JP2002145779A - 関節痛治療または予防用組成物 - Google Patents
関節痛治療または予防用組成物Info
- Publication number
- JP2002145779A JP2002145779A JP2000344315A JP2000344315A JP2002145779A JP 2002145779 A JP2002145779 A JP 2002145779A JP 2000344315 A JP2000344315 A JP 2000344315A JP 2000344315 A JP2000344315 A JP 2000344315A JP 2002145779 A JP2002145779 A JP 2002145779A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- weight
- glucosamine
- composition
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000006820 Arthralgia Diseases 0.000 title claims abstract description 45
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 238000011282 treatment Methods 0.000 title description 3
- 238000011321 prophylaxis Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract description 32
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims abstract description 31
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229960002442 glucosamine Drugs 0.000 claims abstract description 31
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 27
- 150000002302 glucosamines Chemical class 0.000 claims abstract description 19
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 18
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 17
- 229920002567 Chondroitin Polymers 0.000 claims abstract description 15
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims abstract description 15
- 235000010374 vitamin B1 Nutrition 0.000 claims description 44
- 239000011691 vitamin B1 Substances 0.000 claims description 44
- 229960003495 thiamine Drugs 0.000 claims description 40
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 38
- 229930003451 Vitamin B1 Natural products 0.000 claims description 35
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 26
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 13
- 229940011671 vitamin b6 Drugs 0.000 claims description 13
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- 239000011726 vitamin B6 Substances 0.000 claims description 11
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- 239000011715 vitamin B12 Substances 0.000 claims description 6
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 abstract description 23
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- 230000001668 ameliorated effect Effects 0.000 abstract 1
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- -1 shicotiamine Chemical compound 0.000 description 17
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
- 230000000694 effects Effects 0.000 description 11
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
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- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 description 8
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- JTLXCMOFVBXEKD-FOWTUZBSSA-N fursultiamine Chemical compound C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N JTLXCMOFVBXEKD-FOWTUZBSSA-N 0.000 description 7
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 6
- 229950006836 fursultiamine Drugs 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 description 6
- 235000010355 mannitol Nutrition 0.000 description 6
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- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 6
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 5
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 5
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- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 5
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
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Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000344315A JP2002145779A (ja) | 2000-11-10 | 2000-11-10 | 関節痛治療または予防用組成物 |
| US09/986,442 US20020099032A1 (en) | 2000-11-10 | 2001-11-08 | Preparations and method of producing the same |
| KR1020010069694A KR100861430B1 (ko) | 2000-11-10 | 2001-11-09 | 제제 및 그의 제조 방법 |
| CN01143682A CN1357328A (zh) | 2000-11-10 | 2001-11-10 | 制剂和生产该制剂的方法 |
| HK02108345.3A HK1046646A1 (zh) | 2000-11-10 | 2002-11-18 | 製劑和生產該製劑的方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000344315A JP2002145779A (ja) | 2000-11-10 | 2000-11-10 | 関節痛治療または予防用組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003316550A Division JP2004026846A (ja) | 2003-09-09 | 2003-09-09 | 関節痛治療または予防用組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002145779A true JP2002145779A (ja) | 2002-05-22 |
| JP2002145779A5 JP2002145779A5 (https=) | 2004-09-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000344315A Withdrawn JP2002145779A (ja) | 2000-11-10 | 2000-11-10 | 関節痛治療または予防用組成物 |
Country Status (1)
| Country | Link |
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| JP (1) | JP2002145779A (https=) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005154281A (ja) * | 2003-11-20 | 2005-06-16 | Ominedo Yakuhin Kogyo Kk | 関節障害予防及び治療用医薬組成物 |
| JP2005232089A (ja) * | 2004-02-19 | 2005-09-02 | Aloe Seiyaku Kk | 骨量増加作用を有する機能性経口投与剤 |
| WO2006070726A1 (ja) * | 2004-12-27 | 2006-07-06 | Yaizu Suisankagaku Industry Co., Ltd. | 口腔内崩壊型ｎ－アセチルグルコサミン錠剤及びその製造方法 |
| JP2007137842A (ja) * | 2005-11-21 | 2007-06-07 | Medicaraise Corp | 錠核部を外層部で包接した二層形状からなる有核錠 |
| JP2007297309A (ja) * | 2006-04-28 | 2007-11-15 | Zeria Pharmaceut Co Ltd | 経口固形製剤 |
| WO2008038423A1 (fr) * | 2006-09-28 | 2008-04-03 | Kobayashi Pharmaceutical Co., Ltd. | Composition antiphlogistique et analgésique pour une utilisation orale |
| JP2009184967A (ja) * | 2008-02-06 | 2009-08-20 | Suntory Holdings Ltd | グルコサミンを含有する経口投与用固形製剤 |
| JP2010037302A (ja) * | 2008-08-07 | 2010-02-18 | Takeda Chem Ind Ltd | 医薬組成物及び関節障害の予防治療剤 |
| JPWO2013129551A1 (ja) * | 2012-02-29 | 2015-07-30 | ロート製薬株式会社 | 固形組成物 |
| CN109942568A (zh) * | 2019-04-03 | 2019-06-28 | 赤峰制药股份有限公司 | 一种硝酸硫胺制备方法 |
-
2000
- 2000-11-10 JP JP2000344315A patent/JP2002145779A/ja not_active Withdrawn
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005154281A (ja) * | 2003-11-20 | 2005-06-16 | Ominedo Yakuhin Kogyo Kk | 関節障害予防及び治療用医薬組成物 |
| JP2005232089A (ja) * | 2004-02-19 | 2005-09-02 | Aloe Seiyaku Kk | 骨量増加作用を有する機能性経口投与剤 |
| WO2006070726A1 (ja) * | 2004-12-27 | 2006-07-06 | Yaizu Suisankagaku Industry Co., Ltd. | 口腔内崩壊型ｎ－アセチルグルコサミン錠剤及びその製造方法 |
| JP2007137842A (ja) * | 2005-11-21 | 2007-06-07 | Medicaraise Corp | 錠核部を外層部で包接した二層形状からなる有核錠 |
| JP2007297309A (ja) * | 2006-04-28 | 2007-11-15 | Zeria Pharmaceut Co Ltd | 経口固形製剤 |
| WO2008038423A1 (fr) * | 2006-09-28 | 2008-04-03 | Kobayashi Pharmaceutical Co., Ltd. | Composition antiphlogistique et analgésique pour une utilisation orale |
| JP2009184967A (ja) * | 2008-02-06 | 2009-08-20 | Suntory Holdings Ltd | グルコサミンを含有する経口投与用固形製剤 |
| JP2010037302A (ja) * | 2008-08-07 | 2010-02-18 | Takeda Chem Ind Ltd | 医薬組成物及び関節障害の予防治療剤 |
| JPWO2013129551A1 (ja) * | 2012-02-29 | 2015-07-30 | ロート製薬株式会社 | 固形組成物 |
| CN109942568A (zh) * | 2019-04-03 | 2019-06-28 | 赤峰制药股份有限公司 | 一种硝酸硫胺制备方法 |
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