JP2002020259A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation containing an ascorbic acid phosphoric acid ester magnesium salt, free from stickiness when applied and tense feeling when finished and affording favorable feeling with dampishness when applied. SOLUTION: This skin care preparation containing an ascorbic acid phosphoric acid ester magnesium salt is such as to be formulated with a dextrin fatty acid ester.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin having a good feeling upon use. More specifically, the present invention relates to an external preparation for skin which prevents stickiness when used with ascorbic acid phosphate magnesium salt and a tight feeling at the time of finishing by using dextrin fatty acid ester and magnesium ascorbic acid phosphate salt in combination. .

[0002]

2. Description of the Related Art Magnesium ascorbic acid phosphate is a stable derivative having a vitamin C action and is well soluble in water. Therefore, it has been widely used as a general whitening component and an antioxidant component in skin external preparations. I have. However, an external preparation for skin containing magnesium ascorbic acid phosphate ester may be applied on the skin and may be sticky before it is completely absorbed into the skin, or may have a feeling of being used when it is finished. Conventionally, the type and amount of the humectant or oil to be blended or the amount of blending is adjusted, or spherical silicon dioxide powder is added (Japanese Unexamined Patent Publication No. 11-279024) to suppress this sticky feeling.

[0003] However, the above countermeasures have reduced the sticky feeling of use to some extent, but the effect is not sufficient, and the feeling of tightness of the finish has not been solved at all. A new problem of a drop in the feeling was also generated.

[0004]

Accordingly, in the present invention, there is no stickiness at the time of use and no tightness at the time of finishing, and a good moist feeling can be exhibited.
It was intended to obtain a skin external preparation containing ascorbic acid phosphate magnesium salt.

[0005]

As a result of various investigations to solve the above-mentioned problems, a dextrin fatty acid ester was used in combination with a dextrin fatty acid ester in an external preparation for skin containing magnesium ascorbic acid phosphate to make it sticky at the time of use. The present inventors have found that there is no tightness at the time of finishing and a good moist feeling can be exhibited, and the present invention has been completed.

[0006]

Embodiments of the present invention will be described below.

Ascorbic acid phosphate magnesium salt used in the emulsified composition of the present invention is not particularly limited as long as it is generally used as a skin external preparation raw material. For example, commercially available VC-PMg (Manufacturer: Nikko Chemicals), VCP-MG (Manufacturer: Kyowa Hakko),
L-ascorbyl magnesium phosphate (manufacturer; Wako Pure Chemical Industries), ASD (manufacturer: Wakamoto Pharmaceutical), ascorbic acid PM “SDK” (manufacturer: Showa Denko), Seamate (manufacturer: Takeda Pharmaceutical). The amount of magnesium ascorbic acid phosphate is
It is preferably 0.01 to 20% by weight based on the total amount of the external preparation for skin.

In the external preparation for skin of the present invention, as the dextrin fatty acid ester used in combination with the magnesium ascorbic acid phosphate, an ester of dextrin and a higher fatty acid having 6 to 22 carbon atoms is used. Dextrin caproate, dextrin 2-ethylhexanoate, dextrin caprylate, dextrin undecanoate, dextrin laurate, dextrin myristate, dextrin palmitate, dextrin stearate, dextrin isostearate, dextrin arachinate, dextrin behenate, coconut fatty acid Dextrin and the like, and one or more of these are selected and used. Alternatively, commercially available fatty acid dextrins, Leopearl KE, Leopearl KL, Leopearl TT, and Leopearl TL (all manufactured by Chiba Flour Milling Co., Ltd.) may be used. Among these fatty acid dextrins, dextrin palmitate and dextrin 2-ethylhexanoate are most preferable in terms of stability and usability.

The amount of the dextrin fatty acid ester in the present invention is 0.1 to 10 with respect to the total amount of the emulsified composition.
%, More preferably 0.5 to 7% by weight.

[0010] In the skin external preparation of the present invention, other components usually used in the skin external preparation can be appropriately blended as long as the effects of the present invention are not impaired. For example, ultraviolet absorbers, humectants, whitening ingredients, anti-inflammatory agents, antioxidants, oils, surfactants, silicone oils, water-soluble polymers, chelating agents, fragrances, preservatives, antibacterial agents, bactericides, pigments, Pigments and the like can be added as needed.

The form and form that the external preparation for skin of the present invention can take is not particularly limited.

[0012]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

According to the formulations shown in Table 1, a skin lightening agent according to the present invention for external application to skin according to Example 1 and Comparative Examples 1 and 2
Was prepared. Each serum is heated to 75 ° C, dissolved,
The A component was added to the homogenized B component, and the mixture was emulsified with a homomixer. After cooling, the C component was added at 40 ° C., followed by mixing and homogenization.

[0014]

[Table 1]

Example 2 Skin Cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 3.0 (3) Reduced Lanolin 3.0 (4) Squalane 29.5 (5) 2-Ethyl Dextrin hexanoate 2.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20EO) sorbitan monolaurate 5.0 (8) Propylene glycol 5.0 (9) Xanthan gum 0. 3 (10) Purified water 38.2 (11) Magnesium ascorbic acid phosphate ester 5.0 (12) Sodium hyaluronate 1.0 Production method: Mix and dissolve the oil phase components of (1) to (7) Heat to 75 ° C. On the other hand, the aqueous phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component for preliminary emulsification, the mixture is uniformly emulsified by a homomixer and then cooled. At 40 ° C., add (11) and (12), mix and homogenize.

Example 3 Makeup Base Cream (1) Squalane 5.0 (% by weight) (2) Cetanol 2.0 (3) Dextrin Palmitate 2.0 (4) Glyceryl tri-2-ethylhexanoic acid Ester 2.5 (5) Self-emulsifying glyceryl monostearate 2.0 (6) Propylene glycol 10.0 (7) Xanthan gum 0.3 (8) Purified water 72.6 (9) Titanium oxide 1.0 ( 10) Bengala 0.1 (11) Yellow iron oxide 0.4 (12) Fragrance 0.1 (13) Ascorbic acid phosphoric acid ester magnesium salt 2.0 Production method: Mix the oil phase components of (1) to (5) And heated to 75 ° C. to make it uniform. On the other hand, the components (6) to (8)
The mixture was heated and dissolved at ℃ to make it uniform, and the pigments of (9) to (11) were added thereto and uniformly dispersed with a homomixer to obtain an aqueous phase component. The oil phase component is added to the aqueous phase component, emulsified by a homomixer, cooled, and the components (12) and (13) are added and mixed at 40 ° C.

Example 4 Emulsion Foundation (1) Beeswax 2.0 (% by weight) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Dextrin 2-ethylhexanoate 0 (5) Decaglyceryl monoisopalmitate 9.0 (6) 1,3-butylene glycol 8.0 (7) Xanthan gum 0.3 (8) Purified water 48.5 (9) Titanium oxide 9.0 ( 10) Talc 7.4 (11) Bengala 0.5 (12) Yellow iron oxide 1.1 (13) Black iron oxide 0.1 (14) Fragrance 0.1 (15) Ascorbic acid phosphate magnesium salt 3. 0 Production method: The oil phase components (1) to (5) are mixed and heated to 75 ° C. to make uniform. On the other hand, the aqueous phase components (6) to (8) are mixed,
The mixture is heated to 75 ° C. and dissolved to make it uniform. The pigments (9) to (13) are added to the mixture, and the mixture is uniformly dispersed with a homomixer. The oil phase component is added and emulsified, then cooled, and the components (14) and (15) are added and mixed at 40 ° C.

Example 5 Sunscreen Prevention Emulsion (1) Paraffin Wax 1.0 (% by weight) (2) Liquid Paraffin 10.0 (3) Cetyl Palmitate 3.0 (4) Dextrin Palmitate 1.0 (5) Sucrose palmitate 1.5 (6) Sucrose stearate 0.8 (7) Glycerin 12.0 (8) 1,3-butylene glycol 8.0 (9) Methyl paraoxybenzoate 0. 1 (10) Xanthan gum 0.3 (11) Purified water 47.3 (12) Fine particle titanium oxide 10.0 (13) Ascorbic acid phosphoric acid ester magnesium salt 5.0 Production method: Oil phase of (1) to (6) The ingredients are mixed and heated to 75 ° C. to homogeneity. On the other hand, the aqueous phase components (7) to (11) are mixed,
Heat and melt at 75 ° C. to make uniform, add (12) to this, and uniformly disperse with a homomixer. The oil phase component is added and emulsified, followed by cooling. At 40 ° C., add the component (13) and mix.

Example 6 Whitening Emulsion (1) Glyceryl tri-2-ethylhexanoate 7.8 (% by weight) (2) Hydrogenated soybean lecithin 0.5 (3) Dextrin palmitate 1.0 (4) 40) Polyglyceryl distearate 2.5 (5) Glycerin 7.5 (6) Xanthan gum 0.4 (7) Methyl parahydroxybenzoate 0.1 (8) 1,3-butylene glycol 10.0 (9) Purified water 0 (10) Magnesium ascorbic acid phosphate ester 3.0 (11) Sodium citrate 0.5 (12) Diethylenetriaminepentaacetic acid pentasodium 0.1 (13) Purified water 26.6 Production method: (1) to (5) ) And the aqueous phase components (6) to (9) are mixed and dissolved, and heated to 75 ° C. The oil phase component is added to the water phase component, uniformly emulsified by a homomixer, and then cooled. A solution obtained by uniformly dissolving the components (10) to (12) in (13) is added at 40 ° C.

For Examples 1 to 6 and Comparative Examples 1 and 2, five panelists specialized in sensory evaluation
The usability evaluation was performed. The evaluations were "sticky when using and whether or not there was a sense of tightness when finished".
1 "," Slightly present: 2 "," Not so much: 3 "," Not so: 4 ", and further, regarding the presence or absence of moist feeling," No: 1 "," Not so much: 2 "," Slightly " It is in:
The average value was calculated in four steps of “3” and “presence: 4”. The results are shown in Table 2.

[0021]

[Table 2]

As shown in Table 2, in Example 1 of the present invention, although the amount of oil and humectant was larger than that of Comparative Example 1 in which the amount of oil and humectant that could cause stickiness was reduced, It is evaluated that the stickiness is slightly less,
The feeling of tightness and moistness was also excellent. Further, in Comparative Example 2 in which spherical silicon dioxide was added, the stickiness was improved to some extent, but not as in Example 1 in which the dextrin fatty acid ester was blended, and the evaluation of the feeling of tightness and moistness was poor. . Also in Examples 2 to 6, there was no stickiness at the time of use and no tightness at the time of finishing, and a good moist feeling was observed.

[0023]

As described in detail above, according to the present invention, a magnesium ascorbate phosphoric acid ester which is free from stickiness at the time of use and firmness at the time of finishing and can exhibit a good moist feeling. Could be obtained.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 N 7/035 7/035 7/42 7/42 31/665 31/665 31/721 31/721 A61P 17/00 A61P 17/00 F term (reference) 4C083 AB082 AB172 AB232 AB242 AB442 AC012 AC022 AC072 AC102 AC122 AC302 AC422 AC442 AC482 AC532 AC901 AC902 AD212 AD222 AD241 AD242 AD352 AD512 AD572 CC02 CC05 CC12 CC14 CC19 DD23 DD27 DD31 EE12 EE16 EE17 4C086 DA37 EA20 MA02 MA04 MA63 NA05 ZA89 ZC75

Claims (1)

[Claims] 1. An external preparation for skin containing magnesium ascorbic acid phosphate and dextrin fatty acid ester.