JP2001518304A - アンギオスタチン成分を含む融合タンパク質及び抗腫瘍療法におけるその使用 - Google Patents
アンギオスタチン成分を含む融合タンパク質及び抗腫瘍療法におけるその使用Info
- Publication number
- JP2001518304A JP2001518304A JP2000513958A JP2000513958A JP2001518304A JP 2001518304 A JP2001518304 A JP 2001518304A JP 2000513958 A JP2000513958 A JP 2000513958A JP 2000513958 A JP2000513958 A JP 2000513958A JP 2001518304 A JP2001518304 A JP 2001518304A
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- seq
- protein
- multifunctional protein
- angiostatin
- interferon
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6060997P | 1997-10-01 | 1997-10-01 | |
| US60/060,609 | 1997-10-01 | ||
| PCT/US1998/020464 WO1999016889A1 (en) | 1997-10-01 | 1998-09-30 | Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001518304A true JP2001518304A (ja) | 2001-10-16 |
| JP2001518304A5 JP2001518304A5 (https=) | 2006-01-05 |
Family
ID=22030604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000513958A Withdrawn JP2001518304A (ja) | 1997-10-01 | 1998-09-30 | アンギオスタチン成分を含む融合タンパク質及び抗腫瘍療法におけるその使用 |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1019515A1 (https=) |
| JP (1) | JP2001518304A (https=) |
| AU (1) | AU9673998A (https=) |
| CA (1) | CA2303401A1 (https=) |
| WO (1) | WO1999016889A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2313251A1 (en) * | 1997-12-08 | 1999-06-17 | Beth Israel Deaconess Medical Center | Mutants of endostatin, "em 1" having anti-angiogenic activity and methods of use thereof |
| US6797488B1 (en) | 1997-12-08 | 2004-09-28 | Beth Israel Deaconess Medical Center | Methods of producing anti-angiogenic proteins |
| WO1999061464A1 (en) * | 1998-05-28 | 1999-12-02 | Korea Green Cross Corporation | Process of purifying angiogenesis inhibitors |
| US6500431B1 (en) * | 1998-07-13 | 2002-12-31 | University Of Southern California | Inhibitors of angiogenesis and tumor growth |
| AU3755900A (en) * | 1999-03-15 | 2000-10-04 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| US6943153B1 (en) | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| AU2004240199B2 (en) * | 1999-04-30 | 2007-05-17 | Novartis Vaccines And Diagnostics S.R.L. | Conserved Neisserial antigens |
| CA2400403C (en) * | 2000-02-18 | 2011-07-19 | New York Medical College | 1-nitroacridine/tumor inhibitor compositions |
| AU8591901A (en) | 2000-09-05 | 2002-03-22 | Karolinska Innovations Ab | Materials and methods relating to endothelial cell growth inhibitors |
| AU2002239366A1 (en) | 2000-11-28 | 2002-06-11 | Geetha Kassam | Anti-angiogenic polypeptides |
| US20030086903A1 (en) | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
| US20030158112A1 (en) | 2002-02-15 | 2003-08-21 | Johns Hopkins University School Of Medicine | Selective induction of apoptosis to treat ocular disease |
| CN100543036C (zh) * | 2002-05-06 | 2009-09-23 | 得克萨斯州大学系统董事会 | 递送治疗或诊断试剂的导向蛋白质 |
| JP4511108B2 (ja) * | 2002-05-31 | 2010-07-28 | オンコリクス インコーポレイテッド | ヒトプロラクチン拮抗剤−血管新生阻害剤融合蛋白質 |
| EP1581164A4 (en) | 2002-12-13 | 2008-03-12 | Mediomics Llc | COMPOSITIONS AND METHODS FOR INHIBITING GROWTH OF TUMORS AND METASTASES |
| WO2008124086A2 (en) * | 2007-04-05 | 2008-10-16 | President And Fellows Of Harvard College | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
| EP2628748A1 (en) | 2012-02-14 | 2013-08-21 | Szilak Laboratories Bioinformatics & Molecule-Design Ltd. | Angiostatin chimeras and uses thereof |
| TWI698240B (zh) | 2012-05-15 | 2020-07-11 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| EP2995626B1 (en) * | 2013-05-06 | 2018-07-11 | China Pharmaceutical University | Bifunctional fusion proteins to inhibit angiogenesis in tumour microenvironment and to activate adaptive immune responses and the genes and uses thereof |
| EP3800191B1 (en) | 2014-03-17 | 2025-08-20 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
| WO2015168474A1 (en) | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
| US11021519B2 (en) | 2015-03-02 | 2021-06-01 | Adverum Biotechnologies, Inc. | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
| CN114058636A (zh) * | 2021-11-16 | 2022-02-18 | 大连润生康泰医学检验实验室有限公司 | 一种转甲状腺素蛋白基因的克隆、表达与纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8315980D0 (en) * | 1983-06-10 | 1983-07-13 | Biogen Nv | Producing hybrid dna sequences |
| AU615919B2 (en) * | 1987-07-01 | 1991-10-17 | Beecham Group Plc | Hybrid plasminogen activators |
| ATE240740T1 (de) * | 1991-03-15 | 2003-06-15 | Amgen Inc | Pegylation von polypeptiden |
| ATE355379T1 (de) * | 1994-04-26 | 2006-03-15 | Childrens Medical Center | Angiostatin und verfahren zu seiner nutzung zur vermeidung der angiogenese |
| NZ307044A (en) * | 1995-04-26 | 2002-03-01 | Childrens Medical Center | Angiostatin fragments with antiangiogenic activity |
| US5824299A (en) * | 1995-06-22 | 1998-10-20 | President & Fellows Of Harvard College | Modulation of endothelial cell proliferation with IP-10 |
| JP3840262B2 (ja) * | 1995-10-23 | 2006-11-01 | ザ チルドレンズ メディカル センター コーポレイション | 治療用の抗血管新生組成物および方法 |
| US5837680A (en) * | 1996-02-16 | 1998-11-17 | Children's Medical Center Corporation | Pharmaceutical compositions comprising troponin subunits, fragments and analogs thereof and methods of their use to inhibit angiogenesis |
| AU761027B2 (en) * | 1998-08-25 | 2003-05-29 | Merck Patent Gmbh | Expression and export of angiostatin and endostatin as immunofusis |
-
1998
- 1998-09-30 CA CA002303401A patent/CA2303401A1/en not_active Abandoned
- 1998-09-30 AU AU96739/98A patent/AU9673998A/en not_active Abandoned
- 1998-09-30 JP JP2000513958A patent/JP2001518304A/ja not_active Withdrawn
- 1998-09-30 WO PCT/US1998/020464 patent/WO1999016889A1/en not_active Ceased
- 1998-09-30 EP EP98950775A patent/EP1019515A1/en not_active Withdrawn
- 1998-09-30 EP EP05019787A patent/EP1705248A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999016889A1 (en) | 1999-04-08 |
| CA2303401A1 (en) | 1999-04-08 |
| EP1705248A1 (en) | 2006-09-27 |
| EP1019515A1 (en) | 2000-07-19 |
| AU9673998A (en) | 1999-04-23 |
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