JP2001525797A5 - - Google Patents

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Publication number
JP2001525797A5
JP2001525797A5 JP1998520739A JP52073998A JP2001525797A5 JP 2001525797 A5 JP2001525797 A5 JP 2001525797A5 JP 1998520739 A JP1998520739 A JP 1998520739A JP 52073998 A JP52073998 A JP 52073998A JP 2001525797 A5 JP2001525797 A5 JP 2001525797A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1998520739A
Other languages
English (en)
Japanese (ja)
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JP2001525797A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/019670 external-priority patent/WO1998018324A1/en
Publication of JP2001525797A publication Critical patent/JP2001525797A/ja
Publication of JP2001525797A5 publication Critical patent/JP2001525797A5/ja
Pending legal-status Critical Current

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JP52073998A 1996-10-28 1997-10-27 ウイルスrnaへのミスコーディングリボヌクレオシドアナログの組込みによるウイルス変異の誘導 Pending JP2001525797A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2940496P 1996-10-28 1996-10-28
US60/029,404 1996-10-28
US4053597P 1997-02-27 1997-02-27
US60/040,535 1997-02-27
PCT/US1997/019670 WO1998018324A1 (en) 1996-10-28 1997-10-27 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral rna

Publications (2)

Publication Number Publication Date
JP2001525797A JP2001525797A (ja) 2001-12-11
JP2001525797A5 true JP2001525797A5 (enExample) 2005-06-16

Family

ID=26704916

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52073998A Pending JP2001525797A (ja) 1996-10-28 1997-10-27 ウイルスrnaへのミスコーディングリボヌクレオシドアナログの組込みによるウイルス変異の誘導

Country Status (7)

Country Link
US (1) US6063628A (enExample)
EP (1) EP0948256A4 (enExample)
JP (1) JP2001525797A (enExample)
AU (1) AU740916B2 (enExample)
CA (1) CA2269213A1 (enExample)
NZ (2) NZ507848A (enExample)
WO (1) WO1998018324A1 (enExample)

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AU740916B2 (en) * 1996-10-28 2001-11-15 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
US6887707B2 (en) * 1996-10-28 2005-05-03 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
US6423695B1 (en) * 1998-01-13 2002-07-23 Ribapharm, Inc. Cytokine related treatments of disease
WO2000057907A2 (en) * 1999-03-26 2000-10-05 Walter Reed Army Institute Of Research Multivalent dengue virus vaccine
AU8038400A (en) * 1999-09-09 2001-04-10 Zymetx, Inc. Method of treatment of influenza
AU7938900A (en) * 1999-10-27 2001-05-08 Cytos Biotechnology Ag Method for creating divergent populations of nucleic acid molecules and proteins
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
KR20030005197A (ko) 2000-02-18 2003-01-17 샤이어 바이오켐 인코포레이티드 뉴클레오시드유도체를 이용한 플라비바이러스 감염의 치료또는 예방 방법
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) * 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
KR20090089922A (ko) * 2000-10-18 2009-08-24 파마셋 인코포레이티드 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드
SI1355916T1 (sl) * 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
US8481712B2 (en) 2001-01-22 2013-07-09 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
WO2002069903A2 (en) * 2001-03-06 2002-09-12 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
AU2002326736B2 (en) * 2001-08-24 2007-08-02 Koronis Pharmaceuticals, Inc. Mutagenic nucleoside analogs for the treatment of viral disease
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス(ケイマン)リミテツド 4’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
US7049303B2 (en) * 2001-11-07 2006-05-23 Medical Research Council Inhibition of viruses
US20040138170A1 (en) * 2002-03-06 2004-07-15 Montgomery John A. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
CN1678326A (zh) * 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'-c-甲基-3'-o-l-缬氨酸酯核糖呋喃基胞苷
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
DE60326961D1 (de) 2002-07-26 2009-05-14 Novartis Vaccines & Diagnostic Modifizierte kleine irns moleküle und methoden zu deren anwendung
JP2006519753A (ja) * 2002-11-15 2006-08-31 イデニクス(ケイマン)リミテツド 2’−分枝ヌクレオシドおよびフラビウイルス科ウイルス突然変異
MXPA05006230A (es) * 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
CA2529311A1 (en) * 2003-03-28 2004-10-07 Pharmasset, Inc. Compounds for the treatment of flaviviridae infections
WO2005018330A1 (en) * 2003-08-18 2005-03-03 Pharmasset, Inc. Dosing regimen for flaviviridae therapy
US20070042352A1 (en) * 2003-08-18 2007-02-22 Dawn Patricia Wooley Retroviral vector and cell-based assay for measuring the mutations rate of retroviruses employing same
JP2008532950A (ja) * 2005-03-08 2008-08-21 バイオタ サイエンティフィック マネージメント ピーティーワイ リミテッド 治療薬としての二環式ヌクレオシドおよび二環式ヌクレオチド
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
US7572921B2 (en) * 2005-04-05 2009-08-11 Boehringer Ingelheim International Gmbh Substituted benzylimidazoles useful for the treatment of inflammatory diseases
EP1976382B1 (en) * 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
EP1859690A1 (en) 2006-05-26 2007-11-28 Health Concern B.V. Premix for cholesterol lowering food products
WO2009043096A1 (en) * 2007-10-05 2009-04-09 Arana Therapeutics (Vic) Pty Ltd Improved method for mutagenesis
BRPI0819831A2 (pt) * 2007-11-29 2019-09-24 Boehringer Ingelheim Int derivados de amidas de áciodo 6,7-diidro-5h-imidazo[1,2-a]imidazol-3-carboxílico
JP4621926B2 (ja) * 2008-07-24 2011-02-02 国立大学法人九州大学 酵素基質修飾ヌクレオシド三リン酸、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法
JP5146785B2 (ja) * 2008-07-24 2013-02-20 国立大学法人九州大学 酵素基質修飾ヌクレオシド三リン酸誘導体
WO2010108140A1 (en) * 2009-03-20 2010-09-23 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
BRPI1012581A2 (pt) 2009-06-02 2016-03-29 Boehringer Ingelheim Int derivados de amidas de ácido 6, 7-di-hidro-5h-imidazol[1,2-a]imidazol-3-carboxílico
EP2445914B1 (en) 2009-06-02 2015-07-22 Boehringer Ingelheim International GmbH DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES
JP5704481B2 (ja) * 2010-01-22 2015-04-22 国立大学法人九州大学 核酸検出用キット
CN105061534A (zh) 2010-09-22 2015-11-18 艾丽奥斯生物制药有限公司 取代的核苷酸类似物
EP2697242B1 (en) 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
EP2696679B1 (en) 2011-04-13 2017-08-02 Merck Sharp & Dohme Corp. 2'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
PH12013502141A1 (en) 2011-04-13 2014-01-06 Merck Sharp & Dohme 2'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
US9408863B2 (en) 2011-07-13 2016-08-09 Merck Sharp & Dohme Corp. 5′-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
WO2013009735A1 (en) 2011-07-13 2013-01-17 Merck Sharp & Dohme Corp. 5'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
HK1203075A1 (en) 2011-12-22 2015-10-16 艾丽奥斯生物制药有限公司 Substituted phosphorothioate nucleotide analogs
EP2828277A1 (en) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
WO2015167616A1 (en) * 2014-05-02 2015-11-05 Nitor Therapeutics Guanosine as an immunepotentiator mediated through toll receptors
US12227769B2 (en) 2018-10-19 2025-02-18 The University Of Chicago Methods and compositions for treating negative-sense single-stranded RNA virus

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
US4072574A (en) * 1976-07-30 1978-02-07 The Institute For Cancer Research System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents
US5512431A (en) * 1994-06-29 1996-04-30 Darwin Molecular Corporation Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing
AU740916B2 (en) * 1996-10-28 2001-11-15 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA

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