JP2001525797A5 - - Google Patents

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Publication number
JP2001525797A5
JP2001525797A5 JP1998520739A JP52073998A JP2001525797A5 JP 2001525797 A5 JP2001525797 A5 JP 2001525797A5 JP 1998520739 A JP1998520739 A JP 1998520739A JP 52073998 A JP52073998 A JP 52073998A JP 2001525797 A5 JP2001525797 A5 JP 2001525797A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1998520739A
Other languages
English (en)
Japanese (ja)
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JP2001525797A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/019670 external-priority patent/WO1998018324A1/en
Publication of JP2001525797A publication Critical patent/JP2001525797A/ja
Publication of JP2001525797A5 publication Critical patent/JP2001525797A5/ja
Pending legal-status Critical Current

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JP52073998A 1996-10-28 1997-10-27 ウイルスrnaへのミスコーディングリボヌクレオシドアナログの組込みによるウイルス変異の誘導 Pending JP2001525797A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2940496P 1996-10-28 1996-10-28
US60/029,404 1996-10-28
US4053597P 1997-02-27 1997-02-27
US60/040,535 1997-02-27
PCT/US1997/019670 WO1998018324A1 (en) 1996-10-28 1997-10-27 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral rna

Publications (2)

Publication Number Publication Date
JP2001525797A JP2001525797A (ja) 2001-12-11
JP2001525797A5 true JP2001525797A5 (https=) 2005-06-16

Family

ID=26704916

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52073998A Pending JP2001525797A (ja) 1996-10-28 1997-10-27 ウイルスrnaへのミスコーディングリボヌクレオシドアナログの組込みによるウイルス変異の誘導

Country Status (7)

Country Link
US (1) US6063628A (https=)
EP (1) EP0948256A4 (https=)
JP (1) JP2001525797A (https=)
AU (1) AU740916B2 (https=)
CA (1) CA2269213A1 (https=)
NZ (2) NZ335000A (https=)
WO (1) WO1998018324A1 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0948256A4 (en) * 1996-10-28 2007-10-24 Univ Washington INDUCTION OF VIRAL MUTATIONS BY INTRODUCTION TO ERROR-CODED RIBONUCLEOSIDE ANALOGUES IN VIRAL RNA
US6887707B2 (en) * 1996-10-28 2005-05-03 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
US6423695B1 (en) * 1998-01-13 2002-07-23 Ribapharm, Inc. Cytokine related treatments of disease
JP2002540168A (ja) * 1999-03-26 2002-11-26 ウォルター リード アーミー インスティテュート オブ リサーチ 多価デングウイルスワクチン
WO2001017518A2 (en) * 1999-09-09 2001-03-15 Zymetx, Inc. Method of treatment of influenza
AU7938900A (en) * 1999-10-27 2001-05-08 Cytos Biotechnology Ag Method for creating divergent populations of nucleic acid molecules and proteins
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
CN1427722A (zh) 2000-02-18 2003-07-02 希拉生物化学股份有限公司 用核苷类似物治疗或预防黄病毒感染的方法
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR20080021797A (ko) 2000-05-26 2008-03-07 이데닉스(케이만)리미티드 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물
KR20090089922A (ko) * 2000-10-18 2009-08-24 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
US8481712B2 (en) 2001-01-22 2013-07-09 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
WO2002057425A2 (en) * 2001-01-22 2002-07-25 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2002252183A1 (en) * 2001-03-06 2002-09-19 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
EP1425022A4 (en) * 2001-08-24 2009-04-29 Koronis Pharmaceuticals Inc MUTAGENIC NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF VIRAL DISEASE
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス(ケイマン)リミテツド 4’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
US7049303B2 (en) * 2001-11-07 2006-05-23 Medical Research Council Inhibition of viruses
US20040138170A1 (en) * 2002-03-06 2004-07-15 Montgomery John A. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
PL374781A1 (en) * 2002-06-28 2005-10-31 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
WO2004011647A1 (en) 2002-07-26 2004-02-05 Chiron Corporation Modified small interfering rna molecules and methods of use
HUE033832T2 (en) * 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
RU2005121904A (ru) * 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
RU2005133093A (ru) * 2003-03-28 2006-07-27 Фармассет, Инк. (Us) Соединения для лечения флавивирусных инфекций
WO2005018330A1 (en) * 2003-08-18 2005-03-03 Pharmasset, Inc. Dosing regimen for flaviviridae therapy
US20070042352A1 (en) * 2003-08-18 2007-02-22 Dawn Patricia Wooley Retroviral vector and cell-based assay for measuring the mutations rate of retroviruses employing same
EP1858889A1 (en) 2005-03-08 2007-11-28 Biota Scientific Management Pty. Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
WO2006107923A1 (en) * 2005-04-05 2006-10-12 Boehringer Ingelheim International Gmbh Substituted benzylimidazoles useful for the treatment of inflammatory diseases
EP1976382B1 (en) * 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
EP1859690A1 (en) 2006-05-26 2007-11-28 Health Concern B.V. Premix for cholesterol lowering food products
WO2009043096A1 (en) * 2007-10-05 2009-04-09 Arana Therapeutics (Vic) Pty Ltd Improved method for mutagenesis
MY151004A (en) * 2007-11-29 2014-03-31 Boehringer Ingelheim Int Derivatives of 6,7-dihydro-5h-imidazo[1,2-?]imidazole-3-carboxylic acid amides
JP4621926B2 (ja) * 2008-07-24 2011-02-02 国立大学法人九州大学 酵素基質修飾ヌクレオシド三リン酸、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法
JP5146785B2 (ja) * 2008-07-24 2013-02-20 国立大学法人九州大学 酵素基質修飾ヌクレオシド三リン酸誘導体
AU2010226466A1 (en) * 2009-03-20 2011-10-20 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
WO2010141330A1 (en) 2009-06-02 2010-12-09 Boehringer Ingelheim International Gmbh DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES
EA019990B1 (ru) 2009-06-02 2014-07-30 Бёрингер Ингельхайм Интернациональ Гмбх ПРОИЗВОДНЫЕ АМИДОВ 6,7-ДИГИДРО-5H-ИМИДАЗО[1,2-a]ИМИДАЗОЛ-3-КАРБОНОВОЙ КИСЛОТЫ
JP5704481B2 (ja) * 2010-01-22 2015-04-22 国立大学法人九州大学 核酸検出用キット
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
WO2012142093A2 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
BR112013026345A2 (pt) 2011-04-13 2019-04-24 Merck Sharp & Dohe Corp. composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv
WO2012142075A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
US9416154B2 (en) 2011-07-13 2016-08-16 Merck Sharp & Dohme Corp. 5′-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013009737A1 (en) 2011-07-13 2013-01-17 Merck Sharp & Dohme Corp. 5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
WO2015167616A1 (en) * 2014-05-02 2015-11-05 Nitor Therapeutics Guanosine as an immunepotentiator mediated through toll receptors
WO2020081937A1 (en) * 2018-10-19 2020-04-23 The University Of Chicago Methods and compositions for treating negative-sense single-stranded rna virus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072574A (en) * 1976-07-30 1978-02-07 The Institute For Cancer Research System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents
US5512431A (en) * 1994-06-29 1996-04-30 Darwin Molecular Corporation Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing
EP0948256A4 (en) * 1996-10-28 2007-10-24 Univ Washington INDUCTION OF VIRAL MUTATIONS BY INTRODUCTION TO ERROR-CODED RIBONUCLEOSIDE ANALOGUES IN VIRAL RNA

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