JP2002177387A - Syringe - Google Patents

Abstract

PROBLEM TO BE SOLVED: To perform the injection or mixing of a drug for a short time by simple operation without generating contamination. SOLUTION: A syringe 100 is constituted of a syringe main body 1 and a container 10. The syringe main body 1 has an outer cylinder 2, the first needle pipe 3 arranged to the bottom part 2a of the outer cylinder 2, the pipe body 4 arranged in the outer cylinder 2 and communicating with the first needle pipe 3 on the leading end side thereof, the second needle pipe 5 arranged to the rear end of the pipe body 4 and the connection part 6 formed to the outer peripheral part of the second needle pipe 5. The container 10 is constituted of a container main body 11 and the gasket 12 capable of sliding along the inner surface of the container main body 11 in a liquidtight state and houses a drug. The gasket 12 has a thin-walled part 14 through which the second needle pipe 5 can pierce and a locking part 16 with which the connection part 6 is locked. The container 10 is used so as to be replaced with other same container housing a drug containing a different component.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe, and more particularly to a syringe used for compounding a drug solution.

[0002]

2. Description of the Related Art Prior to administration of an infusion to a patient, drugs such as vitamins, heparin and antibiotics are added to the infusion filled in the infusion bag as required. I have.

[0003] To mix such a drug, first, the puncture needle of the syringe is pierced into the elastic stopper of the infusion bag, and the plunger is pulled to collect the infusion in the infusion bag into the syringe. Transfer to a container containing the drug (powder) to be blended, dissolve and mix the drug in this container, then aspirate and collect the drug mixture again with the syringe,
This is performed by inserting a puncture needle into an elastic stopper of the infusion bag and pushing the plunger to inject the drug mixture into the infusion bag.

[0004] However, such a chemical solution is formulated
There is a disadvantage that the operation procedure is complicated and the time required for blending is long. In particular, prompt response is essential for emergency patients, but it is disadvantageous when formulating a drug solution to be administered to such patients.

Furthermore, since the compounding operation of the above-mentioned chemical solution, particularly the dissolution and mixing of the chemical, are mostly performed in contact with the atmosphere, there is a risk of bacterial contamination and foreign matter contamination.

[0006] In particular, when a plurality of drugs are blended,
Since the above-mentioned compounding operation is repeatedly performed, the above-mentioned drawback has become more remarkable.

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a syringe which can perform injection and compounding of a medicine in a short time by a simple operation without causing contamination.

[0008]

This and other objects are achieved by the present invention which is defined below as (1) to (7). Further, the following (8) to (12) are preferable.

(1) An outer cylinder, a first needle tube installed at the distal end of the outer cylinder, a tubular body installed inside the outer cylinder, and having a distal end communicating with the inside of the first needle tube, A syringe body including a second needle tube installed on the rear end side of the body, and a connecting portion formed on an outer peripheral portion of the second needle tube, a bottomed cylindrical container body, and the container body A gasket slidable in a liquid-tight manner along the inner surface of the container, and a container in which a medicine is stored, wherein the gasket has a thin portion through which the second needle tube can pierce, And at least one container formed with a locking portion for locking the connecting portion, wherein the container is inserted into the outer cylinder from the gasket side, and the second needle tube is thinned to a thickness of the gasket. The container main body is inserted into the syringe main body while the connecting portion and the locking portion are locked while piercing the syringe main body. A syringe that at least discharges the liquid in the container via the first needle tube by relatively moving in the axial direction with respect to and sliding the gasket in the container main body. A syringe which is used in exchange for another container containing a medicine having a different component from the medicine.

(2) The syringe according to the above (1), wherein the replacement of the container is performed while the first needle tube is connected to a bag containing a liquid.

(3) The syringe according to the above (1) or (2), wherein the medicine is a solid or a liquid.

(4) The syringe according to any one of (1) to (3), further comprising a regulating means for regulating an axial position of the gasket with respect to the container body.

(5) The syringe according to any one of (1) to (4), further comprising a film for sealing an opening of the container body.

(6) The syringe according to any one of (1) to (5), wherein the gasket can reciprocate in the container body by locking the locking portion and the connecting portion.

(7) The syringe according to any one of (1) to (6), further comprising an enclosing member that encloses the second needle tube and is piercable by the second needle tube.

(8) The syringe according to any one of (1) to (7), wherein the inside of the container is in a reduced pressure state.

(9) The syringe according to any one of (1) to (8), wherein the locking portion is constituted by a concave portion, and the connecting portion is constituted by a convex portion fitted into the concave portion.

(10) The syringe according to any one of (1) to (9), further comprising a cap for enclosing the first needle tube.

(11) The syringe according to any one of (1) to (10), wherein a gripping member is mounted on a bottom of the container body.

(12) The syringe according to any one of the above (1) to (11), wherein the drug is in the form of a powder and is used by being dissolved or dispersed in a liquid introduced into the container body.

[0021]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a syringe according to the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings. The syringe 100 of the present invention includes a syringe main body 1 and a container 10. Hereinafter, these configurations will be sequentially described.

FIG. 1 is a longitudinal sectional view showing an example of the configuration of a syringe body according to the present invention, and FIG. 2 is a view taken along the line II-II in FIG. For convenience of description, the upper side in FIG. 1 is referred to as a front end, and the lower side is referred to as a rear end. As shown in FIG. 1, the syringe body 1 has a cylindrical outer cylinder 2 having a bottom 2a on the distal end side.
A first needle tube 3 protruding from the bottom portion 2a is installed at a tip end of the first needle tube 3.

The first needle tube 3 in the illustrated configuration example is, for example, an elastic stopper 106 for sealing the opening of the infusion bag 105.
(See FIGS. 7 and 8), and a plurality of side holes 31 communicating with the inner cavity of the first needle tube 3 are formed in a side portion near the distal end portion. In the syringe of the present invention, the first needle tube 3 is not limited to a bottle needle as shown, but may be a normal metal puncture needle or the like.

Inside the outer cylinder 2, a tube 4 whose leading end communicates with the inner cavity of the first needle tube 3 is installed substantially concentrically with the outer cylinder 2. In the illustrated example, the tube 4 is formed integrally with the first needle tube 3, and is fixed to the bottom 2 a of the outer cylinder 2 preferably by fusion or adhesion.

At the rear end of the tube 4, a sharp needle tip (blade point)
A second needle tube 5 having 51 is installed with the needle tip 51 facing the rear end.

On the outer peripheral portion of the second needle tube 5, there is formed a connecting portion 6 which is locked to a locking portion 16 formed on a gasket 12 of the container 10 described later. As shown in FIG. 2, the connecting portion 6 is composed of a pair of fan-shaped (wing-shaped) small pieces protruding in the radial direction of the second needle tube 5. In the illustrated example, the connecting portion 6 is formed integrally with the tube 4.

The constituent materials of the outer cylinder 2, the first needle tube 3, the tube 4, and the connecting portion 6 are, for example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1). , Polycarbonate, acrylic resin, acrylonitrile-butadiene-
Styrene copolymer, polyester such as polyethylene terephthalate, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6.6, nylon 6
Various resins such as 10, nylon 12) or ceramics such as alumina are exemplified. Among them, polypropylene, polyester, poly- (4-methylpentene-1) and the like are preferable in that molding is easy. Resins are preferred. In addition, it is preferable that these materials are substantially transparent in order to secure internal visibility.

The second needle tube 5 is preferably made of, for example, a metal such as stainless steel, titanium, or aluminum or a hard resin. Around the second needle tube 5, a covering member 7 that covers at least the needle tip 51 of the second needle tube 5 is provided. The encapsulating member 7 serves to prevent contamination of the needle tip 51 when not in use and to prevent the liquid in the tube body 4 from leaking from the needle tip 51.

As such an enclosing member 7, for example,
A film made of various rubber materials such as natural rubber, isoprene rubber, butadiene rubber, silicone rubber, and latex rubber, which can be easily penetrated by the needle tip 51, is preferably used.

A plate-like flange 2c is formed integrally with the outer cylinder 2 around the rear end opening 2b of the outer cylinder 2. When a container 10 to be described later is inserted into the outer cylinder 2 or pulled out from the outer cylinder 2, a finger is put on the flange 2c to fix the syringe body 1.

In the syringe body 1 when not in use,
A film 8 for sealing the rear end opening 2b of the outer cylinder 2 preferably in an airtight manner is attached to the rear end surface of the flange 2c. Thereby, contamination inside the syringe main body 1 is prevented, and sterility is maintained. When using the syringe body 1, the film 8 is peeled off. At this time, a tab 81 is formed at the edge of the film 8 so that the film 8 can be easily peeled off.

The film 8 is a single layer made of a resin such as a polyester such as polyethylene, polypropylene, ionomer or polyethylene terephthalate, a resin such as polystyrene, poly- (4-methylpentene-1) or polyamide, or a metal foil such as an aluminum foil. Or a laminate obtained by laminating (laminating) two or more of these layers. Since the laminate of the metal foil and the resin layer has low gas permeability, the use of such a film 8 improves the hermeticity of the outer cylinder 2 and effectively prevents invasion of bacteria and the like. It is preferable because it is possible.

A cap 9 for covering the first needle tube 3 is mounted on the distal end side of the outer cylinder 2. This cap 9
It has a function of preventing danger and preventing contamination of the first needle tube 3. In the syringe of the present invention, the films 8, 19
The cap 9 and the cap 9 may be provided as needed, and may not be present.

FIG. 3 is a longitudinal sectional view showing a configuration example of the container according to the present invention, FIG. 4 is a plan view of a gasket in the container shown in FIG. 3, FIG. 5 is a sectional view taken along line VV in FIG. FIG.
FIG. 6 is a sectional view taken along line VI-VI in FIG. 4. For convenience of explanation, the upper side in FIGS. 3, 5, and 6 is referred to as a front end, and the lower side is referred to as a rear end.

As shown in FIG. 3, the container 10 is mainly composed of a bottomed cylindrical container body 11 having an open end, and a gasket 12 which can slide in a liquid-tight manner along the inner surface of the container body 11. It is composed of

The container body 11 is made of the same resin material or glass material as the outer cylinder 2 and the like, and is preferably substantially transparent in order to secure the visibility inside. The outer diameter of the container body 11 is smaller than the inner diameter of the outer cylinder 2, and
The inner diameter of the container body 11 is larger than the outer diameter of the tube 4 and the maximum diameter of the connecting portion 6. Thereby, the container main body 11 can be inserted to the inner part of the outer cylinder 2.

The total length of the container body 11 is preferably substantially equal to or greater than the total length of the outer cylinder 2.
In particular, when the container main body 11 is inserted to the innermost part of the outer cylinder 2 so that the medicinal solution in the container 10 can be drained as much as possible regardless of the posture of the container 10, the rear end face 122 of the gasket 12 Inner bottom surface 113 of container body 11
It is preferable that it is in such a degree that it can come into contact with.

On the inner surface of the container body 11,
A predetermined distance from 11 to the rear end side (for example, about 5 to 20 mm)
A ring-shaped protrusion 112 is formed at the separated position along the inner periphery of the container body 11. This protrusion 112
It is a restricting means for restricting the gasket 12 in the axial direction with respect to the container body 11 by engaging with a rear end face 122 of the gasket 12 described later. That is, when the inside of the container 10 is in a reduced pressure state, the role of preventing the gasket 12 from moving to the rear end side of the container body 11 due to the pressure difference from the atmospheric pressure, and the second needle tube 5 is inserted into the thin portion 14. When the gasket 12 is passed through, the gasket 12 prevents the gasket 12 from moving to the rear end side of the container main body 11, or when the gasket 12 moves to the front end side of the container main body 11 or when the container 10 is moved to the syringe main body 1.
When the gasket 12 is removed from the container body 11, the gasket 12 serves to prevent the gasket 12 from easily coming off.

In the container 10 when not in use, the container body 1
It is preferable that a film 19 that hermetically seals the front end opening 111 is adhered to the front end of one. This allows
The inside of the locking portion 16 of the gasket 12 and the space 15 are prevented from being contaminated, and sterility is maintained. When the inside of the container 10 is kept in a reduced pressure state when not in use, the use of the gas-impermeable film 19 allows the airtightness of the distal end opening 111 to be obtained, which is advantageous for maintaining the reduced pressure state in the container 10. As the film 19, the same film as the film 8 can be used.

As shown in FIGS. 4, 5 and 6, the gasket 12 is made of various rubber materials (particularly vulcanized) such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber and silicone rubber. Treated) or various elastomers such as polyurethane-based, polyester-based, polyamide-based, olefin-based, and styrene-based elastomers, or a columnar member made of an elastic material such as a mixture thereof. The gasket 12 is not limited to the whole made of the above material, but may be one in which at least the protrusion 18 and the thin portion 14 are made of the above material.

At the center of the gasket 12, there is formed a thin portion 14 through which the second needle tube 5 of the syringe main body 1 can penetrate. The thickness of the thin portion 14 is, for example, 0.5 to 1
It is about 0 mm.

Further, a space 15 for accommodating and holding the encapsulating member 7 when the second needle tube 5 is pierced into the thin portion 14 is formed on the distal end side of the thin portion 14.
A locking portion 16 is formed on the more distal side. The locking portion 16 is a concave portion to which the connecting portion 6 of the syringe body 1 is locked and connected. The space 161 has a pair of fan-shaped cross sections communicating with the space 15, and the gasket communicates with the space 161. 12 connected to the distal end surface 121 of the connecting portion 6
And an opening 162 that can pass through.

In the space 161, the connecting portion 6 is rotatable at a predetermined angle (for example, about 50 to 130 °), and the contact surface 16 is substantially perpendicular to the distal end surface 121 of the gasket 12.
3, 163, and its rotation is regulated. Connecting part 6
In the state in which the connecting portion 6 is in contact with the contact surface 163, the movement of the connecting portion 6 in the leading end direction and the rear end direction with respect to the locking portion 16 is restricted. The contour shape of the opening 162 is
It is substantially equal to the connecting portion 6 (see FIG. 4).

A space 13 in which the needle tip 51 is located when the second needle tube 5 is punctured into the thin portion 14 is formed on the rear end side of the thin portion 14. One end of the gasket 12 communicates with the space 13 and the other end of the gasket 12
At least one vent hole 17 released to the outer peripheral surface 123 of the
Are formed. The vent hole 17 is for discharging water vapor when the medicine contained in the container 10 is freeze-dried. Therefore, this ventilation hole 17 is
It is provided as necessary depending on the form of the medicine stored in the inside.

A plurality of ring-shaped projections 18 are formed on the outer peripheral surface 123 of the gasket 12 over the entire circumference.
When the gasket 12 slides, the projecting portion 18 has a function of closely adhering to the inner peripheral surface of the container body 11 to maintain airtightness and to maintain appropriate slidability.

In such a container 10, the container body 11 also has a function as a plunger for moving the gasket 12 with respect to the container body 11, and the gasket 12 seals the container body 11. It has both a function as a stop member and a function of obtaining communication / interruption with the inside of the second needle tube 5. Therefore, the container 10 can be composed of only the container body 11 and the gasket 12, which are the minimum necessary members, and the number of parts is smaller than that of a conventional container having a rubber stopper and a plunger rod dedicated to piercing the needle tube. The configuration is extremely simple and the operation is easy.

The inside of such a container 10 may be empty when not in use, but it is usually preferable that a predetermined amount of medicine is previously stored. The drug may be liquid or solid (including semi-solid). A typical example of a solid drug is a tablet or a powder (granule) drug 120 as shown in the figure, and in particular, a powdery powder in that it is easily dissolved or dispersed by a liquid introduced into the container 10. Are preferred. Such a powdered drug 120 can be easily obtained by, for example, freeze-drying.

When a solid drug is placed in the container 10, the inside of the container 10 may be in a state substantially equal to the atmospheric pressure, but may be in a reduced pressure state (for example, 0.1 to 760).
mmHg).

The drug 120 enclosed in one container 10 is usually composed of a single active ingredient, but may be a combination preparation containing two or more active ingredients.

Specific examples of the drug 120 include vitamins (multivitamins), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, antitumor agents, analgesics, inotropic agents, intravenous anesthetics, Parkinson's agent, ulcer treatment agent, corticosteroid agent, agent for arrhythmia, correction electrolyte and the like.

According to the present invention, in order to prevent the solid medicine, which has not been completely dissolved or dispersed in the container 10, from being discharged from the side hole 31, the inside of the tube 4 and the inner cavity of the second needle tube 5, etc. A filter (not shown) may be provided in the flow path, on the rear end face 122 of the gasket 12, or the like to block the passage of the solid medicine. For this filter,
For example, a membrane filter, a mesh, a woven fabric, a nonwoven fabric and the like can be mentioned.

It is preferable that at least the interior of the syringe body 1 and the container 10 have been previously subjected to a sterilization treatment such as high-pressure steam sterilization, gas sterilization or radiation sterilization.

Next, an example of a method of using the syringe 100 of the present invention will be described with reference to FIGS.

A. How to use when the pressure in the container 10 is reduced beforehand [1] First, as shown in FIG. 7, the cap 9 is removed, and the first needle tube 3 of the syringe 100 is infused with the drug 120. The elastic plug 106 that seals the opening of the bag 105 is pierced.

[2] Next, the films 8 and 19 are peeled off, and the container 10 is inserted into the outer cylinder 2 from the front end side through the rear end opening 2 b of the outer cylinder 2, and the connecting portion 6 is connected to the gasket 12.
The second needle tube 5 is inserted into the thin portion 14 of the gasket 12, and the needle tip 51 is positioned in the space 13.

Here, since the inside of the container 10 is previously depressurized, the pressure difference from the atmospheric pressure causes the infusion bag 10
As shown by the arrow in FIG. 7, the infusion 107 in the container 5 passes through the side hole 31, the lumen of the first needle tube 3, the tube 4, and the lumen of the second needle tube 5 sequentially, and Will be introduced.

The needle tip 51 penetrates the enclosing member 7 prior to the puncturing of the thin portion 14, and the encapsulating member 7
In the space 15 of the gasket 12, it is held in a state of being compressed in a bellows shape.

[3] Next, the container 10 is shaken or vibrated to dissolve or disperse the drug 120 in the infusion introduced into the container 10, and the drug solution 10 containing the active ingredient of the drug 120 is dispensed.
8 is assumed. The chemical solution 108 includes a chemical 120
, A suspension (emulsion) and the like.

[4] Next, as shown in FIG.
The rear end (bottom) is pressed in the direction of the front end, and the container body 11 is inserted into the outer cylinder 2. Since the connecting portion 6 and the locking portion 16 are locked, only the container body 11 moves in the distal direction while the gasket 12 is connected to the rear end of the tube 4.
As a result, the volume of the portion surrounded by the rear end of the gasket 12 and the container body 11 is reduced, and the chemical solution 108 in the container 10 is reduced.
Is the lumen of the second needle tube 5, as shown by the arrow in FIG.
The liquid is injected into the infusion bag 105 through the tube 4, the lumen of the first needle tube 3, and the side hole 31 sequentially, and is mixed with the infusion.

[5] In the chemical liquid injection operation of [4], even if the container main body 11 is inserted into the outer cylinder 2 until the rear end face 122 of the gasket 12 contacts the bottom inner surface 113 of the container main body 11, Since the drug solution 108 remains in the body 4 and the lumen of the first needle tube 3, the entire amount of the drug solution 108 cannot be injected into the infusion bag 105 by a single pushing operation of the container 10. Therefore, once the container main body 11 is inserted into the outer cylinder 2 to a certain depth, the container main body 11 is pulled to the rear end side, and the infusion 107 in the infusion bag 105 is introduced into the container 10 along the same route as described above. Remaining chemical solution 1
08 is diluted, and the container main body 11 is pressed and inserted into the outer cylinder 2 again. By repeating such reciprocating motion of the container body 11 several times, the drug solution 108 can be supplied into the infusion bag 105 without waste, and a correct amount of drug can be mixed.

When the container body 11 is pulled to the rear end side, the container 10 is rotated counterclockwise in FIG. Contact As a result, the connecting portion 6 cannot pass through the opening 162, and only the container main body 11 is pulled out while the gasket 12 is connected to the rear end of the pipe 4, and the rear end of the gasket 12 and the container main body 11 The volume of the portion surrounded by is increased, and the infusion 107 is introduced.

Further, when the projection 18 passes through the projection 112 of the container body 11 when sliding the gasket 12, a predetermined resistance is applied, so that the gasket 12 is prevented from being accidentally pulled out of the container body 11. You.

[6] When a drug having a different component is further mixed into the infusion bag 105, the container 1 is kept while the first needle tube 3 is inserted into the elastic stopper 106 of the infusion bag 105.
0 is withdrawn from the syringe body 1, a similar container 10 containing a drug to be newly blended is set in the syringe body 1 in the same manner as in the above [2], and the same operation as in the following [3] to [5] I do. As described above, when a plurality of types of drugs having different components are blended, a plurality of containers 10 containing the respective drugs may be prepared, and these may be appropriately replaced and used, so that the operation is extremely simple. The time required for compounding is also short. Then, the order of mixing can be arbitrarily selected. Further, in the case of such a compounding agent, the chance of contact with the outside air is extremely small, and there is no possibility of bacterial contamination or foreign matter contamination.

The used container 10 should be filled with a gasket 1 in order to minimize the amount of liquid remaining in the container 10.
2 is preferably withdrawn from the syringe body 1 while the rear end face 122 is in contact with or close to the bottom inner surface 113 of the container body 11.

When the gasket 12 is removed from the second needle tube 5, the envelope member 7 that has been compressed in a bellows shape
Instantaneously restores the original shape and encloses the needle tip 51,
The liquid is prevented from leaking from the needle tip 51 and scattering around.

B. Usage method when the pressure in the container 10 is substantially equal to the atmospheric pressure First, the films 8 and 19 are peeled off, and the container 10 is inserted into the outer tube 2 from the front end side through the rear end opening 2b of the outer tube 2. Then, the connecting portion 6 is passed through the opening 162 of the gasket 12 and locked in the space 161, and the second needle tube 5 is pierced into the thin portion 14 of the gasket 12 to position the needle point 51 in the space 13.

Next, the container body 11 is pressed in the distal direction, and the container body 11 is inserted into the outer cylinder 2 to reduce the volume of the portion surrounded by the rear end of the gasket 12 and the container body 11. .

Next, the cap 9 is removed, and the first needle tube 3 is inserted into the elastic stopper 106 of the infusion bag 105. This operation may be performed before the operation of inserting the container body 11 into the outer cylinder 2.

Next, the container body 11 is pulled to the rear end side, and the infusion 107 in the infusion bag 105 is introduced into the container 10 along the same route as described above. After that, the same operation as in the above [3] to [6] is performed.

C. Liquid medicine (medical solution) in advance in the container 10
How to use when is stored After performing the same operation as in [1] and [2], the same operation as in [4] to [6] is performed.

Basically, the above [1], [2], [4]
The same as in [6]. Hereinafter, a brief description will be given.

First, the cap 9 is removed and the syringe 10
The first needle tube 3 is pierced through an elastic stopper 106 that seals the opening of the infusion bag 105 in which the medicine 120 is to be blended.

Next, the container 1 is inserted through the rear end opening 2 b of the outer cylinder 2.
0 is inserted into the outer cylinder 2 from the distal end side, the second needle tube 5 is pierced into the thin portion of the container 10, and the needle tip 51 is communicated with the inside of the container.

The encapsulating member 7 is pierced through the second needle tube 5 and is held in a state of being compressed in a bellows shape.

Next, the gasket 12 is pressed by the tube 4 and slid with respect to the container body 11 to reduce the volume of the portion surrounded by the gasket 12 and the container body 11. As a result, the drug solution in the container 10 is filled with the lumen of the second needle tube 5 and the tube 4.
The liquid is sequentially injected into the infusion bag 105 through the lumen of the first needle tube 3 and the side hole 31 and is mixed with the infusion.

If necessary, the gasket 12 is connected to the container body 1
By reciprocating within 1, the infusion is introduced into the container 10, the remaining drug solution is diluted and returned into the infusion bag 105. As a result, the drug solution can be supplied into the infusion bag 105 without waste, and a precise amount of the drug can be mixed.

When a drug having a different component is further mixed into the infusion bag 105, the first needle tube 3 is connected to the drug solution bag 1.
05 while piercing the elastic stopper 106, replace the used container with a container containing a drug to be newly blended,
Thereafter, the same operation as described above is performed.

When the used container is removed from the outer cylinder 2, the envelope member 7 that has been compressed in a bellows shape is instantaneously restored to the original shape, and the needle tip of the second needle tube 5 is moved. Since the liquid is encapsulated, the liquid is prevented from leaking from the needle tip and scattering around.

In the injector of the present invention, the container 10
Whatever form of C can be used for the syringe body 1 by appropriately replacing them. It should be noted that the compounding (injection) of the above-described drugs is performed in the infusion bag 1
However, the present invention is not limited to the above-described method, and may be performed on, for example, a bag for storing a liquid other than an infusion such as a physiological saline solution or a dialysate, blood, or plasma. Further, it can be used for administration of a drug solution to a living body such as intravenous injection, arterial injection, and subcutaneous injection.

FIG. 9 is a partial longitudinal sectional view showing another example of the configuration of the syringe of the present invention. The syringe 101 shown in the figure is different from the syringe 100 in the configuration of the connecting part and the locking part, and the other parts are almost the same.

The connecting portion 6A of the syringe 101 is
The needle tube 5 has a circular convex portion formed on the outer periphery of the end of the needle tube 5 on the side of the tube body 4, and a male screw 61 is formed on the outer peripheral surface thereof.

On the other hand, the locking portion 16A of the syringe 101
Is formed at a substantially central portion on the distal end side of the gasket 12A, is constituted by a circular concave portion released to the distal end surface 121, and has a female screw 164 screwed with the male screw 61 on its inner peripheral surface.
Are formed. The engagement between the connecting portion 6A and the locking portion 16A is performed by relatively rotating the syringe body 1A and the container 10A and screwing the male screw 61 and the female screw 164 together.

FIG. 10 is a plan view showing another configuration example of the container according to the present invention, FIG. 11 is a longitudinal sectional view showing the configuration of the tip of the container 10B shown in FIG. 10, and FIG. 12 is a gasket of the container 10B. It is a longitudinal cross-sectional view which shows the structure at the time of movement.
For convenience of description, the upper side in FIGS. 11 and 12 is referred to as a front end, and the lower side is referred to as a rear end.

The container 10B shown in these figures is different from the container 10 or 10A mainly in the configuration of the gasket and the restricting means for restricting the position of the gasket in the axial direction with respect to the container main body 11. In the container 10B, the protrusion 112 is not provided on the inner peripheral surface of the container body 11.

The gasket 20 in the container 10B has a thin portion 22 similar to the above at substantially the center, and a space 21 similar to the above is formed at the rear end side of the thin portion 22. Further, a core material 23 made of, for example, the above-described resin is buried in the gasket 20 on the tip side from the thin portion 22. A substantially central portion of the core member 23 includes a space 24 for storing and holding the same encapsulating member 7 as described above, and a locking portion 25 formed of a circular recess similar to the locking portion 16A communicating with the space 24. Are formed. In addition, the locking portion 25
The inner peripheral surface of the female screw 2 is screwed with the male screw on the outer periphery of the connecting portion.
6 are formed.

At the front end of the core member 23, three fan-shaped small pieces 27 extending radially from the center of the core member 23 at intervals of 120 ° are formed. On the other hand, a ring-shaped locking member 28 is fixed to the distal end of the container main body 11 by fitting to the distal end portion 114 of the container main body 11. As shown in FIG. 11, the inner opening of the locking member 28
The trunk 231 of the core member 23 is inserted.

The inner opening of the locking member 28 has a portion whose diameter is substantially equal to or slightly larger than the outer diameter of the body portion 231 of the core member 23 (to correspond to the small piece 27,
(Formed at three locations at 120 ° intervals from the center)
An inner diameter enlarged portion 29 having an inner diameter larger than the diameter of a circle connecting the outermost circumferences of the small pieces 27 is arranged alternately along the circumferential direction. In this case, each inner diameter enlarged portion 29
Are arranged at intervals of 120 ° from the center, and have an inner diameter and an opening angle larger than those of the small pieces 27.

In the state shown in FIGS. 10 and 11, the distal end surface of the gasket 20 abuts on the rear end surface (the inner surface of the container) of the locking member 28, and each small piece 27 of the core material 23 is
Since the locking member 28 is locked at the portion between the adjacent inner diameter enlarged portions 29 and is in a so-called locked state, the movement of the gasket 20 to the front end side and the rear end side is restricted.

Further, the core member 23 is
When each of the small pieces 27 is overlapped on the corresponding enlarged inner diameter portion 29, the three small pieces 27 pass through the enlarged inner diameter portion 29 at the same time, and the movement restriction to the rear end side is released as shown in FIG. The gasket 20 can slide in the container body 11 toward the rear end. Note that, in the container 10 </ b> B having such a restricting means, the same configuration as the locking portion 16 may be used instead of the locking portion 25.

FIGS. 13, 15 and 17 are longitudinal sectional views showing other examples of the structure of the container according to the present invention.
4 and 16 are bottom views of the container shown in FIGS. 13 and 15, respectively. In each of the containers shown in these figures, a ring-shaped rib 115 is formed on the outer periphery of the rear end (bottom) of the container main body 11, and the rib 115 is engaged with the rib 115 and fixed to the bottom of the container main body 11. (A container moving auxiliary tool) 30A to 30C are provided.

The gripping member 30A shown in FIG. 13 and FIG.
Has an engaging portion 300 to be engaged with the rib 115 and a flange 301 formed on the opposite side to the engaging portion 300.

The gripping member 30B shown in FIGS. 15 and 16
Has an engaging portion 300 to be engaged with the rib 115, and a flange 302 formed on the opposite side to the engaging portion 300,
The engagement portion 300 and the flange 302 are connected by a shaft 303.

The gripping member 30C shown in FIG.
5 is formed, and a concave portion 304 suitable for grasping by a finger or the like is formed on the outer periphery on the opposite side to the engaging portion 300.

In such a container, the holding members 30A to 30A
Since the operation of moving the container with respect to the syringe main body is performed by gripping the flange 301, 302 or the concave portion 304 of the OC with a finger or the like, the operation, particularly the operation of moving the container in the direction of pulling the container from the syringe main body, can be easily and reliably performed. it can. This is particularly effective when the length of the container body 11 is relatively short.

The shape and structure of the holding member are not limited to those shown in the drawings. In addition, in the configuration examples illustrated in FIGS. 13 to 17, the container body 11 and the holding members 30A to 30C are configured as separate members, but they may be formed integrally.

Although the syringe according to the present invention has been described with respect to each configuration example shown in the accompanying drawings, the present invention is not limited to these. For example, the configuration of the connecting portion and the locking portion is not limited to the configuration including the convex portion and the concave portion as illustrated, but may be, for example, surfaces that are joined to each other.
In this case, it is only possible to slide the gasket 12 toward the rear end side with respect to the container body 11 by inserting the container body 11 into the outer cylinder.

[0097]

As described above, according to the syringe of the present invention, for example, injection of a liquid into a bag or compounding of a medicine can be performed in a short time by a simple operation, and the response to an emergency can be performed. This is advantageous. In addition, during operation such as compounding of a drug, there is very little chance that various parts of the syringe such as the inside of the container come into contact with the outside air, so that bacterial contamination and contamination of foreign matter can be prevented.

Then, by replacing the container, a plurality of drugs having different components can be blended by a simple operation.

In particular, when compounding a plurality of drugs having different active ingredients, the first needle tube of the syringe is punctured into a bag or the like, and a plurality of containers each containing a different drug are appropriately replaced and used. And the above-mentioned effects of excellent operability and aseptic retention can be more effectively exhibited.

Further, when the gasket can be reciprocated in the container body by locking the locking portion and the connecting portion, the medicine in the container can be discharged without waste.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view showing a configuration example of a syringe body according to the present invention.

FIG. 2 is a view taken along the line II-II in FIG.

FIG. 3 is a longitudinal sectional view showing a configuration example of a container in the present invention.

FIG. 4 is a plan view of a gasket in the container shown in FIG.

FIG. 5 is a sectional view taken along line VV in FIG.

FIG. 6 is a sectional view taken along line VI-VI in FIG. 4;

FIG. 7 is a longitudinal sectional view showing a use state of the syringe of the present invention.

FIG. 8 is a longitudinal sectional view showing a use state of the syringe of the present invention.

FIG. 9 is a partial longitudinal sectional view showing another configuration example of the syringe of the present invention.

FIG. 10 is a plan view showing another configuration example of the container according to the present invention.

11 is a longitudinal sectional view showing a configuration of a tip portion of the container shown in FIG.

12 is a longitudinal sectional view showing a configuration (at the time of moving a gasket) of a distal end portion of the container shown in FIG.

FIG. 13 is a longitudinal sectional view showing another configuration example of the container according to the present invention.

FIG. 14 is a bottom view of the container shown in FIG.

FIG. 15 is a longitudinal sectional view showing another configuration example of the container according to the present invention.

FIG. 16 is a bottom view of the container shown in FIG.

FIG. 17 is a longitudinal sectional view showing another configuration example of the container according to the present invention.

[Explanation of symbols]

 100, 101 Syringe 1, 1A Syringe body 2 Outer cylinder 2a Bottom part 2b Rear end opening 2c Flange 3 First needle tube 31 Side hole 4 Tube 5 Second needle tube 51 Needle tip 6, 6A Connecting part 61 Male screw 7 Enclosure member Reference Signs List 8 Film 81 Tab 9 Cap 10, 10A, 10B Container 11 Container main body 111 Tip opening 112 Projecting portion 113 Bottom inner surface 114 Tip edge 115 Rib 12, 12A Gasket 121 Tip end surface 122 Rear end surface 123 Outer peripheral surface 13 Space 14 Thin portion 15 Space 16, 16A Locking portion 161 Space 162 Opening 163 Locking surface 164 Female screw 17 Vent hole 18 Projecting portion 19 Film 20 Gasket 21 Space 22 Thin portion 23 Core material 231 Body portion 24 Space 25 Locking portion 26 Female screw 27 Small piece 28 Locking Member 29 Inner diameter enlarged part 30A, 30B, 30C Gripping part 300 engagement portion 301, 302 the flange 303 shaft 304 recess 105 infusion bag 106 elastic stopper 107 infusion 108 chemical 120 drug

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Sumio Hama 1500 Inoguchi, Nakai-machi, Ashigara-kami, Kanagawa Prefecture Inside Terumo Corporation (72) Inventor Junji Kimura 1500 Inoguchi, Nakai-machi, Inagara-gun, Kanagawa Prefecture Terumo Corporation F-term (reference) 4C066 AA10 CC09 DD08 GG18 LL06

Claims (7)

[Claims] 1. An outer cylinder, and a first cylinder installed at a distal end of the outer cylinder.
A needle tube installed in the outer cylinder, a distal end side communicating with the inside of the first needle tube, a second needle tube installed at a rear end side of the tubular body, and a second needle tube. A syringe body composed of a connecting portion formed on the outer peripheral portion, a cylindrical container body with a bottom, and a gasket slidable in a liquid-tight manner along the inner surface of the container body, and a medicine inside. Wherein the gasket includes the second
A thin wall portion through which the needle tube can be pierced, and at least one container formed with a locking portion for locking the connecting portion, wherein the container is inserted into the outer cylinder from the gasket side. Then, the second needle tube is pierced into the thin portion of the gasket, and the container main body is axially relatively moved with respect to the syringe main body in a state where the connecting portion and the locking portion are locked. A syringe that moves and slides the gasket in the container body to discharge at least the liquid in the container through the first needle tube. A syringe which is used in exchange for another container in which is stored. 2. The syringe according to claim 1, wherein the replacement of the container is performed while the first needle tube is connected to a bag containing a liquid. 3. The syringe according to claim 1, wherein the drug is a solid or a liquid. 4. The syringe according to claim 1, further comprising regulating means for regulating an axial position of the gasket with respect to the container body. 5. The syringe according to claim 1, further comprising a film for sealing an opening of the container body. 6. The syringe according to claim 1, wherein the gasket can reciprocate within the container body by locking the locking portion and the connecting portion. 7. The syringe according to claim 1, further comprising an encapsulating member that encloses the second needle tube and that can be pierced with the second needle tube.