JP2002020252A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for the oral cavity comprising an encapsulant easy to crush the encapsulant with the teeth and capable of surely change both the flavor and texture of the composition as a result of breaking the encapsulant. SOLUTION: This composition for the oral cavity is characterized by comprising an encapsulant >3 mm in average particle size with the encapsulating film consisting mainly of a water-insoluble or sparingly water-soluble film- forming substance, readily breakable through crushing in the oral cavity.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition containing a capsule, and more particularly, to a capsule composition which is easily destroyed by chewing in the oral cavity at the time of use. The present invention relates to a composition for the oral cavity in which a change in flavor and a change in texture can be realized when done.

[0002]

2. Description of the Related Art Various proposals have heretofore been made for blending a capsule containing a medicinal ingredient, a sweetener, a pigment and the like into an oral composition, for example, the following. (A) Dentifrice using gelatin capsule (JP-A-49
(B) Coated particle-containing dentifrice using a wax-like lipophilic substance as a coating agent (Japanese Patent Publication No. Sho 58-20928, Japanese Patent Publication No. Sho No. 5)
(C) Defoaming dentifrice containing agar microcapsules containing silicone oil (JP-A-55-100309) (d) Water-insoluble on the capsule film Microcapsules covered with salt precipitates (JP-B-63-48580) (e) Dentifrices containing agar capsules having a particle size of 0.3 to 3 mm (JP-A-8-169811, JP-A-8-1698)
No. 13)

[0003]

However, capsules containing gelatin as a film-forming substance are difficult to stabilize in water-based preparations such as toothpastes, mouthwashes, etc. It was difficult to use. Further, an oral composition containing particles coated with a wax-like lipophilic substance,
There is a problem that the particles are too hard to chew and the contents are not easily released. Furthermore, when microcapsules having a particle size of 0.3 to 3 mm using water-insoluble agar as a coating agent are used, the capsules are too small, and the feeling of use when chewed in the mouth and the contents released from the capsules are released. I can't feel the change when it was done.

[0004] As described above, the capsules used in the conventional oral composition are inferior in chewability in the oral cavity, a change in flavor due to capsule destruction, and a feeling of use giving texture change. Is desired.

[0005]

Means for Solving the Problems and Embodiments of the Invention The present inventor has conducted intensive studies in order to respond to the above demands.
As a capsule, a capsule-forming material containing water-insoluble or hardly soluble film-forming substance as a main component and having an average particle size larger than 3 mm which is easily broken by chewing in the oral cavity is used. The present inventors have found that the agent is easily chewed and destroyed, and at the same time, the contents contained in the capsule are released in a sufficient amount to give a change in flavor and a change in texture, and the present invention has been accomplished.

Hereinafter, the present invention will be described in more detail.
The composition for the oral cavity of the present invention contains a capsule in which a film-forming substance insoluble or hardly soluble in water has a capsule film as a main component and an average particle size which is easily broken by chewing in the oral cavity and is larger than 3 mm. Things.

Here, as the film-forming substance insoluble or hardly soluble in water, one or two or more gel substances formed by the reaction of a sol solution of agar and an anionic polymer with a polyvalent metal ion are used. Can be used.
There is no particular limitation on the type of agar, but those having a jelly strength of 500 g or more (weight per 1 cm ² when a weight of 1.5% by weight is applied to a gel and can withstand for 20 seconds) are at the time of production. Preferred without breakage.

[0008] As an anionic polymer, COO is contained in the molecule.
^- group, SO ₃ ^- group, those having a OPO ₃ ^2-group, is not particularly limited be natural of synthetic, preferably alginate, pectate, low methoxyl pectin, carboxymethylcellulose salts, carrageenans , Polyacrylates and the like. As a polyvalent metal ion for gelling a sol solution of an anionic polymer, a calcium ion, a magnesium ion, a strontium ion, a barium ion, an aluminum ion, and an iron (III) ion are preferable. Are inorganic salts such as chloride, sulfate, nitrate and phosphate of each ion,
Organic salts such as acetate, citrate, lactate, succinate and tartrate can be used, but chloride, acetate, citrate and lactate are preferred.

On the other hand, the contents of the capsule are appropriately selected according to the type of the oral composition, the flavor and texture to be imparted to the oral composition, and include various active ingredients, flavors, sweeteners, pigments and the like. And its form is liquid,
Although there is no particular limitation to gel, powder, etc., lipophilic components are preferably used. If necessary, various fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, silicone oils and the like can be used.

There is no limitation on the production method of the capsule, and any known production methods such as a double nozzle dropping method, an interfacial polymerization method, a cured film in liquid method, and a coacervation method can be used. The double nozzle dropping method is preferred.

In the present invention, the capsule has an average particle diameter of more than 3 mm, preferably 3.5 to 30 m.
m, more preferably 5 to 20 mm, still more preferably 5 to 20 mm
Use a 10 mm one. In capsules having an average particle size of 3 mm or less, when crushing, they escape from the teeth and cannot be crushed well, or the amount of contents released when crushed is too small to change the flavor or texture. However, the object of the present invention cannot be achieved. Further, if the average particle size exceeds 30 mm, it may be difficult to contain it in the mouth.

In the capsules used in the present invention, the amount or coverage of the film-forming substance is 1 to 50%.
In particular, it is preferably 10 to 30%.

The amount of the above-mentioned capsules to be mixed with the oral composition is selected according to the kind of the capsule contents and the like.
Usually, it is preferably 0.1 to 30% (mass percentage, hereinafter the same) of the whole composition, particularly preferably 0.5 to 10%.

The oral composition of the present invention is prepared and applied as dentifrices, toothpastes such as toothpastes, lubricating dentifrices, liquid dentifrices, mouthwashes, troches, mouth fresheners and the like. Ingredients such as abrasives, thickeners, binders, surfactants, sweeteners, flavors, coloring agents, preservatives, active ingredients, and the like, can be included. In this case, some or all of the sweetener, flavor, coloring agent, active ingredient, and the like can be used as the capsule contents.

As an example of the above components, the abrasive may be
Silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tertiary phosphoric acid Examples include magnesium, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, zeolite, aluminum silicate, zirconium silicate, and a synthetic resin-based abrasive.

Examples of the thickener include glycerin, sorbitol, xylitol, propylene glycol, polyethylene glycol and the like.

Examples of the binder include carrageenan, sodium alginate, propylene glycol alginate, xanthan gum, polyacrylic acid, sodium polyacrylate, carboxyvinyl polymer, tragacanth gum, guar gum, locust bean gum, sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropyl Examples include cellulose, methylcellulose, gellan gum, gelatin, curdlan, gum arabic, agar, pectin, polyvinyl alcohol, polyvinylpyrrolidone, pullulan and the like.

Examples of the surfactant include anionic surfactants, cationic surfactants, and nonionic surfactants. Specific examples thereof include sodium lauryl sulfate, sodium N-lauroyl sarcosine, and α-olefin sulfone. Acid sodium, N-acylglutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyltaurate, sucrose fatty acid ester, alkylolamide, polyoxyethylene hydrogenated castor oil, polyglycerin Fatty acid esters,
Pluronic, polyoxyethylene sorbitan monostearate and the like.

As sweeteners, sodium saccharin,
Examples include stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin, sucralose, aspartame and the like.

Fragrances include mastic oil, parsley oil, peppermint oil, spearmint oil, anise oil, eucalyptus oil,
Winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil,
Lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil,
Natural flavors such as rose oil, jasmine oil, iris concrete, absolute peppermint, absolute rose, orange flower, and menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, thymol, linalool, linalool acetate, limonene , Menthone, menthyl acetate, pinene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, etc. Dating, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol Hexenol, dimethyl sulfide, cyclotene, furfural, trimethyl pyrazine, ethyl lactate, separately perfumes such as ethyl thioacetate, and / or strawberry flavor natural flavors also blended fragrance containing apple flavor, banana flavor, pineapple flavor, grape flavor,
Mango flavor, tropical fruit flavor,
Known flavors used in oral compositions such as butter flavor, milk flavor, fruit mix flavor and the like can be used, and are not limited to the flavors of Examples.
Examples of the coloring agent include Blue No. 1, Yellow No. 4, and titanium dioxide.

Examples of the active ingredient include cationic fungicides such as chlorohexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, and decalinium chloride, phenolic compounds such as triclosan, hinokitiol, and biosol, dextranase, and mutanase. Enzymes such as lysozyme, amylase, protease, lytic enzyme and superoxide dismutase; vitamins such as vitamin E and vitamin C; alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; Sodium, fluorides such as stannous fluoride, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyallantoin, dihydrocholesterol, glycyrrhizic acid, glycyrrhetic Phosphate, bisabolol, glycerophosphate, chlorophyll, sodium chloride, polyvinyl pyrrolidone, polyethylene glycol, water-soluble inorganic phosphoric acid compounds and the like, can be blended these known active ingredients one or more.

[0022]

EFFECT OF THE INVENTION The capsule-containing oral composition of the present invention can easily chew the capsule in the oral cavity, and can reliably change the flavor and texture of the oral composition by breaking the capsule.

[0023]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition,% is a mass percentage in the following examples.

[Examples and Comparative Examples] 3 having an average particle size of 1 mm, 4 mm and 5 mm comprising the following capsule film and contents.
Various types of capsules were produced by a double nozzle dropping method. Capsule formulation Capsule coating formulation Agar (jelly strength 700 g / cm ² ) 5% Purified water 95% Total 100% Content formulation Tri (caprylic / capric acid) glycerin 85% Perfume with composition shown below 15% Total 100% Perfume formulation 1-menthol 20% spearmint oil 10 peppermint oil 10 peppermint oil 5 anethole 2 sage oil 1 rosemary oil 1 thyme oil 1 lemon oil 10 cardamom oil 0.5 coriander oil 0.5 cassia oil 0.5 mastic oil 0.1 Clove oil 0.1 tri (caprylic / capric acid) glycerin balance 100%

On the other hand, the following toothpaste was produced by a conventional method. Dentifrice prescription Calcium hydrogen phosphate dihydrate for dentifrice 45% 70% sorbite solution 23 Propylene glycol 3 Sodium carboxymethyl cellulose 1.2 Saccharin sodium 0.1 Sodium lauryl sulfate 1.5 Methyl paraben 0.3 Sodium monofluorophosphate 0.73 Perfume 1 Purified water balance 100%

Next, 5 parts by mass of the above capsule and dentifrice 9
A mixture of 5 parts by mass was used as a sample, and sensory evaluation was performed on the ease of biting of the capsule in the mouth and changes in flavor and texture during use according to the following criteria. Table 1 shows the results.

[0027]

[Table 1] Easiness of biting The sample contains toothpaste in the mouth and is chewed several times to evaluate the feeling of biting and the amount of remaining bite. 5 points: The feeling of biting is high, and there is no biting after several times of chewing. 4 points: The feeling of crushing was somewhat high, and there was no bite remaining after several chews. 3 points: There is a feeling of crushing, but a bite remains. 2 points: The feeling of crushing is poor, and many bites remain. 1 point: There is no feeling of biting, and many bites remain. Changes in flavor and texture Evaluate changes in flavor and texture by chewing several times with a sample toothpaste in the mouth 5 points: feel a strong change 4 points: feel a slightly strong change 3 points: feel a change 2 points: change I can hardly feel one point: I do not feel change

As can be seen from the results in Table 1, those having an average capsule particle size of more than 3 mm were easy to chew and were able to give favorable changes in flavor and texture.

 ──────────────────────────────────────────────────続 き Continuing on the front page F term (reference) 4C076 AA54 AA58 BB22 CC10 DD37T DD39T DD46 EE01H EE30H EE47H EE53T FF31 GG01 4C083 AA111 AA112 AA122 AB052 AB282 AC062 AC122 AC132 AC392 AC482 AC792 AC862 AD272 AD371 BB60

Claims (3)

[Claims] 1. A capsule-forming material comprising a water-insoluble or hardly water-soluble film-forming substance as a main component, and a capsule having an average particle size larger than 3 mm which is easily broken by chewing in the oral cavity. Oral composition. 2. The oral composition according to claim 1, wherein the film-forming substance is agar. 3. The oral composition according to claim 1, wherein the film-forming substance is a gel substance formed by a reaction between a sol solution of an anionic polymer and a polyvalent metal ion.