JP2002167331A - Digestion and absorption accelator - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide low cost, orally administrative growth accelerator for the aged, sick or wounded such as patients just after operation and domestic animals. SOLUTION: This growth accelerator contains phosphatidylcholine as an active ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a digestion / absorption promoter containing phosphatidylcholine as an active ingredient. The digestion-absorption promoter of the present invention can promote the growth of infants and children by the effect of promoting digestion and absorption, and also promote weight gain of injured persons, including elderly persons who have lost weight and post-operative patients. Therefore, it can be used as a nutritional supplement directly administered orally or as an additive to be added to foods and drinks. In addition, the digestion and absorption promoter of the present invention can promote the growth of animals by the effect of promoting digestion and absorption, and thus can be used as a nutritional supplement directly administered orally or an additive to be added to feed. In addition, the present invention relates to a food or drink which has a phosphatidylcholine and imparts an effect of promoting digestion and absorption. Furthermore, the present invention relates to a feed for livestock which has a phosphatidylcholine blending effect and has an effect of promoting digestion and absorption.

[0002]

2. Description of the Related Art In an aging society in recent years, physiological problems such as aging, a decrease in the function of lipid metabolism, a decrease in immune function, a decrease in digestion and absorptive capacity, and an increase in geriatric diseases have become problems. ing. Under these circumstances, the weight loss of the elderly and the decrease in basic physical strength due to these causes the further worsening of symptoms. Therefore, it is an important issue how to suppress a decrease in basic physical strength due to weight loss of the elderly. In addition, from the viewpoint of a decrease in basic physical strength due to a decrease in weight, the same applies to a victim. Currently, the elderly and the disabled respond to weight loss and delayed body weight recovery through the use of symptomatic dietary supplements. There has been a demand for foods that can be efficiently digested and absorbed and increase body weight. In addition, in infants with a poor nutrient absorption ability, the provision of a material having a high nutrient absorption rate is significant and important in supporting growth.

Further, in recent years, there has been a demand for more efficient production of livestock products, and it has become an important issue how to prevent losses in livestock breeding and breeding. In general, it is said that if the weight of a born newborn is lighter than the average weight of a normal newborn, the difference in weight will not be eliminated if the subsequent eating environment is the same. In general, the greater the number of offspring, the greater the likelihood of having lower weight offspring. And, when a baby with a low weight is born, the baby can significantly impair the economic value of livestock. Therefore, in order to restore the weight of such a newborn baby to an average weight, it is necessary to feed a larger amount of a nutritious feed. However, feeding a large amount of a nutritious feed causes a decrease in production efficiency. Therefore, an inexpensive and nutritious feed to be given to such newborn babies has been demanded. In addition, the use of inexpensive and highly nutritious feed is significant and important because it has the effect of accelerating the growth of livestock and improving production efficiency.

[0004] On the other hand, phosphatidylcholine is a kind of phospholipid and is present in egg yolk, soybean, milk and the like, and is distributed in vivo as a constituent of cell membranes and serum lipoproteins. Phospholipids are broadly divided into two groups, glycerophospholipids and sphingophospholipids. Glycerophospholipids are L-α-glycerophosphate (sn-glycerol-3-phosphat)
e) is a derivative of Phosphatidic acid (Phosphatic acid (phos)
phatidic acid). Furthermore, various amyl alcohols and polyols are ester-bonded to the phosphoric acid moiety,
It forms various glycerophospholipids such as phosphatidylcholine and phosphatidylethanolamine. Constituent components of phospholipids derived from milk and soybeans are shown in Table 1 (Ed. Komoda, Lecithin-Basics and Applications, published by Koshobo, 199).
1).

[0005]

[Table 1]

[0006] The phospholipid acts as a maintenance substance for biological membranes such as cells and blood cells, enhances membrane fluidity, and enhances the action of membrane-bound proteins and receptors. At the cellular level, there is a selective permeability of substances that go against the concentration gradient, but these functions are involved.
It is known to have various effects such as affecting the immune response. However, it has not been reported that phospholipids have a digestive absorption promoting effect.

[0007]

DISCLOSURE OF THE INVENTION The present invention relates to problems such as the above-mentioned problems of poor absorption of nutrients of infants and infants, a problem of a decrease in basal physical strength due to weight loss of the elderly and the sick, and a difference in weight of newborn domestic animals. It is an object of the present invention to provide an orally ingestible digestion and absorption promoter for infants, the elderly, the sick and the livestock, focusing on the problem of reduced production efficiency.

[0008]

Means for Solving the Problems The present inventors have made intensive studies to solve the above problems, and found that phosphatidylcholine, a kind of phospholipid, has a digestive absorption promoting effect. Was completed.

[0009]

DESCRIPTION OF THE PREFERRED EMBODIMENTS In the present invention, phosphatidylcholine is used as an active ingredient of a digestion and absorption promoter. As phosphatidylcholine, those derived from egg yolk, soybean and milk can be used. As an active ingredient of the digestion and absorption enhancer, a concentrate of these materials or a product obtained by purifying phosphatidylcholine from these materials to increase the purity may be used. For example, dairy products such as milk and whey protein concentrate (WPC) fractions obtained by extraction with ether or acetone, aqueous fractions containing butter curd or butter serum obtained by heating and melting butter, these Is purified by dialysis, ammonium sulfate fractionation, gel filtration, isoelectric point precipitation, ion exchange chromatography, or by solvent fractionation (JP-A-3-47192, M. Faure, Bull.
Soc. Biol., 32, 503 (1950)).

The digestion and absorption enhancer containing phosphatidylcholine of the present invention as an active ingredient may be phosphatidylcholine alone or may contain sugar, protein, lipid and the like as constituents. In addition, it can be in the form of a liquid, powder, tablet or the like as appropriate, and can be directly orally administered as a nutritional supplement. In order to exhibit the digestion and absorption promoting effect, it is preferable to administer the digestion and absorption enhancer of the present invention so that the ratio of phosphatidylcholine to all administered foods and drinks is 0.1% by weight or more. Further, the digestion-absorption promoter of the present invention can be added to foods and drinks and livestock feeds, and can be used as foods and drinks and livestock feeds having a digestive absorption promotion effect. In order to impart a digestive absorption-promoting effect to food and drink or livestock feed, it is preferable to add phosphatidylcholine in an amount of 0.1% by weight or more in the final product. Also, a phospholipid composition capable of fortifying an effective amount of phosphatidylcholine without using high-purity phosphatidylcholine may be used. Next, the present invention will be described in more detail with reference to Examples and Test Examples.

[0011]

Example 1 (Preparation of phosphatidylcholine) A reaction solution obtained by allowing a protease to act on a 10% by weight aqueous solution of whey protein concentrate (WPC) was extracted with a chloroform-methanol (2: 1) solution, and then concentrated. The mixture was further extracted with acetone to obtain a complex lipid fraction. Next, the complex lipid fraction was subjected to fluorosilyl column chromatography and stepwise extracted with a chloroform-methanol solution to obtain phosphatidylcholine. After the phosphatidylcholine was subjected to thin-layer chromatography, the color was developed with a Dittmer reagent, and the content of the phosphatidylcholine was 96.3% as measured by densitometry. The phosphatidylcholine thus obtained can be used as it is as a digestion and absorption promoter.

[0012]

[Test Example 1] (Growth-promoting effect on neonatal rats) Test feeds and control feeds were prepared according to the formulation shown in Table 2, and seven 1-week-old SD rats were grouped into a test feed group. , A control feed was administered to the test stomach, and a control feed was administered to the stomach for one week until reaching 2 weeks of age, and a certain amount of each was administered to the control feed group.

[0013]

[Table 2]

The energy of these feeds was 151.8 kcal / 100 ml, the content of phosphatidylcholine was 0.545 g / 100 ml in the test feed, and 0.1% in the control feed.
It was 045 g / 100 ml. And weight changes during the administration period,
The feed intake and feed efficiency, body length, small intestinal weight and small intestinal muscle layer thickness after administration were measured. Table 3 shows the results.

[0015]

[Table 3]

Analysis of the results by the Mann-Whitney test revealed that the weight of the test feed group was significantly higher than that of the control feed group, and that the feed efficiency was also significantly increased. In addition, since the body length, small intestine weight and small intestinal muscle layer thickness of the test feed group were significantly larger than those of the control feed group, this weight increase was due to the increase in body length and the growth of supporting tissues such as the small intestine. It can be seen that this is not so-called obesity in which adipose tissue has increased.

Thus, it has been clarified that ingestion of phosphatidylcholine increased feed efficiency, and as a result, the growth of rats was promoted. During the test period, no pathological changes were observed in the rats.

[0018]

[Test Example 2] (Effect of promoting digestion and absorption on aging-promoting mouse) According to the composition shown in Table 4, a test feed and a control feed were prepared, and an 11-week-old SAMP / 8 mouse (aging-promoting mouse) was used as an aging model. The test feed group and the control feed group were each administered a fixed amount of the test feed group and the control feed group for 28 days. In addition, the normal model of 11 weeks old
SAMR / 1 mice (normal mice) were also tested in the same manner as the aging-promoting mice.

[0019]

[Table 4]

Then, changes in body weight, feed intake and feed efficiency during the administration period, small intestinal weight and small intestinal muscle layer thickness after the administration were measured. Table 5 shows the results.

[0021]

[Table 5]

The results were analyzed by the Kruskal-Wallis test. The body weight of the test feed group was significantly higher than that of the control feed group, and the feed efficiency was significantly higher in both the senescence-accelerated mouse and the normal mouse. Was rising. Also, since the small intestinal muscle layer thickness of the test feed group was significantly larger than that of the control feed group, this weight increase was due to the growth of the supporting tissue in the small intestine, and the so-called obesity in which the fat tissue increased. It turns out that it is not.

This increase in body weight was remarkably observed in senescence-accelerated mice as compared with normal mice. This indicates that the present invention can restore weight loss due to aging. Note that no pathological changes were observed in the mice during the test period.

[0024]

Example 2 (Production of digestion and absorption promoter) The components were mixed in accordance with the formulation shown in Table 6 and molded under pressure to produce a digestion and absorption promoter.

[0025]

[Table 6]

[0026]

Example 3 (Production of a Beverage Having an Effect of Promoting Digestion and Absorption) The components were mixed according to the composition shown in Table 7, filled in a container, and then sterilized by heating to produce a beverage having an effect of enhancing digestion and absorption. did.

[0027]

[Table 7]

[0028]

Example 4 (Manufacture of jelly imparting digestive absorption promoting effect) Ingredients were mixed according to the composition shown in Table 8, filled in a container, heat sterilized, and cooled to impart digestive absorption promoting effect. Jelly was manufactured.

[0029]

[Table 8]

[0030]

Example 5 (Manufacture of pig feed having an effect of promoting digestion and absorption) Ingredients were mixed in accordance with the composition shown in Table 9 to produce a feed of pig (multiple fetus) having an effect of promoting digestion and absorption.

[0031]

[Table 9]

When this feed was administered to a two-month-old pig for one month, the weight was higher than that of an average pig of the same age. No pathological changes were observed in this pig.

[0033]

Example 6 (Production of cattle feed provided with digestive absorption promoting effect) Ingredients were mixed according to the composition shown in Table 10 to produce cattle (single animal) feed provided with digestive absorption promoting effect.

[0034]

[Table 10]

When the feed was administered to a three-month old cow for one month, the weight was higher than that of an average cow of the same age. No pathological changes were observed in this cow.

[0036]

The digestion and absorption enhancer of the present invention exerts the digestion and absorption promotion effect extremely safely by daily oral administration. The effect of promoting digestion and absorption can promote the growth of infants and infants, and also can promote the weight gain of elderly and sick persons who have lost weight. Extremely useful. In addition, the effect of promoting digestion and absorption can promote weight gain of livestock, which is extremely useful for improving the production efficiency of livestock.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat II (reference) // A23K 1/16 303 A23L 2/00 F 2/26 F term (reference) 2B150 AB01 BC01 DA20 DC08 DD57 4B017 LC03 LG04 LK06 LL09 4B018 LB01 LB08 LE01 MD45 ME14 MF08 4B041 LC10 LD02 LK05 4C086 AA01 AA02 DA41 MA01 MA04 MA52 NA14 ZA69

Claims (3)

[Claims] 1. A digestion / absorption promoter comprising phosphatidylcholine as an active ingredient. 2. A food or drink which has a phosphatidylcholine and a digestive absorption promoting effect. 3. Livestock feed containing phosphatidylcholine and having an effect of promoting digestion and absorption.