JP2001517081A - 機能性タンパク質の産生：剪断応力と重力との釣合い - Google Patents

機能性タンパク質の産生：剪断応力と重力との釣合い

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Publication number
JP2001517081A
JP2001517081A JP54098398A JP54098398A JP2001517081A JP 2001517081 A JP2001517081 A JP 2001517081A JP 54098398 A JP54098398 A JP 54098398A JP 54098398 A JP54098398 A JP 54098398A JP 2001517081 A JP2001517081 A JP 2001517081A
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JP
Japan
Prior art keywords
cells
shear stress
culture
rotating wall
cell
Prior art date
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Ceased
Application number
JP54098398A
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English (en)
Japanese (ja)
Inventor
ジョン グッドウィン，トーマス
グラント ハモンド，ティモシー
ハワード ケイセン，ジェイムズ
Original Assignee
ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンティッド バイ ザ アドミニストレイター オブ ザ ナショナル アエロノーティクス アンド スペイス アドミニストレイション（ナサ）
アドミニストレイターズ オブ ザ トゥレイン エデュケイション ファンド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンティッド バイ ザ アドミニストレイター オブ ザ ナショナル アエロノーティクス アンド スペイス アドミニストレイション（ナサ）, アドミニストレイターズ オブ ザ トゥレイン エデュケイション ファンド filed Critical ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンティッド バイ ザ アドミニストレイター オブ ザ ナショナル アエロノーティクス アンド スペイス アドミニストレイション（ナサ）
Publication of JP2001517081A publication Critical patent/JP2001517081A/ja
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP54098398A 1997-04-08 1998-04-07 機能性タンパク質の産生：剪断応力と重力との釣合い Ceased JP2001517081A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4320597P 1997-04-08 1997-04-08
US60/043,205 1997-04-08
PCT/US1998/006826 WO1998045468A1 (en) 1997-04-08 1998-04-07 Production of functional proteins: balance of shear stress and gravity

Publications (1)

Publication Number Publication Date
JP2001517081A true JP2001517081A (ja) 2001-10-02

Family

ID=21926026

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54098398A Ceased JP2001517081A (ja) 1997-04-08 1998-04-07 機能性タンパク質の産生：剪断応力と重力との釣合い

Country Status (7)

Country Link
EP (1) EP0972069A1 (pt)
JP (1) JP2001517081A (pt)
AU (1) AU6953498A (pt)
BR (1) BR9808510A (pt)
CA (1) CA2286349A1 (pt)
IL (1) IL132264A0 (pt)
WO (1) WO1998045468A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010524495A (ja) * 2007-04-28 2010-07-22 ヒョンジン ヤン， 粉末状の足場を用いた細胞間の信号調節による細胞培養方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1141266A4 (en) * 1998-12-24 2002-09-25 Florence Medical Ltd EXPRESSION VECTORS, WHICH MULTIPLE, SHEAR RESPECTING ELEMENTS (SSRE) INCLUDE AND A GENE AND METHOD FOR THEIR APPLICATION
AU2005270968A1 (en) * 2004-08-04 2006-02-16 Merck Serono Sa Capsules containing transfected cells, method for preparing the same and uses thereof for immunization and vaccination
EP2454373B1 (en) * 2009-07-15 2014-11-19 AbbVie Inc. Enhancement of cellular production through mechanotransduction

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988623A (en) * 1988-06-30 1991-01-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Rotating bio-reactor cell culture apparatus
WO1991011535A1 (en) * 1990-01-30 1991-08-08 Childrens Hospital Of Los Angeles Inhibition of transcription by double-stranded oligonucleotides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010524495A (ja) * 2007-04-28 2010-07-22 ヒョンジン ヤン， 粉末状の足場を用いた細胞間の信号調節による細胞培養方法

Also Published As

Publication number Publication date
AU6953498A (en) 1998-10-30
BR9808510A (pt) 2000-05-23
CA2286349A1 (en) 1998-10-15
IL132264A0 (en) 2001-03-19
WO1998045468A1 (en) 1998-10-15
EP0972069A1 (en) 2000-01-19

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