AU740916B2 - Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA - Google Patents
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA Download PDFInfo
- Publication number
- AU740916B2 AU740916B2 AU50959/98A AU5095998A AU740916B2 AU 740916 B2 AU740916 B2 AU 740916B2 AU 50959/98 A AU50959/98 A AU 50959/98A AU 5095998 A AU5095998 A AU 5095998A AU 740916 B2 AU740916 B2 AU 740916B2
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- Australia
- Prior art keywords
- analog
- ribonucleoside
- virus
- rna
- cytidine
- Prior art date
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2940496P | 1996-10-28 | 1996-10-28 | |
| US60/029404 | 1996-10-28 | ||
| US4053597P | 1997-02-27 | 1997-02-27 | |
| US60/040535 | 1997-02-27 | ||
| PCT/US1997/019670 WO1998018324A1 (en) | 1996-10-28 | 1997-10-27 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral rna |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU5095998A AU5095998A (en) | 1998-05-22 |
| AU740916B2 true AU740916B2 (en) | 2001-11-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU50959/98A Ceased AU740916B2 (en) | 1996-10-28 | 1997-10-27 | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6063628A (enExample) |
| EP (1) | EP0948256A4 (enExample) |
| JP (1) | JP2001525797A (enExample) |
| AU (1) | AU740916B2 (enExample) |
| CA (1) | CA2269213A1 (enExample) |
| NZ (2) | NZ335000A (enExample) |
| WO (1) | WO1998018324A1 (enExample) |
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| US20040006002A1 (en) * | 2001-09-28 | 2004-01-08 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
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| MXPA04012802A (es) * | 2002-06-28 | 2005-04-19 | Idenix Cayman Ltd | Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae. |
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| WO2004046331A2 (en) * | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
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| CN1980678A (zh) * | 2003-03-28 | 2007-06-13 | 法莫赛特股份有限公司 | 治疗黄病毒感染的化合物 |
| WO2005019424A2 (en) * | 2003-08-18 | 2005-03-03 | Wright State University | Retroviral vector and cell-based assay for measuring the mutation rate of retroviruses employing same |
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| JP5254033B2 (ja) * | 2005-12-23 | 2013-08-07 | イデニク プハルマセウティカルス，インコーポレイテッド | 分岐型ヌクレオシドを調製するための合成中間体の製造方法 |
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| PL2225238T3 (pl) * | 2007-11-29 | 2015-03-31 | Boehringer Ingelheim Int | Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego |
| JP5146785B2 (ja) * | 2008-07-24 | 2013-02-20 | 国立大学法人九州大学 | 酵素基質修飾ヌクレオシド三リン酸誘導体 |
| JP4621926B2 (ja) * | 2008-07-24 | 2011-02-02 | 国立大学法人九州大学 | 酵素基質修飾ヌクレオシド三リン酸、核酸プローブ、マルチラベル化核酸プローブ、マルチラベル化核酸プローブの製造方法および標的核酸の検出方法 |
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| JP5704481B2 (ja) * | 2010-01-22 | 2015-04-22 | 国立大学法人九州大学 | 核酸検出用キット |
| EA025341B1 (ru) | 2010-09-22 | 2016-12-30 | Алиос Биофарма, Инк. | Замещенные аналоги нуклеотидов |
| WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| EP2696679B1 (en) | 2011-04-13 | 2017-08-02 | Merck Sharp & Dohme Corp. | 2'-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| EA201391519A1 (ru) | 2011-04-13 | 2014-03-31 | Мерк Шарп И Доум Корп. | 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний |
| WO2013009737A1 (en) | 2011-07-13 | 2013-01-17 | Merck Sharp & Dohme Corp. | 5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases |
| EP2731434A4 (en) | 2011-07-13 | 2014-12-31 | Merck Sharp & Dohme | 5'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES |
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| US8916538B2 (en) | 2012-03-21 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| NZ630805A (en) | 2012-03-22 | 2016-01-29 | Alios Biopharma Inc | Pharmaceutical combinations comprising a thionucleotide analog |
| EP3136858A4 (en) * | 2014-05-02 | 2018-01-03 | Nitor Therapeutics | Guanosine as an immunepotentiator mediated through toll receptors |
| WO2020081937A1 (en) * | 2018-10-19 | 2020-04-23 | The University Of Chicago | Methods and compositions for treating negative-sense single-stranded rna virus |
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| US5512431A (en) * | 1994-06-29 | 1996-04-30 | Darwin Molecular Corporation | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
| US6063628A (en) * | 1996-10-28 | 2000-05-16 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
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| US4072574A (en) * | 1976-07-30 | 1978-02-07 | The Institute For Cancer Research | System for in vitro assay for mutagenicity and/or carcinogenicity of chemicals or other exogenous agents |
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1997
- 1997-10-27 EP EP97913882A patent/EP0948256A4/en not_active Withdrawn
- 1997-10-27 NZ NZ33500097A patent/NZ335000A/xx unknown
- 1997-10-27 US US08/958,065 patent/US6063628A/en not_active Expired - Lifetime
- 1997-10-27 WO PCT/US1997/019670 patent/WO1998018324A1/en not_active Ceased
- 1997-10-27 JP JP52073998A patent/JP2001525797A/ja active Pending
- 1997-10-27 NZ NZ507848A patent/NZ507848A/en not_active IP Right Cessation
- 1997-10-27 CA CA 2269213 patent/CA2269213A1/en not_active Abandoned
- 1997-10-27 AU AU50959/98A patent/AU740916B2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512431A (en) * | 1994-06-29 | 1996-04-30 | Darwin Molecular Corporation | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
| US6132776A (en) * | 1994-06-29 | 2000-10-17 | University Of Washington | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
| US6063628A (en) * | 1996-10-28 | 2000-05-16 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998018324A1 (en) | 1998-05-07 |
| CA2269213A1 (en) | 1998-05-07 |
| NZ335000A (en) | 2000-12-22 |
| US6063628A (en) | 2000-05-16 |
| JP2001525797A (ja) | 2001-12-11 |
| EP0948256A4 (en) | 2007-10-24 |
| EP0948256A1 (en) | 1999-10-13 |
| NZ507848A (en) | 2005-01-28 |
| AU5095998A (en) | 1998-05-22 |
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