JP2002080365A5 - - Google Patents
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- Publication number
- JP2002080365A5 JP2002080365A5 JP2001204280A JP2001204280A JP2002080365A5 JP 2002080365 A5 JP2002080365 A5 JP 2002080365A5 JP 2001204280 A JP2001204280 A JP 2001204280A JP 2001204280 A JP2001204280 A JP 2001204280A JP 2002080365 A5 JP2002080365 A5 JP 2002080365A5
- Authority
- JP
- Japan
- Prior art keywords
- tocopherol
- fat
- soluble substance
- solution
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 polyoxyethylene Polymers 0.000 description 24
- 239000000126 substance Substances 0.000 description 20
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 235000014113 dietary fatty acids Nutrition 0.000 description 12
- 229930195729 fatty acid Natural products 0.000 description 12
- 239000000194 fatty acid Substances 0.000 description 12
- 230000003381 solubilizing effect Effects 0.000 description 10
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 9
- GZIFEOYASATJEH-UHFFFAOYSA-N 2,8-dimethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 description 7
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical group OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 7
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 7
- 239000004359 castor oil Substances 0.000 description 6
- 235000019438 castor oil Nutrition 0.000 description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 6
- 229940042585 tocopherol acetate Drugs 0.000 description 6
- 229930003427 Vitamin E Natural products 0.000 description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 4
- 239000011732 tocopherol Substances 0.000 description 4
- 229930003799 tocopherol Natural products 0.000 description 4
- 229960001295 tocopherol Drugs 0.000 description 4
- 235000010384 tocopherol Nutrition 0.000 description 4
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 4
- 229940046009 vitamin E Drugs 0.000 description 4
- 235000019165 vitamin E Nutrition 0.000 description 4
- 239000011709 vitamin E Substances 0.000 description 4
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 4
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
- 229920001214 Polysorbate 60 Polymers 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 150000005215 alkyl ethers Chemical class 0.000 description 3
- 235000001968 nicotinic acid Nutrition 0.000 description 3
- 239000011664 nicotinic acid Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 229960000984 tocofersolan Drugs 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 2
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000223 polyglycerol Polymers 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000002076 α-tocopherol Substances 0.000 description 2
- 235000004835 α-tocopherol Nutrition 0.000 description 2
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 2
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 description 1
- IELOKBJPULMYRW-IKTKBOKFSA-N 4-oxo-4-[[(2S)-2,5,7,8-tetramethyl-2-[(4S,8S)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]butanoic acid Chemical compound CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@](C)(CC1)Oc(c(C)c2C)c1c(C)c2OC(CCC(O)=O)=O IELOKBJPULMYRW-IKTKBOKFSA-N 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 1
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000009931 pascalization Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229930003802 tocotrienol Natural products 0.000 description 1
- 239000011731 tocotrienol Substances 0.000 description 1
- 235000019148 tocotrienols Nutrition 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001204280A JP4117119B2 (ja) | 2000-07-05 | 2001-07-05 | 脂溶性物質の可溶化液剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000-203394 | 2000-07-05 | ||
| JP2000203394 | 2000-07-05 | ||
| JP2001204280A JP4117119B2 (ja) | 2000-07-05 | 2001-07-05 | 脂溶性物質の可溶化液剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002080365A JP2002080365A (ja) | 2002-03-19 |
| JP2002080365A5 true JP2002080365A5 (https=) | 2008-01-24 |
| JP4117119B2 JP4117119B2 (ja) | 2008-07-16 |
Family
ID=26595408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001204280A Expired - Fee Related JP4117119B2 (ja) | 2000-07-05 | 2001-07-05 | 脂溶性物質の可溶化液剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4117119B2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002020268A (ja) * | 2000-07-10 | 2002-01-23 | Takeda Chem Ind Ltd | 脂溶性物質含有内服液剤 |
| CN1863505A (zh) | 2003-10-10 | 2006-11-15 | 卫材株式会社 | 新型液体制剂组合物 |
| JP2007277207A (ja) * | 2006-03-15 | 2007-10-25 | Rohto Pharmaceut Co Ltd | 内服用製剤 |
| JP6131522B2 (ja) * | 2011-03-25 | 2017-05-24 | 大正製薬株式会社 | ロキソプロフェン含有外用剤 |
| JP6420969B2 (ja) * | 2014-05-22 | 2018-11-07 | 株式会社 沖縄リサーチセンター | ポリメトキシフラボノイド溶解組成物及びその製造方法 |
| BR112020003233B1 (pt) * | 2017-12-20 | 2023-11-07 | Firmenich S.A. | Composições para cuidado oral |
| JP6904289B2 (ja) * | 2018-03-19 | 2021-07-14 | ライオン株式会社 | 水性眼科用組成物 |
| JP7623277B2 (ja) * | 2019-03-27 | 2025-01-28 | 千寿製薬株式会社 | 水性製剤 |
-
2001
- 2001-07-05 JP JP2001204280A patent/JP4117119B2/ja not_active Expired - Fee Related
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