and can preestablish the release triggered time, send triggering signal to driver element 5 after arriving setting-up time, driven plunger 7 travels forward and reaches the purpose that discharges medicine.
Claims (2)
1. timely capsule medicine releasing set for digestive tract, it is characterized in that: it has capsule shell, timing controlled mechanism and piston; Capsule shell is tightly connected by rear end housing (1) and front end shell (9) two parts and forms, timing controlled mechanism comprises magnetic switch (2), power supply (3), power management and timing control unit (4) and driver element (5), wherein the part of magnetic switch (2), power supply (3), power management and timing control unit (4) and driver element (5) be sealed in rear end housing (1) in; The piston (7) that driver element (5) passes in sealant and the front end shell (9) is connected, the housing inner chamber in piston (7) the place ahead is medicine holding bin (8), and the export-oriented check valve (10) of at least one and medicine holding bin (8) internal communication is set at the front end of front end shell (9).
2, timely capsule medicine releasing set for digestive tract according to claim 1, it is characterized in that: described driver element comprises heating resistor (12), fuse (11) and spring (6), the spring (6) of piston (7) and compressive state is fixedly connected on the heating resistor (12) by fuse (11), with piston (8) fixedly bottom the front end shell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610054178XA CN100490916C (en) | 2006-04-03 | 2006-04-03 | Capsule type timely medicine releasing set for digestive tract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB200610054178XA CN100490916C (en) | 2006-04-03 | 2006-04-03 | Capsule type timely medicine releasing set for digestive tract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1887373A true CN1887373A (en) | 2007-01-03 |
| CN100490916C CN100490916C (en) | 2009-05-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB200610054178XA Expired - Fee Related CN100490916C (en) | 2006-04-03 | 2006-04-03 | Capsule type timely medicine releasing set for digestive tract |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100490916C (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101837163A (en) * | 2010-04-12 | 2010-09-22 | 上海现代药物制剂工程研究中心有限公司 | Heparin rectum iontophoretic drug delivery system |
| CN106730284A (en) * | 2016-11-24 | 2017-05-31 | 上海理工大学 | Microcapsules formula gastrointestinal drug discharges system |
| CN107242916A (en) * | 2016-12-23 | 2017-10-13 | 中国疾病预防控制中心寄生虫病预防控制所 | A kind of cartridge-type self-timing feeds the device of dog anthelmintic |
| CN112604134A (en) * | 2020-12-08 | 2021-04-06 | 中山大学 | Minimally invasive implantable magnetic field driven on-demand drug delivery device |
| CN112604137A (en) * | 2020-12-28 | 2021-04-06 | 杭州电子科技大学 | In-vivo drug release capsule robot and using method thereof |
| WO2021201379A1 (en) * | 2020-04-03 | 2021-10-07 | 재단법인대구경북과학기술원 | Drug delivery device |
| US11179341B2 (en) | 2017-05-17 | 2021-11-23 | Massachusetts Institute Of Technology | Self-righting articles |
| US11202903B2 (en) | 2018-05-17 | 2021-12-21 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| US11541216B2 (en) | 2019-11-21 | 2023-01-03 | Massachusetts Institute Of Technology | Methods for manufacturing tissue interfacing components |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2928477C3 (en) * | 1979-07-14 | 1982-04-15 | Battelle-Institut E.V., 6000 Frankfurt | Device for the release of substances at defined locations in the digestive tract |
-
2006
- 2006-04-03 CN CNB200610054178XA patent/CN100490916C/en not_active Expired - Fee Related
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101837163A (en) * | 2010-04-12 | 2010-09-22 | 上海现代药物制剂工程研究中心有限公司 | Heparin rectum iontophoretic drug delivery system |
| CN101837163B (en) * | 2010-04-12 | 2013-04-10 | 上海现代药物制剂工程研究中心有限公司 | Heparin rectum iontophoretic drug delivery system |
| CN106730284A (en) * | 2016-11-24 | 2017-05-31 | 上海理工大学 | Microcapsules formula gastrointestinal drug discharges system |
| CN107242916A (en) * | 2016-12-23 | 2017-10-13 | 中国疾病预防控制中心寄生虫病预防控制所 | A kind of cartridge-type self-timing feeds the device of dog anthelmintic |
| CN107242916B (en) * | 2016-12-23 | 2023-08-11 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | Cartridge clip type device for feeding dog insect repellent at automatic timing |
| US11541016B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US11369574B2 (en) | 2017-05-17 | 2022-06-28 | Massachusetts Institute Of Technology | Self-righting systems and related components and methods |
| US11179341B2 (en) | 2017-05-17 | 2021-11-23 | Massachusetts Institute Of Technology | Self-righting articles |
| US11712421B2 (en) | 2017-05-17 | 2023-08-01 | Massachusetts Institute Of Technology | Self-actuating articles |
| US11207272B2 (en) | 2017-05-17 | 2021-12-28 | Massachusetts Institute Of Technology | Tissue anchoring articles |
| US11311489B2 (en) | 2017-05-17 | 2022-04-26 | Massachusetts Institute Of Technology | Components with high API loading |
| US11607390B2 (en) | 2017-05-17 | 2023-03-21 | Massachusetts Institute Of Technology | Self-righting systems and related components and methods |
| US11541015B2 (en) | 2017-05-17 | 2023-01-03 | Massachusetts Institute Of Technology | Self-righting systems, methods, and related components |
| US11202903B2 (en) | 2018-05-17 | 2021-12-21 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| US11771829B2 (en) | 2019-02-01 | 2023-10-03 | Massachusetts Institute Of Technology | Systems and methods for liquid injection |
| US11541216B2 (en) | 2019-11-21 | 2023-01-03 | Massachusetts Institute Of Technology | Methods for manufacturing tissue interfacing components |
| WO2021201379A1 (en) * | 2020-04-03 | 2021-10-07 | 재단법인대구경북과학기술원 | Drug delivery device |
| CN112604134A (en) * | 2020-12-08 | 2021-04-06 | 中山大学 | Minimally invasive implantable magnetic field driven on-demand drug delivery device |
| CN112604137A (en) * | 2020-12-28 | 2021-04-06 | 杭州电子科技大学 | In-vivo drug release capsule robot and using method thereof |
| CN112604137B (en) * | 2020-12-28 | 2022-05-06 | 杭州电子科技大学 | In-vivo drug release capsule robot and using method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100490916C (en) | 2009-05-27 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090527 Termination date: 20100403 |