JP2001525797A - ウイルスｒｎａへのミスコーディングリボヌクレオシドアナログの組込みによるウイルス変異の誘導 - Google Patents
ウイルスｒｎａへのミスコーディングリボヌクレオシドアナログの組込みによるウイルス変異の誘導Info
- Publication number
- JP2001525797A JP2001525797A JP52073998A JP52073998A JP2001525797A JP 2001525797 A JP2001525797 A JP 2001525797A JP 52073998 A JP52073998 A JP 52073998A JP 52073998 A JP52073998 A JP 52073998A JP 2001525797 A JP2001525797 A JP 2001525797A
- Authority
- JP
- Japan
- Prior art keywords
- virus
- rna
- analog
- cytidine
- uridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- C12N15/102—Mutagenizing nucleic acids
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- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
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- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2940496P | 1996-10-28 | 1996-10-28 | |
| US60/029,404 | 1996-10-28 | ||
| US4053597P | 1997-02-27 | 1997-02-27 | |
| US60/040,535 | 1997-02-27 | ||
| PCT/US1997/019670 WO1998018324A1 (en) | 1996-10-28 | 1997-10-27 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral rna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001525797A true JP2001525797A (ja) | 2001-12-11 |
| JP2001525797A5 JP2001525797A5 (https=) | 2005-06-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP52073998A Pending JP2001525797A (ja) | 1996-10-28 | 1997-10-27 | ウイルスｒｎａへのミスコーディングリボヌクレオシドアナログの組込みによるウイルス変異の誘導 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6063628A (https=) |
| EP (1) | EP0948256A4 (https=) |
| JP (1) | JP2001525797A (https=) |
| AU (1) | AU740916B2 (https=) |
| CA (1) | CA2269213A1 (https=) |
| NZ (2) | NZ507848A (https=) |
| WO (1) | WO1998018324A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010010966A1 (ja) * | 2008-07-24 | 2010-01-28 | 国立大学法人九州大学 | ヌクレオシド三リン酸誘導体、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法 |
| JP2011026324A (ja) * | 2008-07-24 | 2011-02-10 | Kyushu Univ | 酵素基質修飾ヌクレオシド三リン酸誘導体 |
| JP2011169878A (ja) * | 2010-01-22 | 2011-09-01 | Kyushu Univ | 核酸検出用キット |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887707B2 (en) * | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| NZ507848A (en) * | 1996-10-28 | 2005-01-28 | Univ Washington | Method of increasing the mutation rate of a virus in a non-human by administering an RNA nucleoside analogue to a virally infected cell |
| US6423695B1 (en) * | 1998-01-13 | 2002-07-23 | Ribapharm, Inc. | Cytokine related treatments of disease |
| EP1165127B1 (en) * | 1999-03-26 | 2008-12-31 | Walter Reed Army Institute of Research | Multivalent dengue virus vaccine |
| AU8038400A (en) * | 1999-09-09 | 2001-04-10 | Zymetx, Inc. | Method of treatment of influenza |
| WO2001030989A2 (en) * | 1999-10-27 | 2001-05-03 | Cytos Biotechnology Ag | Method for creating divergent populations of nucleic acid molecules and proteins |
| US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| KR20030005197A (ko) | 2000-02-18 | 2003-01-17 | 샤이어 바이오켐 인코포레이티드 | 뉴클레오시드유도체를 이용한 플라비바이러스 감염의 치료또는 예방 방법 |
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EP1736478B1 (en) * | 2000-05-26 | 2015-07-22 | IDENIX Pharmaceuticals, Inc. | Methods and compositions for treating flaviviruses and pestiviruses |
| WO2002032920A2 (en) | 2000-10-18 | 2002-04-25 | Pharmasset Limited | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
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| US4072574A (en) * | 1976-07-30 | 1978-02-07 | The Institute For Cancer Research | System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents |
| US5512431A (en) * | 1994-06-29 | 1996-04-30 | Darwin Molecular Corporation | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
| NZ507848A (en) * | 1996-10-28 | 2005-01-28 | Univ Washington | Method of increasing the mutation rate of a virus in a non-human by administering an RNA nucleoside analogue to a virally infected cell |
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1997
- 1997-10-27 NZ NZ507848A patent/NZ507848A/en not_active IP Right Cessation
- 1997-10-27 AU AU50959/98A patent/AU740916B2/en not_active Ceased
- 1997-10-27 US US08/958,065 patent/US6063628A/en not_active Expired - Lifetime
- 1997-10-27 JP JP52073998A patent/JP2001525797A/ja active Pending
- 1997-10-27 NZ NZ33500097A patent/NZ335000A/xx unknown
- 1997-10-27 WO PCT/US1997/019670 patent/WO1998018324A1/en not_active Ceased
- 1997-10-27 EP EP97913882A patent/EP0948256A4/en not_active Withdrawn
- 1997-10-27 CA CA 2269213 patent/CA2269213A1/en not_active Abandoned
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010010966A1 (ja) * | 2008-07-24 | 2010-01-28 | 国立大学法人九州大学 | ヌクレオシド三リン酸誘導体、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法 |
| JP2010047559A (ja) * | 2008-07-24 | 2010-03-04 | Kyushu Univ | 酵素基質修飾ヌクレオシド三リン酸、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法 |
| JP2011026324A (ja) * | 2008-07-24 | 2011-02-10 | Kyushu Univ | 酵素基質修飾ヌクレオシド三リン酸誘導体 |
| US8198418B2 (en) | 2008-07-24 | 2012-06-12 | Kyushu University, National University Corporation | Nucleoside triphosphate derivative, nucleic acid probe, multilabeled nucleic acid probe, method for production of multilabeled nucleic acid probe, and method for detection of target nucleic acid |
| JP2011169878A (ja) * | 2010-01-22 | 2011-09-01 | Kyushu Univ | 核酸検出用キット |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0948256A4 (en) | 2007-10-24 |
| AU5095998A (en) | 1998-05-22 |
| NZ335000A (en) | 2000-12-22 |
| AU740916B2 (en) | 2001-11-15 |
| US6063628A (en) | 2000-05-16 |
| WO1998018324A1 (en) | 1998-05-07 |
| EP0948256A1 (en) | 1999-10-13 |
| NZ507848A (en) | 2005-01-28 |
| CA2269213A1 (en) | 1998-05-07 |
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