CA2269213A1 - Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral rna - Google Patents
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral rna Download PDFInfo
- Publication number
- CA2269213A1 CA2269213A1 CA 2269213 CA2269213A CA2269213A1 CA 2269213 A1 CA2269213 A1 CA 2269213A1 CA 2269213 CA2269213 CA 2269213 CA 2269213 A CA2269213 A CA 2269213A CA 2269213 A1 CA2269213 A1 CA 2269213A1
- Authority
- CA
- Canada
- Prior art keywords
- analog
- rna
- virus
- cytidine
- ribonucleoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
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- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24261—Methods of inactivation or attenuation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2940496P | 1996-10-28 | 1996-10-28 | |
| US60/029,404 | 1996-10-28 | ||
| US4053597P | 1997-02-27 | 1997-02-27 | |
| US60/040,535 | 1997-02-27 | ||
| PCT/US1997/019670 WO1998018324A1 (en) | 1996-10-28 | 1997-10-27 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral rna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2269213A1 true CA2269213A1 (en) | 1998-05-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2269213 Abandoned CA2269213A1 (en) | 1996-10-28 | 1997-10-27 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral rna |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6063628A (https=) |
| EP (1) | EP0948256A4 (https=) |
| JP (1) | JP2001525797A (https=) |
| AU (1) | AU740916B2 (https=) |
| CA (1) | CA2269213A1 (https=) |
| NZ (2) | NZ335000A (https=) |
| WO (1) | WO1998018324A1 (https=) |
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| EP0948256A4 (en) * | 1996-10-28 | 2007-10-24 | Univ Washington | INDUCTION OF VIRAL MUTATIONS BY INTRODUCTION TO ERROR-CODED RIBONUCLEOSIDE ANALOGUES IN VIRAL RNA |
| US6887707B2 (en) * | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| US6423695B1 (en) * | 1998-01-13 | 2002-07-23 | Ribapharm, Inc. | Cytokine related treatments of disease |
| JP2002540168A (ja) * | 1999-03-26 | 2002-11-26 | ウォルター リード アーミー インスティテュート オブ リサーチ | 多価デングウイルスワクチン |
| WO2001017518A2 (en) * | 1999-09-09 | 2001-03-15 | Zymetx, Inc. | Method of treatment of influenza |
| AU7938900A (en) * | 1999-10-27 | 2001-05-08 | Cytos Biotechnology Ag | Method for creating divergent populations of nucleic acid molecules and proteins |
| US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| CN1427722A (zh) | 2000-02-18 | 2003-07-02 | 希拉生物化学股份有限公司 | 用核苷类似物治疗或预防黄病毒感染的方法 |
| MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| KR20090089922A (ko) * | 2000-10-18 | 2009-08-24 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| US8481712B2 (en) | 2001-01-22 | 2013-07-09 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| WO2002057425A2 (en) * | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| AU2002252183A1 (en) * | 2001-03-06 | 2002-09-19 | Biocryst Pharmaceuticals, Inc. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| EP1425022A4 (en) * | 2001-08-24 | 2009-04-29 | Koronis Pharmaceuticals Inc | MUTAGENIC NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF VIRAL DISEASE |
| JP2005536440A (ja) * | 2001-09-28 | 2005-12-02 | イデニクス（ケイマン）リミテツド | ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物 |
| US7049303B2 (en) * | 2001-11-07 | 2006-05-23 | Medical Research Council | Inhibition of viruses |
| US20040138170A1 (en) * | 2002-03-06 | 2004-07-15 | Montgomery John A. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| NZ537662A (en) * | 2002-06-28 | 2007-10-26 | Idenix Cayman Ltd | 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| PL374781A1 (en) * | 2002-06-28 | 2005-10-31 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| WO2004011647A1 (en) | 2002-07-26 | 2004-02-05 | Chiron Corporation | Modified small interfering rna molecules and methods of use |
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|---|---|---|---|---|
| US4072574A (en) * | 1976-07-30 | 1978-02-07 | The Institute For Cancer Research | System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents |
| US5512431A (en) * | 1994-06-29 | 1996-04-30 | Darwin Molecular Corporation | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
| EP0948256A4 (en) * | 1996-10-28 | 2007-10-24 | Univ Washington | INDUCTION OF VIRAL MUTATIONS BY INTRODUCTION TO ERROR-CODED RIBONUCLEOSIDE ANALOGUES IN VIRAL RNA |
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- 1997-10-27 WO PCT/US1997/019670 patent/WO1998018324A1/en not_active Ceased
- 1997-10-27 JP JP52073998A patent/JP2001525797A/ja active Pending
- 1997-10-27 CA CA 2269213 patent/CA2269213A1/en not_active Abandoned
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- 1997-10-27 US US08/958,065 patent/US6063628A/en not_active Expired - Lifetime
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| EP0948256A1 (en) | 1999-10-13 |
| AU740916B2 (en) | 2001-11-15 |
| JP2001525797A (ja) | 2001-12-11 |
| EP0948256A4 (en) | 2007-10-24 |
| NZ507848A (en) | 2005-01-28 |
| WO1998018324A1 (en) | 1998-05-07 |
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